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antibody from Proteintech Group
Targeting: CDKN2A
ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p14ARF, p16, p16INK4a, p19, p19Arf
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- Antibody Data
- Antigen structure
- References [583]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 10883-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10883-1-AP, RRID:AB_2078303
- Product name
- P16-INK4A antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated P16-INK4A antibody (Cat. #10883-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Oxidative Stress and Hormone-Regulated Dermal Papilla Cell-Targeted Nanomodulators: Reverse Cellular Senescence for Androgenetic Alopecia Therapy.
DNA Polymerase Gamma Acetylation Governs Mitochondrial Homeostasis and Vascular Cell Senescence.
NAT10 Promotes Tubular Epithelial Cell Senescence in Cisplatin-Induced Acute Kidney Injury by Regulating DDX17.
Targeting the LHX1-LDB1 Complex Restores STING-dependent Senescence Surveillance and Inhibits Head and Neck Cancer Progression.
MUS81 inhibits cell proliferation and migration in breast cancer by promoting the expression of CDKN2A(p16(INK4a)).
Analysis of molecular subtypes and prognostic signature of senescence-associated secretory phenotype in pancreatic cancer.
Small molecule HCY-NBD stabilizes GSTM2 via cys174 sulfenylation to attenuate high glucose induced endothelial cell senescence and calcification.
The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs.
Inflammation Affects the Osteogenic Differentiation of Aged Periodontal Ligament Cells via NF-κB/FOXO3a/c-JUN Signalling.
SETD7 regulates decidual senescence through FOXO1-dependent mechanisms in human endometrial stromal cells.
Novel PMVs/ZIP4/Zinc/Prelamin A Axis Promotes Nuclear Dysmorphism and Vascular Aging in Humans and Rodents Post-Injury: Effective Treatment With Platelet Membrane-Coated ZIF-8 Nanoparticles.
DHODH inhibition impairs mitochondrial function and extravillous trophoblast invasion: Protective roles of quercetin and riboflavin.
m(1)A-Dependent TRMT6/61A-ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment.
Rejuvenation of THY1(+) nucleus pulposus-derived stem cells promotes intervertebral disc regeneration through FGF10-FGFR1-CREB pathway and mitochondrial fission.
Mechanism of platelet-rich plasma inhibiting inflammatory response, oxidative stress, and senescence in synovial fibroblasts of patients with knee osteoarthritis via UBE2C based on transcriptome sequencing analysis.
cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis.
Age and gender effects on echocardiographic and histopathological cardiac phenotypes in healthy adult mice.
Recycling senescent cell lipids for targeted senotherapy.
PRMT5 is Frequently Upregulated and a Potential Therapeutic Target in MTAP-deficient Malignant Peripheral Nerve Sheath Tumors.
Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A.
Screening of metabolic-related biomarkers linking intervertebral disc degeneration and type 2 diabetes based on comprehensive bioinformatics analysis and machine learning.
Nobiletin's role in idiopathic pulmonary fibrosis via the PI3K/AKT/MDM2/p53 signaling pathway.
Ionizable Coenzyme-Engineered Lipid/Fiber Microplexes Boost Ribosomal Translation to Improve mRNA Therapy for Degenerative Diseases.
Neuroprotective effects of SRS11-92 against oxidative stress-induced senescence via Nrf2/HO-1/NF-κB in Alzheimer's disease models.
Suppression of HIF-1α alleviates the symptoms associated with diabetic retinopathy in mice.
Fe-Mn-IGF-AMD nanoparticles in accurate detection and treatment of liver cirrhosis via regulating relaxation coefficients and attenuating hepatocyte senescence.
PRKN-Mediated Ubiquitin-Proteasome Degradation of METTL3 Promotes Cellular Senescence.
Astragalus polysaccharides inhibit arsenic trioxide-induced BMSCs damage through inhibition of Jnk and p38 signaling pathways.
Steap4 Promotes Senile Osteoporosis via Fe(2+)-ROS/C/EBPβ Feedback-Driven Ferroptosis and Adipogenesis in Senescent BMSCs.
Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program.
Novel senescence inducer ICA-11c, a derivative of icaritin, YAP-dependently suppresses hepatocellular carcinoma cells.
Engineered microalgae-driven gel platform promotes the repairing of senescence-associated intervertebral disc degeneration in rats and goats.
Near-infrared photobiomodulation therapy for age-related erectile dysfunction: molecular and physiological restoration in a mouse model.
Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells.
The UBC/SIRT5/DRP1 axis regulates mitochondrial dynamics to alleviate Staphylococcus aureus-induced oxidative stress and senescence in bovine mammary epithelial cells.
A Human Kidney Tubuloid Model of Repeated Cisplatin-Induced Cellular Senescence and Fibrosis for Drug Screening.
Remodeling Cellular Uptake via Inducing Clustering of Urokinase Receptors in Hydrogel Microspheres for Alleviating Cartilage Senescence.
FSHR-targeting tetrahedral DNA frameworks ameliorate ovarian aging through oxidative stress elimination.
Cardiospermum halicacabum Extract Attenuates UVB-Induced Photoaging in Human Skin Fibroblasts via Inhibition of the PI3K/Akt/mTOR Signaling Pathway.
Supramolecular delivery of senolytics enables targeted anti-senescence therapy and accelerated fracture healing.
Meox1 promotes hepatocellular carcinoma progression potentially via regulation of cell cycle and p21 expression.
3D-printed titanium scaffolds coated with a multifunctional photothermal-responsive hydrogel promote osteoporotic bone defect repair.
The multilayer coatings on polylactic acid implants spatiotemporally regulates the microenvironment to enhance antibacterial and osseointegration capacity.
Trichosanthes kirilowii extract alleviated liver fibrosis and acute myocardial infarction by inhibiting VCAN to restrain monocyte senescence: Insights from bioinformatic analyses and experimental validation.
Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging.
KLOTHO Deficiency Drives Ovarian Aging by Inducing Granulosa Cell Senescence and Dysfunction.
Tubeimoside Ⅰ targets sodium/potassium ATPase alpha 1 subunit to selectively eliminate senescent cells and alleviate aging-associated abnormalities.
Youthful Brain-Derived Extracellular Vesicle-Loaded GelMA Hydrogel Promotes Scarless Wound Healing in Aged Skin by Modulating Senescence and Mitochondrial Function.
Upregulation of SIRT1 ameliorates apoptosis of rat nucleus pulposus cells under oxidative stress through FoxO1/β-catenin pathway.
The Punicalagin Compound Mitigates Bronchial Epithelial Cell Senescence Induced by Cigarette Smoke Extract through the PAR2/mTOR Pathway.
Exendin-4 Reduces Senescence of Inflammation-Induced Periodontal Ligament Stem Cells Through SIRT1/Notch1 Signaling.
Fatty Acid Transporter CD36 Promotes Ox-LDL-Induced Senescence of Vascular Endothelial Cells in Preeclampsia.
Unveiling tumor senescence-driven prognostic heterogeneity via MALISS in stage II/III colorectal cancer.
3D-cultured hADSCs-derived exosomes deliver circ_0011129 to synergistically attenuate skin photoaging.
GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation.
Excessive DAO inhibits myoblast migration, leading to impaired myotube fusion and muscle strength decline by reducing ECM.
CPP-calcification of articular cartilage is associated with elevated cytokine levels in synovial fluid.
Methionine ameliorates intestinal injury in senescence-accelerated mouse prone-8 mice by reducing sulfate-reducing bacteria and enhancing barrier function.
Shenyuan granules improve cellular senescence through Klotho-mediated p16/p21 signaling pathway in diabetic kidney disease.
Tobacco smoking exposure-mediated ELAVL1 regulates bladder cancer cell senescence via autophagy activation.
ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation.
Kuntai Capsules Improve Premature Ovarian Failure by Regulating AMPK-Mediated Autophagy.
Mechanism of mitofusin 2, mitochondria-associated membrane, and the mitochondrial pathway in alleviating oxidative stress and cell senescence in bovine mammary epithelial cells.
Nuclear FGF2 orchestrates phase separation-mediated rDNA chromatin architecture to control BMSCs cell fate.
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development.
mTOR dysregulation induces IL-6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis.
CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.
Matrix stiffness induces endothelial network senescence.
A TEMPO-loaded DNA hydrogel enabling integrated early diagnosis and treatment of osteoarthritis.
SARS-CoV-2 spike triggers TLR7-dependent endolysosome dysfunction and senescence in human astrocytes.
Paeonol reduces IL-1β induced apoptosis and degeneration by regulating MAPK pathway in nucleus pulposus cells.
SLC38A1 protects against aging-related oxidative stress and lipid peroxidation in C2C12 myoblasts: Implication of a ferroptosis-related regulator for skeletal muscle aging.
Transcriptomic Analysis of the Effects of Hydroxysafflor Yellow A on hUC-MSC Senescence via the ECM-Receptor Interaction Pathway.
Disruption of ovarian function and induction of apoptosis in female mice by Brefeldin A: Mechanistic insights into reproductive toxicity.
Upregulation of ACSL1 in synovial macrophages promotes lipid peroxidation via the IκB/NF-κB pathway to accelerate osteoarthritis.
Targeting LARP1 to mitigate aging in lens epithelial cells: mechanistic insights into mitochondrial dysfunction.
Ferroptosis promotes sepsis-related lung injury via endothelial cell senescence.
PDZK1 Protects Against RPE Senescence by Targeting the 14-3-3ε-mTOR Axis to Attenuate Early Diabetic Retinopathy.
Oleuropein Aglycone Modulates Oxidative Stress and Autophagy-Related Pathways in Human Skeletal Muscle Cells.
Elevating cytosolic NADPH metabolism in endothelial cells ameliorates vascular aging.
Senescent bone marrow mesenchymal stem cells exacerbate subchondral bone sclerosis and osteoarthritis via the senescence-associated secretory phenotype.
Kaempferol ameliorates BMSCs senescence in postmenopausal osteoporosis by targeting Sp1 to activate FUNDC1-mediated mitophagy.
Biochanin A alleviates endothelial cell senescence via epigenetic regulation of the HDAC1/H3K4me3/NFKB1 axis.
Hyperosmolarity-Induced Oxidative Stress Leads to Senescence in Human Corneal Epithelial Cells (HCEPC) via DNA Damage, Metabolic Disturbance and Mitophagy Decline.
Trilaciclib triggers a neutrophil-related immune response and sensitizes non-small cell lung cancer to anti-PD-1 therapy.
Clinical value and mechanism of CDKN2A in clear cell renal cell carcinoma.
Identifying SUMOylation-related genes in liver fibrosis with bioinformatics and experimental models for diagnostic insights.
Nogo-B Silencing Expedites the Senescence of Platelet-Derived Growth Factor-BB-Induced Human Hepatic Stellate Cells Via Autophagy.
Astragalus polysaccharide alleviates oxidative stress and senescence in chondrocytes in osteoarthritis via GCN2/ATF4/TXN axis.
Knockdown of C3aR alleviates age-related bone loss via activation of YAP1/β-catenin signaling.
Melatonin-mediated cGAS-STING signal in senescent macrophages promote TNBC chemotherapy resistance and drive the SASP.
A Binary siRNA-Loaded Tetrahedral DNA Nanobox for Synergetic Anti-Aging Therapy.
Resveratrol Promotes Wound Healing by Enhancing Angiogenesis via Inhibition of Ferroptosis.
Targeting COPA to Enhance Erdafitinib Sensitivity in FGFR-Altered Bladder Cancer.
The important role of cuproptosis and cuproptosis-related genes in the development of thyroid carcinoma revealed by transcriptomic analysis and experiments.
Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism.
The mechanism of telomerase Cajal body protein 1 regulating senescence of mouse bone marrow mesenchymal stem cells.
Quercetin ameliorates ox-LDL-induced cellular senescence of aortic endothelial cells and macrophages by p16/p21, p53/SERPINE1, and AMPK/mTOR pathways.
Conditional sequential delivery of ginkgetin and rapamycin orchestrates inflammation and autophagy to alleviate intervertebral disc degeneration.
Delta Opioid Peptide [d-Ala2, d-Leu5]-Enkephalin Improves Physical and Cognitive Function and Increases Lifespan in Aged Female Mice.
p16INK4a Deletion Alleviated Obesity-Associated Kidney Fibrosis by Regulating Metabolic Reprogramming and the Inflammasome Pathway.
Lactate promotes premature aging of preeclampsia placentas through histone lactylation-regulated GADD45A.
Mesenchymal stem cell-specific Sirt1 overexpression prevents sarcopenia induced by 1,25-dihydroxyvitamin D deficiency.
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models.
Targeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS-mutant cancer models.
Targeting DUSP3 promotes cell senescence by activating the notch1 pathway to treat hepatocellular carcinoma.
ADAM10-mediated β-klotho degradation: a key to FGF21 resistance in senescent vascular endothelial cells.
Fibroblast hierarchy dynamics during mammary gland morphogenesis and tumorigenesis.
Senescent cartilage endplate stem cells-derived exosomes induce oxidative stress injury in nucleus pulposus cells and aggravate intervertebral disc degeneration by regulating FOXO3.
Mai-wei-yang-fei decoction protects against pulmonary fibrosis by reducing telomere shortening and inhibiting AECII senescence via FBW7/TPP1 regulation.
Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging-Related Pathways.
Suppression of MRPL23 induces cellular senescence in hepatocellular carcinoma by targeting HMGB1.
Multi-omics analysis of canine aging markers and evaluation of stem cell intervention.
SLC38A9 is directly involved in Tat-induced endolysosome dysfunction and senescence in astrocytes.
PELI1 silencing delays intervertebral disc degeneration by impeding nucleus pulposus cell death.
RIOK1 phase separation restricts PTEN translation via stress granules activating tumor growth in hepatocellular carcinoma.
TLR7 Mediates HIV-1 Tat-Induced Cellular Senescence in Human Astrocytes.
Targeting IGF1-Induced Cellular Senescence to Rejuvenate Hair Follicle Aging.
Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.
Tβ4-Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing.
Proteomics analysis reveals FEN1 as a promising therapeutic target against small cell neuroendocrine carcinoma of the cervix.
Increased CDKN2A expression correlates with resistance to platinum-based therapy and decreased infiltration of B lymphocytes in colon adenocarcinoma.
Systematic pharmacology and experimental validation revealed the mechanism of Bupleurum chinense DC -mediated autophagy in alleviating osteoarthritis.
C-C chemokine ligand 5 from women subcutaneous adipose tissue has a central role in vascular aging.
Small extracellular vesicles derived from mesenchymal stromal cells loaded with β-nicotinamide mononucleotide activate NAD(+)/SIRT3 signaling pathway-mediated mitochondrial autophagy to delay skin aging.
GNF-5837 alleviates intervertebral disc ageing by upregulating glutathione peroxidase 7.
Saffron extract alleviates D-gal-induced late-onset hypogonadism by activating the PI3K-Akt-Nrf2 signaling pathway.
TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression.
LncRNA-ANRIL regulates CDKN2A to promote malignant proliferation of Kasumi-1 cells.
DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD.
NEK2 Promotes ESCC Malignant Progression by Inhibiting Cellular Senescence via the FOXM1/c-Myc/p27 Signaling Pathway.
Chronic environmental exposure to polystyrene microplastics increases the risk of nonalcoholic fatty liver disease.
Senescent Fibroblasts Drive FAP/OLN Imbalance Through mTOR Signaling to Exacerbate Inflammation and Bone Resorption in Periodontitis.
PD-1-Enhanced Treg Cell Senescence in Advanced Maternal Age.
Regulation of senescence-associated secretory phenotypes in osteoarthritis by cytosolic UDP-GlcNAc retention and O-GlcNAcylation.
Autophagy-dependent splicing control directs translation toward inflammation during senescence.
Efficacy of Naringenin against aging and degeneration of nucleus pulposus cells through IGFBP3 inhibition.
Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype.
Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification.
Cxcl9 modulates aging associated microvascular metabolic and angiogenic dysfunctions in subcutaneous adipose tissue.
Loss of CDKN2A Enhances the Efficacy of Immunotherapy in EGFR-Mutant Non-Small Cell Lung Cancer.
3D-cultured DFAT spheroid-derived exosomes promote aged wound healing via modulation of the NF-κB/Serpine1 pathway.
PINK1 overexpression suppresses p38 MAPK/NF‑κB signaling to attenuate chondrocyte senescence in osteoarthritis.
Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice.
Fluorescence lifetime clocks quantify senescence and aging.
Inhibition of matrix metalloproteinase-9 attenuates kidney fibrosis and cellular senescence in the transition from acute kidney injury to chronic kidney disease.
KDM4A-induced tumor senescence enhances the efficacy of immunotherapy by inhibiting AGT-PHB1 axis-mediated mitophagy in colorectal cancer.
Nanovaccine loaded with seno-antigen target senescent cells to improve metabolic disorders of adipose tissue and cardiac dysfunction.
1,8-Cineole ameliorates vascular endothelial senescence in diabetes mellitus by directly targeting and deubiquitinating PPAR-γ in vivo and in vitro.
ZNF865 (BLST) Regulates Back Pain via Cell Senescence and DNA Damage Mechanisms.
Targeting intrinsically disordered nuclear protein 1 (NUPR1) with single-domain antibodies alleviates triple-negative breast cancer (TNBC) progression in vivo.
Harnessing Senolytics and PARP Inhibition to Expand the Antitumor Activity of CDK4/6 Inhibitors in Prostate Cancer.
The SARS-CoV-2 nucleocapsid protein induces microglia senescence-mediated cognitive impairment via Glycolysis.
WWP2-induced inhibition of hepatocellular carcinoma cellular senescence via the ubiquitination and degradation of p21.
Biodentine Counteracts the Aging Process of Human Dental Pulp Stem Cells Through Wnt/β-Catenin Pathway.
Dissolvable microneedle-assisted transdermal administration of diacerein nanoparticles achieved satisfactory therapeutic effects in tendon-bone insertion repair by reducing oxidative stress and inflammation.
Role of UVA-driven cellular senescence via mTOR activation in dihydrotestosterone-induced hair loss in androgenetic alopecia mouse model.
SERPINF1 knockdown attenuates chondrocyte senescence, hypertrophy, and inflammation in osteoarthritis to offer a potential therapeutic strategy.
Advanced glycation end products induce inflammaging in periodontal ligament fibroblasts through RAGE/AKT/mTOR/glycolysis pathway.
CD81(+) senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis.
Identifying ENO1 as a protein target of chlorogenic acid to inhibit cellular senescence and prevent skin photoaging in mice.
IFI30 Knockdown Inhibits ESCC Progression by Promoting Apoptosis and Senescence via Activation of JNK and P21/P16 Pathways.
Blockade of ZMIZ1-GATA4 Axis Regulation Restores Youthfulness to Aged Cartilage.
LncRNA NEAT1-206 regulates autophagy of human umbilical cord mesenchymal stem cells through the WNT5A/Ca(2+) signaling pathway under senescence stress.
Development and Validation of a Prognostic Model for Lung Adenocarcinoma Based on CAF-Related Genes: Unveiling the Role of COX6A1 in Cancer Progression and CAF Infiltration.
TRAF7 knockdown induces cellular senescence and synergizes with lomustine to inhibit glioma progression and recurrence.
Synonymous mutations promote tumorigenesis by disrupting m(6)A-dependent mRNA metabolism.
The IL-6 autocrine loop promoting IFN-γ-induced fibroblast senescence is involved in psychological stress-mediated exacerbation of vitiligo.
Granulosa cell RNA-Seq insights into senescence and sphingolipid metabolism disorder in PCOS: aspirin as a potential therapeutic drug.
Hepatic-specific vitamin D receptor downregulation alleviates aging-related metabolic dysfunction-associated steatotic liver disease.
Comprehensive analysis of prognosis and tumor immune microenvironment of cuproptosis-related gene CDKN2A in lung adenocarcinoma.
The dual HDAC/PI3K inhibitor CUDC-907 inhibits the growth and proliferation of MYC-driven Group 3 medulloblastoma.
Ginsenoside Rg2 Attenuates Aging-Induced Liver Injury via Inhibiting Caspase 8-Mediated Pyroptosis, Apoptosis and Modulating Gut Microbiota.
Metochalcone induces senescence-associated secretory phenotype via JAK2/STAT3 pathway in breast cancer.
Young TSPC-Derived Exosomal circPVT1 Ameliorates Aging-Impaired Cell Function via SIRT1/NF-κB.
Cadmium-induced annulus fibrosus cell senescence contributes to intervertebral disc degeneration via the JNK/p53 signaling pathway.
FBLN5 was Regulated by PRDM9, and Promoted Senescence and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.
FTO Stabilizes MIS12 to Inhibit Vascular Smooth Muscle Cell Senescence in Atherosclerotic Plaque.
Dissecting the functions and regulatory mechanisms of disulfidoptosis-related RPN1 in pan-cancer: modulation of immune microenvironment and cellular senescence.
β-cryptoxanthin suppresses oxidative stress via activation of the Nrf2/HO-1 signaling pathway in diabetic kidney disease.
Taraxasterol exhibits dual biological effects on anti-aging and anti-cancer in lung cells.
EMF treatment delays mesenchymal stem cells senescence during long-term in vitro expansion by modulating autophagy.
Urolithin A alleviates cell senescence by inhibiting ferroptosis and enhances corneal epithelial wound healing.
Monoacylglycerol lipase blockades the senescence-associated secretory phenotype by interfering with NF-κB activation and promotes docetaxel efficacy in prostate cancer.
Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice.
STING1-accelerated vascular smooth muscle cell senescence-associated vascular calcification in diabetes is ameliorated by oleoylethanolamide via improved mitochondrial DNA oxidative damage.
TG2 participates in pulmonary vascular remodelling by regulating the senescence of pulmonary artery smooth muscle cells.
Integrative analysis of the transcriptome and metabolome reveals the importance of hepatokine FGF21 in liver aging.
10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically.
Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice.
The up-regulation of SYNCRIP promotes the proliferation and tumorigenesis via DNMT3A/p16 in colorectal cancer.
Downregulation of stromal interaction molecule-1 is implicated in the age-associated vasoconstriction dysfunction of aorta, intrarenal, and coronary arteries.
