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Learn20657-1-AP
antibody from Proteintech Group
Targeting: MTOR
FLJ44809, FRAP, FRAP1, FRAP2, RAFT1, RAPT1
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [194]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 20657-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20657-1-AP, RRID:AB_10734440
- Product name
- mTOR antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated mTOR antibody (Cat. #20657-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references BMSC-Exosomes attenuate ALP dysfunction by restoring lysosomal function via the mTOR/TFEB Axis to reduce cerebral ischemia-reperfusion injury.
SQSTM1/p62 is a prognostic molecular marker and potential therapeutic target for pancreatic neuroendocrine tumours.
Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin.
Nanoparticles for inducing Gaucher disease-like damage in cancer cells.
Corynoxine triggers cell death via activating PP2A and regulating AKT-mTOR/GSK3β axes in NSCLC.
Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression.
Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis.
Autophagy and LC3-associated phagocytosis contribute negatively to the killing capability of THP-1-derived macrophages against Candida albicans at the mid-stage.
Novel soybean polypeptide dglycin alleviates atherosclerosis in apolipoprotein E-deficient mice.
AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer.
A novel organic arsenic derivative MZ2 remodels metabolism and triggers mtROS-mediated apoptosis in acute myeloid leukemia.
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
PARP1-catalyzed PARylation of YY1 mediates endoplasmic reticulum stress in granulosa cells to determine primordial follicle activation.
DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma.
Dezocine inhibits cell proliferation, migration, and invasion by targeting CRABP2 in ovarian cancer.
Bifidobacterium infantis Promotes Foxp3 Expression in Colon Cells via PD-L1-Mediated Inhibition of the PI3K-Akt-mTOR Signaling Pathway.
Sophocarpine inhibits tumor progression by antagonizing the PI3K/AKT/mTOR signaling pathway in castration-resistant prostate cancer.
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Cell marathon: long-distance cell migration and metastasis-associated gene analysis using a folding paper system.
VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.
Dietary N-carbamylglutamate or L-arginine improves fetal intestinal amino acid profiles during intrauterine growth restriction in undernourished ewes.
Complement C1q binding protein regulates T cells' mitochondrial fitness to affect their survival, proliferation, and anti-tumor immune function.
FAIM regulates autophagy through glutaminolysis in lung adenocarcinoma.
Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome.
COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR.
Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway.
Polyphyllin II induced apoptosis of NSCLC cells by inhibiting autophagy through the mTOR pathway.
L-Theanine Regulates the Abundance of Amino Acid Transporters in Mice Duodenum and Jejunum via the mTOR Signaling Pathway.
The surface morphology of Platycodon grandiflorus polysaccharide and its anti-apoptotic effect by targeting autophagy.
ORP5 promotes tumor metastasis via stabilizing c-Met in renal cell carcinoma.
Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.
Increased Nuclear Transporter Importin 7 Contributes to the Tumor Growth and Correlates With CD8 T Cell Infiltration in Cervical Cancer.
Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells.
Qingjie Fuzheng Granule Inhibits EMT and Induces Autophagy in Colorectal Cancer via mTOR Signaling Pathways.
OM-MSCs Alleviate the Golgi Apparatus Stress Response following Cerebral Ischemia/Reperfusion Injury via the PEDF-PI3K/Akt/mTOR Signaling Pathway.
Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses.
Autophagy Contributes to the Rapamycin-Induced Improvement of Otitis Media.
Long-Term Administration of Triterpenoids From Ganoderma lucidum Mitigates Age-Associated Brain Physiological Decline via Regulating Sphingolipid Metabolism and Enhancing Autophagy in Mice.
Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis.
The New PI3K/mTOR Inhibitor GNE-477 Inhibits the Malignant Behavior of Human Glioblastoma Cells.
Rapamycin Modulates the Proinflammatory Memory-Like Response of Microglia Induced by BAFF.
Nano chitosan-zinc complex improves the growth performance and antioxidant capacity of the small intestine in weaned piglets.
Protective effect of carvacrol on liver injury in type 2 diabetic db/db mice.
Knockdown of CLN5 inhibits the tumorigenic properties of glioblastoma cells via the Akt/mTOR signaling pathway.
Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.
Effects of photoperiod on morphology and function in testis and epididymis of Cricetulus barabensis.
FoxP3-miR-150-5p/3p suppresses ovarian tumorigenesis via an IGF1R/IRS1 pathway feedback loop.
PIWIL2 interacting with IKK to regulate autophagy and apoptosis in esophageal squamous cell carcinoma.
Autophagy and post-ischemic conditioning in retinal ischemia.
LncRNA 0003250 accelerates heart autophagy and binds to miR-17-5p as a competitive endogenous RNA in chicken induced by selenium deficiency.
Elevated ZBTB7A expression in the tumor invasive front correlates with more tumor budding formation in gastric adenocarcinoma.
Sublethal irradiation promotes the metastatic potential of hepatocellular carcinoma cells.
Resveratrol attenuates cigarette smoke induced endothelial apoptosis by activating Notch1 signaling mediated autophagy.
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
Long non-coding RNA IGF2-AS represses breast cancer tumorigenesis by epigenetically regulating IGF2.
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.
Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway.
Esterase D stabilizes FKBP25 to suppress mTORC1.
High intensity interval training ameliorates cognitive impairment in T2DM mice possibly by improving PI3K/Akt/mTOR Signaling-regulated autophagy in the hippocampus.
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression.
Tripterygium glycoside suppresses epithelial‑to‑mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway.
Cyanidin-3-glucoside suppresses the progression of lung adenocarcinoma by downregulating TP53I3 and inhibiting PI3K/AKT/mTOR pathway.
1,3-dichloro-2-propanol induced lipid accumulation by blocking autophagy flux in HepG2 cells.
The Evaluation of the Antioxidant and Intestinal Protective Effects of Baicalin-Copper in Deoxynivalenol-Challenged Piglets.
Preventive Electroacupuncture Ameliorates D-Galactose-Induced Alzheimer's Disease-Like Pathology and Memory Deficits Probably via Inhibition of GSK3β/mTOR Signaling Pathway.
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6.
The knockdown of the sepiapterin reductase gene suppresses the proliferation of breast cancer by inducing ROS-mediated apoptosis.
Hyperoside Protects Human Umbilical Vein Endothelial Cells Against Anticardiolipin Antibody-Induced Injury by Activating Autophagy.
Deciphering the Pharmacological Mechanisms of Taohe-Chengqi Decoction Extract Against Renal Fibrosis Through Integrating Network Pharmacology and Experimental Validation In Vitro and In Vivo.
Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model.
Inhibition of JNK-Mediated Autophagy Promotes Proscillaridin A- Induced Apoptosis via ROS Generation, Intracellular Ca(+2) Oscillation and Inhibiting STAT3 Signaling in Breast Cancer Cells.
RSK-3 promotes cartilage regeneration via interacting with rpS6 in cartilage stem/progenitor cells.
Aberrant miR-1246 expression promotes radioresistance in non-small cell lung cancer: a potential prognostic biomarker and radiotherapy sensitization target.
Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy.
BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.
Staphylococcal enterotoxin M induced inflammation and impairment of bovine mammary epithelial cells.
mTOR-autophagy promotes pulmonary senescence through IMP1 in chronic toxicity of methamphetamine.
Apigenin induced autophagy and stimulated autophagic lipid degradation.
Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice.
Drp1-mediated mitochondrial fission induced autophagy attenuates cell apoptosis caused by 3-chlorpropane-1,2-diol in HEK293 cells.
Galectin-3 mediates pulmonary vascular endothelial cell dynamics via TRPC1/4 under acute hypoxia.
MiR-145 alleviates Hcy-induced VSMC proliferation, migration, and phenotypic switch through repression of the PI3K/Akt/mTOR pathway.
Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway.
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Proteomics analysis of tumor exosomes reveals vital pathways of Jinfukang inhibiting circulating tumor cells metastasis in lung cancer.
Deletion of the Impg2 gene causes the degeneration of rod and cone cells in mice.
Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro.
miR‑96 exerts an oncogenic role in the progression of cervical cancer by targeting CAV‑1.
Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling.
Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFα-NLRP3 signalling axis.
Insulin secretion impairment induced by rosuvastatin partly though autophagy in INS-1E cells.
Knockdown of lncRNA OGFRP1 Inhibits Proliferation and Invasion of JEG-3 Cells Via AKT/mTOR Pathway.
CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with status epilepticus.
The Combination of Fasting, Acute Resistance Exercise, and Protein Ingestion Led to Different Responses of Autophagy Markers in Gastrocnemius and Liver Samples.
l-Theanine regulates glucose, lipid, and protein metabolism via insulin and AMP-activated protein kinase signaling pathways.
Estrogen receptor β induces autophagy of osteosarcoma through the mTOR signaling pathway.
Extracellular vesicles from skin precursor-derived Schwann cells promote axonal outgrowth and regeneration of motoneurons via Akt/mTOR/p70S6K pathway.
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway.
Overexpression of Mucin 1 Suppresses the Therapeutical Efficacy of Disulfiram against Canine Mammary Tumor.
MicroRNA‑22 mediates the cisplatin resistance of osteosarcoma cells by inhibiting autophagy via the PI3K/Akt/mTOR pathway.
Hepatic CD147 knockout modulates liver steatosis and up-regulates autophagy in high-fat-diet-induced NAFLD mice.
Saikosaponin A Inhibits Triple-Negative Breast Cancer Growth and Metastasis Through Downregulation of CXCR4.
A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation.
Overexpression of CENPF correlates with poor prognosis and tumor bone metastasis in breast cancer.
CSN6 Promotes the Migration and Invasion of Cervical Cancer Cells by Inhibiting Autophagic Degradation of Cathepsin L.
Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.
Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway.
Glycyrrhizic acid ameliorates LPS-induced acute lung injury by regulating autophagy through the PI3K/AKT/mTOR pathway.
