Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS7862 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- BAG5 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human BAG5.
- Description
- Bag-5 (Bcl-2-associated athanogene 5), also known as Bag family molecular chaperone regulator 5, is a member of the Bag family of proteins and contains four Bag domains. Via their Bag domain, Bag proteins bind with high affinity to the HSC 70/HSP 70 ATPase domain, regulating chaperone activity and apoptosis. Bag-5 is a component of the HSP 70/Parkin complex and acts to inhibit Parkin E3 ubiquitin ligase activity and HSP 70 chaperone activity. In this complex, Bag-5 directly interacts with the ATPase domain of HSP 70 and the N-terminal linker region of Parkin. Bag-5 expression is induced upon dopaminergic neuron injury and functions to sensitize the neurons to injuryinduced cell death. In addition, Bag-5 may be a useful target in therapies for neurodegenerative diseases such as Parkinson£ªs disease which is caused by a mutation in the gene encoding Parkin.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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