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- Antigen structure
- References [19]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 17340-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- MAP2K4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MAP2K4 antibody (Cat. #17340-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Indirubin treatment was associated with modulation of the PI3K/AKT and MAPK pathways and induction of apoptosis and autophagy.
The chemokine CCL20 promotes hepatocyte cholesterol deposition during metabolic dysfunction-associated steatohepatitis by regulating OLR1 expression.
Integrating UHPLC-QE-MS and Bioinformatics with Experimental Validation Reveals MAPK/FOS-Mediated Podocyte Apoptosis as the Key Mechanism of Alpiniae oxyphyllae and Saposhnikovia divaricata in Treating Diabetic Kidney Disease.
Ganoderic acid a derivative induces apoptosis of cervical cancer cells by inhibiting JNK pathway.
Inhibition of LCP2 in T cells alleviated apoptosis and oxidative stress via PD-1/PD-L1 in diabetic retinopathy.
tRF-22-WE8SPOX52 promotes progression of breast cancer by down-regulating MAP2K4.
The aberrantly activated AURKB supports and complements the function of AURKA in CALR mutated cells through regulating the cell growth and differentiation.
UBE2M inhibits neoplastic cell proliferation via MKK7-JNK-EGR1 axis in melanoma.
Mefunidone ameliorates acute liver failure in mice by inhibiting MKK4-JNK pathway.
Targeting PRSS23 with tipranavir induces gastric cancer stem cell apoptosis and inhibits growth of gastric cancer via the MKK3/p38 MAPK-IL24 pathway.
Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway.
A new prognosis prediction model combining TNM stage with MAP2K4 and JNK in postoperative pancreatic cancer patients.
Regulation of CREB Phosphorylation in Nucleus Accumbens after Relief Conditioning.
Dual effects of JNK activation in blood-milk barrier damage induced by zinc oxide nanoparticles.
NR4A1 counteracts JNK activation incurred by ER stress or ROS in pancreatic β-cells for protection.
Huai Qi Huang-induced Apoptosis via Down-regulating PRKCH and Inhibiting RAF/MEK/ERK Pathway in Ph(+) Leukemia Cells.
Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3β/β-catenin signaling pathway.
Androgen-induced miR-27A acted as a tumor suppressor by targeting MAP2K4 and mediated prostate cancer progression.
LPS induced miR-181a promotes pancreatic cancer cell migration via targeting PTEN and MAP2K4.
Xie X, Liu C, Liu X, Hou L, Zhang Y, Huang L, Peng W, Liu Y
Scientific reports 2026 Jan 13;16(1):5155
Scientific reports 2026 Jan 13;16(1):5155
The chemokine CCL20 promotes hepatocyte cholesterol deposition during metabolic dysfunction-associated steatohepatitis by regulating OLR1 expression.
Yin M, Zhang Y, Liu S, Wang Q, Zhang Y, Min J, Yang J, Zhao Y, Zhou Z, Li X, Liu S
Metabolism: clinical and experimental 2025 Sep;170:156301
Metabolism: clinical and experimental 2025 Sep;170:156301
Integrating UHPLC-QE-MS and Bioinformatics with Experimental Validation Reveals MAPK/FOS-Mediated Podocyte Apoptosis as the Key Mechanism of Alpiniae oxyphyllae and Saposhnikovia divaricata in Treating Diabetic Kidney Disease.
Wang X, Zhang L, Tang R, Zhang W, Xie Y, Li K
Pharmaceuticals (Basel, Switzerland) 2025 Sep 27;18(10)
Pharmaceuticals (Basel, Switzerland) 2025 Sep 27;18(10)
Ganoderic acid a derivative induces apoptosis of cervical cancer cells by inhibiting JNK pathway.
Wang M, Han Q, Zhang X, Dong X, Ran J, Wei F, Luo Y, Sun X
Chinese herbal medicines 2025 Oct;17(4):756-767
Chinese herbal medicines 2025 Oct;17(4):756-767
Inhibition of LCP2 in T cells alleviated apoptosis and oxidative stress via PD-1/PD-L1 in diabetic retinopathy.
Lu M, Ye X, Deng X, Jiao F, Ren H, Xing Y
International immunopharmacology 2025 Oct 10;163:115240
International immunopharmacology 2025 Oct 10;163:115240
tRF-22-WE8SPOX52 promotes progression of breast cancer by down-regulating MAP2K4.
Fu Y, Hu H, Wang D, Qian T, Huang X, Zhong S
Medical oncology (Northwood, London, England) 2025 Jun 10;42(7):248
Medical oncology (Northwood, London, England) 2025 Jun 10;42(7):248
The aberrantly activated AURKB supports and complements the function of AURKA in CALR mutated cells through regulating the cell growth and differentiation.