Transiently formed nucleus-to-cilium microtubule arrays mediate senescence initiation in a KIFC3-dependent manner.
Tryptanthrin targets GSTP1 to induce senescence and increases the susceptibility to apoptosis by senolytics in liver cancer cells.
Bazi Bushen attenuates osteoporosis in SAMP6 mice by regulating PI3K-AKT and apoptosis pathways.
LTF ameliorates cartilage endplate degeneration by suppressing calcification, senescence and matrix degradation through the JAK2/STAT3 pathway.
Plasma-derived exosome miR-10a-5p promotes premature ovarian failure by target BDNF via the TrkB/Akt/mTOR signaling pathway.
Exosomes Derived from Rejuvenated Stem Cells Inactivate NLRP3 Inflammasome and Pyroptosis of Nucleus Pulposus Cells via the Transfer of Antioxidants.
Loss of p14 diminishes immunogenicity in melanoma via non-canonical Wnt signaling by reducing the peptide surface density.
Seno-antigen-pulsed dendritic cell vaccine induce anti-aging immunity to improve adipose tissue senescence and metabolic abnormalities.
Human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles mitigate photoaging via TIMP1/Notch1.
Formononetin Mitigates Liver Fibrosis via Promoting Hepatic Stellate Cell Senescence and Inhibiting EZH2/YAP Axis.
Enhanced SIRT1 Activity by Galangin Mitigates UVB-Induced Senescence in Dermal Fibroblasts via p53 Acetylation Regulation and Activation.
HIV Protein Nef Induces Cardiomyopathy Through Induction of Bcl2 and p21.
A TBK1-independent primordial function of STING in lysosomal biogenesis.
Nur77 ameliorates cyclophosphamide-induced ovarian insufficiency in mice by inhibiting oxidative damage and cell senescence.
Blockade of the lncRNA-PART1-PHB2 axis confers resistance to PARP inhibitor and promotes cellular senescence in ovarian cancer.
Partial reduction of interleukin-33 signaling improves senescence and renal injury in diabetic nephropathy.
MDM2 accelerated renal senescence via ubiquitination and degradation of HDAC1.
Repurposing cyclovirobuxine D as a novel inhibitor of colorectal cancer progression via modulating the CCT3/YAP axis.
PINK1/Parkin-Mediated Mitophagy Ameliorates Mitochondrial Dysfunction in Lacrimal Gland Acinar Cells During Aging.
Inhibition of the E3 ligase UBR5 stabilizes TERT and protects vascular organoids from oxidative stress.
The Role of the Cytoskeletal Regulatory Protein, Mammalian Enabling Protein (Mena), in Invasion and Metastasis of HPV16-Related Oral Squamous Cell Carcinoma.
Expanding the landscape of oncogenic drivers and treatment options in acral and mucosal melanomas by targeted genomic profiling.
Phillyrin: A potential therapeutic agent for osteoarthritis via modulation of NF-κB and Nrf2 signaling pathways.
2,7-Phloroglucinol-6,6'-bieckol from Ecklonia cava ameliorates nanoplastics-induced premature endothelial senescence and dysfunction.
Melatonin attenuates dental pulp stem cells senescence due to vitro expansion via inhibiting MMP3.
Prognostic value of CDKN2A in head and neck squamous cell carcinoma via pathomics and machine learning.
Glucose-modified BSA/procyanidin C1 NPs penetrate the blood-brain barrier and alleviate neuroinflammation in Alzheimer's disease models.
N6-Methyladenosine Modification of lncCCKAR-5 Regulates Autophagy in Human Umbilical Cord Mesenchymal Stem Cells by Destabilizing LMNA and Inhibits Diabetic Wound Healing.
Uptake of ox-LDL by binding to LRP6 mediates oxidative stress-induced BMSCs senescence promoting obesity-related bone loss.
Macrophage-derived ectosomal miR-350-3p promotes osteoarthritis progression through downregulating chondrocyte H3K36 methyltransferase NSD1.
Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl(3) model.
SVHRSP Alleviates Age-Related Cognitive Deficiency by Reducing Oxidative Stress and Neuroinflammation.
Inactivation of Myostatin Delays Senescence via TREX1-SASP in Bovine Skeletal Muscle Cells.
Chemotherapy-induced PTEN-L secretion promotes the selection of PTEN-deficient tumor cells.
Mechanisms of PM(10) Disruption of the Nrf2 Pathway in Cornea.
Hypermethylation of Bmp2 and Fgfr2 Promoter Regions in Bone Marrow Mesenchymal Stem Cells Leads to Bone Loss in Prematurely Aged Mice.
Single-cell RNA sequencing reveals epithelial cells driving brain metastasis in lung adenocarcinoma.
Promoting collateral formation in type 2 diabetes mellitus using ultra-small nanodots with autophagy activation and ROS scavenging.
Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells.
Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles.
MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer.
FGF receptors mediate cellular senescence in the cystic fibrosis airway epithelium.
Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis.
Dasabuvir alleviates 5-fluorouracil-induced intestinal injury through anti-senescence and anti-inflammatory.
CBLL1 promotes endometrial stromal cell senescence via inhibiting PTEN in recurrent spontaneous abortion.
Static magnetic field-modulated mesenchymal stem cell-derived mitochondria-containing microvesicles for enhanced intervertebral disc degeneration therapy.
Molecular characterization and clinical relevance of metabolic signature subtypes in gastric cancer.
Empagliflozin protects against heart failure with preserved ejection fraction partly by inhibiting the senescence-associated STAT1-STING axis.
Nur77 improves ovarian function in reproductive aging mice by activating mitophagy and inhibiting apoptosis.
An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo.
Procyanidin C1 inhibits bleomycin-induced pulmonary fibrosis in mice by selective clearance of senescent myofibroblasts.
Cellular and molecular mechanisms of highly active mesenchymal stem cells in the treatment of senescence of rhesus monkey ovary.
Jianpi Huayu Decoction suppresses cellular senescence in colorectal cancer via p53-p21-Rb pathway: Network pharmacology and in vivo validation.
Vitamin D-mediated tsRNA-07804 triggers mitochondrial dysfunction and suppresses non-small cell lung cancer progression by targeting CRKL.
Flavonoid 4,4'-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy.
Anoikis-related gene CDKN2A predicts prognosis and immune response and mediates proliferation and migration in thyroid carcinoma.
Attenuation of pro-tumorigenic senescent secretory phenotype by StN, a novel derivative of stevioside, potentiates its inhibitory activity on hepatocellular carcinoma.
Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells.
TRAF2 inhibits senescence in hepatocellular carcinoma cells via regulating the ROMO1/ NAD(+)/SIRT3/SOD2 axis.
Effects of MMP2 and its inhibitor TIMP2 on DNA damage, apoptosis and senescence of human lens epithelial cells induced by oxidative stress.
ROS-Induced Gingival Fibroblast Senescence: Implications in Exacerbating Inflammatory Responses in Periodontal Disease.
Macrophage polarization and macrophage-related factor expression in hypertrophy of the ligamentum flavum.
Rheb1 deficiency elicits mitochondrial dysfunction and accelerates podocyte senescence through promoting Atp5f1c acetylation.
Lycopodium japonicum Thunb. inhibits chondrocyte apoptosis, senescence and inflammation in osteoarthritis through STING/NF-κB signaling pathway.
miR-548az-5p induces amniotic epithelial cell senescence by regulating KATNAL1 expression in labor.
Identifying novel aging-related diagnostic and prognostic models and aging-targeted drugs for sepsis patients.
SIRT7 inhibits the aging and inflammatory damage of hPDLFs by suppressing the AKT/mTOR.
RNA-binding protein HNRNPD promotes chondrocyte senescence and osteoarthritis progression through upregulating FOXM1.
Taurine rescues intervertebral disc degeneration by activating mitophagy through the PINK1/Parkin pathway.
Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors.
Response to Letter to the Editor, "Senolytic Treatment Improve Small Intestine Regeneration in Aging".
SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure.
Investigating the Effects of Chelidonic Acid on Oxidative Stress-Induced Premature Cellular Senescence in Human Skin Fibroblast Cells.
Injectable Hydrogel-Encapsulating Pickering Emulsion for Overcoming Lenvatinib-Resistant Hepatocellular Carcinoma via Cuproptosis Induction and Stemness Inhibition.
METTL3 Promotes Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration by Regulating TLR2 m6A Methylation and Gut Microbiota.
Excess iron accumulation mediated senescence in diabetic kidney injury.
Terazosin attenuates abdominal aortic aneurysm formation by downregulating Peg3 expression to inhibit vascular smooth muscle cell apoptosis and senescence.
Expression of Multicopy Tandem Recombinant Ginseng Hexapeptide in Bacillus subtilis and the Evaluation of Antiaging Activity.
ACAT2 suppresses the ubiquitination of YAP1 to enhance the proliferation and metastasis ability of gastric cancer via the upregulation of SETD7.
Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome.
Medium-chain chlorinated paraffins (MCCPs) induce renal cell aging and ferroptosis.
Chronic low-dose deltamethrin exposure induces colon injury and aggravates DSS-induced colitis via promoting cellular senescence.
P16(INK4a) Regulates ROS-Related Autophagy and CDK4/6-Mediated Proliferation: A New Target of Myocardial Regeneration Therapy.
1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice.
Decrease in the expression of muscle-specific miRNAs, miR-133a and miR-1, in myoblasts with replicative senescence.
Adipocyte-Derived Exosomal NOX4-Mediated Oxidative Damage Induces Premature Placental Senescence in Obese Pregnancy.
Cyclohexene oxide CA, a derivative of zeylenone, exhibits anti-cancer activity in glioblastoma by inducing G0/G1 phase arrest through interference with EZH2.
Arctiin-encapsulated DSPE-PEG bubble-like nanoparticles inhibit alveolar epithelial type 2 cell senescence to alleviate pulmonary fibrosis via the p38/p53/p21 pathway.
TRAF3IP2 drives mesenchymal stem cell senescence via regulation of NAMPT-mediated NAD biosynthesis.
miR-656-3p inhibits melanomas in vitro and in vivo by inducing senescence via inhibiting LMNB2.
Discovery of Salidroside as a Novel Non-Coding RNA Modulator to Delay Cellular Senescence and Promote BK-Dependent Apoptosis in Cerebrovascular Smooth Muscle Cells of Simulated Microgravity Rats.
Multi-omic analysis of mandibuloacral dysplasia type A patient iPSC-derived MSC senescence reveals miR-311 as a novel biomarker for MSC senescence.
Serum response factor activates peroxidasin transcription to block senescence of hepatic stellate cells.
Death-seq identifies regulators of cell death and senolytic therapies.
Activation of Nrf2/ARE pathway by Anisodamine (654-2) for Inhibition of cellular aging and alleviation of Radiation-Induced lung injury.
Bazi Bushen maintains intestinal homeostasis through inhibiting TLR4/NFκB signaling pathway and regulating gut microbiota in SAMP6 mice.
PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway.
BSHXF-medicated serum combined with ADSCs regulates the TGF-β1/Smad pathway to repair oxidatively damaged NPCs and its component analysis.
High expression of CDKN2A is associated with poor prognosis in colorectal cancer and may guide PD-1-mediated immunotherapy.
Red Ginseng Improves D-galactose-Induced Premature Ovarian Failure in Mice Based on Network Pharmacology.
CX3CR1(hi) macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue.
Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells.
The cell senescence regulator p16 is a promising cancer prognostic and immune check-point inhibitor (ICI) therapy biomarker.
[Research of epigallocatechin gallate in delaying chondrocyte senescence].
Exercise protects aged mice against coronary endothelial senescence via FUNDC1-dependent mitophagy.
TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease.
Induction of Sestrin2 by pterostilbene suppresses ethanol-triggered hepatocyte senescence by degrading CCN1 via p62-dependent selective autophagy.
Integrated metabolomics and phosphoproteomics reveal the protective role of exosomes from human umbilical cord mesenchymal stem cells in naturally aging mouse livers.
Inhibition of tyrosine kinase Fgr prevents radiation-induced pulmonary fibrosis (RIPF).
Dexamethasone Induces Senescence-Associated Changes in Trabecular Meshwork Cells by Increasing ROS Levels Via the TGFβ/Smad3-NOX4 Axis.
Dendrobine Alleviates Cellular Senescence and Osteoarthritis via the ROS/NF-κB Axis.
PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation.
Irisin ameliorates D-galactose-induced skeletal muscle fibrosis via the PI3K/Akt pathway.
Evaluation of toxicological effects of bisphenol S with an in vitro human bone marrow mesenchymal stem cell: Implications for bone health.
Long noncoding RNA SNHG1 alleviates high glucose-induced vascular smooth muscle cells calcification/senescence by post-transcriptionally regulating Bhlhe40 and autophagy via Atg10.
IL-17A promotes endothelial cell senescence by up-regulating the expression of FTO through activating JNK signal pathway.
PBX1-SIRT1 Positive Feedback Loop Attenuates ROS-Mediated HF-MSC Senescence and Apoptosis.
Involvement of lncRNA TUG1 in HIV-1 Tat-Induced Astrocyte Senescence.
BMF-AS1/BMF Promotes Diabetic Vascular Calcification and Aging both In Vitro and In Vivo.
Dual network analysis of transcriptome data for discovery of new therapeutic targets in non-small cell lung cancer.
Downregulation of ALKBH5 rejuvenates aged human mesenchymal stem cells and enhances their therapeutic efficacy in myocardial infarction.
Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity.
Cholesteryl Hemiazelate Present in Cardiovascular Disease Patients Causes Lysosome Dysfunction in Murine Fibroblasts.
Testosterone attenuates senile cavernous fibrosis by regulating TGFβR1 and galectin-1 signaling pathways through miR-22-3p.
N-Acetylserotonin Protects Rat Nucleus Pulposus Cells Against Oxidative Stress Injury by Activating the PI3K/AKT Signaling Pathway.
Inhibition of Polyamine Catabolism Reduces Cellular Senescence.
Prolonged Exposure to High Glucose Induces Premature Senescence Through Oxidative Stress and Autophagy in Retinal Pigment Epithelial Cells.
Quercetin ameliorates oxidative stress-induced senescence in rat nucleus pulposus-derived mesenchymal stem cells via the miR-34a-5p/SIRT1 axis.
Boron-Doped Carbon Nanodots as a Theranostic Agent for Colon Cancer Stem Cells.
Sortilin Is Upregulated in Osteoarthritis-Dependent Cartilage Calcification and Associated with Cellular Senescence.
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy.
Androgen Receptor Activation Induces Senescence in Thyroid Cancer Cells.
A stress-induced cilium-to-PML-NB route drives senescence initiation.
Circulating Exosomal miR-181b-5p Promoted Cell Senescence and Inhibited Angiogenesis to Impair Diabetic Foot Ulcer via the Nuclear Factor Erythroid 2-Related Factor 2/Heme Oxygenase-1 Pathway.
Senotherapy Protects against Cisplatin-Induced Ovarian Injury by Removing Senescent Cells and Alleviating DNA Damage.
Pygo1 Regulates the Behavior of Human Non-Small-Cell Lung Cancer via the Wnt/β-Catenin Pathway.
Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE.
Cigarette Smoke Exposure Increases Glucose-6-phosphate Dehydrogenase, Autophagy, Fibrosis, and Senescence in Kidney Cells In Vitro and In Vivo.
PGF2α-FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI-1 Signal Pathway.
Reversion of glucocorticoid-induced senescence and collagen synthesis decrease by LY294002 is mediated through p38 in skin.
Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity.
Mechanism of Ba Zhen Tang Delaying Skin Photoaging Based on Network Pharmacology and Molecular Docking.
Mannan-Binding Lectin via Interaction With Cell Surface Calreticulin Promotes Senescence of Activated Hepatic Stellate Cells to Limit Liver Fibrosis Progression.
Long-Term Social Isolation-Induced Autophagy Inhibition and Cell Senescence Aggravate Cognitive Impairment in D(+)Galactose-Treated Male Mice.
NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma.
A novel signature to guide osteosarcoma prognosis and immune microenvironment: Cuproptosis-related lncRNA.
Palmitic Acid, A Critical Metabolite, Aggravates Cellular Senescence Through Reactive Oxygen Species Generation in Kawasaki Disease.
Prognostic and immune correlation evaluation of a novel cuproptosis-related genes signature in hepatocellular carcinoma.
Stress-induced premature senescence is associated with a prolonged QT interval and recapitulates features of cardiac aging.
Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration.
High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER(+) breast cancer.
Increasing cell size remodels the proteome and promotes senescence.
Elimination of senescent cells inhibits epithelial-mesenchymal transition of retinal pigment epithelial cells.
Expression of active B-Raf proto-oncogene in kidney collecting ducts induces cyst formation in normal mice and accelerates cyst growth in mice with polycystic kidney disease.
Effective-component compatibility of Bufei Yishen formula III ameliorated COPD by improving airway epithelial cell senescence by promoting mitophagy via the NRF2/PINK1 pathway.
Unveiling the anti-senescence effects and senescence-associated secretory phenotype (SASP) inhibitory mechanisms of Scutellaria baicalensis Georgi in low glucose-induced astrocytes based on boolean network.
Avenanthramide C induces cellular senescence in colorectal cancer cells via suppressing β-catenin-mediated the transcription of miR-183/96/182 cluster.
SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity.
Circular RNA PVT1 inhibits tendon stem/progenitor cell senescence by sponging microRNA-199a-5p.
The LncRNA RP11-301G19.1/miR-582-5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway.
Loss of legumain induces premature senescence and mediates aging-related renal fibrosis.
P16ink4a overexpression ameliorates cardiac remodeling of mouse following myocardial infarction via CDK4/pRb pathway.
Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes.
Cholesteryl hemiazelate causes lysosome dysfunction impacting vascular smooth muscle cell homeostasis.
Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary.
A Small Molecule That Promotes Cellular Senescence Prevents Fibrogenesis and Tumorigenesis.
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening.
Loss of lamin-B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus.
An in vitro senescence model of gingival epithelial cell induced by hydrogen peroxide treatment.
Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion-Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency.
Galangin Reverses H(2)O(2)-Induced Dermal Fibroblast Senescence via SIRT1-PGC-1α/Nrf2 Signaling.
Ubiquitin-specific protease 3 attenuates interleukin-1β-mediated chondrocyte senescence by deacetylating forkhead box O-3 via sirtuin-3.
Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis.
Fulminant lung fibrosis in non-resolvable COVID-19 requiring transplantation.
HMGB1 induces radioresistance through PI3K/AKT/ATM pathway in esophageal squamous cell carcinoma.
Lnc-IL7R alleviates PM(2.5)-mediated cellular senescence and apoptosis through EZH2 recruitment in chronic obstructive pulmonary disease.
Procyanidin B2 ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
Artesunate Inhibits the Cell Growth in Colorectal Cancer by Promoting ROS-Dependent Cell Senescence and Autophagy.
Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer.
CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation.
Elevated FAM84B promotes cell proliferation via interacting with NPM1 in esophageal squamous cell carcinoma.
Downregulation of IGFBP5 contributes to replicative senescence via ERK2 activation in mouse embryonic fibroblasts.
ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity.
LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation.
FGFR2 accommodates osteogenic cell fate determination in human mesenchymal stem cells.
PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair.
Statins Mitigate Stress-Related Vascular Aging and Atherosclerosis in apoE-Deficient Mice Fed High Fat-Diet: The Role of Glucagon-Like Peptide-1/Adiponectin Axis.
P16 (I NK 4a) Deletion Ameliorates Damage of Intestinal Epithelial Barrier and Microbial Dysbiosis in a Stress-Induced Premature Senescence Model of Bmi-1 Deficiency.
MCC Regulator of WNT Signaling Pathway (MCC) Is a Podocyte Essential Gene.
Neu-P11 - a novel melatonin receptor agonist, could improve the features of type-2 diabetes mellitus in rats.
PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway.
Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway.
One-Two Punch Therapy for the Treatment of T-Cell Malignancies Involving p53-Dependent Cellular Senescence.
FAM134B-Mediated ER-phagy Upregulation Attenuates AGEs-Induced Apoptosis and Senescence in Human Nucleus Pulposus Cells.
Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function.
TFCP2 Overcomes Senescence by Cooperating With SREBP2 to Activate Cholesterol Synthesis in Pancreatic Cancer.
IL-21 Is an Accomplice of PD-L1 in the Induction of PD-1-Dependent Treg Generation in Head and Neck Cancer.
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor-Resistant Melanoma.
TFEB protein expression is reduced in aged brains and its overexpression mitigates senescence-associated biomarkers and memory deficits in mice.
NFATc4 mediates ethanol-triggered hepatocyte senescence.
Th17/IL-17 induces endothelial cell senescence via activation of NF-κB/p53/Rb signaling pathway.
Design and synthesis of water-soluble grifolin prodrugs for DNA methyltransferase 1 (DNMT1) down-regulation.
Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease.
Dipeptidyl peptidase-4 inhibition prevents lung injury in mice under chronic stress via the modulation of oxidative stress and inflammation.
Muse Cells Have Higher Stress Tolerance than Adipose Stem Cells due to the Overexpression of the CCNA2 Gene.
Aging-associated lncRNAs are evolutionarily conserved and participate in NFκB signaling.
Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury.
Smad4 deficiency substitutes Cdkn2b but not Cdkn2a downregulation in pancreatic cancer following induction of genetic events in adult mice.
The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence.
Bmi-1 alleviates adventitial fibroblast senescence by eliminating ROS in pulmonary hypertension.
BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.
Paricalcitol inhibits oxidative stress-induced cell senescence of the bile duct epithelium dependent on modulating Sirt1 pathway in cholestatic mice.
Baicalein Delays H(2)O(2)-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism.
Targeting senescent cells improves functional recovery after spinal cord injury.
Hypoxic preconditioning rejuvenates mesenchymal stem cells and enhances neuroprotection following intracerebral hemorrhage via the miR-326-mediated autophagy.
Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities.
Irradiation Accelerates Plaque Formation and Cellular Senescence in Flow-Altered Carotid Arteries of Apolipoprotein E Knock-Out Mice.
Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes.
CDC25B induces cellular senescence and correlates with tumor suppression in a p53-dependent manner.
Huaier Inhibits Proliferation, Migration, and Invasion of Cutaneous Squamous Cell Carcinoma Cells by Inhibiting the Methylation Levels of CDKN2A and TP53.
Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome.
Isolation methodology is essential to the evaluation of the extracellular vesicle component of the senescence-associated secretory phenotype.
Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma.
Knockdown of RREB1 inhibits cell proliferation via enhanced p16 expression in gastric cancer.
eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer.
Pim1 knockout alleviates sarcopenia in aging mice via reducing adipogenic differentiation of PDGFRα(+) mesenchymal progenitors.
Artesunate treatment ameliorates ultraviolet irradiation-driven skin photoaging via increasing β-catenin expression.
Urolithin a alleviates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells through SIRT1/PGC-1α pathway.
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
Protective effects of galangin against H(2)O(2)/UVB-induced dermal fibroblast collagen degradation via hsa-microRNA-4535-mediated TGFβ/Smad signaling.
SETD4 in the Proliferation, Migration, Angiogenesis, Myogenic Differentiation and Genomic Methylation of Bone Marrow Mesenchymal Stem Cells.
EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.
The Extracellular Metabolome Stratifies Low and High Risk Potentially Premalignant Oral Keratinocytes and Identifies Citrate as a Potential Non-Invasive Marker of Tumour Progression.
HIV TAT-mediated microglial senescence: Role of SIRT3-dependent mitochondrial oxidative stress.
Extracts of Jasminum sambac flowers fermented by Lactobacillus rhamnosus inhibit H(2) O(2) - and UVB-induced aging in human dermal fibroblasts.
miR-127-3p Is an Epigenetic Activator of Myofibroblast Senescence Situated within the MicroRNA-Enriched Dlk1-Dio3‒Imprinted Domain on Mouse Chromosome 12.
Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell-Derived Exosomes on the Senescence of Nucleus Pulposus Cells.
Melatonin induces the rejuvenation of long-term ex vivo expanded periodontal ligament stem cells by modulating the autophagic process.
Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A.
CDKN2a/p16 Antagonizes Hepatic Stellate Cell Activation and Liver Fibrosis by Modulating ROS Levels.
Resveratrol Inhibits Ischemia-Induced Myocardial Senescence Signals and NLRP3 Inflammasome Activation.
Piwi-interacting RNAs play a role in vitamin C-mediated effects on endothelial aging.
HIV antiretroviral drugs, dolutegravir, maraviroc and ritonavir-boosted atazanavir use different pathways to affect inflammation, senescence and insulin sensitivity in human coronary endothelial cells.
Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells.
High Phosphate Induces and Klotho Attenuates Kidney Epithelial Senescence and Fibrosis.
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.
LncRNA TRPC7-AS1 regulates nucleus pulposus cellular senescence and ECM synthesis via competing with HPN for miR-4769-5p binding.
TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs.
Internalization of the TAT-PBX1 fusion protein significantly enhances the proliferation of human hair follicle-derived mesenchymal stem cells and delays their senescence.
Paclitaxel exposure downregulates miR-522 expression and its downregulation induces paclitaxel resistance in ovarian cancer cells.
Metformin promotes the osseointegration of titanium implants under osteoporotic conditions by regulating BMSCs autophagy, and osteogenic differentiation.
HO-1 overexpression alleviates senescence by inducing autophagy via the mitochondrial route in human nucleus pulposus cells.
FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping.
A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence.
PAI-1 Regulation of TGF-β1-induced Alveolar Type II Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages.
Knockdown of lncRNA MIR503HG suppresses proliferation and promotes apoptosis of non-small cell lung cancer cells by regulating miR-489-3p and miR-625-5p.
Augmentation of Bone Regeneration by Depletion of Stress-Induced Senescent Cells Using Catechin and Senolytics.
Nrf2 modulates immunosuppressive ability and cellular senescence of human umbilical cord mesenchymal stem cells.
Senolytic CAR T cells reverse senescence-associated pathologies.
In Utero Exposure to Gestational Diabetes Alters DNA Methylation and Gene Expression of CDKN2A/B in Langerhans Islets of Rat Offspring.
Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16(INK4A).
Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression.
The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin - SCL/TAL1 - CD44 axis.
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR.
Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model.
Acetyl-11-keto-β-boswellic acid triggers premature senescence via induction of DNA damage accompanied by impairment of DNA repair genes in hepatocellular carcinoma cells in vitro and in vivo.
Role and mechanism of FLNa and UCP2 in the development of cervical cancer.
Increased production of functional small extracellular vesicles in senescent endothelial cells.
A novel STAT3 inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma.
Novel Breast-Specific Long Non-coding RNA LINC00993 Acts as a Tumor Suppressor in Triple-Negative Breast Cancer.
Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence.
NANOG Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence by Upregulating PBX1 and Activating AKT Signaling.
New Insights into Chronological Mobility of Retrotransposons In Vivo.
Overexpression of P16 reversed the MDR1-mediated DDP resistance in the cervical adenocarcinoma by activating the ERK1/2 signaling pathway.
Interferon Regulatory Factor 3 Deficiency Induces Age-Related Alterations of the Retina in Young and Old Mice.
P16 Methylation Leads to Paclitaxel Resistance of Advanced Non-Small Cell Lung Cancer.
Inhibition of polycomb repressor complex 2 ameliorates neointimal hyperplasia by suppressing trimethylation of H3K27 in vascular smooth muscle cells.
Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence.
Tumor necrosis factor-inducible gene 6 reprograms hepatic stellate cells into stem-like cells, which ameliorates liver damage in mouse.
Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications.
Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer.
Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development.
Degradation of Caytaxin Causes Learning and Memory Deficits via Activation of DAPK1 in Aging.
The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways.
Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence.
Radiosensitization of esophageal carcinoma cells by knockdown of HMGB1 expression.
Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways.
Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways.
Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability.
Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis.
MDM2 promotes genome instability by ubiquitinating the transcription factor HBP1.
Fra-1 plays a critical role in angiotensin II-induced vascular senescence.
The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathway.
Correlation of p16 and nm23-H1 expression levels with incidence and prognosis of soft tissue sarcoma.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells.
Overexpression of KLF5 is associated with poor survival and G1/S progression in pancreatic cancer.
Cathepsin S Deficiency Mitigated Chronic Stress-Related Neointimal Hyperplasia in Mice.
Aberrant methylation-induced dysfunction of p16 is associated with osteoblast activation caused by fluoride.
S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α.
lncRNA-ES3/miR-34c-5p/BMF axis is involved in regulating high-glucose-induced calcification/senescence of VSMCs.
Phenotypic and functional differences between senescent and aged murine microglia.
Shuttling SLC2A4RG is regulated by 14-3-3θ to modulate cell survival via caspase-3 and caspase-6 in human glioma.
p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation.
A basal-enriched microRNA is required for prostate tumorigenesis in a Pten knockout mouse model.
Ribociclib (LEE011) suppresses cell proliferation and induces apoptosis of MDA-MB-231 by inhibiting CDK4/6-cyclin D-Rb-E2F pathway.
Roles of p38α and p38β mitogen‑activated protein kinase isoforms in human malignant melanoma A375 cells.
Releasing Behavior of Lipopolysaccharide from Gelatin Modulates Inflammation, Cellular Senescence, and Bone Formation in Critical-Sized Bone Defects in Rat Calvaria.
Dipeptidyl peptidase-4 inhibition prevents vascular aging in mice under chronic stress: Modulation of oxidative stress and inflammation.
Senescence caused by inactivation of the homeodomain transcription factor Pdx1 in adult pancreatic acinar cells in mice.
Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells.
MRTF-A regulates proliferation and survival properties of pro-atherogenic macrophages.
PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis.
Stem cell competition orchestrates skin homeostasis and ageing.
Histone Deacetylation in the Promoter of p16 Is Involved in Fluoride-Induced Human Osteoblast Activation via the Inhibition of Sp1 Binding.
Ribociclib, a selective cyclin D kinase 4/6 inhibitor, inhibits proliferation and induces apoptosis of human cervical cancer in vitro and in vivo.
A novel pancreatic cancer model originated from transformation of acinar cells in adult tree shrew, a primate-like animal.
Coxsackievirus A6 Induces Cell Cycle Arrest in G0/G1 Phase for Viral Production.
NRF2-regulated cell cycle arrest at early stage of oxidative stress response mechanism.
Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence.
Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3.
Lack of Cardiac Improvement After Cardiosphere-Derived Cell Transplantation in Aging Mouse Hearts.
Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma.
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Comparative characterization of SHED and DPSCs during extended cultivation in vitro.
Counteracting survival functions of EBNA3C in Epstein-Barr virus (EBV)-driven lymphoproliferative diseases by combination of SAHA and bortezomib.
Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice.
Glutaredoxin-1 Silencing Induces Cell Senescence via p53/p21/p16 Signaling Axis.
The protein kinase D1-mediated classical protein secretory pathway regulates the Ras oncogene-induced senescence response.
Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer.
Identification of early indicators of altered metabolism in normal development using a rodent model system.
Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice.
Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells.
Overexpression of PP1-NIPP1 limits the capacity of cells to repair DNA double-strand breaks.
Atorvastatin exerts inhibitory effect on endothelial senescence in hyperlipidemic rats through a mechanism involving down-regulation of miR-21-5p/203a-3p.
Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma.
EZH2 inhibition sensitizes tamoxifen‑resistant breast cancer cells through cell cycle regulation.
Young plasma reverses age-dependent alterations in hepatic function through the restoration of autophagy.
Antrocin Sensitizes Prostate Cancer Cells to Radiotherapy through Inhibiting PI3K/AKT and MAPK Signaling Pathways.
LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1.
Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis.
H(2)S Donor NaHS Changes the Production of Endogenous H(2)S and NO in D-Galactose-Induced Accelerated Ageing.
Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation.
Increased dipeptidyl peptidase-4 accelerates diet-related vascular aging and atherosclerosis in ApoE-deficient mice under chronic stress.
Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice.
5-fluorouracil causes endothelial cell senescence: potential protective role of glucagon-like peptide 1.
Potency of Human Cardiosphere-Derived Cells from Patients with Ischemic Heart Disease Is Associated with Robust Vascular Supportive Ability.
A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis.
Activation of Wnt/β-catenin signaling by lithium chloride attenuates d-galactose-induced neurodegeneration in the auditory cortex of a rat model of aging.
miR-21-5p/203a-3p promote ox-LDL-induced endothelial cell senescence through down-regulation of mitochondrial fission protein Drp1.
Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8.
CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.
Knockout of 4.1B triggers malignant transformation in SV40T-immortalized mouse embryo fibroblast cells.
MicroRNA let-7g inhibited hypoxia-induced proliferation of PASMCs via G(0)/G(1) cell cycle arrest by targeting c-myc.
IGFBP-rP1 acts as a potential tumor suppressor via the suppression of ERK signaling pathway in endometrial cancer cells.
Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a) in vivo are not necessarily senescent.
Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions.
Long-term effects of repeated superovulation on the uterus and mammary gland in rhesus monkeys.
N-Stearoyl-L-Tyrosine Inhibits the Senescence of Neural Stem/Progenitor Cells Induced by Aβ 1-42 via the CB2 Receptor.
Antiaging Effect of Inula britannica on Aging Mouse Model Induced by D-Galactose.
Inhibition of BMI1 induces autophagy-mediated necroptosis.
Chemoproteomic Evaluation of Target Engagement by the Cyclin-Dependent Kinase 4 and 6 Inhibitor Palbociclib Correlates with Cancer Cell Response.
Macrophage Migration Inhibitory Factor (MIF) Deficiency Exacerbates Aging-Induced Cardiac Remodeling and Dysfunction Despite Improved Inflammation: Role of Autophagy Regulation.
miR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4/E2F1 signal activation.
HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis.
The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity.
Testosterone Antagonizes Doxorubicin-Induced Senescence of Cardiomyocytes.
Comparison of liver oncogenic potential among human RAS isoforms.
Mechanism of BRG1 silencing in primary cancers.
Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis.
Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon.
Lentivirus-mediated gene silencing of NOB1 suppresses non-small cell lung cancer cell proliferation.
Evaluation of Protein Profiles From Treated Xenograft Tumor Models Identifies an Antibody Panel for Formalin-fixed and Paraffin-embedded (FFPE) Tissue Analysis by Reverse Phase Protein Arrays (RPPA).
Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability.
Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction.
Cathepsin K knockout alleviates aging-induced cardiac dysfunction.
mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.
Patient-derived bladder cancer xenografts in the preclinical development of novel targeted therapies.
Potent effects of dioscin against liver fibrosis.
Fullerenol protects retinal pigment epithelial cells from oxidative stress-induced premature senescence via activating SIRT1.
BCL6 overexpression is associated with decreased p19 ARF expression and confers an independent prognosticator in gallbladder carcinoma.
Ocular expression and distribution of products of the POAG-associated chromosome 9p21 gene region.
Teng-Long-Bu-Zhong-Tang, a Chinese herbal formula, enhances anticancer effects of 5--Fluorouracil in CT26 colon carcinoma.
Notch1 signaling contributes to the oncogenic effect of HBx on human hepatic cells.
Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: role of autophagy.
Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells.
Correlation of MTS1/p16 and nm23 mRNA expression with survival in patients with peripheral synovial sarcoma.
Lan L, Zhou Q, Pan S, Liu H, Du Y, Guan C, Song X, Wang W
Biomaterials research 2026;30:0333
Biomaterials research 2026;30:0333
DNA Polymerase Gamma Acetylation Governs Mitochondrial Homeostasis and Vascular Cell Senescence.
Wang P, Yu L, Cao K, Guo X, Sun L, Zhang S, Zhao T, Yu Y, Xiong M, Liu C, Zhang N, Sun Y, Sun G, Cao L
International journal of biological sciences 2026;22(5):2435-2451
International journal of biological sciences 2026;22(5):2435-2451
NAT10 Promotes Tubular Epithelial Cell Senescence in Cisplatin-Induced Acute Kidney Injury by Regulating DDX17.
Zhu Y, Xu W, Wan C, Deng B, Xie Y, Yang B, Jiang H, Zhang C
International journal of biological sciences 2026;22(4):2177-2195
International journal of biological sciences 2026;22(4):2177-2195
Targeting the LHX1-LDB1 Complex Restores STING-dependent Senescence Surveillance and Inhibits Head and Neck Cancer Progression.
Long M, Chen Y, Du R, Yang J, Wang J, Sun Y, Tian X, Wang S, Zhong Y, Liang W, Zhang J, Shang Z
International journal of biological sciences 2026;22(3):1186-1206
International journal of biological sciences 2026;22(3):1186-1206
MUS81 inhibits cell proliferation and migration in breast cancer by promoting the expression of CDKN2A(p16(INK4a)).
Xie R, Kong D, Su X, Zhang L, Wan J, Yan Y
American journal of translational research 2026;18(2):1077-1087
American journal of translational research 2026;18(2):1077-1087
Analysis of molecular subtypes and prognostic signature of senescence-associated secretory phenotype in pancreatic cancer.
Kuang Y, Jia M, Zhu Y, Xiang Z
PeerJ 2026;14:e20476
PeerJ 2026;14:e20476
Small molecule HCY-NBD stabilizes GSTM2 via cys174 sulfenylation to attenuate high glucose induced endothelial cell senescence and calcification.
Zhang Y, Dong X, Yan X, Zhao C, Chi X, Zhao B, Miao J, Hong F, Lin Z
Redox biology 2026 Mar;90:104058
Redox biology 2026 Mar;90:104058
The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs.
Zhuang Z, Han C, Cai M, Li M, Lin S, Chen L, Zhu Z, Zhang H, Xing C, Han B, Yang R
Journal of advanced research 2026 Mar;81:349-364
Journal of advanced research 2026 Mar;81:349-364
Inflammation Affects the Osteogenic Differentiation of Aged Periodontal Ligament Cells via NF-κB/FOXO3a/c-JUN Signalling.
Zhu L, Tang Z, Hu R, Li Y, Li X, Gu M, Yang Y
Journal of periodontal research 2026 Mar;61(3):292-308
Journal of periodontal research 2026 Mar;61(3):292-308
SETD7 regulates decidual senescence through FOXO1-dependent mechanisms in human endometrial stromal cells.
Yu X, Hou W, Cao Z, Hu W, Ruan J
Journal of assisted reproduction and genetics 2026 Mar;43(3):967-977
Journal of assisted reproduction and genetics 2026 Mar;43(3):967-977
Novel PMVs/ZIP4/Zinc/Prelamin A Axis Promotes Nuclear Dysmorphism and Vascular Aging in Humans and Rodents Post-Injury: Effective Treatment With Platelet Membrane-Coated ZIF-8 Nanoparticles.
Ma T, Bao H, Xu Z, Ren H, Tian W, Chen J, Liu Z, Lu X, Lv F, Yao Q, Qi Y, Huang K
Aging cell 2026 Mar;25(3):e70443
Aging cell 2026 Mar;25(3):e70443
DHODH inhibition impairs mitochondrial function and extravillous trophoblast invasion: Protective roles of quercetin and riboflavin.
Yoshida K, Kusama K, Kanazawa K, Kawaguchi Y, Tsuru A, Yoshie M, Tamura K
Journal of pharmacological sciences 2026 Mar;160(3):143-151
Journal of pharmacological sciences 2026 Mar;160(3):143-151
m(1)A-Dependent TRMT6/61A-ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment.
Li T, Huang M, Cai J, Li X, Xing Y, He R, Wan Z, Gan Y, Li Z, Weng J, Xie Y, Wu Y, Liu X, Wang X, Luo Y, Huang M, Lin J, Yu H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(13):e18536
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(13):e18536
Rejuvenation of THY1(+) nucleus pulposus-derived stem cells promotes intervertebral disc regeneration through FGF10-FGFR1-CREB pathway and mitochondrial fission.
Zhai H, Wang Z, Wang S, Liu Z, Zhao D, Zhang Y, Liu K, Kong X, Meng Q, Gu H, Chen L, Zhang Y, Cheng L
Journal of advanced research 2026 Mar 9;
Journal of advanced research 2026 Mar 9;
Mechanism of platelet-rich plasma inhibiting inflammatory response, oxidative stress, and senescence in synovial fibroblasts of patients with knee osteoarthritis via UBE2C based on transcriptome sequencing analysis.
Zou L, Ma Y, Hu M, Sun Z, Shi Z, Gao J, Cai X
Journal of bioenergetics and biomembranes 2026 Mar 26;58(1)
Journal of bioenergetics and biomembranes 2026 Mar 26;58(1)
cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis.
Zhang Y, Zhu Z, Ji P, Ming J, Zhou Y
Cell death & disease 2026 Mar 25;17(1)
Cell death & disease 2026 Mar 25;17(1)
Age and gender effects on echocardiographic and histopathological cardiac phenotypes in healthy adult mice.
Wen S, Shao X, Zhang X, Zhang N, Chen X, Yue G, Song J
Animal models and experimental medicine 2026 Mar 24;
Animal models and experimental medicine 2026 Mar 24;
Recycling senescent cell lipids for targeted senotherapy.
Ji X, He X, Cai H, Tang P, Zhou H, Wang J, Wu Y, Zhou J, Lin Z, Xu K, Lin C, Wu X, Wang K, Liu W, Feng G, Yan S, Jiang G, Qu Z, Qi Y
Nature communications 2026 Mar 13;17(1)
Nature communications 2026 Mar 13;17(1)
PRMT5 is Frequently Upregulated and a Potential Therapeutic Target in MTAP-deficient Malignant Peripheral Nerve Sheath Tumors.
Wang D, Fishel ML, Samiei A, Gampala S, Hu C, Chen S, Zhang G
bioRxiv : the preprint server for biology 2026 Mar 11;
bioRxiv : the preprint server for biology 2026 Mar 11;
Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A.
Chen J, Xue M, Mi S, Fu A, Chen W, Sun Y, Xia S, Ge Q, Luo J, Yu Q, Wang L, Chen S
Nature communications 2026 Mar 1;17(1)
Nature communications 2026 Mar 1;17(1)
Screening of metabolic-related biomarkers linking intervertebral disc degeneration and type 2 diabetes based on comprehensive bioinformatics analysis and machine learning.
Qiu B, Chen T, Hong Q, Xie X, Xue M, Xu N, Shi C, Xu G, Wang W, Sulaiman M, Xi Y
Biochemistry and biophysics reports 2026 Jun;46:102593
Biochemistry and biophysics reports 2026 Jun;46:102593
Nobiletin's role in idiopathic pulmonary fibrosis via the PI3K/AKT/MDM2/p53 signaling pathway.
Li T, Wang J, Bai L, Zhao Q, Zhu D, Xu Y, Wang Y, Wang Z, Feng F, Zhou X
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):225-242
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):225-242
Ionizable Coenzyme-Engineered Lipid/Fiber Microplexes Boost Ribosomal Translation to Improve mRNA Therapy for Degenerative Diseases.
Ling S, Zhang Y, Chen Y, He W, Wu T, Wang J, Wei Y, Lu M, Zhao WL, Li Q, Du Y, Cui W
Advanced materials (Deerfield Beach, Fla.) 2026 Jan;38(4):e13720
Advanced materials (Deerfield Beach, Fla.) 2026 Jan;38(4):e13720
Neuroprotective effects of SRS11-92 against oxidative stress-induced senescence via Nrf2/HO-1/NF-κB in Alzheimer's disease models.
Guo Y, Cao H, Zuo C, Huang Y, Gu Z, Song Y, Chen X, Jiang Q, Wang F
Inflammopharmacology 2026 Jan;34(1):495-507
Inflammopharmacology 2026 Jan;34(1):495-507
Suppression of HIF-1α alleviates the symptoms associated with diabetic retinopathy in mice.
Wang J, Fang S, Wang J, Liu W, Meng F, Zhou X, Gao L
Experimental eye research 2026 Jan;262:110741
Experimental eye research 2026 Jan;262:110741
Fe-Mn-IGF-AMD nanoparticles in accurate detection and treatment of liver cirrhosis via regulating relaxation coefficients and attenuating hepatocyte senescence.
