MTOR

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]

Description

mechanistic target of rapamycin (serine/threonine kinase)

Protein family

Cancer-related genes, Enzymes, FDA approved drug targets, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

1:p36.22 (11106535 - 11262507)

Ensembl ID

ENSG00000198793  (ver. 84.38)

Orthologs

Mouse Mtor: ENSMUSG00000028991

UniProt

P42345

neXtProt

NX_P42345

Human splice variants
Mouse splice variants