HIF1α/miR-520a-3p/AKT1/mTOR Feedback Promotes The Proliferation And Glycolysis Of Gastric Cancer Cells.
Effects of Exercise Training on the Autophagy-Related Muscular Proteins Expression in Ovariectomized Rats.
HMQ‑T‑F2 suppresses migration of the human cervical cancer HeLa cells by reversing EMT via the PI3K/Akt signaling pathway.
Leucine attenuates muscle atrophy and autophagosome formation by activating PI3K/AKT/mTOR signaling pathway in rotator cuff tears.
The clinical characteristics and molecular mechanism of pituitary adenoma associated with meningioma.
Isodunnianol alleviates doxorubicin-induced myocardial injury by activating protective autophagy.
Effect of Gpx3 gene silencing by siRNA on apoptosis and autophagy in chicken cardiomyocytes.
N-Carbamylglutamate and l-Arginine Promote Intestinal Absorption of Amino Acids by Regulating the mTOR Signaling Pathway and Amino Acid and Peptide Transporters in Suckling Lambs with Intrauterine Growth Restriction.
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
l-Arginine Protects Ovine Intestinal Epithelial Cells from Lipopolysaccharide-Induced Apoptosis through Alleviating Oxidative Stress.
Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model.
Protective effect of p53 knockout on 4-nonylphenol-induced nephrotoxicity in medaka (Oryzias latipes).
Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.
Natural Naphthohydroquinone Dimer Rubioncolin C Exerts Anti-Tumor Activity by Inducing Apoptotic and Autophagic Cell Death and Inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells.
Autophagy Attenuation Hampers Progesterone Synthesis during the Development of Pregnant Corpus Luteum.
Rafoxanide promotes apoptosis and autophagy of gastric cancer cells by suppressing PI3K /Akt/mTOR pathway.
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
The Orexin-A-Regulated Akt/mTOR Pathway Promotes Cell Proliferation Through Inhibiting Apoptosis in Pancreatic Cancer Cells.
FGFR2 Promotes Gastric Cancer Progression by Inhibiting the Expression of Thrombospondin4 via PI3K-Akt-Mtor Pathway.
Rapamycin Reduces Podocyte Apoptosis and is Involved in Autophagy and mTOR/ P70S6K/4EBP1 Signaling.
Epithelial Cells Attenuate Toll-Like Receptor-Mediated Inflammatory Responses in Monocyte-Derived Macrophage-Like Cells to Mycobacterium tuberculosis by Modulating the PI3K/Akt/mTOR Signaling Pathway.
Autophagy activation and the mechanism of retinal microvascular endothelial cells in hypoxia.
Identification of WDR12 as a novel oncogene involved in hepatocellular carcinoma propagation.
UNBS5162 inhibits proliferation of human melanoma cells by inducing apoptosis via the PI3K/Akt pathway.
Triptolide protects podocytes via autophagy in immunoglobulin A nephropathy.
LP1 from Lentinula edodes C(91-3) Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
Brg1 aggravates airway inflammation in asthma via inhibition of the PI3K/Akt/mTOR pathway.
Effects of Acute Cold Stress on Liver O-GlcNAcylation and Glycometabolism in Mice.
Concurrence of autophagy with apoptosis in alveolar epithelial cells contributes to chronic pulmonary toxicity induced by methamphetamine.
T-2 Toxin Exposure Induces Apoptosis in TM3 Cells by Inhibiting Mammalian Target of Rapamycin/Serine/Threonine Protein Kinase(mTORC2/AKT) to Promote Ca(2+)Production.
Migration inhibition of water stress proteins from Nostoc commune Vauch. via activation of autophagy in DLD-1 cells.
Patulin induced ROS-dependent autophagic cell death in Human Hepatoma G2 cells.
EGFR‑associated pathways involved in traditional Chinese medicine (TCM)‑1‑induced cell growth inhibition, autophagy and apoptosis in prostate cancer.
Retigabine ameliorates acute stress-induced impairment of spatial memory retrieval through regulating USP2 signaling pathways in hippocampal CA1 area.
Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression.
Thioredoxin-interacting protein deficiency ameliorates diabetic retinal angiogenesis.
UNBS5162 inhibits the proliferation of human A549 non-small-cell lung cancer cells by promoting apoptosis.
Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation.
Has_circ_0008274 promotes cell proliferation and invasion involving AMPK/mTOR signaling pathway in papillary thyroid carcinoma.
1,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells.
Antagonizing peroxisome proliferator-activated receptor γ facilitates M1-to-M2 shift of microglia by enhancing autophagy via the LKB1-AMPK signaling pathway.
Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy.
Long-term effects of lysine concentration on growth performance, intestinal microbiome, and metabolic profiles in a pig model.
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Ox-LDL-Induced MicroRNA-155 Promotes Autophagy in Human Endothelial Cells via Repressing the Rheb/ mTOR Pathway.
Protective Effects of Fluvastatin on Reproductive Function in Obese Male Rats Induced by High-Fat Diet through Enhanced Signaling of mTOR.
Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway.
Fucosyltransferase VII promotes proliferation via the EGFR/AKT/mTOR pathway in A549 cells.
Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.
Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
The alteration of autophagy and apoptosis in the hippocampus of rats with natural aging-dependent cognitive deficits.
Effects of Long-Term Protein Restriction on Meat Quality, Muscle Amino Acids, and Amino Acid Transporters in Pigs.
PD149163 induces hypothermia to protect against brain injury in acute cerebral ischemic rats.
Vascular endothelial growth factor signaling requires glycine to promote angiogenesis.
Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells.
Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway.
Metformin reduces glycometabolism of papillary thyroid carcinoma in vitro and in vivo.
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways.
LncRNA MEG3 inhibit endometrial carcinoma tumorigenesis and progression through PI3K pathway.
Defective insulin signaling and the protective effects of dimethyldiguanide during follicular development in the ovaries of polycystic ovary syndrome.
Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling.
Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway.
MicroRNA-99a inhibits insulin-induced proliferation, migration, dedifferentiation, and rapamycin resistance of vascular smooth muscle cells by inhibiting insulin-like growth factor-1 receptor and mammalian target of rapamycin.
A taspine derivative supresses Caco-2 cell growth by competitively targeting EphrinB2 and regulating its pathway.
Oral kanglaite injection (KLTI) attenuates the lung cancer-promoting effect of high-fat diet (HFD)-induced obesity.
Thioredoxin-interacting protein regulates lipid metabolism via Akt/mTOR pathway in diabetic kidney disease.
Resveratrol Increases Anti-Proliferative Activity of Bestatin Through Downregulating P-Glycoprotein Expression Via Inhibiting PI3K/Akt/mTOR Pathway in K562/ADR Cells.
Total saponins isolated from Radix et Rhizoma Leonticis suppresses tumor cells growth by regulation of PI3K/Akt/mTOR and p38 MAPK pathways.
Amplified HMGA2 promotes cell growth by regulating Akt pathway in AML.
Paper-based microreactor array for rapid screening of cell signaling cascades.
The mTOR/AP-1/VEGF signaling pathway regulates vascular endothelial cell growth.
Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in rats.
Low doses of single or combined agrichemicals induces α-synuclein aggregation in nigrostriatal system of mice through inhibition of proteasomal and autophagic pathways.
GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy.
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Potent effects of dioscin against obesity in mice.
mTOR inhibitor AZD8055 inhibits proliferation and induces apoptosis in laryngeal carcinoma.
Eupolyphaga sinensis walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling.
Prognostic significance of p53, mTOR, c-Met, IGF-1R, and HSP70 overexpression after the resection of hepatocellular carcinoma.
SOCS3 methylation in synergy with Reg3A overexpression promotes cell growth in pancreatic cancer.
Brucine suppresses colon cancer cells growth via mediating KDR signalling pathway.
Liu H, Li C, Zhang X, Chen H, Zhang Q, Zeng Y, Zheng S, Zou J, Zhao Y, Zheng X, Huang G, Zeng Q
Experimental neurology 2024 Jun;376:114726
Experimental neurology 2024 Jun;376:114726
SQSTM1/p62 is a prognostic molecular marker and potential therapeutic target for pancreatic neuroendocrine tumours.
Song YL, Weng JH, Zhao DC, Zhang JL, Chen YJ, Xu BH
Endocrine 2024 Jul;85(1):407-416
Endocrine 2024 Jul;85(1):407-416
Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin.
Chen Z, Guo Q, Huang S, Li L, Wu F, Liu Z, Li Z, Chen T, Song G, Xu S, Chen J, Hou Y
Genes & diseases 2024 Jan;11(1):397-412
Genes & diseases 2024 Jan;11(1):397-412
Nanoparticles for inducing Gaucher disease-like damage in cancer cells.
Yue C, Lu W, Fan S, Huang Z, Yang J, Dong H, Zhang X, Shang Y, Lai W, Li D, Dong T, Yuan A, Wu J, Kang L, Hu Y
Nature nanotechnology 2024 Aug;19(8):1203-1215
Nature nanotechnology 2024 Aug;19(8):1203-1215
Corynoxine triggers cell death via activating PP2A and regulating AKT-mTOR/GSK3β axes in NSCLC.
Hou G, Hu W, Sang Y, Gan X, Xu H, Hu Q, Cao X
Biochemical pharmacology 2024 Apr;222:116110
Biochemical pharmacology 2024 Apr;222:116110
Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression.
Wu T, Zhang Y, Han Q, Lu X, Cheng Y, Chen J, Sha J, Xia W
Oncogene 2023 Sep;42(38):2801-2815
Oncogene 2023 Sep;42(38):2801-2815
Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis.
Li T, Yang S, Liu X, Li Y, Gu Z, Jiang Z
Journal of advanced research 2023 Oct;52:119-134
Journal of advanced research 2023 Oct;52:119-134
Autophagy and LC3-associated phagocytosis contribute negatively to the killing capability of THP-1-derived macrophages against Candida albicans at the mid-stage.