Wang B, Ji T, Zhang Z, Duan Y, Xing Z, Duan J, Zhao S, Jia Y, Wang Q
Colloids and surfaces. B, Biointerfaces 2026 Jan;257:115182
Colloids and surfaces. B, Biointerfaces 2026 Jan;257:115182
PRKN-Mediated Ubiquitin-Proteasome Degradation of METTL3 Promotes Cellular Senescence.
Chen L, Zhang C, Ge Y, Zhou H, Yang S, Wei W, Zhou Q, Xiao K, Huang G, Li X, Wang J, Zheng J, Gu R, Ju Z, Wu S
Aging cell 2026 Jan;25(1):e70347
Aging cell 2026 Jan;25(1):e70347
Astragalus polysaccharides inhibit arsenic trioxide-induced BMSCs damage through inhibition of Jnk and p38 signaling pathways.
Wu W, Bamba D, Zhang Z, Wu F, Li Y, Qi W, Liu Y, Zhang T, Su Y, Wang X, Wang H, Duan S, Ne J, Wang W, Liu J, Tang J, Li F, Wu Q, Li Y, Yang F, Yang L
Chinese herbal medicines 2026 Jan;18(1):178-187
Chinese herbal medicines 2026 Jan;18(1):178-187
Steap4 Promotes Senile Osteoporosis via Fe(2+)-ROS/C/EBPβ Feedback-Driven Ferroptosis and Adipogenesis in Senescent BMSCs.
Wang L, Yin G, Li W, Li M, Lu F, Xu C, Zhao G, Geng D, Bai J, Wang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e09926
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e09926
Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program.
Zhang N, Zhao R, Zhong X, Dong Q, Liu Y, Yu K, Han L, Meng F, Wu J, Chen Q, Li X, Chen Q, Zhang K, Huang H, Zhang J, Wu S, Ren Y, Wang W, Liu Y
Nature communications 2026 Jan 8;17(1):1406
Nature communications 2026 Jan 8;17(1):1406
Novel senescence inducer ICA-11c, a derivative of icaritin, YAP-dependently suppresses hepatocellular carcinoma cells.
Chen HF, Shen S, Wang SL, Ye L, Li JC, Cao WL, Hou ZL, Jia JH, Liu QB, Yao GD, Song SJ
Chemico-biological interactions 2026 Jan 5;423:111814
Chemico-biological interactions 2026 Jan 5;423:111814
Engineered microalgae-driven gel platform promotes the repairing of senescence-associated intervertebral disc degeneration in rats and goats.
Wang Y, Xu T, Wang H, Cai X, Gao S, Liang W, Deng Q, Yakefu A, Maimaiti M, Xun C, Ma L, Sheng W
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114500
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114500
Near-infrared photobiomodulation therapy for age-related erectile dysfunction: molecular and physiological restoration in a mouse model.
Zheng ZJ, Chen Y, Chen QX, Tang WH, Chung E, Hong K, Zhang SD, Lin HC
Asian journal of andrology 2026 Jan 1;28(1):80-88
Asian journal of andrology 2026 Jan 1;28(1):80-88
Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells.
Jin L, Wei L, Hua J, Zhang R, Chen J, He J, Yang Y
Oncology reports 2026 Feb;55(2)
Oncology reports 2026 Feb;55(2)
The UBC/SIRT5/DRP1 axis regulates mitochondrial dynamics to alleviate Staphylococcus aureus-induced oxidative stress and senescence in bovine mammary epithelial cells.
Hu H, Jiang N, Liu J, Bi J, Liu X, Xu B, Cao Y, Guo W, Fu S
PLoS pathogens 2026 Feb;22(2):e1013975
PLoS pathogens 2026 Feb;22(2):e1013975
A Human Kidney Tubuloid Model of Repeated Cisplatin-Induced Cellular Senescence and Fibrosis for Drug Screening.
Nakao Y, Mori M, Sekiguchi Y, Morita I, Shindoh R, Mandai S, Fujiki T, Kikuchi H, Ando F, Susa K, Mori T, Suzuki A, Nashimoto Y, Kaji H, Waseda Y, Yoshida S, Fujii Y, Sohara E, Uchida S, Miyake K, Mori Y
Advanced healthcare materials 2026 Feb;15(7):e01795
Advanced healthcare materials 2026 Feb;15(7):e01795
Remodeling Cellular Uptake via Inducing Clustering of Urokinase Receptors in Hydrogel Microspheres for Alleviating Cartilage Senescence.
Lin Z, Wu C, Du Y, Zhao D, Li Y, Wang L, Kang Y, Li Z, Zuo R, Cui W, Zhao J
Advanced healthcare materials 2026 Feb;15(5):e04034
Advanced healthcare materials 2026 Feb;15(5):e04034
FSHR-targeting tetrahedral DNA frameworks ameliorate ovarian aging through oxidative stress elimination.
Dai Y, Guo Y, Chen D, Li P, Xue L, Feng Y, Tang W, Wu C, Wei S, Dai J, Jiang D, Wang S, Wu M
Journal of nanobiotechnology 2026 Feb 7;24(1)
Journal of nanobiotechnology 2026 Feb 7;24(1)
Cardiospermum halicacabum Extract Attenuates UVB-Induced Photoaging in Human Skin Fibroblasts via Inhibition of the PI3K/Akt/mTOR Signaling Pathway.
Zhao K, Zhang C, Deng C, Zhu W
International journal of molecular sciences 2026 Feb 28;27(5)
International journal of molecular sciences 2026 Feb 28;27(5)
Supramolecular delivery of senolytics enables targeted anti-senescence therapy and accelerated fracture healing.
Fan Y, Wang ZH, Zhang X, Dong Y, Liu X, Luo G, Yang H, Li H, Wang Z, Tang Q, Jin X, Guo DS, Sun T
Journal of nanobiotechnology 2026 Feb 18;24(1)
Journal of nanobiotechnology 2026 Feb 18;24(1)
Meox1 promotes hepatocellular carcinoma progression potentially via regulation of cell cycle and p21 expression.
Ruan J, Xie Y, Zhang C, Sun D
Cell adhesion & migration 2026 Dec;20(1):2658289
Cell adhesion & migration 2026 Dec;20(1):2658289
3D-printed titanium scaffolds coated with a multifunctional photothermal-responsive hydrogel promote osteoporotic bone defect repair.
Wang C, Wang Y, Li X, Cao H, Wang C, Han S, Chen H, Zhao X, Yang S
Materials today. Bio 2026 Apr;37:102879
Materials today. Bio 2026 Apr;37:102879
The multilayer coatings on polylactic acid implants spatiotemporally regulates the microenvironment to enhance antibacterial and osseointegration capacity.
Lyu J, Jiang S, Ma T, Zhang Y, Yu J, Zhang Z, Teng Z, Helili M, Cao S, Geng X, Wang X, Jiang J, Qiu J, Sun X, Liu X, Ma X
Materials today. Bio 2026 Apr;37:102871
Materials today. Bio 2026 Apr;37:102871
Trichosanthes kirilowii extract alleviated liver fibrosis and acute myocardial infarction by inhibiting VCAN to restrain monocyte senescence: Insights from bioinformatic analyses and experimental validation.
Li Z, Wei S, Fu G, Liu R, Zhang S, Liu W, Pan T, Zhang Y, Wen X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157941
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157941
Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging.
Li H, Zhao R, Wan L, Yuan Y, Ma E, Li Y, Chen Z, Liu B, Song Y, Cao Z, Jiao X, Wang Y, Wu P, Jin H, Li J, Yang X, Huang L, Zhang Y, Yang K, Huo J, Jin H, Zhong H, Min M, Zhang S, Cao Y, Li W, Zhang R, Wei C
Nature aging 2026 Apr 6;
Nature aging 2026 Apr 6;
KLOTHO Deficiency Drives Ovarian Aging by Inducing Granulosa Cell Senescence and Dysfunction.
Du W, Liu A, Li H, Ma X, Yang Y
Reproductive sciences (Thousand Oaks, Calif.) 2026 Apr 17;
Reproductive sciences (Thousand Oaks, Calif.) 2026 Apr 17;
Tubeimoside Ⅰ targets sodium/potassium ATPase alpha 1 subunit to selectively eliminate senescent cells and alleviate aging-associated abnormalities.
Jiang H, Xue Y, Miao Z, Zhang Y, Li Z, Chen L, Deng H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 15;156:158202
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 15;156:158202
Youthful Brain-Derived Extracellular Vesicle-Loaded GelMA Hydrogel Promotes Scarless Wound Healing in Aged Skin by Modulating Senescence and Mitochondrial Function.
Wu Y, Mao J, Zhou Y, Hong G, Wu H, Hu Z, Huang X, Shi J, Xie Z, Lan Y
Research (Washington, D.C.) 2025;8:0644
Research (Washington, D.C.) 2025;8:0644
Upregulation of SIRT1 ameliorates apoptosis of rat nucleus pulposus cells under oxidative stress through FoxO1/β-catenin pathway.
Hu H, Wang S, Teng H, Zhao S, Hong W
Folia histochemica et cytobiologica 2025;63(2):53-64
Folia histochemica et cytobiologica 2025;63(2):53-64
The Punicalagin Compound Mitigates Bronchial Epithelial Cell Senescence Induced by Cigarette Smoke Extract through the PAR2/mTOR Pathway.
Xu J, Li X, Zeng X, Bao H, Liu X
Current medicinal chemistry 2025;32(38):8701-8719
Current medicinal chemistry 2025;32(38):8701-8719
Exendin-4 Reduces Senescence of Inflammation-Induced Periodontal Ligament Stem Cells Through SIRT1/Notch1 Signaling.
Xu Y, Zheng J, Liu M, Fu Z, Wang P
Stem cells international 2025;2025:7639451
Stem cells international 2025;2025:7639451
Fatty Acid Transporter CD36 Promotes Ox-LDL-Induced Senescence of Vascular Endothelial Cells in Preeclampsia.
Xiao Y, Tao M, Yu Y, Bai R, Zhuang Y, Huang Q, He J, Lin Z, Gao M, Li J, Wang Y, Xu Y, Shen X, Huang Z, Yao Y, Chen Z, Chen Q, Wang Z
Journal of inflammation research 2025;18:12801-12816
Journal of inflammation research 2025;18:12801-12816
Unveiling tumor senescence-driven prognostic heterogeneity via MALISS in stage II/III colorectal cancer.
Liu X, Liu B, Tong Y, Zhu X, Sang Y, Gao F, Niu X, Tang Y, Xu K, Chen H, Chong W, Li L
Frontiers in immunology 2025;16:1744719
Frontiers in immunology 2025;16:1744719
3D-cultured hADSCs-derived exosomes deliver circ_0011129 to synergistically attenuate skin photoaging.
Zhang Y, Zhou F, Nie G, Li L, Wen J, He S, Yao A
Frontiers in genetics 2025;16:1627472
Frontiers in genetics 2025;16:1627472
GLSP mitigates vascular aging by promoting Sirt7-mediated Keap1 deacetylation and Keap1-Nrf2 dissociation.
Cheng Y, Zheng G, Huang H, Ni J, Zhao Y, Sun Y, Chang Y, Liu S, He F, Li D, Guo Y, Miao Y, Xu M, Wang D, Zhang Y, Hua Y, Yang S, Fan G, Ma C
Theranostics 2025;15(10):4345-4367
Theranostics 2025;15(10):4345-4367
Excessive DAO inhibits myoblast migration, leading to impaired myotube fusion and muscle strength decline by reducing ECM.
Liu X, Xue J, Liang Y, Li Z, Xu R, Yang H, Zhao Y, Wang Q, Hou J, Lu S
Frontiers in bioengineering and biotechnology 2025;13:1606357
Frontiers in bioengineering and biotechnology 2025;13:1606357
CPP-calcification of articular cartilage is associated with elevated cytokine levels in synovial fluid.
Stücker S, Koßlowksi F, Buchholz A, Schwab A, Halm-Pozniak A, Lohmann CH, Bertrand J
Frontiers in cell and developmental biology 2025;13:1535530
Frontiers in cell and developmental biology 2025;13:1535530
Methionine ameliorates intestinal injury in senescence-accelerated mouse prone-8 mice by reducing sulfate-reducing bacteria and enhancing barrier function.
Wu Y, Zhang Y, Zhou M, Liu P, Rao X, Zhang Y, Mi M
Frontiers in nutrition 2025;12:1698518
Frontiers in nutrition 2025;12:1698518
Shenyuan granules improve cellular senescence through Klotho-mediated p16/p21 signaling pathway in diabetic kidney disease.
Guo X, Zhang S, Sun Q, Li H, Wang L
Frontiers in medicine 2025;12:1627412
Frontiers in medicine 2025;12:1627412
Tobacco smoking exposure-mediated ELAVL1 regulates bladder cancer cell senescence via autophagy activation.
Pu Q, Gao F, Xiao Y, Wu J, Wang C, Mo X, Zhang Z, Zheng R, Wu D
Toxicology 2025 Sep;516:154193
Toxicology 2025 Sep;516:154193
ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation.
Luo Y, Zeng Y, Liu Y, Liu S, Dai Y, Pan W, Zhang L, Zhu R, Feng D, Du K, Zhang X, Jia B, Tian F, Zhou L, Gu C
Oncogene 2025 Sep;44(34):3096-3112
Oncogene 2025 Sep;44(34):3096-3112
Kuntai Capsules Improve Premature Ovarian Failure by Regulating AMPK-Mediated Autophagy.
Ye X, Chen M, Zhong J, Chen H, Lin X
Reproductive sciences (Thousand Oaks, Calif.) 2025 Sep;32(9):2970-2984
Reproductive sciences (Thousand Oaks, Calif.) 2025 Sep;32(9):2970-2984
Mechanism of mitofusin 2, mitochondria-associated membrane, and the mitochondrial pathway in alleviating oxidative stress and cell senescence in bovine mammary epithelial cells.
Hu H, Liu J, Yin J, Hu G, Huang B, Tu L, Liu X, Xu B, Cao Y, Guo W, Fu S
Journal of dairy science 2025 Sep;108(9):10151-10172
Journal of dairy science 2025 Sep;108(9):10151-10172
Nuclear FGF2 orchestrates phase separation-mediated rDNA chromatin architecture to control BMSCs cell fate.
Zhang H, Wang Z, Liu Z, Li X, Sun W, Zhen W, Xu F, Wang R, Yin Q, Cao S, Wu M, He J, Xu J, Li Y, Yuan Q
Bone research 2025 Sep 24;13(1):80
Bone research 2025 Sep 24;13(1):80
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
Ma Y, Huang J, Gong J, Li L, Zhao Y, Jin Y, Gu J, Liu H, Wang Y, Sun Y
Chinese medicine 2025 Sep 22;20(1):146
Chinese medicine 2025 Sep 22;20(1):146
Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development.
Jiang Y, Shi Y, Lv M, Wang T, Wang P, Yuan X, Gao F, Ma B
Cell biology and toxicology 2025 Sep 2;41(1):129
Cell biology and toxicology 2025 Sep 2;41(1):129
mTOR dysregulation induces IL-6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis.
Babaei-Jadidi R, Clements D, Wu Y, Chen K, Miller S, Platé M, Lim K, Rue R, Krymskaya VP, Chambers R, Rawlins EL, Xu Y, Johnson SR
Nature communications 2025 Oct 9;16(1):8996
Nature communications 2025 Oct 9;16(1):8996
CTRP9 as a myokine mitigates sarcopenia via the LAMP-2A/NLRP3 pathway.
Li L, Zuo A, Yin R, Liu Q, Liu C, Li N, Xu D, Zhang S, Li J, Lei S, Ruan S, Li T, Guo Y
Cell death & disease 2025 Oct 7;16(1):710
Cell death & disease 2025 Oct 7;16(1):710
Matrix stiffness induces endothelial network senescence.
Song J, Rindone AN, Guan Y, Daswani PS, Elisseeff JH, Gerecht S
bioRxiv : the preprint server for biology 2025 Oct 6;
bioRxiv : the preprint server for biology 2025 Oct 6;
A TEMPO-loaded DNA hydrogel enabling integrated early diagnosis and treatment of osteoarthritis.
Huang H, Tang M, Hu P, Zhan Y, Sun W, Zheng W, Zhu J, Chen J, Xue S, Huang S, Han W, Zhang C, Ding C, Zhang Y, Li S, Ruan G
Journal of nanobiotechnology 2025 Oct 31;23(1):695
Journal of nanobiotechnology 2025 Oct 31;23(1):695
SARS-CoV-2 spike triggers TLR7-dependent endolysosome dysfunction and senescence in human astrocytes.
Hasler WA, McKay E, Datta G, Johnson S, Rezagholizadeh N, Chen X
Journal of neuroinflammation 2025 Oct 31;22(1):254
Journal of neuroinflammation 2025 Oct 31;22(1):254
Paeonol reduces IL-1β induced apoptosis and degeneration by regulating MAPK pathway in nucleus pulposus cells.
Yu C, Wei X, Wang J, Wang L, Wang J
Biochemical and biophysical research communications 2025 Oct 20;785:152687
Biochemical and biophysical research communications 2025 Oct 20;785:152687
SLC38A1 protects against aging-related oxidative stress and lipid peroxidation in C2C12 myoblasts: Implication of a ferroptosis-related regulator for skeletal muscle aging.
Chen X, Zhang Y, Zhao Y, Zhou M, Cheng P, Yang H, Shu Y, Duan L, Wu Y, Sun Y, Gao Y, Zhao K, Xiao Q, Yu J
Experimental gerontology 2025 Oct 15;210:112880
Experimental gerontology 2025 Oct 15;210:112880
Transcriptomic Analysis of the Effects of Hydroxysafflor Yellow A on hUC-MSC Senescence via the ECM-Receptor Interaction Pathway.
Wang S, Zhu Q, Feng X, Chou X, Lu T
International journal of molecular sciences 2025 Oct 1;26(19)
International journal of molecular sciences 2025 Oct 1;26(19)
Disruption of ovarian function and induction of apoptosis in female mice by Brefeldin A: Mechanistic insights into reproductive toxicity.
Jiang Y, Lv M, Fan H, Shi Y, Wang T, Wang P, Yuan X, Gao F, Ma B
Animal models and experimental medicine 2025 Nov;8(11):2053-2068
Animal models and experimental medicine 2025 Nov;8(11):2053-2068
Upregulation of ACSL1 in synovial macrophages promotes lipid peroxidation via the IκB/NF-κB pathway to accelerate osteoarthritis.
Yao Z, Yuan Z, Li Y, Li X, Peng C, Jin J, Zhang H, Bai X, Pan J, Cai D
Journal of orthopaedic translation 2025 Nov;55:360-375
Journal of orthopaedic translation 2025 Nov;55:360-375
Targeting LARP1 to mitigate aging in lens epithelial cells: mechanistic insights into mitochondrial dysfunction.
Qi H, Sun L, Chai J, Ma J, Yu H, Xia M, Hu X
Experimental eye research 2025 Nov;260:110582
Experimental eye research 2025 Nov;260:110582
Ferroptosis promotes sepsis-related lung injury via endothelial cell senescence.
Yao Y, Wang S, Shi W, Yang L, Tian Y, Wang D, Xia D
Cellular signalling 2025 Nov;135:112018
Cellular signalling 2025 Nov;135:112018
PDZK1 Protects Against RPE Senescence by Targeting the 14-3-3ε-mTOR Axis to Attenuate Early Diabetic Retinopathy.
Zhao J, Zhang J, Liu Y, Wang L, Huang C, Chi W, An M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e11288
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e11288
Oleuropein Aglycone Modulates Oxidative Stress and Autophagy-Related Pathways in Human Skeletal Muscle Cells.
Polacchini G, Venerando A, Bigot A, Colitti M
BioFactors (Oxford, England) 2025 Nov-Dec;51(6):e70058
BioFactors (Oxford, England) 2025 Nov-Dec;51(6):e70058
Elevating cytosolic NADPH metabolism in endothelial cells ameliorates vascular aging.
Wu D, Tan B, Cheng Z, Li H, Li H, Yin Y, Ma F, Chen T, Dong X, Wang W, Hu Q
Nature communications 2025 Nov 3;16(1):9667
Nature communications 2025 Nov 3;16(1):9667
Senescent bone marrow mesenchymal stem cells exacerbate subchondral bone sclerosis and osteoarthritis via the senescence-associated secretory phenotype.
Yang D, Xu X, Xu K, Yang M, Hao Y, Aihaiti Y, Li E, Yan Y, Lu C, Xu P
Stem cell research & therapy 2025 Nov 27;16(1):699
Stem cell research & therapy 2025 Nov 27;16(1):699
Kaempferol ameliorates BMSCs senescence in postmenopausal osteoporosis by targeting Sp1 to activate FUNDC1-mediated mitophagy.
Wang L, Qu Y, Hu Z, Lei P, Tian X, Yang X, Chen S, Li C, Wei B, Li L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157456
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157456
Biochanin A alleviates endothelial cell senescence via epigenetic regulation of the HDAC1/H3K4me3/NFKB1 axis.
Wang X, Tu Q, Mao A, Meng K, Lv J, Li B, Zhang T, Zhang H, Ding Y, Cao Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157385
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157385
Hyperosmolarity-Induced Oxidative Stress Leads to Senescence in Human Corneal Epithelial Cells (HCEPC) via DNA Damage, Metabolic Disturbance and Mitophagy Decline.
Zhang Y, Fan T
Antioxidants (Basel, Switzerland) 2025 Nov 19;14(11)
Antioxidants (Basel, Switzerland) 2025 Nov 19;14(11)
Trilaciclib triggers a neutrophil-related immune response and sensitizes non-small cell lung cancer to anti-PD-1 therapy.
Gao Y, He Y, Wang C, Zuo R, Tian X, Zuo D, Luo Y, Liu W, Feng Y, Ling A, Yue P, Gong W, Wang Y, Chen L, Liu Z, Chen P, Guo H
Cell reports. Medicine 2025 Nov 18;6(11):102434
Cell reports. Medicine 2025 Nov 18;6(11):102434
Clinical value and mechanism of CDKN2A in clear cell renal cell carcinoma.
