27156-1-AP

antibody from Proteintech Group

Targeting: ATM ATA, ATC, ATD, ATDC, TEL1, TELO1

Provider product page for 27156-1-AP

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Antibody data

Antibody Data
Antigen structure
References [36]
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Product number: 27156-1-AP - Provider product page
Provider: Proteintech Group
Product name: ATM antibody
Antibody type: Polyclonal
Description: ATM antibody (Cat. #27156-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ATM protein structure - 27156-1-AP shown in red.

Submitted references An interpretable artificial intelligence framework for designing synthetic lethality-based anti-cancer combination therapies.

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CircUGGT2 facilitates progression and cisplatin resistance of bladder cancer through nonhomologous end-joining pathway.

Lyu F, Huang S, Yan Z, He Q, Liu C, Cheng L, Cong Y, Chen K, Song Y, Xing Y
Cellular signalling 2024 Jul;119:111164

OTUB1 Targets CHK1 for Deubiquitination and Stabilization to Facilitate Lung Cancer Progression and Radioresistance.

Wang J, Liu Y, Wu D, Tian C, Gao J, Yang Q, Hong X, Gu F, Zhang K, Hu Y, Xu S, Liu L, Zeng Y
International journal of radiation oncology, biology, physics 2024 Jul 15;119(4):1222-1233

A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells.

Schmit MM, Baxley RM, Wang L, Hinderlie P, Kaufman M, Simon E, Raju A, Miller JS, Bielinsky AK
Open biology 2024 Jan;14(1):230407

Guanosine diphosphate-mannose suppresses homologous recombination repair and potentiates antitumor immunity in triple-negative breast cancer.

Ding JH, Xiao Y, Yang F, Song XQ, Xu Y, Ding XH, Ding R, Shao ZM, Di GH, Jiang YZ
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LCP1-mediated cytoskeleton alterations involve in arsenite-triggered malignant phenotype of human immortalized prostate stromal cells.

Yang Y, Zhou M, Huang Y, Ye X, Mo Y, Huang Y, Wang S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114548

FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA.

Geng Y, Long X, Zhang Y, Wang Y, You G, Guo W, Zhuang G, Zhang Y, Cheng X, Yuan Z, Zan J
Journal of translational medicine 2023 Sep 22;21(1):652

Lnc-PTCHD4-AS inhibits gastric cancer through MSH2-MSH6 dimerization and ATM-p53-p21 activation.

Wang J, Mi Y, Sun X, Xue X, Zhao H, Zhang M, Hu B, Bukhari I, Zheng P
Aging 2023 Nov 27;15(22):13558-13578

A prognostic risk model for programmed cell death and revealing TRIB3 as a promising apoptosis suppressor in renal cell carcinoma.

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C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.

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Nerve Injury-Induced γH2AX Reduction in Primary Sensory Neurons Is Involved in Neuropathic Pain Processing.

Zhang Y, Gong H, Wang JS, Li MN, Cao DL, Gu J, Zhao LX, Zhang XD, Deng YT, Dong FL, Gao YJ, Sun WX, Jiang BC
International journal of molecular sciences 2023 Jun 15;24(12)

TRIM24 is critical for the cellular response to DNA double-strand breaks through regulating the recruitment of MRN complex.

Wang Y, Yao Y, Wei Q, Long S, Chen Y, Xie J, Tan R, Jiang W, Zhang Q, Wu D, Xiao S, Wan F, Fu K
Oncogene 2023 Feb;42(8):586-600

Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis.

Zhou Y, Tang J, Lan J, Zhang Y, Wang H, Chen Q, Kang Y, Sun Y, Feng X, Wu L, Jin H, Chen S, Peng Y
Acta pharmaceutica Sinica. B 2023 Feb;13(2):577-597

PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma.

Zhao M, Li Y, Lu C, Ding F, Xu M, Ge X, Li M, Wang Z, Yin J, Zhang J, Wang X, Ge Z, Xiao H, Xiao Y, Liu H, Liu W, Cao Y, Wang Q, You Y, Wang X, Yang K, Shi Z, Qian X
Cancer research 2023 Apr 4;83(7):1094-1110

ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway.

Wen X, Chen S, Chen X, Qiu H, Wang W, Zhang N, Liu W, Wang T, Ding X, Zhang L
Frontiers in oncology 2022;12:887068

Targeting MDC1 promotes apoptosis and sensitizes Imatinib resistance in CML cells by mainly disrupting non-homologous end-joining repair.

Liang Y, Qin Y, Jiang G, Feng W, Yuan Y
Medical oncology (Northwood, London, England) 2022 Sep 29;39(12):226

Single-cell profiling-guided combination therapy of c-Fos and histone deacetylase inhibitors in diffuse large B-cell lymphoma.