Li D, Wang L, Zhao Z, Bai C, Li X
Immunology letters 2023 Nov;263:25-32
Immunology letters 2023 Nov;263:25-32
Novel soybean polypeptide dglycin alleviates atherosclerosis in apolipoprotein E-deficient mice.
Zhao H, Dan P, Xi J, Chen Z, Zhang P, Wei W, Zhao Y
International journal of biological macromolecules 2023 Nov 1;251:126347
International journal of biological macromolecules 2023 Nov 1;251:126347
AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer.
Li Y, She W, Xu X, Liu Y, Wang X, Tian S, Li S, Wang M, Yu C, Liu P, Huang T, Wei Y
Journal of Zhejiang University. Science. B 2023 Mar 15;24(3):232-247
Journal of Zhejiang University. Science. B 2023 Mar 15;24(3):232-247
A novel organic arsenic derivative MZ2 remodels metabolism and triggers mtROS-mediated apoptosis in acute myeloid leukemia.
Chen G, She W, Yu C, Rouzi T, Li X, Ma L, Zhang N, Jiang H, Liu X, Wu J, Wang Q, Shen H, Zhou F
Journal of cancer research and clinical oncology 2023 Jul;149(8):4225-4242
Journal of cancer research and clinical oncology 2023 Jul;149(8):4225-4242
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
Li M, Zhang Y, Han T, Guan L, Fan D, Wu Q, Liu J, Xu Y, Fan Y
Phytochemistry 2023 Jan;205:113487
Phytochemistry 2023 Jan;205:113487
PARP1-catalyzed PARylation of YY1 mediates endoplasmic reticulum stress in granulosa cells to determine primordial follicle activation.
Chen W, E Q, Sun B, Zhang P, Li N, Fei S, Wang Y, Liu S, Liu X, Zhang X
Cell death & disease 2023 Aug 15;14(8):524
Cell death & disease 2023 Aug 15;14(8):524
DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma.
Chen X, Yang G, Guo X, Zhang J, Sun W, Liu D, Wang H, Liu S
Oxidative medicine and cellular longevity 2022;2022:2543220
Oxidative medicine and cellular longevity 2022;2022:2543220
Dezocine inhibits cell proliferation, migration, and invasion by targeting CRABP2 in ovarian cancer.
Zhang C, Pan R, Ma S, Xu S, Wang B
Open medicine (Warsaw, Poland) 2022;17(1):2052-2061
Open medicine (Warsaw, Poland) 2022;17(1):2052-2061
Bifidobacterium infantis Promotes Foxp3 Expression in Colon Cells via PD-L1-Mediated Inhibition of the PI3K-Akt-mTOR Signaling Pathway.
Zhou L, Xie Y, Li Y
Frontiers in immunology 2022;13:871705
Frontiers in immunology 2022;13:871705
Sophocarpine inhibits tumor progression by antagonizing the PI3K/AKT/mTOR signaling pathway in castration-resistant prostate cancer.
Weng M, Shi C, Han H, Zhu H, Xiao Y, Guo H, Yu Z, Wu C
PeerJ 2022;10:e14042
PeerJ 2022;10:e14042
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G
Cancer communications (London, England) 2022 Sep;42(9):848-867
Cancer communications (London, England) 2022 Sep;42(9):848-867
Cell marathon: long-distance cell migration and metastasis-associated gene analysis using a folding paper system.
Huang CH, Lei KF
Lab on a chip 2022 Oct 11;22(20):3827-3836
Lab on a chip 2022 Oct 11;22(20):3827-3836
VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.
Pu Z, Duda DG, Zhu Y, Pei S, Wang X, Huang Y, Yi P, Huang Z, Peng F, Hu X, Fan X
Journal of translational medicine 2022 May 13;20(1):212
Journal of translational medicine 2022 May 13;20(1):212
Dietary N-carbamylglutamate or L-arginine improves fetal intestinal amino acid profiles during intrauterine growth restriction in undernourished ewes.
Zhang H, Liu X, Zheng Y, Zhang Y, Loor JJ, Wang H, Wang M
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2022 Mar;8(1):341-349
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2022 Mar;8(1):341-349
Complement C1q binding protein regulates T cells' mitochondrial fitness to affect their survival, proliferation, and anti-tumor immune function.
Tian H, Wang G, Wang Q, Zhang B, Jiang G, Li H, Chai D, Fang L, Wang M, Zheng J
Cancer science 2022 Mar;113(3):875-890
Cancer science 2022 Mar;113(3):875-890
FAIM regulates autophagy through glutaminolysis in lung adenocarcinoma.
Han T, Wang P, Wang Y, Xun W, Lei J, Wang T, Lu Z, Gan M, Zhang W, Yu B, Wang JB
Autophagy 2022 Jun;18(6):1416-1432
Autophagy 2022 Jun;18(6):1416-1432
Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome.
Xiao N, Wang J, Wang T, Xiong X, Zhou J, Su X, Peng J, Yang C, Li X, Lin G, Lu G, Gong F, Cheng L
eLife 2022 Jun 24;11
eLife 2022 Jun 24;11
COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR.
Zhang CY, Tan XH, Yang HH, Jin L, Hong JR, Zhou Y, Huang XT
International journal of molecular sciences 2022 Jul 27;23(15)
International journal of molecular sciences 2022 Jul 27;23(15)
Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway.
Qin J, Sun X, Ma Y, Cheng Y, Ma Q, Jing W, Qu S, Liu L
Bioorganic & medicinal chemistry 2022 Feb 1;55:116594
Bioorganic & medicinal chemistry 2022 Feb 1;55:116594
Polyphyllin II induced apoptosis of NSCLC cells by inhibiting autophagy through the mTOR pathway.
Jiao Y, Xin M, Xu J, Xiang X, Li X, Jiang J, Jia X
Pharmaceutical biology 2022 Dec;60(1):1781-1789
Pharmaceutical biology 2022 Dec;60(1):1781-1789
L-Theanine Regulates the Abundance of Amino Acid Transporters in Mice Duodenum and Jejunum via the mTOR Signaling Pathway.
Liu K, Peng Y, Lin L, Gong Z, Xiao W, Li Y
Nutrients 2022 Dec 28;15(1)
Nutrients 2022 Dec 28;15(1)
The surface morphology of Platycodon grandiflorus polysaccharide and its anti-apoptotic effect by targeting autophagy.
Cheng G, Zhang S, Lv M, Qi C, Fan R, Guo X, Liu J, Zhao X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Aug;103:154212
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Aug;103:154212
ORP5 promotes tumor metastasis via stabilizing c-Met in renal cell carcinoma.
Song L, Zhang L, Zhou Y, Shao X, Xu Y, Pei D, Wang Q
Cell death discovery 2022 Apr 21;8(1):219
Cell death discovery 2022 Apr 21;8(1):219
Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.
Jin C, Ou Q, Chen J, Wang T, Zhang J, Wang Z, Wang Y, Tian H, Xu JY, Gao F, Wang J, Li J, Lu L, Xu GT
Stem cell research & therapy 2022 Apr 1;13(1):136
Stem cell research & therapy 2022 Apr 1;13(1):136
Increased Nuclear Transporter Importin 7 Contributes to the Tumor Growth and Correlates With CD8 T Cell Infiltration in Cervical Cancer.
Chen J, Hu Y, Teng Y, Yang B
Frontiers in cell and developmental biology 2021;9:732786
Frontiers in cell and developmental biology 2021;9:732786
Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells.
Sun Y, Qin H, Zhang H, Feng X, Yang L, Hou DX, Chen J
Food & nutrition research 2021;65
Food & nutrition research 2021;65
Qingjie Fuzheng Granule Inhibits EMT and Induces Autophagy in Colorectal Cancer via mTOR Signaling Pathways.
Zhu X, Chen Y, Lin M, Huang B, Lin J
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9950499
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9950499
OM-MSCs Alleviate the Golgi Apparatus Stress Response following Cerebral Ischemia/Reperfusion Injury via the PEDF-PI3K/Akt/mTOR Signaling Pathway.
He J, Liu J, Huang Y, Tang X, Xiao H, Liu Z, Jiang Z, Zeng L, Hu Z, Lu M
Oxidative medicine and cellular longevity 2021;2021:4805040
Oxidative medicine and cellular longevity 2021;2021:4805040
Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses.
Wang C, Chen H, Jiang HH, Mao BB, Yu H
Frontiers in neuroscience 2021;15:772401
Frontiers in neuroscience 2021;15:772401
Autophagy Contributes to the Rapamycin-Induced Improvement of Otitis Media.
Xie D, Zhao T, Zhang X, Kui L, Wang Q, Wu Y, Zheng T, Ma P, Zhang Y, Molteni H, Geng R, Yang Y, Li B, Zheng QY
Frontiers in cellular neuroscience 2021;15:753369
Frontiers in cellular neuroscience 2021;15:753369
Long-Term Administration of Triterpenoids From Ganoderma lucidum Mitigates Age-Associated Brain Physiological Decline via Regulating Sphingolipid Metabolism and Enhancing Autophagy in Mice.
Zeng M, Qi L, Guo Y, Zhu X, Tang X, Yong T, Xie Y, Wu Q, Zhang M, Chen D
Frontiers in aging neuroscience 2021;13:628860
Frontiers in aging neuroscience 2021;13:628860
Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis.
Liu Y, Zhong W, Zhang J, Chen W, Lu Y, Qiao Y, Zeng Z, Huang H, Cai S, Dong H
Frontiers in pharmacology 2021;12:739220
Frontiers in pharmacology 2021;12:739220
The New PI3K/mTOR Inhibitor GNE-477 Inhibits the Malignant Behavior of Human Glioblastoma Cells.