Li Y, Wang S, Lin Y, Li J, Lan X, Lv A, Chen J, Liu Z
Discover oncology 2025 Nov 18;16(1):2195
Discover oncology 2025 Nov 18;16(1):2195
Identifying SUMOylation-related genes in liver fibrosis with bioinformatics and experimental models for diagnostic insights.
Su Z, Ding Y, Xue J, Sun J, Ji C
Scientific reports 2025 Nov 13;15(1):39783
Scientific reports 2025 Nov 13;15(1):39783
Nogo-B Silencing Expedites the Senescence of Platelet-Derived Growth Factor-BB-Induced Human Hepatic Stellate Cells Via Autophagy.
Gao L, Zhuang Y, Liu Z
Molecular biotechnology 2025 May;67(5):2023-2034
Molecular biotechnology 2025 May;67(5):2023-2034
Astragalus polysaccharide alleviates oxidative stress and senescence in chondrocytes in osteoarthritis via GCN2/ATF4/TXN axis.
Chen K, Qin C, Ji C, Yu Y, Wu Y, Xu L, Jiang Y, Zou G
International journal of biological macromolecules 2025 May;310(Pt 3):143285
International journal of biological macromolecules 2025 May;310(Pt 3):143285
Knockdown of C3aR alleviates age-related bone loss via activation of YAP1/β-catenin signaling.
Li F, Cui S
The Journal of biological chemistry 2025 May;301(5):108500
The Journal of biological chemistry 2025 May;301(5):108500
Melatonin-mediated cGAS-STING signal in senescent macrophages promote TNBC chemotherapy resistance and drive the SASP.
Zhang X, Zhuang M, Zhang H, Zhu Y, Yang J, Wu X, Yu X, Tao J, Liu X
The Journal of biological chemistry 2025 May;301(5):108438
The Journal of biological chemistry 2025 May;301(5):108438
A Binary siRNA-Loaded Tetrahedral DNA Nanobox for Synergetic Anti-Aging Therapy.
Yue Z, Yang Y, Nie L, Sun Y, Wang Q, Lin Y, Gao Y, Cai X
Small (Weinheim an der Bergstrasse, Germany) 2025 May;21(18):e2408323
Small (Weinheim an der Bergstrasse, Germany) 2025 May;21(18):e2408323
Resveratrol Promotes Wound Healing by Enhancing Angiogenesis via Inhibition of Ferroptosis.
Pan Y, Xia M, Luo J, Lu S
Food science & nutrition 2025 May;13(5):e70254
Food science & nutrition 2025 May;13(5):e70254
Targeting COPA to Enhance Erdafitinib Sensitivity in FGFR-Altered Bladder Cancer.
Zhao H, Gao X, Jiang Y, Yu Y, Wang L, Sun J, Wang M, Xiong X, Huang C, Zhang H, Jiang G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(18):e2413209
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(18):e2413209
The important role of cuproptosis and cuproptosis-related genes in the development of thyroid carcinoma revealed by transcriptomic analysis and experiments.
Liu Y, He Y, Lei S
Brazilian journal of otorhinolaryngology 2025 May-Jun;91(3):101560
Brazilian journal of otorhinolaryngology 2025 May-Jun;91(3):101560
Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism.
Jiang J, Gao Y, Wang J, Huang Y, Yang R, Zhang Y, Ma Y, Wen Y, Luo G, Zhang S, Cao Y, Yu M, Wang Q, Hu S, Wang K, Guo X, Gonzalez FJ, Liu Y, Liu H, Xie Q, Xie C
Cell metabolism 2025 May 6;37(5):1119-1136.e13
Cell metabolism 2025 May 6;37(5):1119-1136.e13
The mechanism of telomerase Cajal body protein 1 regulating senescence of mouse bone marrow mesenchymal stem cells.
Lin SQ, Tian N, Yao X, Pan XH, Li ZA, Wang Q, Gao J, Zhao XL, Ruan GP
Stem cell research & therapy 2025 May 30;16(1):267
Stem cell research & therapy 2025 May 30;16(1):267
Quercetin ameliorates ox-LDL-induced cellular senescence of aortic endothelial cells and macrophages by p16/p21, p53/SERPINE1, and AMPK/mTOR pathways.
Liang X, Zhang J, Yu J, Zhao J, Yang S
European journal of medical research 2025 May 3;30(1):359
European journal of medical research 2025 May 3;30(1):359
Conditional sequential delivery of ginkgetin and rapamycin orchestrates inflammation and autophagy to alleviate intervertebral disc degeneration.
Chen J, Gan X, Su S, Jiao S, Gong Z, Liu Z, Wu X, Jiang J, Zhang J, Wan J
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113556
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113556
Delta Opioid Peptide [d-Ala2, d-Leu5]-Enkephalin Improves Physical and Cognitive Function and Increases Lifespan in Aged Female Mice.
Huo L, Zhang H, Tang C, Cui G, Xue T, Guo H, Yao F, Zhang W, Feng W
Molecular neurobiology 2025 Mar;62(3):3568-3582
Molecular neurobiology 2025 Mar;62(3):3568-3582
p16INK4a Deletion Alleviated Obesity-Associated Kidney Fibrosis by Regulating Metabolic Reprogramming and the Inflammasome Pathway.
Liu Q, Wang F, Du Y, Liu Y, Zhang Z, Zhang X, Li J, Huang G, Liu F, Li B, Xiao W, Sui C, Bao N, Zhuang R, Gao C, Wang X, Gu X
Journal of cellular and molecular medicine 2025 Mar;29(5):e70444
Journal of cellular and molecular medicine 2025 Mar;29(5):e70444
Lactate promotes premature aging of preeclampsia placentas through histone lactylation-regulated GADD45A.
Li X, Wang Q, Fei J, Jin Z, Wu Y, Tao Y, Jiang C, Wang X, Yang N, Ding B, Dou C
Placenta 2025 Mar 6;161:39-51
Placenta 2025 Mar 6;161:39-51
Mesenchymal stem cell-specific Sirt1 overexpression prevents sarcopenia induced by 1,25-dihydroxyvitamin D deficiency.
Chen H, Ren B, Wang J, Liu X, Yi X, Goltzman D, Miao D
Aging 2025 Mar 31;17(4):1026-1042
Aging 2025 Mar 31;17(4):1026-1042
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
Xu Y, You J, Yao J, Hou B, Wang W, Hao Z
Urolithiasis 2025 Mar 29;53(1):61
Urolithiasis 2025 Mar 29;53(1):61
High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models.
Chen L, Wu B, Mo L, Chen H, Yin X, Zhao Y, Cui Z, Cui F, Chen L, Deng Q, Gao C, Yao P, Li Y, Tang Y
Nature communications 2025 Mar 24;16(1):2878
Nature communications 2025 Mar 24;16(1):2878
Targeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS-mutant cancer models.
Shen S, Zhang Q, Wang Y, Chen H, Gong S, Liu Y, Gai C, Chen H, Zhu E, Yang B, Liu L, Cao S, Zhao M, Ren W, Li M, Peng Z, Zhang L, Zhang S, Shen J, Zhang B, Lee PK, Li K, Li L, Yang H
The Journal of clinical investigation 2025 Mar 17;135(6)
The Journal of clinical investigation 2025 Mar 17;135(6)
Targeting DUSP3 promotes cell senescence by activating the notch1 pathway to treat hepatocellular carcinoma.
Zhang WJ, Peng JL, Dai DF, Huang C, Chen XP
Tissue & cell 2025 Jun;94:102781
Tissue & cell 2025 Jun;94:102781
ADAM10-mediated β-klotho degradation: a key to FGF21 resistance in senescent vascular endothelial cells.
Huang Y, Zhang Y, Yang N, Qian Z, Fang Z, Zeng L, Huang Y, Li H, Luo M, Yan J, Ruan L, Zhang C, Zhang L
GeroScience 2025 Jun;47(3):5089-5110
GeroScience 2025 Jun;47(3):5089-5110
Fibroblast hierarchy dynamics during mammary gland morphogenesis and tumorigenesis.
Pascual R, Cheng J, De Smet AH, Capaldo BD, Tsai M, Kordafshari S, Vaillant F, Song X, Giner G, Milevskiy MJG, Jackling FC, Pal B, Dite T, Yousef J, Dagley LF, Smyth GK, Fu N, Lindeman GJ, Chen Y, Visvader JE
The EMBO journal 2025 Jun;44(11):3266-3300
The EMBO journal 2025 Jun;44(11):3266-3300
Senescent cartilage endplate stem cells-derived exosomes induce oxidative stress injury in nucleus pulposus cells and aggravate intervertebral disc degeneration by regulating FOXO3.
Bian Z, Zhai Y, Zhang Y, Wang T, Li H, Ouyang J, Liu C, Wang S, Hu Z, Chang X, Zhang C, Liu M, Li C
Free radical biology & medicine 2025 Jun;233:39-54
Free radical biology & medicine 2025 Jun;233:39-54
Mai-wei-yang-fei decoction protects against pulmonary fibrosis by reducing telomere shortening and inhibiting AECII senescence via FBW7/TPP1 regulation.
Wang J, Zhao Y, Wei Y, Li T, Huang T, Pan T, Wu J, Bai L, Zhu D, Zhao Q, Wang Z, Feng F, Zhou X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156682
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156682
Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging-Related Pathways.
Meng F, He J, Zhang X, Lyu W, Wei R, Wang S, Du Z, Wang H, Bi J, Hua X, Zhang C, Guan Y, Lyu G, Tian XL, Zhang L, Xie W, Tao W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(22):e2412747
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(22):e2412747
Suppression of MRPL23 induces cellular senescence in hepatocellular carcinoma by targeting HMGB1.
Huang YB, Xu SM, Li M, Chen J, Lu CH, Liu QQ
Discover oncology 2025 Jun 9;16(1):1041
Discover oncology 2025 Jun 9;16(1):1041
Multi-omics analysis of canine aging markers and evaluation of stem cell intervention.
Li B, Ding Y, Han M, Zhang Z, Ling Z, Zhu W, Zhao X, Zhang Y, Lv C, Li N, Liao M, Hua J
Communications biology 2025 Jun 10;8(1):905
Communications biology 2025 Jun 10;8(1):905
SLC38A9 is directly involved in Tat-induced endolysosome dysfunction and senescence in astrocytes.
Rezagholizadeh N, Datta G, Hasler WA, Nguon EC, Smokey EV, Khan N, Chen X
Life science alliance 2025 Jul;8(7)
Life science alliance 2025 Jul;8(7)
PELI1 silencing delays intervertebral disc degeneration by impeding nucleus pulposus cell death.
Wei X, Yu C, Wang J
Connective tissue research 2025 Jul;66(4):298-310
Connective tissue research 2025 Jul;66(4):298-310
RIOK1 phase separation restricts PTEN translation via stress granules activating tumor growth in hepatocellular carcinoma.
Meng F, Li H, Huang Y, Wang C, Liu Y, Zhang C, Chen D, Zeng T, Zhang S, Li Y, Zhang B, Lang C, Xia J, Xiong W, Pan S, Sun X, Thorne RF, Liu Y, Wang J, Zhang S, Song R, Wang J, Liu L
Nature cancer 2025 Jul;6(7):1223-1241
Nature cancer 2025 Jul;6(7):1223-1241
TLR7 Mediates HIV-1 Tat-Induced Cellular Senescence in Human Astrocytes.
Rezagholizadeh N, Datta G, Hasler WA, Nguon EC, Smokey EV, Chen X
Aging cell 2025 Jul;24(7):e70086
Aging cell 2025 Jul;24(7):e70086
Targeting IGF1-Induced Cellular Senescence to Rejuvenate Hair Follicle Aging.
Wang Y, Yang J, Luo Y, Zhao Z, Yuan Y, Li J, Liu Y, Yi Y, Xu X, Lan Y, Zou J, Li Q, Wang L, Pan Y, Yang Y, Xiong M, Wu M, Li J, Li W, Zhang Y, Cao Y, Zhu Y, Xiao ZJ
Aging cell 2025 Jul;24(7):e70053
Aging cell 2025 Jul;24(7):e70053
Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.
Tang Q, Tang K, Markby GR, Parys M, Phadwal K, MacRae VE, Corcoran BM
Autophagy 2025 Jul;21(7):1433-1455
Autophagy 2025 Jul;21(7):1433-1455
Tβ4-Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing.
Ding Y, Wang J, Li J, Cheng Y, Zhou S, Zhang Y, Zhao Y, Zhou M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2505009
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2505009
Proteomics analysis reveals FEN1 as a promising therapeutic target against small cell neuroendocrine carcinoma of the cervix.
Liu J, Zhong M, Yang K, Wang J, Ma H, Wang W, Sun L, Liu L, Xu J, Cui X, Hao J, Li L
Scientific reports 2025 Jul 30;15(1):27827
Scientific reports 2025 Jul 30;15(1):27827
Increased CDKN2A expression correlates with resistance to platinum-based therapy and decreased infiltration of B lymphocytes in colon adenocarcinoma.
Gu R, Li S, Yu B, Gu J, Guan B, Wu H
Functional & integrative genomics 2025 Jul 3;25(1):144
Functional & integrative genomics 2025 Jul 3;25(1):144
Systematic pharmacology and experimental validation revealed the mechanism of Bupleurum chinense DC -mediated autophagy in alleviating osteoarthritis.
Wang Y, Wang C, Zhu Y, Chen K, Yu Y, Li R, Huang S, Tao T, Jiang Y
Journal of ethnopharmacology 2025 Jul 24;351:120042
Journal of ethnopharmacology 2025 Jul 24;351:120042
C-C chemokine ligand 5 from women subcutaneous adipose tissue has a central role in vascular aging.
Le Pelletier L, Ngono Ayissi K, Gorwood J, Capel E, Morichon R, Mantecon M, Auclair M, Alili R, Katlama C, Cuzin L, Atlan M, Beaupère C, Poitou C, Boccara F, Fève B, Capeau J, Lagathu C, Béréziat V
Cardiovascular diabetology 2025 Jul 18;24(1):295
Cardiovascular diabetology 2025 Jul 18;24(1):295
Small extracellular vesicles derived from mesenchymal stromal cells loaded with β-nicotinamide mononucleotide activate NAD(+)/SIRT3 signaling pathway-mediated mitochondrial autophagy to delay skin aging.
Sun Z, Li J, Zheng Y, Zhang J, Bai W, Deng X, Wu Z, Xu X, Ding W, Qian H, Tan Y
Stem cell research & therapy 2025 Jul 1;16(1):339
Stem cell research & therapy 2025 Jul 1;16(1):339
GNF-5837 alleviates intervertebral disc ageing by upregulating glutathione peroxidase 7.
Xu Y, Chen R, Zhuang Y, Xu W
International journal of immunopathology and pharmacology 2025 Jan-Dec;39:3946320251343365
International journal of immunopathology and pharmacology 2025 Jan-Dec;39:3946320251343365
Saffron extract alleviates D-gal-induced late-onset hypogonadism by activating the PI3K-Akt-Nrf2 signaling pathway.
Liu H, Guo Z, Zang Z, Jia B, Zhou Y, Zhang H, Fu Q
Journal of ethnopharmacology 2025 Jan 31;340:119273
Journal of ethnopharmacology 2025 Jan 31;340:119273
TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression.
Cao M, Shao Z, Qian X, Chen M, Deng C, Chen X, Tang T, Zhang K, Chu S, Zheng J, Bai J, Li Z
Cell death & disease 2025 Jan 31;16(1):56
Cell death & disease 2025 Jan 31;16(1):56
LncRNA-ANRIL regulates CDKN2A to promote malignant proliferation of Kasumi-1 cells.
Xu J, Zhang J, Zhang C, Hu H, Wang S, Deng F, Zhou W, Liu Y, Hu C, Huang H, Wei S
Cell division 2025 Jan 28;20(1):2
Cell division 2025 Jan 28;20(1):2
DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD.
Zhan Y, Huang Q, Deng Z, Chen S, Yang R, Zhang J, Zhang Y, Peng M, Wu J, Gu Y, Zeng Z, Xie J
Journal of advanced research 2025 Feb;68:201-214
Journal of advanced research 2025 Feb;68:201-214
NEK2 Promotes ESCC Malignant Progression by Inhibiting Cellular Senescence via the FOXM1/c-Myc/p27 Signaling Pathway.
Li J, Wang Y, Wei S, Xu S, Dai S, Zhang L, Tian Z, Zhao L, Lv H
Molecular carcinogenesis 2025 Feb;64(2):244-259
Molecular carcinogenesis 2025 Feb;64(2):244-259
Chronic environmental exposure to polystyrene microplastics increases the risk of nonalcoholic fatty liver disease.
Shi Y, Hong R, Fan Z, Huan R, Gao Y, Ma M, Liu T, Pan C
Toxicology 2025 Feb;511:154067
Toxicology 2025 Feb;511:154067
Senescent Fibroblasts Drive FAP/OLN Imbalance Through mTOR Signaling to Exacerbate Inflammation and Bone Resorption in Periodontitis.
Yin C, Fu L, Guo S, Liang Y, Shu T, Shao W, Xia H, Xia T, Wang M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2409398
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2409398
PD-1-Enhanced Treg Cell Senescence in Advanced Maternal Age.
Gong GS, Zhang YJ, Hu XH, Lin XX, Liao AH
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2411613
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2411613
Regulation of senescence-associated secretory phenotypes in osteoarthritis by cytosolic UDP-GlcNAc retention and O-GlcNAcylation.
Kang D, Lee J, Yook G, Jeong S, Shin J, Kim MS, Kim YJ, Jung H, Ahn J, Kim TW, Chang MJ, Chang CB, Kang SB, Yang WH, Lee YH, Cho JW, Yi EC, Kang C, Kim JH
Nature communications 2025 Feb 4;16(1):1094
Nature communications 2025 Feb 4;16(1):1094
Autophagy-dependent splicing control directs translation toward inflammation during senescence.
Kim J, Lee Y, Jeon T, Ju S, Kim JS, Kim MS, Kang C
Developmental cell 2025 Feb 3;60(3):364-378.e7
Developmental cell 2025 Feb 3;60(3):364-378.e7
Efficacy of Naringenin against aging and degeneration of nucleus pulposus cells through IGFBP3 inhibition.
Tang X, Zhong J, Luo H, Zhou F, Wang L, Lin S, Xiong J, Lv H, Zhou Z, Yu H, Cao K
Scientific reports 2025 Feb 25;15(1):6780
Scientific reports 2025 Feb 25;15(1):6780
Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype.
Joung J, Heo Y, Kim Y, Kim J, Choi H, Jeon T, Jang Y, Kim EJ, Lee SH, Suh JM, Elledge SJ, Kim MS, Kang C
Nature communications 2025 Feb 17;16(1):1696
Nature communications 2025 Feb 17;16(1):1696
Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification.
Mao Z, Liu W, Zou R, Sun L, Huang S, Wu L, Chen L, Wu J, Lu S, Song Z, Li X, Huang Y, Rao Y, Huang YY, Li B, Hu Z, Li J
Signal transduction and targeted therapy 2025 Feb 17;10(1):67
Signal transduction and targeted therapy 2025 Feb 17;10(1):67
Cxcl9 modulates aging associated microvascular metabolic and angiogenic dysfunctions in subcutaneous adipose tissue.
Fu X, Zhao Y, Cui X, Huang S, Lv Y, Li C, Gong F, Yang Z, Yang X, Xiao R
Angiogenesis 2025 Feb 11;28(2):17
Angiogenesis 2025 Feb 11;28(2):17
Loss of CDKN2A Enhances the Efficacy of Immunotherapy in EGFR-Mutant Non-Small Cell Lung Cancer.
Wang S, Lai JC, Li Y, Tang C, Lu J, Han M, Ye X, Jia L, Cui W, Yang J, Wu C, Wang L
Cancer research 2025 Feb 1;85(3):585-601
Cancer research 2025 Feb 1;85(3):585-601
3D-cultured DFAT spheroid-derived exosomes promote aged wound healing via modulation of the NF-κB/Serpine1 pathway.
Ma X, Wei W, Zeng H, Dong M
Tissue & cell 2025 Dec;97:103049
Tissue & cell 2025 Dec;97:103049
PINK1 overexpression suppresses p38 MAPK/NF‑κB signaling to attenuate chondrocyte senescence in osteoarthritis.
Jie L, Zhang Y, Liu J, Fu H, Zhu Z, Huang Z, Shi X, Wang P, Yin S
International journal of molecular medicine 2025 Dec;56(6)
International journal of molecular medicine 2025 Dec;56(6)
Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice.
Zhu Y, Zhang Y, Zhang Q, Song P, Zhang J, Ma A, Wang C, Gao P, Yang T, Zhou L, Shi Q, Wong YK, Luo Y, Tang H, Wang J
Exploration (Beijing, China) 2025 Dec;5(6):20240069
Exploration (Beijing, China) 2025 Dec;5(6):20240069
Fluorescence lifetime clocks quantify senescence and aging.
Yan C, Liu C, Liu B, Zheng Q, Zhao X, Lu S, Fu X, Li W, Li J, Li D, Yao Y, Zhang Y, Zhu H, Shi P, Zhu WH, Guo Z
Nature aging 2025 Dec;5(12):2532-2545
Nature aging 2025 Dec;5(12):2532-2545
Inhibition of matrix metalloproteinase-9 attenuates kidney fibrosis and cellular senescence in the transition from acute kidney injury to chronic kidney disease.
Shen D, Lin L, Su Y, Xu J, Jiang W, Zhang Z, Fang Y, Ding X, Xu X
Renal failure 2025 Dec;47(1):2499897
Renal failure 2025 Dec;47(1):2499897
KDM4A-induced tumor senescence enhances the efficacy of immunotherapy by inhibiting AGT-PHB1 axis-mediated mitophagy in colorectal cancer.
