ABIN966363

antibody from antibodies-online

Targeting: NFKBIA IkappaBalpha, IKBA, MAD-3, NFKBI

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN966363

Provider

antibodies-online

Product name

anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) (pSer32), (pSer36) antibody

Antibody type

Polyclonal

Antigen

The antiserum was produced against synthesized phosphopeptide derived from human IB- around the phosphorylation site of serine 32/36 (H-D-SP-G-L-D-SP -M-K).

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

pSer32,pSer36

Vial size

100 μg

Concentration

100ug/100ul.

Storage

-20°C

References

Submitted references

DNA damage-induced activation of p53 by the checkpoint kinase Chk2.

Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, Yoshida H, Liu D, Elledge SJ, Mak TW
Science (New York, N.Y.) 2000 Mar 10;287(5459):1824-7

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A role for ATR in the DNA damage-induced phosphorylation of p53.

Tibbetts RS, Brumbaugh KM, Williams JM, Sarkaria JN, Cliby WA, Shieh SY, Taya Y, Prives C, Abraham RT
Genes & development 1999 Jan 15;13(2):152-7

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DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization.

Shieh SY, Taya Y, Prives C
The EMBO journal 1999 Apr 1;18(7):1815-23

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53.

Honda R, Tanaka H, Yasuda H
FEBS letters 1997 Dec 22;420(1):25-7