MAP2K4

gene product
JNKK1, MEK4, MKK4, PRKMK4, SERK1
This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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Antibodypedia Validation Initiative

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Enhanced validation
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Eligible for validation within AVI
1247 antibodies from 38 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
OriGene
42 antibodies
antibodies-online
495 antibodies
GeneTex
19 antibodies
Novus Biologicals
28 antibodies
Biorbyt
57 antibodies
Acris Antibodies GmbH
25 antibodies
Abnova Corporation
15 antibodies
LifeSpan BioSciences, Inc.
153 antibodies