Cai T, Liang Z, Chen Z, Li Y, Xiao W, Liang W, Xie H, Liu H, Zeng Z, Yang X, Luo S, Zheng X, Zhong K, Huang L, Xiong L, Kang L
Autophagy 2025 Dec;21(12):2982-3003
Autophagy 2025 Dec;21(12):2982-3003
Nanovaccine loaded with seno-antigen target senescent cells to improve metabolic disorders of adipose tissue and cardiac dysfunction.
Zhang K, Yin Q, Ma Y, Cao M, Li L, Jin X, Leng J
Human vaccines & immunotherapeutics 2025 Dec;21(1):2479229
Human vaccines & immunotherapeutics 2025 Dec;21(1):2479229
1,8-Cineole ameliorates vascular endothelial senescence in diabetes mellitus by directly targeting and deubiquitinating PPAR-γ in vivo and in vitro.
Fu L, Tai S, Liao J, Du Y, Zhang G, Guo D, Chen X, Zheng T, Hu X, Yao W, Tao L, Wang X, Xu Y, Shen X
Journal of pharmaceutical analysis 2025 Dec;15(12):101307
Journal of pharmaceutical analysis 2025 Dec;15(12):101307
ZNF865 (BLST) Regulates Back Pain via Cell Senescence and DNA Damage Mechanisms.
Lewis C, Levis H, Holbrook J, Polaski JT, Jacobsen TD, Mizels J, Gullbrand SE, Diekman B, Iatridis JC, Gertz J, Lawrence B, Bowles RD
bioRxiv : the preprint server for biology 2025 Dec 25;
bioRxiv : the preprint server for biology 2025 Dec 25;
Targeting intrinsically disordered nuclear protein 1 (NUPR1) with single-domain antibodies alleviates triple-negative breast cancer (TNBC) progression in vivo.
Wang T, Wang M, Chen X, Yin Y, Xu J, Sun Y, Wu A, Liu Z, Ma Z
Cell death & disease 2025 Dec 22;16(1):913
Cell death & disease 2025 Dec 22;16(1):913
Harnessing Senolytics and PARP Inhibition to Expand the Antitumor Activity of CDK4/6 Inhibitors in Prostate Cancer.
Brandariz J, de Llobet L, Esquefa V, Aguilar D, Salca A, Arce-Gallego S, Cresta Morgado P, Sole A, Agundez L, Mir G, Castro N, Casals T, Oliveira A, Casanova-Salas I, Malumbres M, Carles J, Morellá-Aucejo Á, Bernardos A, Martínez-Máñez R, Mateo J, Herranz N
Molecular cancer therapeutics 2025 Dec 2;24(12):1959-1976
Molecular cancer therapeutics 2025 Dec 2;24(12):1959-1976
The SARS-CoV-2 nucleocapsid protein induces microglia senescence-mediated cognitive impairment via Glycolysis.
Yang NS, Sha HX, Zhang CY, Chen H, Liu YB, Xiong JB, Duan JX, Zhang J, Guan CX, Zhou Y, Su F, Zhong WJ
Molecular medicine (Cambridge, Mass.) 2025 Dec 12;32(1):7
Molecular medicine (Cambridge, Mass.) 2025 Dec 12;32(1):7
WWP2-induced inhibition of hepatocellular carcinoma cellular senescence via the ubiquitination and degradation of p21.
Chen X, Wang J, Yan Z, Du X, Zhang Z, Liu X, Hu L, He K, Zhang J, Han Y
Cell death & disease 2025 Dec 12;17(1):96
Cell death & disease 2025 Dec 12;17(1):96
Biodentine Counteracts the Aging Process of Human Dental Pulp Stem Cells Through Wnt/β-Catenin Pathway.
Zhang Q, Cao S, Zhang M, Wu D, Zhang C, Li J
International dental journal 2025 Aug;75(4):100819
International dental journal 2025 Aug;75(4):100819
Dissolvable microneedle-assisted transdermal administration of diacerein nanoparticles achieved satisfactory therapeutic effects in tendon-bone insertion repair by reducing oxidative stress and inflammation.
Sun J, Chen QZ, Hong AZ, Ju F, Wang HL, Zhang B, Liu W, Sun YC, Tan J, Yang QQ, Zhou YL
Materials today. Bio 2025 Aug;33:101999
Materials today. Bio 2025 Aug;33:101999
Role of UVA-driven cellular senescence via mTOR activation in dihydrotestosterone-induced hair loss in androgenetic alopecia mouse model.
Wei D, Zhang H, Xu W, Zhang B, Zhang L, Lan L, Li Y, Shi Y, Song X
Journal of photochemistry and photobiology. B, Biology 2025 Aug;269:113200
Journal of photochemistry and photobiology. B, Biology 2025 Aug;269:113200
SERPINF1 knockdown attenuates chondrocyte senescence, hypertrophy, and inflammation in osteoarthritis to offer a potential therapeutic strategy.
Dong L, Yang Z, Liu J, Wu R, Liao Y, Kuang L
Cellular signalling 2025 Aug;132:111840
Cellular signalling 2025 Aug;132:111840
Advanced glycation end products induce inflammaging in periodontal ligament fibroblasts through RAGE/AKT/mTOR/glycolysis pathway.
Xiong L, Shu J, Gao H, Qin Y, Zhang Y, Chang X, Dong Q, Chen H
Acta odontologica Scandinavica 2025 Aug 21;84:479-490
Acta odontologica Scandinavica 2025 Aug 21;84:479-490
CD81(+) senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis.
Fu L, Yin C, Zhao Q, Guo S, Shao W, Xia T, Sun Q, Chen L, Li J, Wang M, Xia H
eLife 2025 Aug 13;13
eLife 2025 Aug 13;13
Identifying ENO1 as a protein target of chlorogenic acid to inhibit cellular senescence and prevent skin photoaging in mice.
He X, Wang C, Zhang Q, Yang T, Guo Q, Wang Y, Guo J, Wang P, Zhang J, Tang H, Zhu Y, Wang J
Aging cell 2025 Apr;24(4):e14433
Aging cell 2025 Apr;24(4):e14433
IFI30 Knockdown Inhibits ESCC Progression by Promoting Apoptosis and Senescence via Activation of JNK and P21/P16 Pathways.
Xie W, Wei S, Feng C, Fu Y, Zhang Z, Dai S, Zhang C, Zhao L, Shan B
Thoracic cancer 2025 Apr;16(7):e70063
Thoracic cancer 2025 Apr;16(7):e70063
Blockade of ZMIZ1-GATA4 Axis Regulation Restores Youthfulness to Aged Cartilage.
Nam J, Woo H, Yang J, Kim SJ, Lee KP, Yu JH, Park TJ, Eyun SI, Yang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2404311
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2404311
LncRNA NEAT1-206 regulates autophagy of human umbilical cord mesenchymal stem cells through the WNT5A/Ca(2+) signaling pathway under senescence stress.
Wang W, Wang Y, Duan C, Tian W, Gao L
Non-coding RNA research 2025 Apr;11:234-248
Non-coding RNA research 2025 Apr;11:234-248
Development and Validation of a Prognostic Model for Lung Adenocarcinoma Based on CAF-Related Genes: Unveiling the Role of COX6A1 in Cancer Progression and CAF Infiltration.
Zhu X, Li B, Qin L, Liang T, Hu W, Li J, Wang J
International journal of molecular sciences 2025 Apr 8;26(8)
International journal of molecular sciences 2025 Apr 8;26(8)
TRAF7 knockdown induces cellular senescence and synergizes with lomustine to inhibit glioma progression and recurrence.
Chen Y, Zhou T, Zhou R, Sun W, Li Y, Zhou Q, Xu D, Zhao Y, Hu P, Liang J, Zhang Y, Zhong B, Yao J, Jing D
Journal of experimental & clinical cancer research : CR 2025 Apr 4;44(1):112
Journal of experimental & clinical cancer research : CR 2025 Apr 4;44(1):112
Synonymous mutations promote tumorigenesis by disrupting m(6)A-dependent mRNA metabolism.
Lan Y, Xia Z, Shao Q, Lin P, Lu J, Xiao X, Zheng M, Chen D, Dou Y, Xie Q
Cell 2025 Apr 3;188(7):1828-1841.e15
Cell 2025 Apr 3;188(7):1828-1841.e15
The IL-6 autocrine loop promoting IFN-γ-induced fibroblast senescence is involved in psychological stress-mediated exacerbation of vitiligo.
Cao C, Xu W, Lei J, Zheng Y, Zhang A, Xu A, Lin F, Zhou M
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Apr 29;74(1):72
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Apr 29;74(1):72
Granulosa cell RNA-Seq insights into senescence and sphingolipid metabolism disorder in PCOS: aspirin as a potential therapeutic drug.
Shi W, Lin H, Di W, He C, Shen Y
Reproductive biology and endocrinology : RB&E 2025 Apr 26;23(1):61
Reproductive biology and endocrinology : RB&E 2025 Apr 26;23(1):61
Hepatic-specific vitamin D receptor downregulation alleviates aging-related metabolic dysfunction-associated steatotic liver disease.
Zhu F, Lin BR, Lin SH, Yu CH, Yang YM
World journal of gastroenterology 2025 Apr 14;31(14):104117
World journal of gastroenterology 2025 Apr 14;31(14):104117
Comprehensive analysis of prognosis and tumor immune microenvironment of cuproptosis-related gene CDKN2A in lung adenocarcinoma.
Song T, Li S, Zhao K, Zou D, Zhang M, Wang H
BMC pulmonary medicine 2025 Apr 14;25(1):179
BMC pulmonary medicine 2025 Apr 14;25(1):179
The dual HDAC/PI3K inhibitor CUDC-907 inhibits the growth and proliferation of MYC-driven Group 3 medulloblastoma.
Gou P, Fang C, Xu M, Zhang D, Wu X, Zhang L, Li X, Li M, Gan L, Luo J, Cui H, Liang P
Cell death discovery 2025 Apr 14;11(1):172
Cell death discovery 2025 Apr 14;11(1):172
Ginsenoside Rg2 Attenuates Aging-Induced Liver Injury via Inhibiting Caspase 8-Mediated Pyroptosis, Apoptosis and Modulating Gut Microbiota.
Gao XF, Ji BY, Zhang JJ, Wang Z, Jiang S, Hu JN, Gong XJ, Zhang JT, Tsopmejio ISN, Li W
The American journal of Chinese medicine 2024;52(5):1427-1449
The American journal of Chinese medicine 2024;52(5):1427-1449
Metochalcone induces senescence-associated secretory phenotype via JAK2/STAT3 pathway in breast cancer.
Zhou J, Wan F, Xiao B, Li X, Peng C, Peng FU
Oncology research 2024;32(5):943-953
Oncology research 2024;32(5):943-953
Young TSPC-Derived Exosomal circPVT1 Ameliorates Aging-Impaired Cell Function via SIRT1/NF-κB.
Han W, Gu D, Li X, Chen H, Tao X, Chen L
Tissue engineering. Part C, Methods 2024;30(6):248-254
Tissue engineering. Part C, Methods 2024;30(6):248-254
Cadmium-induced annulus fibrosus cell senescence contributes to intervertebral disc degeneration via the JNK/p53 signaling pathway.
Liu X, Zhao W, Hu M, Zhang Y, Wang J, Zhang L
Iranian journal of basic medical sciences 2024;27(5):588-595
Iranian journal of basic medical sciences 2024;27(5):588-595
FBLN5 was Regulated by PRDM9, and Promoted Senescence and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.
Zhao M, Rong R, Zhang C, Yang H, Han X, Fan Z, Zheng Y, Zhang J
Current stem cell research & therapy 2024;19(3):417-425
Current stem cell research & therapy 2024;19(3):417-425
FTO Stabilizes MIS12 to Inhibit Vascular Smooth Muscle Cell Senescence in Atherosclerotic Plaque.
Sun J, Wang M, Jia F, Song J, Ren J, Hu B
Journal of inflammation research 2024;17:1857-1871
Journal of inflammation research 2024;17:1857-1871
Dissecting the functions and regulatory mechanisms of disulfidoptosis-related RPN1 in pan-cancer: modulation of immune microenvironment and cellular senescence.
Qin L, Liang T, Zhang H, Gong X, Wei M, Song X, Hu Y, Zhu X, Hu W, Li J, Wang J
Frontiers in immunology 2024;15:1512445
Frontiers in immunology 2024;15:1512445
β-cryptoxanthin suppresses oxidative stress via activation of the Nrf2/HO-1 signaling pathway in diabetic kidney disease.
Ke J, Zang H, Liu Y, Teng Q, Hua J, Peng D, Wang P
Frontiers in pharmacology 2024;15:1480629
Frontiers in pharmacology 2024;15:1480629
Taraxasterol exhibits dual biological effects on anti-aging and anti-cancer in lung cells.
Xie J, Ou Y, Fu Q, Ye Z, Chen Y, Yang Z, Lin L, Wu Q, Wu D, Gan R, Wang J, Luo Q, Zeng K, Miao H
American journal of cancer research 2024;14(6):2755-2769
American journal of cancer research 2024;14(6):2755-2769
EMF treatment delays mesenchymal stem cells senescence during long-term in vitro expansion by modulating autophagy.
Cai W, Xiao Y, Yan J, Peng H, Tu C
Frontiers in cell and developmental biology 2024;12:1489774
Frontiers in cell and developmental biology 2024;12:1489774
Urolithin A alleviates cell senescence by inhibiting ferroptosis and enhances corneal epithelial wound healing.
Guo XX, Chang XJ, Pu Q, Li AL, Li J, Li XY
Frontiers in medicine 2024;11:1441196
Frontiers in medicine 2024;11:1441196
Monoacylglycerol lipase blockades the senescence-associated secretory phenotype by interfering with NF-κB activation and promotes docetaxel efficacy in prostate cancer.
Yu J, Zhang M, Li T, Gao W, Yang Z, Wang K, Liu Z, Zhu S, Wen S, Zhao Y, Cai Q, Shang Z, Wang Y, Niu Y
Oncogene 2024 Sep;43(38):2835-2849
Oncogene 2024 Sep;43(38):2835-2849
Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice.
Zumerle S, Sarill M, Saponaro M, Colucci M, Contu L, Lazzarini E, Sartori R, Pezzini C, Rinaldi A, Scanu A, Sgrignani J, Locatelli P, Sabbadin M, Valdata A, Brina D, Giacomini I, Rizzo B, Pierantoni A, Sharifi S, Bressan S, Altomare C, Goshovska Y, Giraudo C, Luisetto R, Iaccarino L, Torcasio C, Mosole S, Pasquini E, Rinaldi A, Pellegrini L, Peron G, Fassan M, Masiero S, Giori AM, Dall'Acqua S, Auwerx J, Cippà P, Cavalli A, Bolis M, Sandri M, Barile L, Montopoli M, Alimonti A
Nature aging 2024 Sep;4(9):1231-1248
Nature aging 2024 Sep;4(9):1231-1248
STING1-accelerated vascular smooth muscle cell senescence-associated vascular calcification in diabetes is ameliorated by oleoylethanolamide via improved mitochondrial DNA oxidative damage.
Chen Z, Li X, Sun X, Xiao S, Chen T, Ren L, Liu N
Free radical biology & medicine 2024 Sep;222:437-455
Free radical biology & medicine 2024 Sep;222:437-455
TG2 participates in pulmonary vascular remodelling by regulating the senescence of pulmonary artery smooth muscle cells.
Zhang M, Li L, Zhang W, Li M, Yan G, Tang C
Cellular signalling 2024 Sep;121:111296
Cellular signalling 2024 Sep;121:111296
Integrative analysis of the transcriptome and metabolome reveals the importance of hepatokine FGF21 in liver aging.
Wang W, Qian J, Shang M, Qiao Y, Huang J, Gao X, Ye Z, Tong X, Xu K, Li X, Liu Z, Zhou L, Zheng S
Genes & diseases 2024 Sep;11(5):101161
Genes & diseases 2024 Sep;11(5):101161
10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically.
Geng N, Fan M, Kuang B, Zhang F, Xian M, Deng L, Chen C, Pan Y, Chen J, Feng N, Liang L, Ye Y, Liu K, Li X, Du Y, Guo F
Nature communications 2024 Sep 4;15(1):7712
Nature communications 2024 Sep 4;15(1):7712
Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice.
Tan Y, Huang Z, Jin Y, Wang J, Fan H, Liu Y, Zhang L, Wu Y, Liu P, Li T, Ran J, Tian H, Lam SM, Liu M, Zhou J, Yang Y
Nature communications 2024 Sep 27;15(1):8273
Nature communications 2024 Sep 27;15(1):8273
The up-regulation of SYNCRIP promotes the proliferation and tumorigenesis via DNMT3A/p16 in colorectal cancer.
Li C, Lu T, Chen H, Yu Z, Chen C
Scientific reports 2024 Sep 16;14(1):21570
Scientific reports 2024 Sep 16;14(1):21570
Downregulation of stromal interaction molecule-1 is implicated in the age-associated vasoconstriction dysfunction of aorta, intrarenal, and coronary arteries.
Wang H, Zeng P, Zhu PH, Wang ZF, Cai YJ, Deng CY, Yang H, Mai LP, Zhang MZ, Kuang SJ, Rao F, Xu JS
European journal of pharmacology 2024 Sep 15;979:176832
European journal of pharmacology 2024 Sep 15;979:176832
Transiently formed nucleus-to-cilium microtubule arrays mediate senescence initiation in a KIFC3-dependent manner.
Robichaud JH, Zhang Y, Chen C, He K, Huang Y, Zhang X, Sun X, Ma X, Hardiman G, Morrison CG, Dong Z, LeBrasseur NK, Ling K, Hu J
Nature communications 2024 Sep 12;15(1):7977
Nature communications 2024 Sep 12;15(1):7977
Tryptanthrin targets GSTP1 to induce senescence and increases the susceptibility to apoptosis by senolytics in liver cancer cells.
Zhang Y, Xiao B, Yuan S, Ding L, Pan Y, Jiang Y, Sun S, Ke X, Cai L, Jia L
Redox biology 2024 Oct;76:103323
Redox biology 2024 Oct;76:103323
Bazi Bushen attenuates osteoporosis in SAMP6 mice by regulating PI3K-AKT and apoptosis pathways.
Xu Z, Zhang Z, Zhou H, Lin S, Gong B, Li Z, Zhao S, Hou Y, Peng Y, Bian Y
Journal of cellular and molecular medicine 2024 Oct;28(20):e70161
Journal of cellular and molecular medicine 2024 Oct;28(20):e70161
LTF ameliorates cartilage endplate degeneration by suppressing calcification, senescence and matrix degradation through the JAK2/STAT3 pathway.
Li T, Liu Y, Cao J, Pan C, Ding R, Zhao J, Liu J, He D, Jia J, Cheng X
Journal of cellular and molecular medicine 2024 Oct;28(19):e18267
Journal of cellular and molecular medicine 2024 Oct;28(19):e18267
Plasma-derived exosome miR-10a-5p promotes premature ovarian failure by target BDNF via the TrkB/Akt/mTOR signaling pathway.
Bao Z, Li J, Cai J, Yao S, Yang N, Yang J, Zhao B, Chen Y, Wu X
International journal of biological macromolecules 2024 Oct;277(Pt 1):134195
International journal of biological macromolecules 2024 Oct;277(Pt 1):134195
Exosomes Derived from Rejuvenated Stem Cells Inactivate NLRP3 Inflammasome and Pyroptosis of Nucleus Pulposus Cells via the Transfer of Antioxidants.
Peng S, Liu X, Chang L, Liu B, Zhang M, Mao Y, Shen X
Tissue engineering and regenerative medicine 2024 Oct;21(7):1061-1077
Tissue engineering and regenerative medicine 2024 Oct;21(7):1061-1077
Loss of p14 diminishes immunogenicity in melanoma via non-canonical Wnt signaling by reducing the peptide surface density.
Wohlfarth J, Kosnopfel C, Faber D, Berthold M, Siedel C, Bernhardt M, Schlosser A, Aprati T, Liu D, Schrama D, Houben R, Schadendorf D, Goebeler M, Meierjohann S, Schilling B
Molecular oncology 2024 Oct;18(10):2449-2470
Molecular oncology 2024 Oct;18(10):2449-2470
Seno-antigen-pulsed dendritic cell vaccine induce anti-aging immunity to improve adipose tissue senescence and metabolic abnormalities.
Cao Y, Du X, Yu J, Wang Y, Jin X, Gu B, Yin Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117433
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117433
Human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles mitigate photoaging via TIMP1/Notch1.
Zhang H, Xiao X, Wang L, Shi X, Fu N, Wang S, Zhao RC
Signal transduction and targeted therapy 2024 Oct 30;9(1):294
Signal transduction and targeted therapy 2024 Oct 30;9(1):294
Formononetin Mitigates Liver Fibrosis via Promoting Hepatic Stellate Cell Senescence and Inhibiting EZH2/YAP Axis.
Yuan Z, Meng J, Shen X, Wang M, Yu Y, Shi L, Li YL, Hassan HM, Li H, He ZX, Qin T
Journal of agricultural and food chemistry 2024 Oct 3;
Journal of agricultural and food chemistry 2024 Oct 3;
Enhanced SIRT1 Activity by Galangin Mitigates UVB-Induced Senescence in Dermal Fibroblasts via p53 Acetylation Regulation and Activation.
Wen SY, Ng SC, Chiu YT, Tai PY, Chen TJ, Chen CJ, Huang CY, Kuo WW
Journal of agricultural and food chemistry 2024 Oct 23;72(42):23286-23294
Journal of agricultural and food chemistry 2024 Oct 23;72(42):23286-23294
HIV Protein Nef Induces Cardiomyopathy Through Induction of Bcl2 and p21.
Kondrachuk O, Ciccone P, Ford N, Hong K, Kimura Y, Zi J, Yusuf S, Alkousa A, Tailor N, Rajkumar R, Rappaport J, Gupta MK
International journal of molecular sciences 2024 Oct 23;25(21)
International journal of molecular sciences 2024 Oct 23;25(21)
A TBK1-independent primordial function of STING in lysosomal biogenesis.