Wang L, Wu Z, Xia Y, Lu X, Li J, Fan L, Qiao C, Qiu H, Gu D, Xu W, Li J, Jin H
Clinical and translational medicine 2022 May;12(5):e798

Acquired temozolomide resistance in MGMT(low) gliomas is associated with regulation of homologous recombination repair by ROCK2.

Zhang X, Li T, Yang M, Du Q, Wang R, Fu B, Tan Y, Cao M, Chen Y, Wang Q, Hu R
Cell death & disease 2022 Feb 10;13(2):138

Asparaginyl endopeptidase (AEP) regulates myocardial apoptosis in response to radiation exposure via alterations in NRF2 activation.

Cao L, Xu C, Yi P, Li H, Lin Y, Cai G, Wang S, Ou D, Li M, Chen J
American journal of cancer research 2021;11(4):1206-1225

Upregulation of Chemoresistance by Mg(2+) Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells.

Onuma S, Manabe A, Yoshino Y, Matsunaga T, Asai T, Ikari A
Cells 2021 May 12;10(5)

AIMP3 inhibits cell growth and metastasis of lung adenocarcinoma through activating a miR-96-5p-AIMP3-p53 axis.

Ding L, Fang Y, Li Y, Hu Q, Ai M, Deng K, Huang X, Xin H
Journal of cellular and molecular medicine 2021 Mar;25(6):3019-3030

MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway.

Ling Q, Li F, Zhang X, Mao S, Lin X, Pan J, Ye W, Wei W, Qian Y, Hu C, Huang X, Wang J, Wang H, Huang J, Wang Y, Jin J
EBioMedicine 2021 Jul;69:103441

p53-dependent elimination of aneuploid mitotic offspring by entosis.

Liang J, Niu Z, Zhang B, Yu X, Zheng Y, Wang C, Ren H, Wang M, Ruan B, Qin H, Zhang X, Gu S, Sai X, Tai Y, Gao L, Ma L, Chen Z, Huang H, Wang X, Sun Q
Cell death and differentiation 2021 Feb;28(2):799-813

MET inhibition enhances PARP inhibitor efficacy in castration-resistant prostate cancer by suppressing the ATM/ATR and PI3K/AKT pathways.

Zhou S, Dai Z, Wang L, Gao X, Yang L, Wang Z, Wang Q, Liu Z
Journal of cellular and molecular medicine 2021 Dec;25(24):11157-11169

Mutant IDH1 Enhances Temozolomide Sensitivity via Regulation of the ATM/CHK2 Pathway in Glioma.

Lin L, Cai J, Tan Z, Meng X, Li R, Li Y, Jiang C
Cancer research and treatment 2021 Apr;53(2):367-377

Synthesis, docking studies and antitumor activity of phenanthroimidazole derivatives as promising c-myc G-quadruplex DNA stabilizers.

Wu Q, Song Y, Liu R, Wang R, Mei W, Chen W, Yang H, Wang X
Bioorganic chemistry 2020 Sep;102:104074

UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.

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RNF8 promotes efficient DSB repair by inhibiting the pro-apoptotic activity of p53 through regulating the function of Tip60.

Chen H, Shan J, Liu J, Feng Y, Ke Y, Qi W, Liu W, Zeng X
Cell proliferation 2020 Mar;53(3):e12780

Novel SAHA‑bendamustine hybrid NL‑101 in combination with daunorubicin synergistically suppresses acute myeloid leukemia.

Jin J, Li X, Guo W, Li F, Huang J, Huang X, Pan J, Huang S, Ye W, Ling Q, Jin J
Oncology reports 2020 Jul;44(1):273-282

Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin.

Guo J, Zhang J, Liang L, Liu N, Qi M, Zhao S, Su J, Liu J, Peng C, Chen X, Liu H
Journal of cellular and molecular medicine 2020 Apr;24(7):4324-4340

A novel alkylating deacetylase inhibitor molecule EDO-S101 in combination with cytarabine synergistically enhances apoptosis of acute myeloid leukemia cells.

Jin J, Mao S, Li F, Li X, Huang X, Yu M, Guo W, Jin J
Medical oncology (Northwood, London, England) 2019 Aug 1;36(9):77

Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.

Mao Z, Han X, Chen D, Xu Y, Xu L, Yin L, Sun H, Qi Y, Fang L, Liu K, Peng J
British journal of pharmacology 2019 Apr;176(7):919-937

2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid, a glutathione reductase inhibitor, induces G(2)/M cell cycle arrest through generation of thiol oxidative stress in human esophageal cancer cells.

Li X, Jiang Z, Feng J, Zhang X, Wu J, Chen W
Oncotarget 2017 Sep 22;8(37):61846-61860

Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.

Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J, Zhou Z
Journal of agricultural and food chemistry 2017 Jul 26;65(29):5973-5984

Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.

Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J
Plant foods for human nutrition (Dordrecht, Netherlands) 2017 Dec;72(4):425-431

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