Explore
Validate
Learn
Western blot
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [23]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- NB100-306 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-306, RRID:AB_2160703
- Product name
- Mouse Monoclonal ATM Antibody
- Antibody type
- Monoclonal
- Description
- Protein G purified.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1.0 mg/ml
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references Localization of the kinase Ataxia Telangiectasia Mutated to Adenovirus E4 mutant DNA replication centers is important for its inhibitory effect on viral DNA accumulation.
Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes.
Polo-like kinase 1 (Plk1) overexpression enhances ionizing radiation-induced cancer formation in mice.
Early Passage Mesenchymal Stem Cells Display Decreased Radiosensitivity and Increased DNA Repair Activity.
A single non-synonymous NCOA5 variation in type 2 diabetic patients with hepatocellular carcinoma impairs the function of NCOA5 in cell cycle regulation.
Enhanced chemotherapeutic efficacy of apigenin liposomes in colorectal cancer based on flavone-membrane interactions.
Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis.
A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus.
DNA damage response in neonatal and adult stromal cells compared with induced pluripotent stem cells.
Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo.
A-TWinnipeg: Pathogenesis of rare ATM missense mutation c.6200C>A with decreased protein expression and downstream signaling, early-onset dystonia, cancer, and life-threatening radiotoxicity.
Antioxidants accelerate lung cancer progression in mice.
Effects of depletion of dihydropyrimidine dehydrogenase on focus formation and RPA phosphorylation.
Effects of depletion of dihydropyrimidine dehydrogenase on focus formation and RPA phosphorylation.
Selenoprotein W promotes cell cycle recovery from G2 arrest through the activation of CDC25B.
Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage.
A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases.
Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis.
MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription.
Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.
HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies.
Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection.
Disappearance of the telomere dysfunction-induced stress response in fully senescent cells.
Gautam D, Stanley G, Owen M, Bridge E
Virology 2019 Jan 15;527:47-56
Virology 2019 Jan 15;527:47-56
Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes.
He DJ, Wang L, Zhang ZB, Guo K, Li JZ, He XC, Cui QH, Zheng P
Zoological research 2018 Nov 18;39(6):387-395
Zoological research 2018 Nov 18;39(6):387-395
Polo-like kinase 1 (Plk1) overexpression enhances ionizing radiation-induced cancer formation in mice.
Li Z, Liu J, Li J, Kong Y, Sandusky G, Rao X, Liu Y, Wan J, Liu X
The Journal of biological chemistry 2017 Oct 20;292(42):17461-17472
The Journal of biological chemistry 2017 Oct 20;292(42):17461-17472
Early Passage Mesenchymal Stem Cells Display Decreased Radiosensitivity and Increased DNA Repair Activity.
Wu PK, Wang JY, Chen CF, Chao KY, Chang MC, Chen WM, Hung SC
Stem cells translational medicine 2017 Jun;6(6):1504-1514
Stem cells translational medicine 2017 Jun;6(6):1504-1514
A single non-synonymous NCOA5 variation in type 2 diabetic patients with hepatocellular carcinoma impairs the function of NCOA5 in cell cycle regulation.
Liu X, Liu F, Gao S, Reske J, Li A, Wu CL, Yang C, Chen F, Luo R, Xiao H
Cancer letters 2017 Apr 10;391:152-161
Cancer letters 2017 Apr 10;391:152-161
Enhanced chemotherapeutic efficacy of apigenin liposomes in colorectal cancer based on flavone-membrane interactions.
Banerjee K, Banerjee S, Mandal M
Journal of colloid and interface science 2017 Apr 1;491:98-110
Journal of colloid and interface science 2017 Apr 1;491:98-110
Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis.
Yang Z, Shen Y, Oishi H, Matteson EL, Tian L, Goronzy JJ, Weyand CM
Science translational medicine 2016 Mar 23;8(331):331ra38
Science translational medicine 2016 Mar 23;8(331):331ra38
A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus.
Takai H, Jenkinson E, Kabir S, Babul-Hirji R, Najm-Tehrani N, Chitayat DA, Crow YJ, de Lange T
Genes & development 2016 Apr 1;30(7):812-26
Genes & development 2016 Apr 1;30(7):812-26
DNA damage response in neonatal and adult stromal cells compared with induced pluripotent stem cells.
Liedtke S, Biebernick S, Radke TF, Stapelkamp D, Coenen C, Zaehres H, Fritz G, Kogler G
Stem cells translational medicine 2015 Jun;4(6):576-89
Stem cells translational medicine 2015 Jun;4(6):576-89
Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo.
