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- Antigen structure
- References [26]
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- Western blot [2]
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- Product number
- ABIN151622 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Ataxia Telangiectasia Mutated (ATM) antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 5C2
- Vial size
- 0.1 mL
- Storage
- Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease.
A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells.
Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.
Cleavage of the BRCT tandem domains of nibrin by the 657del5 mutation affects the DNA damage response less than the Arg215Trp mutation.
Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells.
Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection.
Loss of ATM kinase activity leads to embryonic lethality in mice.
NBS1 deficiency promotes genome instability by affecting DNA damage signaling pathway and impairing telomere integrity.
Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.
mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.
DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation.
Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.
Human MutL-complexes monitor homologous recombination independently of mismatch repair.
Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.
The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.
Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells.
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.
Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity.
The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.
Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1.
Deep senescent human fibroblasts show diminished DNA damage foci but retain checkpoint capacity to oxidative stress.
Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation.
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.
DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.
Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons.
Barnard RA, Regan DP, Hansen RJ, Maycotte P, Thorburn A, Gustafson DL
The Journal of pharmacology and experimental therapeutics 2016 Aug;358(2):282-93
The Journal of pharmacology and experimental therapeutics 2016 Aug;358(2):282-93
A plastic SQSTM1/p62-dependent autophagic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells.
Milan E, Perini T, Resnati M, Orfanelli U, Oliva L, Raimondi A, Cascio P, Bachi A, Marcatti M, Ciceri F, Cenci S
Autophagy 2015;11(7):1161-78
Autophagy 2015;11(7):1161-78
Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.
Aumailley L, Garand C, Dubois MJ, Johnson FB, Marette A, Lebel M
PloS one 2015;10(10):e0140292
PloS one 2015;10(10):e0140292
Cleavage of the BRCT tandem domains of nibrin by the 657del5 mutation affects the DNA damage response less than the Arg215Trp mutation.
Mendez G, Cilli D, Berardinelli F, Viganotti M, Ascenzi P, Tanzarella C, Antoccia A, di Masi A
IUBMB life 2012 Oct;64(10):853-61
IUBMB life 2012 Oct;64(10):853-61
Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells.
Rankin AM, Sarkar S, Faller DV
Journal of cellular physiology 2012 Jun;227(6):2586-94
Journal of cellular physiology 2012 Jun;227(6):2586-94
Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection.
Vogel R, Seyffert M, Strasser R, de Oliveira AP, Dresch C, Glauser DL, Jolinon N, Salvetti A, Weitzman MD, Ackermann M, Fraefel C
Journal of virology 2012 Jan;86(1):143-55
Journal of virology 2012 Jan;86(1):143-55
Loss of ATM kinase activity leads to embryonic lethality in mice.
Daniel JA, Pellegrini M, Lee BS, Guo Z, Filsuf D, Belkina NV, You Z, Paull TT, Sleckman BP, Feigenbaum L, Nussenzweig A
The Journal of cell biology 2012 Aug 6;198(3):295-304
The Journal of cell biology 2012 Aug 6;198(3):295-304
NBS1 deficiency promotes genome instability by affecting DNA damage signaling pathway and impairing telomere integrity.
Hou YY, Toh MT, Wang X
Cell biochemistry and function 2012 Apr;30(3):233-42
Cell biochemistry and function 2012 Apr;30(3):233-42
Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.
Gapud EJ, Dorsett Y, Yin B, Callen E, Bredemeyer A, Mahowald GK, Omi KQ, Walker LM, Bednarski JJ, McKinnon PJ, Bassing CH, Nussenzweig A, Sleckman BP
Proceedings of the National Academy of Sciences of the United States of America 2011 Feb 1;108(5):2022-7
Proceedings of the National Academy of Sciences of the United States of America 2011 Feb 1;108(5):2022-7
mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.
Cam H, Easton JB, High A, Houghton PJ
Molecular cell 2010 Nov 24;40(4):509-20
Molecular cell 2010 Nov 24;40(4):509-20
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.
