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LearnTissue expression
Cell line expression
Protein structure
ATM
ATM serine/threonine kinaseATA, ATC, ATD, ATDC, TEL1, TELO1
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
Top validated antibodies |
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| GeneTex |  GTX70103 |
200 references | Monoclonal |
WB
EL
ICC
IP
IHC
FC
ChIP
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| Novus Biologicals | NB100-309 |
118 references | Monoclonal |
WB
EL
ICC
IP
IHC
FC
ChIP
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| antibodies-online | ABIN151030 |
77 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| Invitrogen Antibodies | MA1-23152 |
3 references | Monoclonal |
WB
EL
IP
IHC
FC
ChIP
OA
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| Proteintech Group | 27156-1-AP |
17 references | Polyclonal |
WB
EL
ICC
IHC
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