Wang Y, Shen H, Sun Q, Zhao L, Liu H, Ye L, Xu Y, Cai J, Li Y, Gao L, Tan Y, Liu B, Chen Q
Frontiers in pharmacology 2021;12:659511
Frontiers in pharmacology 2021;12:659511
Rapamycin Modulates the Proinflammatory Memory-Like Response of Microglia Induced by BAFF.
Wang J, Yang C, Hou X, Xu J, Yun Y, Qin L, Yang P
Frontiers in immunology 2021;12:639049
Frontiers in immunology 2021;12:639049
Nano chitosan-zinc complex improves the growth performance and antioxidant capacity of the small intestine in weaned piglets.
Zhang M, Hou G, Hu P, Feng D, Wang J, Zhu W
The British journal of nutrition 2021 Sep 28;126(6):801-812
The British journal of nutrition 2021 Sep 28;126(6):801-812
Protective effect of carvacrol on liver injury in type 2 diabetic db/db mice.
Zhao W, Chen L, Zhou H, Deng C, Han Q, Chen Y, Wu Q, Li S
Molecular medicine reports 2021 Nov;24(5)
Molecular medicine reports 2021 Nov;24(5)
Knockdown of CLN5 inhibits the tumorigenic properties of glioblastoma cells via the Akt/mTOR signaling pathway.
Xing J, Li Y, Zhao H
Oncology letters 2021 May;21(5):387
Oncology letters 2021 May;21(5):387
Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.
Chen Z, Huo D, Li L, Liu Z, Li Z, Xu S, Huang Y, Wu W, Zhou C, Liu Y, Kuang M, Wu F, Li H, Qian P, Song G, Wu X, Chen J, Hou Y
The Journal of experimental medicine 2021 May 3;218(5)
The Journal of experimental medicine 2021 May 3;218(5)
Effects of photoperiod on morphology and function in testis and epididymis of Cricetulus barabensis.
Mou J, Xu J, Wang Z, Wang C, Yang X, Wang X, Xue H, Wu M, Xu L
Journal of cellular physiology 2021 Mar;236(3):2109-2125
Journal of cellular physiology 2021 Mar;236(3):2109-2125
FoxP3-miR-150-5p/3p suppresses ovarian tumorigenesis via an IGF1R/IRS1 pathway feedback loop.
Zhang Q, Zhou X, Wan M, Zeng X, Luo J, Xu Y, Ji L, Zhang JA, Fan P, Zhong J, Wu J
Cell death & disease 2021 Mar 15;12(3):275
Cell death & disease 2021 Mar 15;12(3):275
PIWIL2 interacting with IKK to regulate autophagy and apoptosis in esophageal squamous cell carcinoma.
Zhao X, Huang L, Lu Y, Jiang W, Song Y, Qiu B, Tao D, Liu Y, Ma Y
Cell death and differentiation 2021 Jun;28(6):1941-1954
Cell death and differentiation 2021 Jun;28(6):1941-1954
Autophagy and post-ischemic conditioning in retinal ischemia.
Mathew B, Chennakesavalu M, Sharma M, Torres LA, Stelman CR, Tran S, Patel R, Burg N, Salkovski M, Kadzielawa K, Seiler F, Aldrich LN, Roth S
Autophagy 2021 Jun;17(6):1479-1499
Autophagy 2021 Jun;17(6):1479-1499
LncRNA 0003250 accelerates heart autophagy and binds to miR-17-5p as a competitive endogenous RNA in chicken induced by selenium deficiency.
Yang J, Shi G, Gong Y, Cai J, Zheng Y, Zhang Z
Journal of cellular physiology 2021 Jan;236(1):157-177
Journal of cellular physiology 2021 Jan;236(1):157-177
Elevated ZBTB7A expression in the tumor invasive front correlates with more tumor budding formation in gastric adenocarcinoma.
Sun Y, He J, Shi DB, Zhang H, Chen X, Xing AY, Gao P
Journal of cancer research and clinical oncology 2021 Jan;147(1):105-115
Journal of cancer research and clinical oncology 2021 Jan;147(1):105-115
Sublethal irradiation promotes the metastatic potential of hepatocellular carcinoma cells.
Cao Y, Yin Y, Wang X, Wu Z, Liu Y, Zhang F, Lin J, Huang Z, Zhou L
Cancer science 2021 Jan;112(1):265-274
Cancer science 2021 Jan;112(1):265-274
Resveratrol attenuates cigarette smoke induced endothelial apoptosis by activating Notch1 signaling mediated autophagy.
Zong DD, Liu XM, Li JH, Ouyang RY, Long YJ, Chen P, Chen Y
Respiratory research 2021 Jan 19;22(1):22
Respiratory research 2021 Jan 19;22(1):22
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
Wu L, Guo X, Wong SY, Lu P, Hartson SD, Medeiros DM, Wang W, Clarke SL, Lucas EA, Smith BJ, Chowanadisai W, Lin D
The Journal of nutritional biochemistry 2021 Feb;88:108542
The Journal of nutritional biochemistry 2021 Feb;88:108542
Long non-coding RNA IGF2-AS represses breast cancer tumorigenesis by epigenetically regulating IGF2.
Zhang Y, Yan H, Jiang Y, Chen T, Ma Z, Li F, Lin M, Xu Y, Zhang X, Zhang J, He H
Experimental biology and medicine (Maywood, N.J.) 2021 Feb;246(4):371-379
Experimental biology and medicine (Maywood, N.J.) 2021 Feb;246(4):371-379
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.
Cui Y, Wang Y, Liu G
Pharmaceutical biology 2021 Dec;59(1):1305-1313
Pharmaceutical biology 2021 Dec;59(1):1305-1313
Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway.
Guo XH, Jiang SS, Zhang LL, Hu J, Edelbek D, Feng YQ, Yang ZX, Hu PC, Zhong H, Yang GH, Yang F
Oncology reports 2021 Dec;46(6)
Oncology reports 2021 Dec;46(6)
Esterase D stabilizes FKBP25 to suppress mTORC1.
Yang Y, Chen X, Yao W, Cui X, Li N, Lin Z, Zhao B, Miao J
Cellular & molecular biology letters 2021 Dec 7;26(1):50
Cellular & molecular biology letters 2021 Dec 7;26(1):50
High intensity interval training ameliorates cognitive impairment in T2DM mice possibly by improving PI3K/Akt/mTOR Signaling-regulated autophagy in the hippocampus.
Li X, He Q, Zhao N, Chen X, Li T, Cheng B
Brain research 2021 Dec 15;1773:147703
Brain research 2021 Dec 15;1773:147703
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Ma L, Li C, Lian S, Xu B, Lv H, Liu Y, Lu J, Ji H, Li S, Guo J, Yang H
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression.
Liu J, Liu L, Han YS, Yi J, Guo C, Zhao HQ, Ling J, Wang YH
Journal of cellular and molecular medicine 2021 Aug;25(15):7342-7353
Journal of cellular and molecular medicine 2021 Aug;25(15):7342-7353
Tripterygium glycoside suppresses epithelial‑to‑mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway.
Tao M, Zheng D, Liang X, Wu D, Hu K, Jin J, He Q
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
Cyanidin-3-glucoside suppresses the progression of lung adenocarcinoma by downregulating TP53I3 and inhibiting PI3K/AKT/mTOR pathway.
Chen X, Zhang W, Xu X
World journal of surgical oncology 2021 Aug 6;19(1):232
World journal of surgical oncology 2021 Aug 6;19(1):232
1,3-dichloro-2-propanol induced lipid accumulation by blocking autophagy flux in HepG2 cells.
Lu J, Fan Y, Liu M, Zhang Q, Guan S
Toxicology 2021 Apr 30;454:152716
Toxicology 2021 Apr 30;454:152716
The Evaluation of the Antioxidant and Intestinal Protective Effects of Baicalin-Copper in Deoxynivalenol-Challenged Piglets.
Zha A, Yuan D, Cui Z, Qi M, Liao S, Liao P, Tan B
Oxidative medicine and cellular longevity 2020;2020:5363546
Oxidative medicine and cellular longevity 2020;2020:5363546
Preventive Electroacupuncture Ameliorates D-Galactose-Induced Alzheimer's Disease-Like Pathology and Memory Deficits Probably via Inhibition of GSK3β/mTOR Signaling Pathway.
Yu CC, Wang J, Ye SS, Gao S, Li J, Wang L, Jiang T, Wang XS, Li BC, Shu Q, Lu W, Du YJ, Kong LH
Evidence-based complementary and alternative medicine : eCAM 2020;2020:1428752
Evidence-based complementary and alternative medicine : eCAM 2020;2020:1428752
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
Jing X, Du L, Niu A, Wang Y, Wang Y, Wang C
BioMed research international 2020;2020:1276328
BioMed research international 2020;2020:1276328
miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6.
An Y, Zhang J, Cheng X, Li B, Tian Y, Zhang X, Zhao F
Cancer cell international 2020;20:237
Cancer cell international 2020;20:237
The knockdown of the sepiapterin reductase gene suppresses the proliferation of breast cancer by inducing ROS-mediated apoptosis.
Zhang X, Chen Y, Wang K, Tang J, Chen Y, Jin G, Liu X
International journal of clinical and experimental pathology 2020;13(9):2228-2239
International journal of clinical and experimental pathology 2020;13(9):2228-2239
Hyperoside Protects Human Umbilical Vein Endothelial Cells Against Anticardiolipin Antibody-Induced Injury by Activating Autophagy.
Wei A, Xiao H, Xu G, Yu X, Guo J, Jing Z, Shi S, Song Y
Frontiers in pharmacology 2020;11:762
Frontiers in pharmacology 2020;11:762
Deciphering the Pharmacological Mechanisms of Taohe-Chengqi Decoction Extract Against Renal Fibrosis Through Integrating Network Pharmacology and Experimental Validation In Vitro and In Vivo.
