Tissue expression
Cell line expression

MAP2K2

gene product
MEK2, PRKMK2 
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
More gene data

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1482 antibodies from 49 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
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2 antibodies
Arigo
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Atlas Antibodies
1 antibody
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2 antibodies
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R&D Systems
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Abbkine Scientific Co.Ltd.
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Creative Diagnostics
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EMD Millipore
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SignalChem
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United States Biological
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Miltenyi Biotec
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Leading Biology
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Abbiotec
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1 antibody
GenWay
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Everest Biotech
1 antibody
RayBiotech, Inc.
1 antibody
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Rockland Immunochemicals, Inc.
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