2974
antibody from Cell Signaling Technology, Inc
Targeting: MTOR
FLJ44809, FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 2974 - Provider product page
- Provider
- Cell Signaling Technology, Inc
- Proper citation
- Cell Signaling Technology Cat#2974, RRID:AB_2262884
- Product name
- Phospho-mTOR (Ser2481) Antibody
- Antibody type
- Polyclonal
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Rabbit
- Storage
- -20°C
Submitted references mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.
Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2.
FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions.
Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, Harper JW, Wei W
Molecular cell 2011 Oct 21;44(2):290-303
Molecular cell 2011 Oct 21;44(2):290-303
Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2.
Hasumi Y, Baba M, Ajima R, Hasumi H, Valera VA, Klein ME, Haines DC, Merino MJ, Hong SB, Yamaguchi TP, Schmidt LS, Linehan WM
Proceedings of the National Academy of Sciences of the United States of America 2009 Nov 3;106(44):18722-7
Proceedings of the National Academy of Sciences of the United States of America 2009 Nov 3;106(44):18722-7
FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions.
Peterson RT, Beal PA, Comb MJ, Schreiber SL
The Journal of biological chemistry 2000 Mar 10;275(10):7416-23
The Journal of biological chemistry 2000 Mar 10;275(10):7416-23
No comments: Submit comment
No validations: Submit validation data