Lv B, Dion WA, Yang H, Xun J, Kim DH, Zhu B, Tan JX
Molecular cell 2024 Oct 17;84(20):3979-3996.e9
Molecular cell 2024 Oct 17;84(20):3979-3996.e9
Nur77 ameliorates cyclophosphamide-induced ovarian insufficiency in mice by inhibiting oxidative damage and cell senescence.
Yao Y, Wang B, Yu K, Song J, Wang L, Yang X, Zhang X, Li Y, Ma X
Journal of ovarian research 2024 Oct 15;17(1):203
Journal of ovarian research 2024 Oct 15;17(1):203
Blockade of the lncRNA-PART1-PHB2 axis confers resistance to PARP inhibitor and promotes cellular senescence in ovarian cancer.
Wu H, Sun C, Cao W, Teng Q, Ma X, Schiöth HB, Dong R, Zhang Q, Kong B
Cancer letters 2024 Oct 10;602:217192
Cancer letters 2024 Oct 10;602:217192
Partial reduction of interleukin-33 signaling improves senescence and renal injury in diabetic nephropathy.
Chen L, Gao C, Yin X, Mo L, Cheng X, Chen H, Jiang C, Wu B, Zhao Y, Li H, Li Y, Li J, Chen L, Deng Q, Yao P, Tang Y
MedComm 2024 Nov;5(11):e742
MedComm 2024 Nov;5(11):e742
MDM2 accelerated renal senescence via ubiquitination and degradation of HDAC1.
Xiang HL, Yuan Q, Zeng JY, Xu ZY, Zhang HZ, Huang J, Song AN, Xiong J, Zhang C
Acta pharmacologica Sinica 2024 Nov;45(11):2328-2338
Acta pharmacologica Sinica 2024 Nov;45(11):2328-2338
Repurposing cyclovirobuxine D as a novel inhibitor of colorectal cancer progression via modulating the CCT3/YAP axis.
Liu Y, Chen L, Wang J, Bao X, Huang J, Qiu Y, Wang T, Yu H
British journal of pharmacology 2024 Nov;181(21):4348-4368
British journal of pharmacology 2024 Nov;181(21):4348-4368
PINK1/Parkin-Mediated Mitophagy Ameliorates Mitochondrial Dysfunction in Lacrimal Gland Acinar Cells During Aging.
Zhao H, Zhang Y, Ren Y, Wang W
Investigative ophthalmology & visual science 2024 Nov 4;65(13):12
Investigative ophthalmology & visual science 2024 Nov 4;65(13):12
Inhibition of the E3 ligase UBR5 stabilizes TERT and protects vascular organoids from oxidative stress.
Zhao H, Cao N, Liu Q, Zhang Y, Jin R, Lai H, Zheng L, Zhang H, Zhu Y, Ma Y, Yang Z, Wu Z, Li W, Liu Y, Cheng L, Chen Y
Journal of translational medicine 2024 Nov 28;22(1):1080
Journal of translational medicine 2024 Nov 28;22(1):1080
The Role of the Cytoskeletal Regulatory Protein, Mammalian Enabling Protein (Mena), in Invasion and Metastasis of HPV16-Related Oral Squamous Cell Carcinoma.
Guo Z, Xie L, Cui H, Yang X, Qi H, Yu M, Gong Y, Tu J, Na S
Cells 2024 Nov 28;13(23)
Cells 2024 Nov 28;13(23)
Expanding the landscape of oncogenic drivers and treatment options in acral and mucosal melanomas by targeted genomic profiling.
Turner JA, Van Gulick RJ, Robinson WA, Mughal T, Tobin RP, MacBeth ML, Holman B, Classon A, Bagby SM, Yacob BW, Hartman SJ, Silverman I, Vorwald VM, Gorden N, Gonzalez R, Gay LM, Ali SM, Benson A, Miller VA, Ross JS, Pitts TM, Rioth MJ, Lewis KD, Medina T, McCarter MD, Gonzalez R, Couts KL
International journal of cancer 2024 Nov 15;155(10):1792-1807
International journal of cancer 2024 Nov 15;155(10):1792-1807
Phillyrin: A potential therapeutic agent for osteoarthritis via modulation of NF-κB and Nrf2 signaling pathways.
Ma J, Wang Z, Sun Y, Zheng R, Tan H, Zhang H, Jin Z, Wu Y, Sun Z
International immunopharmacology 2024 Nov 15;141:112960
International immunopharmacology 2024 Nov 15;141:112960
2,7-Phloroglucinol-6,6'-bieckol from Ecklonia cava ameliorates nanoplastics-induced premature endothelial senescence and dysfunction.
Sim HH, Shiwakoti S, Lee JH, Lee IY, Ok Y, Lim HK, Ko JY, Oak MH
The Science of the total environment 2024 Nov 1;949:175007
The Science of the total environment 2024 Nov 1;949:175007
Melatonin attenuates dental pulp stem cells senescence due to vitro expansion via inhibiting MMP3.
Zhang Z, Bao Y, Wei P, Yan X, Qiu Q, Qiu L
Oral diseases 2024 May;30(4):2410-2424
Oral diseases 2024 May;30(4):2410-2424
Prognostic value of CDKN2A in head and neck squamous cell carcinoma via pathomics and machine learning.
Wang Y, Zhou C, Li T, Luo J
Journal of cellular and molecular medicine 2024 May;28(9):e18394
Journal of cellular and molecular medicine 2024 May;28(9):e18394
Glucose-modified BSA/procyanidin C1 NPs penetrate the blood-brain barrier and alleviate neuroinflammation in Alzheimer's disease models.
Duan L, Hao Z, Ji R, Li X, Wang H, Su Y, Guan F, Ma S
International journal of biological macromolecules 2024 May;268(Pt 1):131739
International journal of biological macromolecules 2024 May;268(Pt 1):131739
N6-Methyladenosine Modification of lncCCKAR-5 Regulates Autophagy in Human Umbilical Cord Mesenchymal Stem Cells by Destabilizing LMNA and Inhibits Diabetic Wound Healing.
Wang J, Wang X, Chen F, Ning Q, Liu Y, Zhu Y, Wei W, Leng M, Wang Z, Jin P, Li Q
The Journal of investigative dermatology 2024 May;144(5):1148-1160.e15
The Journal of investigative dermatology 2024 May;144(5):1148-1160.e15
Uptake of ox-LDL by binding to LRP6 mediates oxidative stress-induced BMSCs senescence promoting obesity-related bone loss.
Meng S, Wang Z, Liu X, Shen K, Gu Y, Yu B, Wang L
Cellular signalling 2024 May;117:111114
Cellular signalling 2024 May;117:111114
Macrophage-derived ectosomal miR-350-3p promotes osteoarthritis progression through downregulating chondrocyte H3K36 methyltransferase NSD1.
Lin R, Yin J, Huang J, Zou L, Liu L, Tang W, Zhang H, Yang L, Zhang Y, Li G, Wang G, Cai D, Zhang H, Liu Y, Shao Y
Cell death discovery 2024 May 8;10(1):223
Cell death discovery 2024 May 8;10(1):223
Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl(3) model.
Jin X, Yue X, Huang Z, Meng X, Xu S, Wu Y, Wan Y, Inoue A, Narisawa M, Hu L, Shi GP, Umegaki H, Murohara T, Lei Y, Kuzuya M, Cheng XW
Cellular and molecular life sciences : CMLS 2024 May 4;81(1):205
Cellular and molecular life sciences : CMLS 2024 May 4;81(1):205
SVHRSP Alleviates Age-Related Cognitive Deficiency by Reducing Oxidative Stress and Neuroinflammation.
Wang Y, Wang Z, Guo S, Li Q, Kong Y, Sui A, Ma J, Lu L, Zhao J, Li S
Antioxidants (Basel, Switzerland) 2024 May 21;13(6)
Antioxidants (Basel, Switzerland) 2024 May 21;13(6)
Inactivation of Myostatin Delays Senescence via TREX1-SASP in Bovine Skeletal Muscle Cells.
Yang M, Gao L, Gao Y, Hao Z, Zhou X, Su G, Bai C, Wei Z, Liu X, Yang L, Li G
International journal of molecular sciences 2024 May 12;25(10)
International journal of molecular sciences 2024 May 12;25(10)
Chemotherapy-induced PTEN-L secretion promotes the selection of PTEN-deficient tumor cells.
Wang M, Pan Z, Chu X, Yao X, Duan X, Wan J, Lou X, Li W, Yan Y, Chen L, An J, Qin Z
Journal of experimental & clinical cancer research : CR 2024 May 11;43(1):140
Journal of experimental & clinical cancer research : CR 2024 May 11;43(1):140
Mechanisms of PM(10) Disruption of the Nrf2 Pathway in Cornea.
Somayajulu M, Muhammed FS, Wright R, McClellan SA, Hazlett LD
International journal of molecular sciences 2024 Mar 28;25(7)
International journal of molecular sciences 2024 Mar 28;25(7)
Hypermethylation of Bmp2 and Fgfr2 Promoter Regions in Bone Marrow Mesenchymal Stem Cells Leads to Bone Loss in Prematurely Aged Mice.
Wang Y, Sun L, Kan T, Xue W, Wang H, Xu P, Zhang L, Yan M, Li H, Yu Z
Aging and disease 2024 Mar 24;16(2):1149-1168
Aging and disease 2024 Mar 24;16(2):1149-1168
Single-cell RNA sequencing reveals epithelial cells driving brain metastasis in lung adenocarcinoma.
Wu Y, Yang F, Luo S, Li X, Gu Z, Fan R, Cao Y, Wang L, Song X
iScience 2024 Mar 15;27(3):109258
iScience 2024 Mar 15;27(3):109258
Promoting collateral formation in type 2 diabetes mellitus using ultra-small nanodots with autophagy activation and ROS scavenging.
Wang Y, Li F, Mao L, Liu Y, Chen S, Liu J, Huang K, Chen Q, Wu J, Lu L, Zheng Y, Shen W, Ying T, Dai Y, Shen Y
Journal of nanobiotechnology 2024 Mar 1;22(1):85
Journal of nanobiotechnology 2024 Mar 1;22(1):85
Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells.
Qiu YD, Yan Q, Wang Y, Ye YF, Wang Y, Wang MY, Wang PP, Zhang SY, Wang DL, Yan H, Ruan J, Zhao YJ, Huang LH, Cho N, Wang K, Zheng XH, Liu ZG
Acta pharmacologica Sinica 2024 Jun;45(6):1276-1286
Acta pharmacologica Sinica 2024 Jun;45(6):1276-1286
Modulating synovial macrophage pyroptosis and mitophagy interactions to mitigate osteoarthritis progression using functionalized nanoparticles.
Qi W, Jin L, Huang S, Aikebaier A, Xue S, Wang Q, Chen Q, Lu Y, Ding C
Acta biomaterialia 2024 Jun;181:425-439
Acta biomaterialia 2024 Jun;181:425-439
MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer.
Zhang H, Li Q, Guo X, Wu H, Hu C, Liu G, Yu T, Hu X, Qiu Q, Guo G, She J, Chen Y
Journal of pharmaceutical analysis 2024 Jun;14(6):100950
Journal of pharmaceutical analysis 2024 Jun;14(6):100950
FGF receptors mediate cellular senescence in the cystic fibrosis airway epithelium.
Easter M, Hirsch MJ, Harris E, Howze PH 4th, Matthews EL, Jones LI, Bollenbecker S, Vang S, Tyrrell DJ, Sanders YY, Birket SE, Barnes JW, Krick S
JCI insight 2024 Jun 25;9(15)
JCI insight 2024 Jun 25;9(15)
Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis.
Geng N, Xian M, Deng L, Kuang B, Pan Y, Liu K, Ye Y, Fan M, Bai Z, Guo F
Journal of orthopaedic translation 2024 Jul;47:50-62
Journal of orthopaedic translation 2024 Jul;47:50-62
Dasabuvir alleviates 5-fluorouracil-induced intestinal injury through anti-senescence and anti-inflammatory.
He S, Wang Z, Xia J, Jia H, Dai Q, Chen C, He F, Wang X, Zhou M
Scientific reports 2024 Jul 8;14(1):15730
Scientific reports 2024 Jul 8;14(1):15730
CBLL1 promotes endometrial stromal cell senescence via inhibiting PTEN in recurrent spontaneous abortion.
Liu X, Wei X, Wu J, Xu Y, Hu J, Qin C, Chen C, Lin Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 31;38(14):e23833
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 31;38(14):e23833
Static magnetic field-modulated mesenchymal stem cell-derived mitochondria-containing microvesicles for enhanced intervertebral disc degeneration therapy.
Shi P, Gao H, Cheng Z, Zhao K, Chen Y, Chen X, Gan W, Zhang A, Yang C, Zhang Y
Journal of nanobiotechnology 2024 Jul 31;22(1):457
Journal of nanobiotechnology 2024 Jul 31;22(1):457
Molecular characterization and clinical relevance of metabolic signature subtypes in gastric cancer.
Chen H, Jing C, Shang L, Zhu X, Zhang R, Liu Y, Wang M, Xu K, Ma T, Jing H, Wang Z, Li X, Chong W, Li L
Cell reports 2024 Jul 23;43(7):114424
Cell reports 2024 Jul 23;43(7):114424
Empagliflozin protects against heart failure with preserved ejection fraction partly by inhibiting the senescence-associated STAT1-STING axis.
Shi Y, Zhao L, Wang J, Liu X, Bai Y, Cong H, Li X
Cardiovascular diabetology 2024 Jul 23;23(1):269
Cardiovascular diabetology 2024 Jul 23;23(1):269
Nur77 improves ovarian function in reproductive aging mice by activating mitophagy and inhibiting apoptosis.
Yao Y, Wang B, Yu K, Song J, Wang L, Zhang X, Li Y
Reproductive biology and endocrinology : RB&E 2024 Jul 23;22(1):86
Reproductive biology and endocrinology : RB&E 2024 Jul 23;22(1):86
An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo.
Lujan C, Tyler EJ, Ecker S, Webster AP, Stead ER, Martinez-Miguel VE, Milligan D, Garbe JC, Stampfer MR, Beck S, Lowe R, Bishop CL, Bjedov I
Genome medicine 2024 Jul 2;16(1):85
Genome medicine 2024 Jul 2;16(1):85
Procyanidin C1 inhibits bleomycin-induced pulmonary fibrosis in mice by selective clearance of senescent myofibroblasts.
Shao M, Qiu Y, Shen M, Liu W, Feng D, Luo Z, Zhou Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23749
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23749
Cellular and molecular mechanisms of highly active mesenchymal stem cells in the treatment of senescence of rhesus monkey ovary.
Wang K, Yao X, Lin SQ, Zhu XQ, Pan XH, Ruan GP
Stem cell research & therapy 2024 Jan 8;15(1):14
Stem cell research & therapy 2024 Jan 8;15(1):14
Jianpi Huayu Decoction suppresses cellular senescence in colorectal cancer via p53-p21-Rb pathway: Network pharmacology and in vivo validation.
Wang S, Xing Y, Wang R, Jin Z
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117347
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117347
Vitamin D-mediated tsRNA-07804 triggers mitochondrial dysfunction and suppresses non-small cell lung cancer progression by targeting CRKL.
Liang Y, Zhang X, Peng J, Liu J, Chen H, Guo S
Journal of cancer research and clinical oncology 2024 Jan 30;150(2):51
Journal of cancer research and clinical oncology 2024 Jan 30;150(2):51
Flavonoid 4,4'-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy.
Wang T, Yang C, Li Z, Li T, Zhang R, Zhao Y, Cheng T, Zong Z, Ma Y, Zhang D, Deng H
Redox biology 2024 Feb;69:103017
Redox biology 2024 Feb;69:103017
Anoikis-related gene CDKN2A predicts prognosis and immune response and mediates proliferation and migration in thyroid carcinoma.
Tang M, Luo W, Zhou Y, Zhang Z, Jiang Z
Translational oncology 2024 Feb;40:101873
Translational oncology 2024 Feb;40:101873
Attenuation of pro-tumorigenic senescent secretory phenotype by StN, a novel derivative of stevioside, potentiates its inhibitory activity on hepatocellular carcinoma.
Guo Y, Wang S, Dong Y, Liu Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114371
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114371
Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells.
Dai W, Liu Z, Yan M, Nian X, Hong F, Zhou Z, Wang C, Fu X, Li X, Jiang M, Zhu Y, Huang Q, Lu X, Hou L, Yan N, Wang Q, Hu J, Mo W, Zhang X, Zhang L
Developmental cell 2024 Feb 26;59(4):482-495.e6
Developmental cell 2024 Feb 26;59(4):482-495.e6
TRAF2 inhibits senescence in hepatocellular carcinoma cells via regulating the ROMO1/ NAD(+)/SIRT3/SOD2 axis.
Yao J, Liang X, Xu S, Liu Y, Shui L, Li S, Guo H, Xiao Z, Zhao Y, Zheng M
Free radical biology & medicine 2024 Feb 1;211:47-62
Free radical biology & medicine 2024 Feb 1;211:47-62
Effects of MMP2 and its inhibitor TIMP2 on DNA damage, apoptosis and senescence of human lens epithelial cells induced by oxidative stress.
Deng X, Zhang Y, He X, Li L, Yue Z, Liang Y, Huang Y
Journal of bioenergetics and biomembranes 2024 Dec;56(6):619-630
Journal of bioenergetics and biomembranes 2024 Dec;56(6):619-630
ROS-Induced Gingival Fibroblast Senescence: Implications in Exacerbating Inflammatory Responses in Periodontal Disease.
Guo S, Fu L, Yin C, Shao W, Sun Q, Chen L, Xia T, Wang M, Xia H
Inflammation 2024 Dec;47(6):1918-1935
Inflammation 2024 Dec;47(6):1918-1935
Macrophage polarization and macrophage-related factor expression in hypertrophy of the ligamentum flavum.
Jiang C, Wang W, Chen YL, Chen JH, Zhang ZW, Li J, Yang ZC, Li XC
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2024 Dec;33(12):4476-4487
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2024 Dec;33(12):4476-4487
Rheb1 deficiency elicits mitochondrial dysfunction and accelerates podocyte senescence through promoting Atp5f1c acetylation.
Lu Q, Hu X, Hou Q, Yu L, Cao K, Ding D, Lu Y, Dai C
Cellular signalling 2024 Dec;124:111451
Cellular signalling 2024 Dec;124:111451
Lycopodium japonicum Thunb. inhibits chondrocyte apoptosis, senescence and inflammation in osteoarthritis through STING/NF-κB signaling pathway.
Ma J, Zhang H, Wang Z, Xu C, Tan H, Sun Y, Zheng R, Jin Z, Li Y, Ge X, Wu Y, Zhou Y
Journal of ethnopharmacology 2024 Dec 5;335:118660
Journal of ethnopharmacology 2024 Dec 5;335:118660
miR-548az-5p induces amniotic epithelial cell senescence by regulating KATNAL1 expression in labor.
Jing D, Liu Q, Zhang H, Li Y, Jiang X, Cai Y, Wang X, Li L
Scientific reports 2024 Dec 5;14(1):30380
Scientific reports 2024 Dec 5;14(1):30380
Identifying novel aging-related diagnostic and prognostic models and aging-targeted drugs for sepsis patients.
Yang K, Lu Y, Gu J, Nie Y, Zhang T
Scientific reports 2024 Dec 28;14(1):31445
Scientific reports 2024 Dec 28;14(1):31445
SIRT7 inhibits the aging and inflammatory damage of hPDLFs by suppressing the AKT/mTOR.
Sun J, Li Y, Meng M, Zeng X, Wang Q, Li W, Luo Y, Chen H, Dong Q
International immunopharmacology 2024 Dec 25;143(Pt 1):113300
International immunopharmacology 2024 Dec 25;143(Pt 1):113300
RNA-binding protein HNRNPD promotes chondrocyte senescence and osteoarthritis progression through upregulating FOXM1.
Jiang H, Zhang Y, Hu G, Ji P, Ming J, Li Y, Zhou Y
Communications biology 2024 Dec 24;7(1):1695
Communications biology 2024 Dec 24;7(1):1695
Taurine rescues intervertebral disc degeneration by activating mitophagy through the PINK1/Parkin pathway.
Lin S, Li T, Zhang B, Wang P
Biochemical and biophysical research communications 2024 Dec 20;739:150587
Biochemical and biophysical research communications 2024 Dec 20;739:150587
Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors.
Merk DJ, Tsiami F, Hirsch S, Walter B, Haeusser LA, Maile JD, Stahl A, Jarboui MA, Lechado-Terradas A, Klose F, Babaei S, Admard J, Casadei N, Roggia C, Spohn M, Schittenhelm J, Singer S, Schüller U, Piccioni F, Persky NS, Claassen M, Tatagiba M, Kahle PJ, Root DE, Templin M, Tabatabai G
Genome biology 2024 Dec 2;25(1):301
Genome biology 2024 Dec 2;25(1):301
Response to Letter to the Editor, "Senolytic Treatment Improve Small Intestine Regeneration in Aging".
Tan D, Xu C, Zhu Q, Fan G, Luo QT
Aging and disease 2024 Dec 1;16(5):2489-2492
Aging and disease 2024 Dec 1;16(5):2489-2492
SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure.
Li H, Wan L, Liu M, Ma E, Huang L, Yang Y, Li Q, Fang Y, Li J, Han B, Zhang C, Sun L, Hou X, Li H, Sun M, Qian S, Duan X, Zhao R, Yang X, Chen Y, Wu S, Zhang X, Zhang Y, Cheng G, Chen G, Gao Q, Xu J, Hou L, Wei C, Zhong H
PLoS pathogens 2024 Aug;20(8):e1012291
PLoS pathogens 2024 Aug;20(8):e1012291
Investigating the Effects of Chelidonic Acid on Oxidative Stress-Induced Premature Cellular Senescence in Human Skin Fibroblast Cells.
Turkoglu B, Mansuroglu B
Life (Basel, Switzerland) 2024 Aug 27;14(9)
Life (Basel, Switzerland) 2024 Aug 27;14(9)
Injectable Hydrogel-Encapsulating Pickering Emulsion for Overcoming Lenvatinib-Resistant Hepatocellular Carcinoma via Cuproptosis Induction and Stemness Inhibition.