Hu X, Yu X, Zhang L, Zhang Q, Ji M, Qi K, Wang S, Li Z, Xu K, Fu C
Experimental cell research 2025 Jan 15;444(2):114377
Experimental cell research 2025 Jan 15;444(2):114377
UBE2M inhibits neoplastic cell proliferation via MKK7-JNK-EGR1 axis in melanoma.
Xu L, Pan C, Wang Y, Ni L, Zeng P, Lin X, Lyu X, Huang S, Dang N
Journal of translational medicine 2025 Dec 8;24(1):52
Journal of translational medicine 2025 Dec 8;24(1):52
Mefunidone ameliorates acute liver failure in mice by inhibiting MKK4-JNK pathway.
Zhang Y, He X, Gu L, Li S, Tang J, Ma R, Yang H, Peng Z
Biochemical pharmacology 2024 Jul;225:116267
Biochemical pharmacology 2024 Jul;225:116267
Targeting PRSS23 with tipranavir induces gastric cancer stem cell apoptosis and inhibits growth of gastric cancer via the MKK3/p38 MAPK-IL24 pathway.
Xiong JX, Li YT, Tan XY, Chen T, Liu BH, Fu L
Acta pharmacologica Sinica 2024 Feb;45(2):405-421
Acta pharmacologica Sinica 2024 Feb;45(2):405-421
Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway.
Gu L, He X, Zhang Y, Li S, Tang J, Ma R, Yang X, Huang H, Peng Y, Xie Y, Peng Z, Meng J, Hu G, Tao L, Liu X, Yang H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114844
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114844
A new prognosis prediction model combining TNM stage with MAP2K4 and JNK in postoperative pancreatic cancer patients.
Liu XD, Zhang ZW, Wu HW, Liang ZY
Pathology, research and practice 2021 Jan;217:153313
Pathology, research and practice 2021 Jan;217:153313
Regulation of CREB Phosphorylation in Nucleus Accumbens after Relief Conditioning.
Soleimanpour E, Bergado Acosta JR, Landgraf P, Mayer D, Dankert E, Dieterich DC, Fendt M
Cells 2021 Jan 26;10(2)
Cells 2021 Jan 26;10(2)
Dual effects of JNK activation in blood-milk barrier damage induced by zinc oxide nanoparticles.
Wu J, Lai X, Cui G, Chen Q, Liu J, Kang Y, Zhang Y, Feng X, Hu C, Shao L
Journal of hazardous materials 2020 Nov 15;399:122809
Journal of hazardous materials 2020 Nov 15;399:122809
NR4A1 counteracts JNK activation incurred by ER stress or ROS in pancreatic β-cells for protection.
Pu ZQ, Liu D, Lobo Mouguegue HPP, Jin CW, Sadiq E, Qin DD, Yu TF, Zong C, Chen JC, Zhao RX, Lin JY, Cheng J, Yu X, Li X, Zhang YC, Liu YT, Guan QB, Wang XD
Journal of cellular and molecular medicine 2020 Dec;24(24):14171-14183
Journal of cellular and molecular medicine 2020 Dec;24(24):14171-14183
Huai Qi Huang-induced Apoptosis via Down-regulating PRKCH and Inhibiting RAF/MEK/ERK Pathway in Ph(+) Leukemia Cells.
Xu WF, Wang ZJ, Li K, Shen YQ, Lu K, Lv XY, Wen YX, Jin RM
Current medical science 2020 Apr;40(2):354-362
Current medical science 2020 Apr;40(2):354-362
Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3β/β-catenin signaling pathway.
Liu Y, Jiang Q, Liu X, Lin X, Tang Z, Liu C, Zhou J, Zhao M, Li X, Cheng Z, Li L, Xie Y, Liu Z, Fang W
EBioMedicine 2019 Oct;48:386-404
EBioMedicine 2019 Oct;48:386-404
Androgen-induced miR-27A acted as a tumor suppressor by targeting MAP2K4 and mediated prostate cancer progression.
Wan X, Huang W, Yang S, Zhang Y, Zhang P, Kong Z, Li T, Wu H, Jing F, Li Y
The international journal of biochemistry & cell biology 2016 Oct;79:249-260
The international journal of biochemistry & cell biology 2016 Oct;79:249-260
LPS induced miR-181a promotes pancreatic cancer cell migration via targeting PTEN and MAP2K4.
Liu J, Xu D, Wang Q, Zheng D, Jiang X, Xu L
Digestive diseases and sciences 2014 Jul;59(7):1452-60
Digestive diseases and sciences 2014 Jul;59(7):1452-60
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- RAW264.7 cells were subjected to SDS PAGE followed by western blot with 17340-1-AP(MAP2K4 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 17340-1-AP(MAP2K4 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MEK4 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human MEK4. This antibody recognizes human, mouse, rat antigen. The MEK4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
