ABIN401483

antibody from antibodies-online

Targeting: ATM ATA, ATC, ATD, ATDC, TEL1, TELO1

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

ABIN401483

Provider

antibodies-online

Product name

anti-Ataxia Telangiectasia Mutated (ATM) (pSer1981) antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide corresponding to a region near serine 1981 of human ATM conjugated to KLH using maleimide

Description

Affinity chromatography

Reactivity

Human

Host

Sheep

Epitope

pSer1981

Isotype

IgG

Vial size

25 μL

Concentration

1.0 mg/mL (by UV absorbance at 280 nm)

Storage

-20°C

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.

Falck J, Coates J, Jackson SP
Nature 2005 Mar 31;434(7033):605-11

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ATM activation in normal human tissues and testicular cancer.

Bartkova J, Bakkenist CJ, Rajpert-De Meyts E, Skakkebaek NE, Sehested M, Lukas J, Kastan MB, Bartek J
Cell cycle (Georgetown, Tex.) 2005 Jun;4(6):838-45

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis.

Bartkova J, Horejsí Z, Koed K, Krämer A, Tort F, Zieger K, Guldberg P, Sehested M, Nesland JM, Lukas C, Ørntoft T, Lukas J, Bartek J
Nature 2005 Apr 14;434(7035):864-70

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Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.

Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB
Genes & development 2004 Jun 15;18(12):1423-38

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.

Bakkenist CJ, Kastan MB
Nature 2003 Jan 30;421(6922):499-506