ABIN196963

antibody from antibodies-online

Targeting: MTOR FLJ44809, FRAP, FRAP1, FRAP2, RAFT1, RAPT1

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN196963

Provider

antibodies-online

Product name

anti-Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) (pSer2448) antibody

Antibody type

Polyclonal

Description

Affinity Chromatography using epitope-specific phosphopeptide.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

pSer2448

Vial size

50 μL

Storage

Store the antibody (in aliquots) at -20°C.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase.

Chiang GG, Abraham RT
The Journal of biological chemistry 2005 Jul 8;280(27):25485-90

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Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase.

Holz MK, Blenis J
The Journal of biological chemistry 2005 Jul 15;280(28):26089-93

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In rat hepatocytes glucagon increases mammalian target of rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream targets induced by insulin and amino acids.

Mothe-Satney I, Gautier N, Hinault C, Lawrence JC Jr, Van Obberghen E
The Journal of biological chemistry 2004 Oct 8;279(41):42628-37

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Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal muscle.

Bolster DR, Kubica N, Crozier SJ, Williamson DL, Farrell PA, Kimball SR, Jefferson LS
The Journal of physiology 2003 Nov 15;553(Pt 1):213-20