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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
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- Western blot [1]
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- Product number
- BS4849 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- p130 Cas (phospho Y249) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic phosphopeptide derived from human p130 Cas around the phosphorylation site of Tyrosine 249.
- Description
- The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins. p130Cas has a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich regionp130Cas is implicated in a variety of biological processes including cell adhesion, cell migration, growth factor stimulation, cytokine receptor engagement and bacterial infection. Physiological functions of p130Cas include cardiovascular development, actin filament assembly and Src-induced cell transformation.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of p-p130 Cas (Y249) pAb at 1:500 dilutionLane1:HEK293T cell lysate treated with EGF(0.1ng/ML,30mins)Lane2:Raw264.7 cell lysate treated with EGF(0.1ng/ML,30mins)Lane3:PC12 cell lysate treated with EGF(0.1ng/ML,30mins)