Zhou S, Ai Z, Li W, You P, Wu C, Li L, Hu Y, Ba Y
Frontiers in pharmacology 2020;11:425
Frontiers in pharmacology 2020;11:425
Chaiyu-Dixian Formula Exerts Protective Effects on Ovarian Follicular Abnormal Development in Chronic Unpredictable Mild Stress (CUMS) Rat Model.
Xu HX, Lin SX, Gong Y, Huo ZX, Zhao CY, Zhu HM, Xi SY
Frontiers in pharmacology 2020;11:245
Frontiers in pharmacology 2020;11:245
Inhibition of JNK-Mediated Autophagy Promotes Proscillaridin A- Induced Apoptosis via ROS Generation, Intracellular Ca(+2) Oscillation and Inhibiting STAT3 Signaling in Breast Cancer Cells.
Saleem MZ, Alshwmi M, Zhang H, Din SRU, Nisar MA, Khan M, Alam S, Alam G, Jin L, Ma T
Frontiers in pharmacology 2020;11:01055
Frontiers in pharmacology 2020;11:01055
RSK-3 promotes cartilage regeneration via interacting with rpS6 in cartilage stem/progenitor cells.
Zhang S, Hamid MR, Wang T, Liao J, Wen L, Zhou Y, Wei P, Zou X, Chen G, Chen J, Zhou G
Theranostics 2020;10(15):6915-6927
Theranostics 2020;10(15):6915-6927
Aberrant miR-1246 expression promotes radioresistance in non-small cell lung cancer: a potential prognostic biomarker and radiotherapy sensitization target.
Fan L, Wang J, Cao Q, Ding X, Li B
American journal of cancer research 2020;10(1):314-335
American journal of cancer research 2020;10(1):314-335
Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy.
Liu Z, Ye S, Zhong X, Wang W, Lai CH, Yang W, Yue P, Luo J, Huang X, Zhong Z, Xiong Y, Fan X, Li L, Wang Y, Ye Q
Molecular medicine reports 2020 Sep;22(3):2373-2385
Molecular medicine reports 2020 Sep;22(3):2373-2385
BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.
Liu J, Shangguan Y, Sun J, Cong W, Xie Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110414
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110414
Staphylococcal enterotoxin M induced inflammation and impairment of bovine mammary epithelial cells.
Zhao Y, Tang J, Yang D, Tang C, Chen J
Journal of dairy science 2020 Sep;103(9):8350-8359
Journal of dairy science 2020 Sep;103(9):8350-8359
mTOR-autophagy promotes pulmonary senescence through IMP1 in chronic toxicity of methamphetamine.
Zhu MJ, Liu BY, Shi L, Wang X, Wang Y
Journal of cellular and molecular medicine 2020 Oct;24(20):12082-12093
Journal of cellular and molecular medicine 2020 Oct;24(20):12082-12093
Apigenin induced autophagy and stimulated autophagic lipid degradation.
Lu J, Meng Z, Chen Y, Yu L, Gao B, Zheng Y, Guan S
Food & function 2020 Oct 21;11(10):9208-9215
Food & function 2020 Oct 21;11(10):9208-9215
Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice.
Feng Z, Pang L, Chen S, Pang X, Huang Y, Qiao Q, Wang Y, Vonglorkham S, Huang Q, Lin X, Wei J
International immunopharmacology 2020 Nov;88:107003
International immunopharmacology 2020 Nov;88:107003
Drp1-mediated mitochondrial fission induced autophagy attenuates cell apoptosis caused by 3-chlorpropane-1,2-diol in HEK293 cells.
Jin C, Zhong Y, Han J, Zhu J, Liu Q, Sun D, Xia X, Peng X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111740
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2020 Nov;145:111740
Galectin-3 mediates pulmonary vascular endothelial cell dynamics via TRPC1/4 under acute hypoxia.
Li Y, Chen X, Zeng X, Chen S, Yang X, Zhang L
Journal of biochemical and molecular toxicology 2020 May;34(5):e22463
Journal of biochemical and molecular toxicology 2020 May;34(5):e22463
MiR-145 alleviates Hcy-induced VSMC proliferation, migration, and phenotypic switch through repression of the PI3K/Akt/mTOR pathway.
Zhang M, Li F, Wang X, Gong J, Xian Y, Wang G, Zheng Z, Shang C, Wang B, He Y, Wang W, Lin R
Histochemistry and cell biology 2020 May;153(5):357-366
Histochemistry and cell biology 2020 May;153(5):357-366
Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway.
Pan H, Liu F, Wang J, Zhao M, Wang D, Jia C, Wang T, Chen Z, Fan Y, Liang D, Meng Q
Molecular carcinogenesis 2020 Jun;59(6):575-589
Molecular carcinogenesis 2020 Jun;59(6):575-589
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.
Mao K, Chen J, Yu H, Li H, Ren Y, Wu X, Wen Y, Zou F, Li W
Aging cell 2020 Jun;19(6):e13163
Aging cell 2020 Jun;19(6):e13163
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Liu JZ, Hu YL, Feng Y, Jiang Y, Guo YB, Liu YF, Chen X, Yang JL, Chen YY, Mao QS, Xue WJ
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
Proteomics analysis of tumor exosomes reveals vital pathways of Jinfukang inhibiting circulating tumor cells metastasis in lung cancer.
Que ZJ, Luo B, Wang CT, Qian FF, Jiang Y, Li Y, Han XH, Li HG, Liu JX, Tian JH
Journal of ethnopharmacology 2020 Jun 28;256:112802
Journal of ethnopharmacology 2020 Jun 28;256:112802
Deletion of the Impg2 gene causes the degeneration of rod and cone cells in mice.
Xu H, Qu C, Gan L, Sun K, Tan J, Liu X, Jiang Z, Tian W, Liu W, Zhang S, Yang Y, Jiang L, Zhu X, Zhang L
Human molecular genetics 2020 Jun 27;29(10):1624-1634
Human molecular genetics 2020 Jun 27;29(10):1624-1634
Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro.
Tan Y, Yin L, Sun Z, Shao S, Chen W, Man X, Du Y, Chen Y
International journal of biological macromolecules 2020 Jun 15;153:349-356
International journal of biological macromolecules 2020 Jun 15;153:349-356
miR‑96 exerts an oncogenic role in the progression of cervical cancer by targeting CAV‑1.
Chen Y, Liu C, Xie B, Chen S, Zhuang Y, Zhang S
Molecular medicine reports 2020 Jul;22(1):543-550
Molecular medicine reports 2020 Jul;22(1):543-550
Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling.
Li J, Ma J, Tian Y, Zhao P, Liu X, Dong H, Zheng W, Feng S, Zhang L, Wu M, Zhu L, Liu S, Zhao D
Journal of ethnopharmacology 2020 Jul 15;257:112796
Journal of ethnopharmacology 2020 Jul 15;257:112796
Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFα-NLRP3 signalling axis.
Peng F, Zhang N, Wang C, Wang X, Huang W, Peng C, He G, Han B
Cell proliferation 2020 Jan;53(1):e12701
Cell proliferation 2020 Jan;53(1):e12701
Insulin secretion impairment induced by rosuvastatin partly though autophagy in INS-1E cells.
Qian L, Zhu K, Lin Y, An L, Huang F, Yao Y, Ren L
Cell biology international 2020 Jan;44(1):127-136
Cell biology international 2020 Jan;44(1):127-136
Knockdown of lncRNA OGFRP1 Inhibits Proliferation and Invasion of JEG-3 Cells Via AKT/mTOR Pathway.
Meng Q, Xue H
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820905823
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820905823
CB2R orchestrates neuronal autophagy through regulation of the mTOR signaling pathway in the hippocampus of developing rats with status epilepticus.
Wu Q, Zhang M, Liu X, Zhang J, Wang H
International journal of molecular medicine 2020 Feb;45(2):475-484
International journal of molecular medicine 2020 Feb;45(2):475-484
The Combination of Fasting, Acute Resistance Exercise, and Protein Ingestion Led to Different Responses of Autophagy Markers in Gastrocnemius and Liver Samples.
Pinto AP, Vieira TS, Marafon BB, Batitucci G, Cabrera EMB, da Rocha AL, Kohama EB, Rodrigues KCC, de Moura LP, Pauli JR, Cintra DE, Ropelle ER, de Freitas EC, da Silva ASR
Nutrients 2020 Feb 28;12(3)
Nutrients 2020 Feb 28;12(3)
l-Theanine regulates glucose, lipid, and protein metabolism via insulin and AMP-activated protein kinase signaling pathways.
Lin L, Zeng L, Liu A, Peng Y, Yuan D, Zhang S, Li Y, Chen J, Xiao W, Gong Z
Food & function 2020 Feb 26;11(2):1798-1809
Food & function 2020 Feb 26;11(2):1798-1809
Estrogen receptor β induces autophagy of osteosarcoma through the mTOR signaling pathway.
Yang Z, Yu W, Liu B, Yang M, Tao H
Journal of orthopaedic surgery and research 2020 Feb 13;15(1):50
Journal of orthopaedic surgery and research 2020 Feb 13;15(1):50
Extracellular vesicles from skin precursor-derived Schwann cells promote axonal outgrowth and regeneration of motoneurons via Akt/mTOR/p70S6K pathway.
Wu X, Wang L, Cong M, Shen M, He Q, Ding F, Shi H
Annals of translational medicine 2020 Dec;8(24):1640
Annals of translational medicine 2020 Dec;8(24):1640
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
Lu XY, Shi XJ, Hu A, Wang JQ, Ding Y, Jiang W, Sun M, Zhao X, Luo J, Qi W, Song BL
Nature 2020 Dec;588(7838):479-484
Nature 2020 Dec;588(7838):479-484
MNAT1 promotes proliferation and the chemo-resistance of osteosarcoma cell to cisplatin through regulating PI3K/Akt/mTOR pathway.
