MAP2K2

gene product
MEK2, PRKMK2
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
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1246 antibodies from 44 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
391 antibodies
Novus Biologicals
95 antibodies
Invitrogen Antibodies
10 antibodies
GeneTex
20 antibodies
Boster Biological Technology
4 antibodies
Cell Signaling Technology, Inc
12 antibodies
Acris Antibodies GmbH
30 antibodies
Biorbyt
110 antibodies
OriGene
55 antibodies
Abnova Corporation
13 antibodies
NovoPro Bioscience Inc.
10 antibodies
Affinity Biosciences
4 antibodies
Aviva Systems Biology
8 antibodies
Abgent
9 antibodies
Arigo
2 antibodies
Atlas Antibodies
1 antibody
Signalway Antibody LLC
2 antibodies
LifeSpan BioSciences, Inc.
170 antibodies