Caserta E, Egriboz O, Wang H, Martin C, Koivisto C, Pecót T, Kladney RD, Shen C, Shim KS, Pham T, Karikomi MK, Mauntel MJ, Majumder S, Cuitino MC, Tang X, Srivastava A, Yu L, Wallace J, Mo X, Park M, Fernandez SA, Pilarski R, La Perle KM, Rosol TJ, Coppola V, Castrillon DH, Timmers C, Cohn DE, O'Malley DM, Backes F, Suarez AA, Goodfellow P, Chamberlin HM, Macrae ER, Shapiro CL, Ostrowski MC, Leone G
Genes & development 2015 Aug 15;29(16):1707-20
Genes & development 2015 Aug 15;29(16):1707-20
A-TWinnipeg: Pathogenesis of rare ATM missense mutation c.6200C>A with decreased protein expression and downstream signaling, early-onset dystonia, cancer, and life-threatening radiotoxicity.
Nakamura K, Fike F, Haghayegh S, Saunders-Pullman R, Dawson AJ, Dörk T, Gatti RA
Molecular genetics & genomic medicine 2014 Jul;2(4):332-40
Molecular genetics & genomic medicine 2014 Jul;2(4):332-40
Antioxidants accelerate lung cancer progression in mice.
Sayin VI, Ibrahim MX, Larsson E, Nilsson JA, Lindahl P, Bergo MO
Science translational medicine 2014 Jan 29;6(221):221ra15
Science translational medicine 2014 Jan 29;6(221):221ra15
Effects of depletion of dihydropyrimidine dehydrogenase on focus formation and RPA phosphorylation.
Someya M, Sakata K, Matsumoto Y, Tauchi H, Kai M, Hareyama M, Fukushima M
Journal of radiation research 2012;53(2):250-6
Journal of radiation research 2012;53(2):250-6
Effects of depletion of dihydropyrimidine dehydrogenase on focus formation and RPA phosphorylation.
Someya M, Sakata K, Matsumoto Y, Tauchi H, Kai M, Hareyama M, Fukushima M
Journal of radiation research 2012;53(2):250-6
Journal of radiation research 2012;53(2):250-6
Selenoprotein W promotes cell cycle recovery from G2 arrest through the activation of CDC25B.
Park YH, Jeon YH, Kim IY
Biochimica et biophysica acta 2012 Dec;1823(12):2217-26
Biochimica et biophysica acta 2012 Dec;1823(12):2217-26
Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage.
Guerra L, Albihn A, Tronnersjö S, Yan Q, Guidi R, Stenerlöw B, Sterzenbach T, Josenhans C, Fox JG, Schauer DB, Thelestam M, Larsson LG, Henriksson M, Frisan T
PloS one 2010 Jan 27;5(1):e8924
PloS one 2010 Jan 27;5(1):e8924
A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases.
Gastaldello S, Hildebrand S, Faridani O, Callegari S, Palmkvist M, Di Guglielmo C, Masucci MG
Nature cell biology 2010 Apr;12(4):351-61
Nature cell biology 2010 Apr;12(4):351-61
Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis.
Shao L, Fujii H, Colmegna I, Oishi H, Goronzy JJ, Weyand CM
The Journal of experimental medicine 2009 Jun 8;206(6):1435-49
The Journal of experimental medicine 2009 Jun 8;206(6):1435-49
MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription.
Caslini C, Connelly JA, Serna A, Broccoli D, Hess JL
Molecular and cellular biology 2009 Aug;29(16):4519-26
Molecular and cellular biology 2009 Aug;29(16):4519-26
Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.
Yalcin S, Zhang X, Luciano JP, Mungamuri SK, Marinkovic D, Vercherat C, Sarkar A, Grisotto M, Taneja R, Ghaffari S
The Journal of biological chemistry 2008 Sep 12;283(37):25692-705
The Journal of biological chemistry 2008 Sep 12;283(37):25692-705
HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies.
Spardy N, Duensing A, Hoskins EE, Wells SI, Duensing S
Cancer research 2008 Dec 1;68(23):9954-63
Cancer research 2008 Dec 1;68(23):9954-63
Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection.
Luo MH, Rosenke K, Czornak K, Fortunato EA
Journal of virology 2007 Feb;81(4):1934-50
Journal of virology 2007 Feb;81(4):1934-50
Disappearance of the telomere dysfunction-induced stress response in fully senescent cells.
Bakkenist CJ, Drissi R, Wu J, Kastan MB, Dome JS
Cancer research 2004 Jun 1;64(11):3748-52
Cancer research 2004 Jun 1;64(11):3748-52
No comments: Submit comment
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ATM [p Ser1981] Antibody (10H11.E12) [NB100-306] - Analysis of ATM-kinase, using ATM [p Ser1981] antibody (10H11.E12) [NB100-306]. Sample: Irradiated or peroxidated human fibroblasts. Observed molecular weight 370 kDa. Theoretical molecular weight 351 kDa.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry: ATM [p Ser1981] Antibody (10H11.E12) [NB100-306] - ATM [p Ser1981] antibody (10H11.E12) [NB100-306] was tested in mouse spleen using DAB with hematoxylin counterstain.