Alimonti A, Nardella C, Chen Z, Clohessy JG, Carracedo A, Trotman LC, Cheng K, Varmeh S, Kozma SC, Thomas G, Rosivatz E, Woscholski R, Cognetti F, Scher HI, Pandolfi PP
The Journal of clinical investigation 2010 Mar;120(3):681-93
The Journal of clinical investigation 2010 Mar;120(3):681-93
DeltaNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation.
Craig AL, Holcakova J, Finlan LE, Nekulova M, Hrstka R, Gueven N, DiRenzo J, Smith G, Hupp TR, Vojtesek B
Molecular cancer 2010 Jul 21;9:195
Molecular cancer 2010 Jul 21;9:195
Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.
Efeyan A, Murga M, Martinez-Pastor B, Ortega-Molina A, Soria R, Collado M, Fernandez-Capetillo O, Serrano M
PloS one 2009;4(5):e5475
PloS one 2009;4(5):e5475
Human MutL-complexes monitor homologous recombination independently of mismatch repair.
Siehler SY, Schrauder M, Gerischer U, Cantor S, Marra G, Wiesmüller L
DNA repair 2009 Feb 1;8(2):242-52
DNA repair 2009 Feb 1;8(2):242-52
Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.
Gonzalez-Suarez I, Redwood AB, Perkins SM, Vermolen B, Lichtensztejin D, Grotsky DA, Morgado-Palacin L, Gapud EJ, Sleckman BP, Sullivan T, Sage J, Stewart CL, Mai S, Gonzalo S
The EMBO journal 2009 Aug 19;28(16):2414-27
The EMBO journal 2009 Aug 19;28(16):2414-27
The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.
Ariumi Y, Kuroki M, Dansako H, Abe K, Ikeda M, Wakita T, Kato N
Journal of virology 2008 Oct;82(19):9639-46
Journal of virology 2008 Oct;82(19):9639-46
Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells.
Fernandes ND, Sun Y, Price BD
The Journal of biological chemistry 2007 Jun 1;282(22):16577-84
The Journal of biological chemistry 2007 Jun 1;282(22):16577-84
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.
Sun Y, Xu Y, Roy K, Price BD
Molecular and cellular biology 2007 Dec;27(24):8502-9
Molecular and cellular biology 2007 Dec;27(24):8502-9
Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity.
Roy K, Wang L, Makrigiorgos GM, Price BD
Biochemical and biophysical research communications 2006 Jun 9;344(3):821-6
Biochemical and biophysical research communications 2006 Jun 9;344(3):821-6
The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.
Jiang X, Sun Y, Chen S, Roy K, Price BD
The Journal of biological chemistry 2006 Jun 9;281(23):15741-6
The Journal of biological chemistry 2006 Jun 9;281(23):15741-6
Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1.
Shiotani B, Kobayashi M, Watanabe M, Yamamoto K, Sugimura T, Wakabayashi K
Molecular cancer research : MCR 2006 Feb;4(2):125-33
Molecular cancer research : MCR 2006 Feb;4(2):125-33
Deep senescent human fibroblasts show diminished DNA damage foci but retain checkpoint capacity to oxidative stress.
Chen JH, Ozanne SE
FEBS letters 2006 Dec 11;580(28-29):6669-73
FEBS letters 2006 Dec 11;580(28-29):6669-73
Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation.
Sun Y, Jiang X, Chen S, Price BD
FEBS letters 2006 Aug 7;580(18):4353-6
FEBS letters 2006 Aug 7;580(18):4353-6
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.
Sun Y, Jiang X, Chen S, Fernandes N, Price BD
Proceedings of the National Academy of Sciences of the United States of America 2005 Sep 13;102(37):13182-7
Proceedings of the National Academy of Sciences of the United States of America 2005 Sep 13;102(37):13182-7
DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.
Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC, Price BD
The Journal of biological chemistry 2005 Apr 15;280(15):15158-64
The Journal of biological chemistry 2005 Apr 15;280(15):15158-64
Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons.
Lai CH, Chun HH, Nahas SA, Mitui M, Gamo KM, Du L, Gatti RA
Proceedings of the National Academy of Sciences of the United States of America 2004 Nov 2;101(44):15676-81
Proceedings of the National Academy of Sciences of the United States of America 2004 Nov 2;101(44):15676-81
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- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