Qiu C, Su W, Shen N, Qi X, Wu X, Wang K, Li L, Guo Z, Tao H, Wang G, Chen B, Xiang H
BMC cancer 2020 Dec 3;20(1):1187
BMC cancer 2020 Dec 3;20(1):1187
Overexpression of Mucin 1 Suppresses the Therapeutical Efficacy of Disulfiram against Canine Mammary Tumor.
Zhao Y, Lin Z, Lin Z, Zhou C, Liu G, Lin J, Zhang D, Lin D
Animals : an open access journal from MDPI 2020 Dec 27;11(1)
Animals : an open access journal from MDPI 2020 Dec 27;11(1)
MicroRNA‑22 mediates the cisplatin resistance of osteosarcoma cells by inhibiting autophagy via the PI3K/Akt/mTOR pathway.
Meng CY, Zhao ZQ, Bai R, Zhao W, Wang YX, Xue HQ, Sun L, Sun C, Feng W, Guo SB
Oncology reports 2020 Apr;43(4):1169-1186
Oncology reports 2020 Apr;43(4):1169-1186
Hepatic CD147 knockout modulates liver steatosis and up-regulates autophagy in high-fat-diet-induced NAFLD mice.
Lou J, Li C, Li ZS, Zhang T, Chen ZN, Bian H
Biochemical and biophysical research communications 2020 Apr 16;524(4):1010-1017
Biochemical and biophysical research communications 2020 Apr 16;524(4):1010-1017
Saikosaponin A Inhibits Triple-Negative Breast Cancer Growth and Metastasis Through Downregulation of CXCR4.
Wang Y, Zhao L, Han X, Wang Y, Mi J, Wang C, Sun D, Fu Y, Zhao X, Guo H, Wang Q
Frontiers in oncology 2019;9:1487
Frontiers in oncology 2019;9:1487
A Peptide Analogue of Selectin Ligands Attenuated Atherosclerosis by Inhibiting Monocyte Activation.
Ye Z, Zhang S, Liu Y, Wang S, Zhang J, Huang R
Mediators of inflammation 2019;2019:8709583
Mediators of inflammation 2019;2019:8709583
Overexpression of CENPF correlates with poor prognosis and tumor bone metastasis in breast cancer.
Sun J, Huang J, Lan J, Zhou K, Gao Y, Song Z, Deng Y, Liu L, Dong Y, Liu X
Cancer cell international 2019;19:264
Cancer cell international 2019;19:264
CSN6 Promotes the Migration and Invasion of Cervical Cancer Cells by Inhibiting Autophagic Degradation of Cathepsin L.
Mao Z, Sang MM, Chen C, Zhu WT, Gong YS, Pei DS
International journal of biological sciences 2019;15(6):1310-1324
International journal of biological sciences 2019;15(6):1310-1324
Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.
Wu H, Ding J, Li S, Lin J, Jiang R, Lin C, Dai L, Xie C, Lin D, Xu H, Gao W, Zhou K
International journal of biological sciences 2019;15(2):325-340
International journal of biological sciences 2019;15(2):325-340
Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway.
Wang Y, Shao Y, Gao Y, Wan G, Wan D, Zhu H, Qiu Y, Ye X
Drug design, development and therapy 2019;13:243-253
Drug design, development and therapy 2019;13:243-253
Glycyrrhizic acid ameliorates LPS-induced acute lung injury by regulating autophagy through the PI3K/AKT/mTOR pathway.
Qu L, Chen C, He W, Chen Y, Li Y, Wen Y, Zhou S, Jiang Y, Yang X, Zhang R, Shen L
American journal of translational research 2019;11(4):2042-2055
American journal of translational research 2019;11(4):2042-2055
HIF1α/miR-520a-3p/AKT1/mTOR Feedback Promotes The Proliferation And Glycolysis Of Gastric Cancer Cells.
Pan C, Liu Q, Wu X
Cancer management and research 2019;11:10145-10156
Cancer management and research 2019;11:10145-10156
Effects of Exercise Training on the Autophagy-Related Muscular Proteins Expression in Ovariectomized Rats.
Zhong W, Shi X, Yuan H, Bu H, Wu L, Wang R
Frontiers in physiology 2019;10:735
Frontiers in physiology 2019;10:735
HMQ‑T‑F2 suppresses migration of the human cervical cancer HeLa cells by reversing EMT via the PI3K/Akt signaling pathway.
Dai B, Yu R, Fan M, Yang T, Wang B, Zhang Y
Oncology reports 2019 Oct;42(4):1451-1458
Oncology reports 2019 Oct;42(4):1451-1458
Leucine attenuates muscle atrophy and autophagosome formation by activating PI3K/AKT/mTOR signaling pathway in rotator cuff tears.
Zheng R, Huang S, Zhu J, Lin W, Xu H, Zheng X
Cell and tissue research 2019 Oct;378(1):113-125
Cell and tissue research 2019 Oct;378(1):113-125
The clinical characteristics and molecular mechanism of pituitary adenoma associated with meningioma.
Zhu H, Miao Y, Shen Y, Guo J, Xie W, Zhao S, Dong W, Zhang Y, Li C
Journal of translational medicine 2019 Oct 29;17(1):354
Journal of translational medicine 2019 Oct 29;17(1):354
Isodunnianol alleviates doxorubicin-induced myocardial injury by activating protective autophagy.
Chen C, Jiang L, Zhang M, Pan X, Peng C, Huang W, Jiang Q
Food & function 2019 May 22;10(5):2651-2657
Food & function 2019 May 22;10(5):2651-2657
Effect of Gpx3 gene silencing by siRNA on apoptosis and autophagy in chicken cardiomyocytes.
Gong Y, Yang J, Cai J, Liu Q, Zhang JM, Zhang Z
Journal of cellular physiology 2019 Jun;234(6):7828-7838
Journal of cellular physiology 2019 Jun;234(6):7828-7838
N-Carbamylglutamate and l-Arginine Promote Intestinal Absorption of Amino Acids by Regulating the mTOR Signaling Pathway and Amino Acid and Peptide Transporters in Suckling Lambs with Intrauterine Growth Restriction.
Zhang H, Peng A, Yu Y, Guo S, Wang M, Coleman DN, Loor JJ, Wang H
The Journal of nutrition 2019 Jun 1;149(6):923-932
The Journal of nutrition 2019 Jun 1;149(6):923-932
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
Zhang X, Liu J, Gu Y, Sun C, Qu F
Cell biology international 2019 Feb;43(2):158-166
Cell biology international 2019 Feb;43(2):158-166
l-Arginine Protects Ovine Intestinal Epithelial Cells from Lipopolysaccharide-Induced Apoptosis through Alleviating Oxidative Stress.
Zhang H, Peng A, Yu Y, Guo S, Wang M, Wang H
Journal of agricultural and food chemistry 2019 Feb 13;67(6):1683-1690
Journal of agricultural and food chemistry 2019 Feb 13;67(6):1683-1690
Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model.
Wang J, Wan D, Wan G, Wang J, Zhang J, Zhu H
Annals of translational medicine 2019 Dec;7(23):756
Annals of translational medicine 2019 Dec;7(23):756
Protective effect of p53 knockout on 4-nonylphenol-induced nephrotoxicity in medaka (Oryzias latipes).
Sayed AEH, Kotb AM, Oda S, Kashiwada S, Mitani H
Chemosphere 2019 Dec;236:124314
Chemosphere 2019 Dec;236:124314
Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.
Xu Q, Long Q, Zhu D, Fu D, Zhang B, Han L, Qian M, Guo J, Xu J, Cao L, Chin YE, Coppé JP, Lam EW, Campisi J, Sun Y
Aging cell 2019 Dec;18(6):e13027
Aging cell 2019 Dec;18(6):e13027
Natural Naphthohydroquinone Dimer Rubioncolin C Exerts Anti-Tumor Activity by Inducing Apoptotic and Autophagic Cell Death and Inhibiting the NF-κB and Akt/mTOR/P70S6K Pathway in Human Cancer Cells.
Wang J, Li L, Wang J, Song L, Tan N, Wang Z
Cells 2019 Dec 7;8(12)
Cells 2019 Dec 7;8(12)
Autophagy Attenuation Hampers Progesterone Synthesis during the Development of Pregnant Corpus Luteum.
Tang Z, Zhang Z, Zhang H, Wang Y, Zhang Y, Zhao J, Yang H, Wang Z
Cells 2019 Dec 27;9(1)
Cells 2019 Dec 27;9(1)
Rafoxanide promotes apoptosis and autophagy of gastric cancer cells by suppressing PI3K /Akt/mTOR pathway.
Liu JZ, Hu YL, Feng Y, Guo YB, Liu YF, Yang JL, Mao QS, Xue WJ
Experimental cell research 2019 Dec 15;385(2):111691
Experimental cell research 2019 Dec 15;385(2):111691
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
Mao Z, Han X, Chen D, Xu Y, Xu L, Yin L, Sun H, Qi Y, Fang L, Liu K, Peng J
British journal of pharmacology 2019 Apr;176(7):919-937
British journal of pharmacology 2019 Apr;176(7):919-937
The Orexin-A-Regulated Akt/mTOR Pathway Promotes Cell Proliferation Through Inhibiting Apoptosis in Pancreatic Cancer Cells.
Suo L, Chang X, Zhao Y
Frontiers in endocrinology 2018;9:647
Frontiers in endocrinology 2018;9:647
FGFR2 Promotes Gastric Cancer Progression by Inhibiting the Expression of Thrombospondin4 via PI3K-Akt-Mtor Pathway.
Huang T, Liu D, Wang Y, Li P, Sun L, Xiong H, Dai Y, Zou M, Yuan X, Qiu H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(4):1332-1345
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(4):1332-1345
Rapamycin Reduces Podocyte Apoptosis and is Involved in Autophagy and mTOR/ P70S6K/4EBP1 Signaling.
