GTX61739

antibody from GeneTex

Targeting: ATM ATA, ATC, ATD, ATDC, TEL1, TELO1

Western blot (Supportive data in Antibodypedia)

Immunocytochemistry (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

GTX61739

Provider

GeneTex

Proper citation

GeneTex Cat#GTX61739, RRID:AB_10633021

Product name

ATM (phospho Ser1981) antibody [EP1890Y]

Antibody type

Monoclonal

Reactivity

Human

Host

Rabbit

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

References

Submitted references

NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy.

Wu Q, Allouch A, Paoletti A, Leteur C, Mirjolet C, Martins I, Voisin L, Law F, Dakhli H, Mintet E, Thoreau M, Muradova Z, Gauthier M, Caron O, Milliat F, Ojcius DM, Rosselli F, Solary E, Modjtahedi N, Deutsch E, Perfettini JL
Cell death and differentiation 2017 Sep;24(9):1632-1644

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Loss of ATM in Airway Epithelial Cells Is Associated with Susceptibility to Oxidative Stress.

Yeo AJ, Fantino E, Czovek D, Wainwright CE, Sly PD, Lavin MF
American journal of respiratory and critical care medicine 2017 Aug 1;196(3):391-393

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The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells.

Chen CW, Tsao N, Huang LY, Yen Y, Liu X, Lehman C, Wang YH, Tseng MC, Chen YJ, Ho YC, Chen CF, Chang ZF
Cell reports 2016 Aug 2;16(5):1287-1299

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RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence.

Cekan P, Hasegawa K, Pan Y, Tubman E, Odde D, Chen JQ, Herrmann MA, Kumar S, Kalab P
Molecular biology of the cell 2016 Apr 15;27(8):1346-57

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Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells.

Li LH, Wu P, Lee JY, Li PR, Hsieh WY, Ho CC, Ho CL, Chen WJ, Wang CC, Yen MY, Yang SM, Chen HW
PloS one 2014;9(8):e104203

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Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling.

Cheung CT, Singh R, Kalra RS, Kaul SC, Wadhwa R
The Journal of biological chemistry 2014 Jun 27;289(26):18258-69

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Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity.

Huang FC, Chang CC, Wang JM, Chang TC, Lin JJ
British journal of pharmacology 2012 Sep;167(2):393-406

Western blot

Supportive validation

Submitted by

GeneTex (provider)

Main image

Experimental details

A. Western blot analysis on HEK293 cell lysates using anti-ATM Phospho (pS1981) RabMAb (cat # GTX61739) dilution at 1:10000. Cells were either (A) untreated or (B) treated with doxorubicin.

Validation comment

WB

Supportive validation

Submitted by

GeneTex (provider)

Main image

Experimental details

WB analysis of lysates from (1) untreated and (2) doxorubicin-treated HEK293 cells (10 μg per lane) using ATM (phospho Ser1981) antibody [EP1890Y] at a dilution of 1:10,000.

Immunohistochemistry

Supportive validation

Submitted by

GeneTex (provider)

Main image

Experimental details

IHC analysis of endometrial carcinoma tissue using ATM (phospho Ser1981) antibody [EP1890Y].

Supportive validation

Submitted by

GeneTex (provider)

Main image

Experimental details

IHC-P analysis of human gastric carcinoma using ATM (phospho Ser1981) antibody [EP1890Y] at a dilution of 1:100.