Jin J, Hu K, Ye M, Wu D, He Q
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(2):765-772
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(2):765-772
Epithelial Cells Attenuate Toll-Like Receptor-Mediated Inflammatory Responses in Monocyte-Derived Macrophage-Like Cells to Mycobacterium tuberculosis by Modulating the PI3K/Akt/mTOR Signaling Pathway.
Yang Y, Sun Y, Xu J, Bao K, Luo M, Liu X, Wang Y
Mediators of inflammation 2018;2018:3685948
Mediators of inflammation 2018;2018:3685948
Autophagy activation and the mechanism of retinal microvascular endothelial cells in hypoxia.
Li R, Wang LZ, Du JH, Zhao L, Yao Y
International journal of ophthalmology 2018;11(4):567-574
International journal of ophthalmology 2018;11(4):567-574
Identification of WDR12 as a novel oncogene involved in hepatocellular carcinoma propagation.
Yin Y, Zhou L, Zhan R, Zhang Q, Li M
Cancer management and research 2018;10:3985-3993
Cancer management and research 2018;10:3985-3993
UNBS5162 inhibits proliferation of human melanoma cells by inducing apoptosis via the PI3K/Akt pathway.
Shi X, Yang L, Xie J, Zhao Y, Cong J, Li Z, Li H, Cheng X, Fan J
Molecular medicine reports 2018 Sep;18(3):3382-3388
Molecular medicine reports 2018 Sep;18(3):3382-3388
Triptolide protects podocytes via autophagy in immunoglobulin A nephropathy.
Liang S, Jin J, Shen X, Jiang X, Li Y, He Q
Experimental and therapeutic medicine 2018 Sep;16(3):2275-2280
Experimental and therapeutic medicine 2018 Sep;16(3):2275-2280
LP1 from Lentinula edodes C(91-3) Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
Batool S, Joseph TP, Hussain M, Vuai MS, Khinsar KH, Din SRU, Padhiar AA, Zhong M, Ning A, Zhang W, Cao J, Huang M
International journal of molecular sciences 2018 Sep 30;19(10)
International journal of molecular sciences 2018 Sep 30;19(10)
Brg1 aggravates airway inflammation in asthma via inhibition of the PI3K/Akt/mTOR pathway.
Zou W, Ding F, Niu C, Fu Z, Liu S
Biochemical and biophysical research communications 2018 Sep 18;503(4):3212-3218
Biochemical and biophysical research communications 2018 Sep 18;503(4):3212-3218
Effects of Acute Cold Stress on Liver O-GlcNAcylation and Glycometabolism in Mice.
Yao R, Yang Y, Lian S, Shi H, Liu P, Liu Y, Yang H, Li S
International journal of molecular sciences 2018 Sep 18;19(9)
International journal of molecular sciences 2018 Sep 18;19(9)
Concurrence of autophagy with apoptosis in alveolar epithelial cells contributes to chronic pulmonary toxicity induced by methamphetamine.
Wang Y, Gu YH, Liang LY, Liu M, Jiang B, Zhu MJ, Wang X, Shi L
Cell proliferation 2018 Oct;51(5):e12476
Cell proliferation 2018 Oct;51(5):e12476
T-2 Toxin Exposure Induces Apoptosis in TM3 Cells by Inhibiting Mammalian Target of Rapamycin/Serine/Threonine Protein Kinase(mTORC2/AKT) to Promote Ca(2+)Production.
Wang J, Yang C, Yuan Z, Yi J, Wu J
International journal of molecular sciences 2018 Oct 27;19(11)
International journal of molecular sciences 2018 Oct 27;19(11)
Migration inhibition of water stress proteins from Nostoc commune Vauch. via activation of autophagy in DLD-1 cells.
Guo S, Liang X, Guo M, Zhang X, Li Z
International journal of biological macromolecules 2018 Nov;119:669-676
International journal of biological macromolecules 2018 Nov;119:669-676
Patulin induced ROS-dependent autophagic cell death in Human Hepatoma G2 cells.
Yang G, Bai Y, Wu X, Sun X, Sun M, Liu X, Yao X, Zhang C, Chu Q, Jiang L, Wang S
Chemico-biological interactions 2018 May 25;288:24-31
Chemico-biological interactions 2018 May 25;288:24-31
EGFR‑associated pathways involved in traditional Chinese medicine (TCM)‑1‑induced cell growth inhibition, autophagy and apoptosis in prostate cancer.
Wu Z, Zhu Q, Zhang Y, Yin Y, Kang D, Cao R, Tian Q, Lu S, Liu P
Molecular medicine reports 2018 Jun;17(6):7875-7885
Molecular medicine reports 2018 Jun;17(6):7875-7885
Retigabine ameliorates acute stress-induced impairment of spatial memory retrieval through regulating USP2 signaling pathways in hippocampal CA1 area.
Li C, Zhang J, Xu H, Chang M, Lv C, Xue W, Song Z, Zhang L, Zhang X, Tian X
Neuropharmacology 2018 Jun;135:151-162
Neuropharmacology 2018 Jun;135:151-162
Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression.
Li Y, Zeng C, Hu J, Pan Y, Shan Y, Liu B, Jia L
Journal of hematology & oncology 2018 Jul 3;11(1):89
Journal of hematology & oncology 2018 Jul 3;11(1):89
Thioredoxin-interacting protein deficiency ameliorates diabetic retinal angiogenesis.
Duan J, Du C, Shi Y, Liu D, Ma J
The international journal of biochemistry & cell biology 2018 Jan;94:61-70
The international journal of biochemistry & cell biology 2018 Jan;94:61-70
UNBS5162 inhibits the proliferation of human A549 non-small-cell lung cancer cells by promoting apoptosis.
Liu C, Xing J, Gao Y
Thoracic cancer 2018 Jan;9(1):105-111
Thoracic cancer 2018 Jan;9(1):105-111
Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation.
Huang L, Chen C, Zhang X, Li X, Chen Z, Yang C, Liang X, Zhu G, Xu Z
Journal of molecular neuroscience : MN 2018 Jan;64(1):129-139
Journal of molecular neuroscience : MN 2018 Jan;64(1):129-139
Has_circ_0008274 promotes cell proliferation and invasion involving AMPK/mTOR signaling pathway in papillary thyroid carcinoma.
Zhou GK, Zhang GY, Yuan ZN, Pei R, Liu DM
European review for medical and pharmacological sciences 2018 Dec;22(24):8772-8780
European review for medical and pharmacological sciences 2018 Dec;22(24):8772-8780
1,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells.
Cheng B, Lu J, Li T, Meng Z, Liu M, Sun M, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Dec;122:143-150
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Dec;122:143-150
Antagonizing peroxisome proliferator-activated receptor γ facilitates M1-to-M2 shift of microglia by enhancing autophagy via the LKB1-AMPK signaling pathway.
Ji J, Xue TF, Guo XD, Yang J, Guo RB, Wang J, Huang JY, Zhao XJ, Sun XL
Aging cell 2018 Aug;17(4):e12774
Aging cell 2018 Aug;17(4):e12774
Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy.
Wu F, Li S, Zhang N, Huang W, Li X, Wang M, Bai D, Han B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:307-314
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:307-314
Long-term effects of lysine concentration on growth performance, intestinal microbiome, and metabolic profiles in a pig model.
Yin J, Li Y, Han H, Liu Z, Zeng X, Li T, Yin Y
Food & function 2018 Aug 15;9(8):4153-4163
Food & function 2018 Aug 15;9(8):4153-4163
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Wu Z, Zhu Q, Yin Y, Kang D, Cao R, Tian Q, Zhang Y, Lu S, Liu P
Cancer medicine 2018 Apr;7(4):1546-1559
Cancer medicine 2018 Apr;7(4):1546-1559
Ox-LDL-Induced MicroRNA-155 Promotes Autophagy in Human Endothelial Cells via Repressing the Rheb/ mTOR Pathway.
Lv J, Yang L, Guo R, Shi Y, Zhang Z, Ye J
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(4):1436-1448
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(4):1436-1448
Protective Effects of Fluvastatin on Reproductive Function in Obese Male Rats Induced by High-Fat Diet through Enhanced Signaling of mTOR.
Cui X, Long C, Zhu J, Tian J
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(2):598-608
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(2):598-608
Combination of Endothelial-Monocyte-Activating Polypeptide-II with Temozolomide Suppress Malignant Biological Behaviors of Human Glioblastoma Stem Cells via miR-590-3p/MACC1 Inhibiting PI3K/AKT/mTOR Signal Pathway.
Zhou W, Liu L, Xue Y, Zheng J, Liu X, Ma J, Li Z, Liu Y
Frontiers in molecular neuroscience 2017;10:68
Frontiers in molecular neuroscience 2017;10:68
Fucosyltransferase VII promotes proliferation via the EGFR/AKT/mTOR pathway in A549 cells.
Liang JX, Gao W, Cai L
OncoTargets and therapy 2017;10:3971-3978
OncoTargets and therapy 2017;10:3971-3978
Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.
Zhao Z, Zhang L, Guo XD, Cao LL, Xue TF, Zhao XJ, Yang DD, Yang J, Ji J, Huang JY, Sun XL
Frontiers in molecular neuroscience 2017;10:293
Frontiers in molecular neuroscience 2017;10:293
Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
Xu L, Yin L, Tao X, Qi Y, Han X, Xu Y, Song S, Li L, Sun P, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):318-328
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):318-328
The alteration of autophagy and apoptosis in the hippocampus of rats with natural aging-dependent cognitive deficits.
Yu Y, Feng L, Li J, Lan X, A L, Lv X, Zhang M, Chen L
Behavioural brain research 2017 Sep 15;334:155-162
Behavioural brain research 2017 Sep 15;334:155-162
Effects of Long-Term Protein Restriction on Meat Quality, Muscle Amino Acids, and Amino Acid Transporters in Pigs.
Yin J, Li Y, Zhu X, Han H, Ren W, Chen S, Bin P, Liu G, Huang X, Fang R, Wang B, Wang K, Sun L, Li T, Yin Y
Journal of agricultural and food chemistry 2017 Oct 25;65(42):9297-9304
Journal of agricultural and food chemistry 2017 Oct 25;65(42):9297-9304
PD149163 induces hypothermia to protect against brain injury in acute cerebral ischemic rats.
Xue TF, Ding X, Ji J, Yan H, Huang JY, Guo XD, Yang J, Sun XL
Journal of pharmacological sciences 2017 Nov;135(3):105-113
Journal of pharmacological sciences 2017 Nov;135(3):105-113
Vascular endothelial growth factor signaling requires glycine to promote angiogenesis.
Guo D, Murdoch CE, Xu H, Shi H, Duan DD, Ahmed A, Gu Y
Scientific reports 2017 Nov 7;7(1):14749
Scientific reports 2017 Nov 7;7(1):14749
Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells.
Song L, Wang Z, Wang Y, Guo D, Yang J, Chen L, Tan N
Molecules (Basel, Switzerland) 2017 Nov 11;22(11)
Molecules (Basel, Switzerland) 2017 Nov 11;22(11)
Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway.
Ke Z, Wang G, Yang L, Qiu H, Wu H, Du M, Chen J, Song J, Jia X, Feng L
Journal of ethnopharmacology 2017 Jul 12;206:160-169
Journal of ethnopharmacology 2017 Jul 12;206:160-169
Metformin reduces glycometabolism of papillary thyroid carcinoma in vitro and in vivo.
Shen CT, Wei WJ, Qiu ZL, Song HJ, Zhang XY, Sun ZK, Luo QY
Journal of molecular endocrinology 2017 Jan;58(1):15-23
Journal of molecular endocrinology 2017 Jan;58(1):15-23
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Xue C, Wang C, Sun Y, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Ma X, Peng J, Liu K
Oncotarget 2017 Jan 31;8(5):8622-8632
Oncotarget 2017 Jan 31;8(5):8622-8632
Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways.
Zhang C, Li C, Chen S, Li Z, Ma L, Jia X, Wang K, Bao J, Liang Y, Chen M, Li P, Su H, Lee SM, Liu K, Wan JB, He C
Scientific reports 2017 Jan 23;7:41082
Scientific reports 2017 Jan 23;7:41082
LncRNA MEG3 inhibit endometrial carcinoma tumorigenesis and progression through PI3K pathway.
Sun KX, Wu DD, Chen S, Zhao Y, Zong ZH
Apoptosis : an international journal on programmed cell death 2017 Dec;22(12):1543-1552
Apoptosis : an international journal on programmed cell death 2017 Dec;22(12):1543-1552
Defective insulin signaling and the protective effects of dimethyldiguanide during follicular development in the ovaries of polycystic ovary syndrome.
Wang F, Wang S, Zhang Z, Lin Q, Liu Y, Xiao Y, Xiao K, Wang Z
Molecular medicine reports 2017 Dec;16(6):8164-8170
Molecular medicine reports 2017 Dec;16(6):8164-8170
Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling.
Li M, Jin C, Xu M, Zhou L, Li D, Yin Y
Cell communication and signaling : CCS 2017 Dec 16;15(1):52
Cell communication and signaling : CCS 2017 Dec 16;15(1):52
Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway.
Du C, Zhang T, Xiao X, Shi Y, Duan H, Ren Y
The Biochemical journal 2017 Aug 2;474(16):2733-2747
The Biochemical journal 2017 Aug 2;474(16):2733-2747
MicroRNA-99a inhibits insulin-induced proliferation, migration, dedifferentiation, and rapamycin resistance of vascular smooth muscle cells by inhibiting insulin-like growth factor-1 receptor and mammalian target of rapamycin.
Zhang ZW, Guo RW, Lv JL, Wang XM, Ye JS, Lu NH, Liang X, Yang LX
Biochemical and biophysical research communications 2017 Apr 29;486(2):414-422
Biochemical and biophysical research communications 2017 Apr 29;486(2):414-422
A taspine derivative supresses Caco-2 cell growth by competitively targeting EphrinB2 and regulating its pathway.
Dai B, Wang W, Ma Y, Liu R, Zhang Y
Oncology reports 2016 Sep;36(3):1526-34
Oncology reports 2016 Sep;36(3):1526-34
Oral kanglaite injection (KLTI) attenuates the lung cancer-promoting effect of high-fat diet (HFD)-induced obesity.
Cao N, Ma X, Guo Z, Zheng Y, Geng S, Meng M, Du Z, Lin H, Duan Y, Du G
Oncotarget 2016 Sep 20;7(38):61093-61106
Oncotarget 2016 Sep 20;7(38):61093-61106
Thioredoxin-interacting protein regulates lipid metabolism via Akt/mTOR pathway in diabetic kidney disease.
Du C, Wu M, Liu H, Ren Y, Du Y, Wu H, Wei J, Liu C, Yao F, Wang H, Zhu Y, Duan H, Shi Y
The international journal of biochemistry & cell biology 2016 Oct;79:1-13
The international journal of biochemistry & cell biology 2016 Oct;79:1-13
Resveratrol Increases Anti-Proliferative Activity of Bestatin Through Downregulating P-Glycoprotein Expression Via Inhibiting PI3K/Akt/mTOR Pathway in K562/ADR Cells.
Wang L, Wang C, Jia Y, Liu Z, Shu X, Liu K
Journal of cellular biochemistry 2016 May;117(5):1233-9
Journal of cellular biochemistry 2016 May;117(5):1233-9
Total saponins isolated from Radix et Rhizoma Leonticis suppresses tumor cells growth by regulation of PI3K/Akt/mTOR and p38 MAPK pathways.
Zhan Y, Liu R, Wang W, Li J, Yang XO, Zhang Y
Environmental toxicology and pharmacology 2016 Jan;41:39-44
Environmental toxicology and pharmacology 2016 Jan;41:39-44
Amplified HMGA2 promotes cell growth by regulating Akt pathway in AML.
Tan L, Wei X, Zheng L, Zeng J, Liu H, Yang S, Tan H
Journal of cancer research and clinical oncology 2016 Feb;142(2):389-99
Journal of cancer research and clinical oncology 2016 Feb;142(2):389-99
Paper-based microreactor array for rapid screening of cell signaling cascades.
Huang CH, Lei KF, Tsang NM
Lab on a chip 2016 Aug 7;16(15):2911-20
Lab on a chip 2016 Aug 7;16(15):2911-20
The mTOR/AP-1/VEGF signaling pathway regulates vascular endothelial cell growth.
Wang S, Lu J, You Q, Huang H, Chen Y, Liu K
Oncotarget 2016 Aug 16;7(33):53269-53276
Oncotarget 2016 Aug 16;7(33):53269-53276
Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in rats.
DU Q, Hao C, Gou J, Li X, Zou K, He X, Li Z
Experimental and therapeutic medicine 2016 Apr;11(4):1433-1440
Experimental and therapeutic medicine 2016 Apr;11(4):1433-1440
Low doses of single or combined agrichemicals induces α-synuclein aggregation in nigrostriatal system of mice through inhibition of proteasomal and autophagic pathways.
Su C, Niu P
International journal of clinical and experimental medicine 2015;8(11):20508-15
International journal of clinical and experimental medicine 2015;8(11):20508-15
GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy.
Zhang Q, Zhuang J, Deng Y, Zhao X, Tang B, Yao D, Zhao W, Chang C, Lu Q, Chen W, Zhang S, Ji C, Cao L, Guo H
Oncotarget 2015 Oct 13;6(31):32177-92
Oncotarget 2015 Oct 13;6(31):32177-92
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Li X, Zou K, Gou J, Du Q, Li D, He X, Li Z
Medical oncology (Northwood, London, England) 2015 Mar;32(3):72
Medical oncology (Northwood, London, England) 2015 Mar;32(3):72
Potent effects of dioscin against obesity in mice.
Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973
Scientific reports 2015 Jan 22;5:7973
mTOR inhibitor AZD8055 inhibits proliferation and induces apoptosis in laryngeal carcinoma.
Zhao L, Teng B, Wen L, Feng Q, Wang H, Li N, Wang Y, Liang Z
International journal of clinical and experimental medicine 2014;7(2):337-47
International journal of clinical and experimental medicine 2014;7(2):337-47
Eupolyphaga sinensis walker displays inhibition on hepatocellular carcinoma through regulating cell growth and metastasis signaling.
Zhang Y, Zhan Y, Zhang D, Dai B, Ma W, Qi J, Liu R, He L
Scientific reports 2014 Jul 1;4:5518
Scientific reports 2014 Jul 1;4:5518
Prognostic significance of p53, mTOR, c-Met, IGF-1R, and HSP70 overexpression after the resection of hepatocellular carcinoma.
Kang GH, Lee BS, Lee ES, Kim SH, Lee HY, Kang DY
Gut and liver 2014 Jan;8(1):79-87
Gut and liver 2014 Jan;8(1):79-87
SOCS3 methylation in synergy with Reg3A overexpression promotes cell growth in pancreatic cancer.
Wang J, Zhou H, Han Y, Liu X, Wang M, Wang X, Yin G, Li X, Xiang M
Journal of molecular medicine (Berlin, Germany) 2014 Dec;92(12):1257-69
Journal of molecular medicine (Berlin, Germany) 2014 Dec;92(12):1257-69
Brucine suppresses colon cancer cells growth via mediating KDR signalling pathway.
Luo W, Wang X, Zheng L, Zhan Y, Zhang D, Zhang J, Zhang Y
Journal of cellular and molecular medicine 2013 Oct;17(10):1316-24
Journal of cellular and molecular medicine 2013 Oct;17(10):1316-24
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 20657-1-AP(MTOR antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 20657-1-AP(MTOR antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MTOR antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human MTOR. This antibody recognizes human,mouse,rat antigen. The MTOR antibody has been validated for the following applications: ELISA, WB, IHC analysis.