Li X, Tang C, Ye H, Fang C
Polymers 2024 Aug 26;16(17)
Polymers 2024 Aug 26;16(17)
METTL3 Promotes Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration by Regulating TLR2 m6A Methylation and Gut Microbiota.
Ni S, Huang X, Li X, Shi C, Fan M, Zhao L, Rong Z, Zhang H
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Aug 1;79(8)
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Aug 1;79(8)
Excess iron accumulation mediated senescence in diabetic kidney injury.
Cheng X, Li Y, Chen L, Jiang C, Peng S, Yao P, Tang Y
Journal of biochemical and molecular toxicology 2024 Apr;38(4):e23683
Journal of biochemical and molecular toxicology 2024 Apr;38(4):e23683
Terazosin attenuates abdominal aortic aneurysm formation by downregulating Peg3 expression to inhibit vascular smooth muscle cell apoptosis and senescence.
Wei X, Li Y, Jiang T, Luo P, Dai Y, Wang Q, Xu M, Yan J, Li Y, Gao J, Liu L, Zhang C, Liu Y
European journal of pharmacology 2024 Apr 5;968:176397
European journal of pharmacology 2024 Apr 5;968:176397
Expression of Multicopy Tandem Recombinant Ginseng Hexapeptide in Bacillus subtilis and the Evaluation of Antiaging Activity.
Xiang Q, Qu L, Lei H, Duan Z, Zhu C, Yuwen W, Ma X, Fan D
Journal of agricultural and food chemistry 2024 Apr 3;72(13):7266-7278
Journal of agricultural and food chemistry 2024 Apr 3;72(13):7266-7278
ACAT2 suppresses the ubiquitination of YAP1 to enhance the proliferation and metastasis ability of gastric cancer via the upregulation of SETD7.
Zhang M, Cai F, Guo J, Liu S, Ma G, Cai M, Zhang R, Deng J
Cell death & disease 2024 Apr 26;15(4):297
Cell death & disease 2024 Apr 26;15(4):297
Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome.
Wu S, Dai X, Xia Y, Zhao Q, Zhao H, Shi Z, Yin X, Liu X, Zhang A, Yao Z, Zhang H, Li Q, Thorne RF, Zhang S, Sheng W, Hu W, Gu H
Cell reports 2024 Apr 23;43(4):114111
Cell reports 2024 Apr 23;43(4):114111
Medium-chain chlorinated paraffins (MCCPs) induce renal cell aging and ferroptosis.
Zhang D, Li Z, Gao Y, Sun H
Aging 2024 Apr 19;16(8):7277-7292
Aging 2024 Apr 19;16(8):7277-7292
Chronic low-dose deltamethrin exposure induces colon injury and aggravates DSS-induced colitis via promoting cellular senescence.
Ma R, Wang X, Ren K, Ma Y, Min T, Yang Y, Xie X, Li K, Zhu K, Yuan D, Mo C, Deng X, Zhang Y, Dang C, Zhang H, Sun T
Ecotoxicology and environmental safety 2024 Apr 1;274:116214
Ecotoxicology and environmental safety 2024 Apr 1;274:116214
P16(INK4a) Regulates ROS-Related Autophagy and CDK4/6-Mediated Proliferation: A New Target of Myocardial Regeneration Therapy.
Sun J, Zhou L, Yang T, Deng B, Bao Y, Gu L, Wang H, Wang L
Oxidative medicine and cellular longevity 2023;2023:1696190
Oxidative medicine and cellular longevity 2023;2023:1696190
1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice.
Chen J, Zhang J, Li J, Qin R, Lu N, Goltzman D, Miao D, Yang R
International journal of biological sciences 2023;19(2):610-624
International journal of biological sciences 2023;19(2):610-624
Decrease in the expression of muscle-specific miRNAs, miR-133a and miR-1, in myoblasts with replicative senescence.
Shintani-Ishida K, Tsurumi R, Ikegaya H
PloS one 2023;18(1):e0280527
PloS one 2023;18(1):e0280527
Adipocyte-Derived Exosomal NOX4-Mediated Oxidative Damage Induces Premature Placental Senescence in Obese Pregnancy.
Tao Y, Chen W, Xu H, Xu J, Yang H, Luo X, Chen M, He J, Bai Y, Qi H
International journal of nanomedicine 2023;18:4705-4726
International journal of nanomedicine 2023;18:4705-4726
Cyclohexene oxide CA, a derivative of zeylenone, exhibits anti-cancer activity in glioblastoma by inducing G0/G1 phase arrest through interference with EZH2.
Su R, Cao W, Ma G, Li W, Li Z, Liu Y, Chen L, Chen Z, Li X, Cui P, Huang G
Frontiers in pharmacology 2023;14:1326245
Frontiers in pharmacology 2023;14:1326245
Arctiin-encapsulated DSPE-PEG bubble-like nanoparticles inhibit alveolar epithelial type 2 cell senescence to alleviate pulmonary fibrosis via the p38/p53/p21 pathway.
Xiong D, Gao F, Shao J, Pan Y, Wang S, Wei D, Ye S, Chen Y, Chen R, Yue B, Li J, Chen J
Frontiers in pharmacology 2023;14:1141800
Frontiers in pharmacology 2023;14:1141800
TRAF3IP2 drives mesenchymal stem cell senescence via regulation of NAMPT-mediated NAD biosynthesis.
Huang X, Liu B, Liang Y, Mai C, Shen Y, Huang X, Chen J, Liang X, Hu B, Li W, Li X, Zhang Y
Heliyon 2023 Sep;9(9):e19505
Heliyon 2023 Sep;9(9):e19505
miR-656-3p inhibits melanomas in vitro and in vivo by inducing senescence via inhibiting LMNB2.
Sun J, Lui K, Pang Q, Xu M, Zhao H, Shao J, Yu Y, Chu X, Liang Y, Xu J, Shen Z
Journal of cancer research and clinical oncology 2023 Sep;149(12):10781-10796
Journal of cancer research and clinical oncology 2023 Sep;149(12):10781-10796
Discovery of Salidroside as a Novel Non-Coding RNA Modulator to Delay Cellular Senescence and Promote BK-Dependent Apoptosis in Cerebrovascular Smooth Muscle Cells of Simulated Microgravity Rats.
Ge Y, Zhang B, Song J, Cao Q, Bu Y, Li P, Bai Y, Yang C, Xie M
International journal of molecular sciences 2023 Sep 26;24(19)
International journal of molecular sciences 2023 Sep 26;24(19)
Multi-omic analysis of mandibuloacral dysplasia type A patient iPSC-derived MSC senescence reveals miR-311 as a novel biomarker for MSC senescence.
He L, Liao J, Liu Z, Wang T, Zhou Y, Wang T, Lei B, Zhou G
Human molecular genetics 2023 Sep 16;32(19):2872-2886
Human molecular genetics 2023 Sep 16;32(19):2872-2886
Serum response factor activates peroxidasin transcription to block senescence of hepatic stellate cells.
Guo Y, Zhou A, Zhang Y, Chen Y, Chen Y, Gao Y, Miao X
Life sciences 2023 Sep 1;328:121824
Life sciences 2023 Sep 1;328:121824
Death-seq identifies regulators of cell death and senolytic therapies.
Colville A, Liu JY, Rodriguez-Mateo C, Thomas S, Ishak HD, Zhou R, Klein JDD, Morgens DW, Goshayeshi A, Salvi JS, Yao D, Spees K, Dixon SJ, Liu C, Rhee JW, Lai C, Wu JC, Bassik MC, Rando TA
Cell metabolism 2023 Oct 3;35(10):1814-1829.e6
Cell metabolism 2023 Oct 3;35(10):1814-1829.e6
Activation of Nrf2/ARE pathway by Anisodamine (654-2) for Inhibition of cellular aging and alleviation of Radiation-Induced lung injury.
Guo H, Chen J, Yu H, Dong L, Yu R, Li Q, Song J, Chen H, Zhang H, Pu J, Wang W
International immunopharmacology 2023 Nov;124(Pt A):110864
International immunopharmacology 2023 Nov;124(Pt A):110864
Bazi Bushen maintains intestinal homeostasis through inhibiting TLR4/NFκB signaling pathway and regulating gut microbiota in SAMP6 mice.
Xu Z, Man SS, Gong BY, Li ZD, Zhou HF, Peng YF, Zhao SW, Hou YL, Wang L, Bian YH
Journal of the science of food and agriculture 2023 Nov;103(14):7273-7283
Journal of the science of food and agriculture 2023 Nov;103(14):7273-7283
PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway.
Ma Z, Ding Y, Ding X, Mou H, Mo R, Tan Q
Cell death discovery 2023 Nov 25;9(1):424
Cell death discovery 2023 Nov 25;9(1):424
BSHXF-medicated serum combined with ADSCs regulates the TGF-β1/Smad pathway to repair oxidatively damaged NPCs and its component analysis.
Duan J, Li Z, Liu E, Long H, Chen L, Yang S
Journal of ethnopharmacology 2023 Nov 15;316:116692
Journal of ethnopharmacology 2023 Nov 15;316:116692
High expression of CDKN2A is associated with poor prognosis in colorectal cancer and may guide PD-1-mediated immunotherapy.
Dong Y, Zheng M, Wang X, Yu C, Qin T, Shen X
BMC cancer 2023 Nov 11;23(1):1097
BMC cancer 2023 Nov 11;23(1):1097
Red Ginseng Improves D-galactose-Induced Premature Ovarian Failure in Mice Based on Network Pharmacology.
Shang Z, Fan M, Zhang J, Wang Z, Jiang S, Li W
International journal of molecular sciences 2023 May 4;24(9)
International journal of molecular sciences 2023 May 4;24(9)
CX3CR1(hi) macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue.
Zhou Z, Zhang H, Tao Y, Jie H, Zhao J, Zang J, Li H, Wang Y, Wang T, Zhao H, Li Y, Guo C, Zhu F, Mao H, Zhang L, Liu F, Wang Q
Cell reports 2023 May 30;42(5):112424
Cell reports 2023 May 30;42(5):112424
Erxian decoction alleviates cisplatin-induced premature ovarian failure in rats by reducing oxidation levels in ovarian granulosa cells.
Liu J, Yang Y, He Y, Feng C, Ou H, Yang J, Chen Y, You F, Shao B, Bao J, Guan X, Chen F, Zhao P
Journal of ethnopharmacology 2023 Mar 25;304:116046
Journal of ethnopharmacology 2023 Mar 25;304:116046
The cell senescence regulator p16 is a promising cancer prognostic and immune check-point inhibitor (ICI) therapy biomarker.
Tu Z, Wang X, Cai H, Sheng Y, Wu L, Huang K, Zhu X
Aging 2023 Mar 23;15(6):2136-2157
Aging 2023 Mar 23;15(6):2136-2157
[Research of epigallocatechin gallate in delaying chondrocyte senescence].
Luo C, Zhou W, Zhang H, Zhu J, Chen L, Gu Y
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 2023 Mar 15;37(3):308-315
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 2023 Mar 15;37(3):308-315
Exercise protects aged mice against coronary endothelial senescence via FUNDC1-dependent mitophagy.
Ma L, Li K, Wei W, Zhou J, Li Z, Zhang T, Wangsun Y, Tian F, Dong Q, Zhang H, Xing W
Redox biology 2023 Jun;62:102693
Redox biology 2023 Jun;62:102693
TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease.
Tang Q, Markby GR, MacNair AJ, Tang K, Tkacz M, Parys M, Phadwal K, MacRae VE, Corcoran BM
Cell proliferation 2023 Jun;56(6):e13435
Cell proliferation 2023 Jun;56(6):e13435
Induction of Sestrin2 by pterostilbene suppresses ethanol-triggered hepatocyte senescence by degrading CCN1 via p62-dependent selective autophagy.
Jiang Y, Zhou Y, Xu W, Wang X, Jin H, Bao X, Lu C
Cell biology and toxicology 2023 Jun;39(3):729-749
Cell biology and toxicology 2023 Jun;39(3):729-749
Integrated metabolomics and phosphoproteomics reveal the protective role of exosomes from human umbilical cord mesenchymal stem cells in naturally aging mouse livers.
Ling M, Tang C, Yang X, Yu N, Song Y, Ding W, Sun Y, Yan R, Wang S, Li X, Gao H, Zhang Z, Xing Y
Experimental cell research 2023 Jun 1;427(1):113566
Experimental cell research 2023 Jun 1;427(1):113566
Inhibition of tyrosine kinase Fgr prevents radiation-induced pulmonary fibrosis (RIPF).
Mukherjee A, Epperly MW, Fisher R, Hou W, Shields D, Saiful Huq M, Pifer PM, Mulherkar R, Wilhite TJ, Wang H, Wipf P, Greenberger JS
Cell death discovery 2023 Jul 17;9(1):252
Cell death discovery 2023 Jul 17;9(1):252
Dexamethasone Induces Senescence-Associated Changes in Trabecular Meshwork Cells by Increasing ROS Levels Via the TGFβ/Smad3-NOX4 Axis.
Li H, Ren J, Cui H, Wang D, Zhao R, Liu X, Tian S, Wang J, Zhang J, Li P, Thorne RF, Duan S
Cell transplantation 2023 Jan-Dec;32:9636897231177356
Cell transplantation 2023 Jan-Dec;32:9636897231177356
Dendrobine Alleviates Cellular Senescence and Osteoarthritis via the ROS/NF-κB Axis.
Chen H, Tu M, Liu S, Wen Y, Chen L
International journal of molecular sciences 2023 Jan 25;24(3)
International journal of molecular sciences 2023 Jan 25;24(3)
PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation.
Peng Z, Tan X, Xie L, Li Z, Zhou S, Li Y
iScience 2023 Jan 20;26(1):105909
iScience 2023 Jan 20;26(1):105909
Irisin ameliorates D-galactose-induced skeletal muscle fibrosis via the PI3K/Akt pathway.
Wu Y, Wu Y, Yu J, Zhang Y, Li Y, Fu R, Sun Y, Zhao K, Xiao Q
European journal of pharmacology 2023 Jan 15;939:175476
European journal of pharmacology 2023 Jan 15;939:175476
Evaluation of toxicological effects of bisphenol S with an in vitro human bone marrow mesenchymal stem cell: Implications for bone health.
Li M, Li T, Yin J, Xie C, Zhu J
Toxicology 2023 Jan 15;484:153408
Toxicology 2023 Jan 15;484:153408
Long noncoding RNA SNHG1 alleviates high glucose-induced vascular smooth muscle cells calcification/senescence by post-transcriptionally regulating Bhlhe40 and autophagy via Atg10.
Li S, Ni Y, Li C, Xiang Q, Zhao Y, Xu H, Huang W, Wang Y, Wang Y, Zhan J, Liu Y
Journal of physiology and biochemistry 2023 Feb;79(1):83-105
Journal of physiology and biochemistry 2023 Feb;79(1):83-105
IL-17A promotes endothelial cell senescence by up-regulating the expression of FTO through activating JNK signal pathway.
Li N, Luo R, Zhang W, Wu Y, Hu C, Liu M, Jiang D, Jiang Z, Zhao X, Wang Y, Li Q
Biogerontology 2023 Feb;24(1):99-110
Biogerontology 2023 Feb;24(1):99-110
PBX1-SIRT1 Positive Feedback Loop Attenuates ROS-Mediated HF-MSC Senescence and Apoptosis.
Wang Y, Sui Y, Niu Y, Liu D, Xu Q, Liu F, Zuo K, Liu M, Sun W, Wang Z, Liu Z, Zou F, Shi J, Liu X, Liu J
Stem cell reviews and reports 2023 Feb;19(2):443-454
Stem cell reviews and reports 2023 Feb;19(2):443-454
Involvement of lncRNA TUG1 in HIV-1 Tat-Induced Astrocyte Senescence.
Pillai PP, Kannan M, Sil S, Singh S, Thangaraj A, Chivero ET, Dagur RS, Tripathi A, Hu G, Periyasamy P, Buch S
International journal of molecular sciences 2023 Feb 22;24(5)
International journal of molecular sciences 2023 Feb 22;24(5)
BMF-AS1/BMF Promotes Diabetic Vascular Calcification and Aging both In Vitro and In Vivo.
Lin X, Xiang QY, Li S, Song WL, Wang YJ, Ni YQ, Zhao Y, Li C, Wang Y, Li HH, Liang Z, Zhan JK, Liu YS
Aging and disease 2023 Feb 1;14(1):170-183
Aging and disease 2023 Feb 1;14(1):170-183
Dual network analysis of transcriptome data for discovery of new therapeutic targets in non-small cell lung cancer.
Bai Y, Zhou L, Zhang C, Guo M, Xia L, Tang Z, Liu Y, Deng S
Oncogene 2023 Dec;42(49):3605-3618
Oncogene 2023 Dec;42(49):3605-3618
Downregulation of ALKBH5 rejuvenates aged human mesenchymal stem cells and enhances their therapeutic efficacy in myocardial infarction.
Gao X, Liang X, Liu B, Hong Y, He H, Shen Y, Chen J, Huang X, Hu B, Li W, Li X, Zhang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23294
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23294
Senescence-associated 13-HODE production promotes age-related liver steatosis by directly inhibiting catalase activity.
Duan J, Dong W, Wang G, Xiu W, Pu G, Xu J, Ye C, Zhang X, Zhu Y, Wang C
Nature communications 2023 Dec 9;14(1):8151
Nature communications 2023 Dec 9;14(1):8151
Cholesteryl Hemiazelate Present in Cardiovascular Disease Patients Causes Lysosome Dysfunction in Murine Fibroblasts.
Lopes E, Machado-Oliveira G, Simões CG, Ferreira IS, Ramos C, Ramalho J, Soares MIL, Melo TMVDPE, Puertollano R, Marques ARA, Vieira OV
Cells 2023 Dec 13;12(24)
Cells 2023 Dec 13;12(24)
Testosterone attenuates senile cavernous fibrosis by regulating TGFβR1 and galectin-1 signaling pathways through miR-22-3p.
Hu Z, Zhang Y, Chen J, Luo M, Wang N, Xiao Y, He Q
Molecular and cellular biochemistry 2023 Aug;478(8):1791-1802
Molecular and cellular biochemistry 2023 Aug;478(8):1791-1802
N-Acetylserotonin Protects Rat Nucleus Pulposus Cells Against Oxidative Stress Injury by Activating the PI3K/AKT Signaling Pathway.
Yidian W, Jihe K, Xudong G, Daxue Z, Mingqiang L, Xuewen K
World neurosurgery 2023 Aug;176:e109-e124
World neurosurgery 2023 Aug;176:e109-e124
Inhibition of Polyamine Catabolism Reduces Cellular Senescence.
Uemura T, Matsunaga M, Yokota Y, Takao K, Furuchi T
International journal of molecular sciences 2023 Aug 29;24(17)
International journal of molecular sciences 2023 Aug 29;24(17)
Prolonged Exposure to High Glucose Induces Premature Senescence Through Oxidative Stress and Autophagy in Retinal Pigment Epithelial Cells.
Chiu CC, Cheng KC, Lin YH, He CX, Bow YD, Li CY, Wu CY, Wang HD, Sheu SJ
Archivum immunologiae et therapiae experimentalis 2023 Aug 28;71(1):21
Archivum immunologiae et therapiae experimentalis 2023 Aug 28;71(1):21
Quercetin ameliorates oxidative stress-induced senescence in rat nucleus pulposus-derived mesenchymal stem cells via the miR-34a-5p/SIRT1 axis.
Zhao WJ, Liu X, Hu M, Zhang Y, Shi PZ, Wang JW, Lu XH, Cheng XF, Tao YP, Feng XM, Wang YX, Zhang L
World journal of stem cells 2023 Aug 26;15(8):842-865
World journal of stem cells 2023 Aug 26;15(8):842-865
Boron-Doped Carbon Nanodots as a Theranostic Agent for Colon Cancer Stem Cells.
Ozkasapoglu S, Caglayan MG, Akkurt F, Ensarioğlu HK, Vatansever HS, Celikkan H
ACS omega 2023 Aug 22;8(33):30285-30293
ACS omega 2023 Aug 22;8(33):30285-30293
Sortilin Is Upregulated in Osteoarthritis-Dependent Cartilage Calcification and Associated with Cellular Senescence.
Richter E, Lohmann CH, Dell'Accio F, Goettsch C, Bertrand J
International journal of molecular sciences 2023 Aug 2;24(15)
International journal of molecular sciences 2023 Aug 2;24(15)
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy.
Dong BQ, Liao ZK, Le Y, Jiang S, Luo LF, Miao F, Le Poole IC, Lei TC
Mechanisms of ageing and development 2023 Apr;211:111779
Mechanisms of ageing and development 2023 Apr;211:111779
Androgen Receptor Activation Induces Senescence in Thyroid Cancer Cells.
Gupta A, Carnazza M, Jones M, Darzynkiewicz Z, Halicka D, O'Connell T, Zhao H, Dadafarin S, Shin E, Schwarcz MD, Moscatello A, Tiwari RK, Geliebter J
Cancers 2023 Apr 7;15(8)
Cancers 2023 Apr 7;15(8)
A stress-induced cilium-to-PML-NB route drives senescence initiation.
Ma X, Zhang Y, Zhang Y, Zhang X, Huang Y, He K, Chen C, Hao J, Zhao D, LeBrasseur NK, Kirkland JL, Chini EN, Wei Q, Ling K, Hu J
Nature communications 2023 Apr 3;14(1):1840
Nature communications 2023 Apr 3;14(1):1840
Circulating Exosomal miR-181b-5p Promoted Cell Senescence and Inhibited Angiogenesis to Impair Diabetic Foot Ulcer via the Nuclear Factor Erythroid 2-Related Factor 2/Heme Oxygenase-1 Pathway.
Wang S, Shi M, Zhou J, Wang W, Zhang Y, Li Y
Frontiers in cardiovascular medicine 2022;9:844047
Frontiers in cardiovascular medicine 2022;9:844047
Senotherapy Protects against Cisplatin-Induced Ovarian Injury by Removing Senescent Cells and Alleviating DNA Damage.
Du D, Tang X, Li Y, Gao Y, Chen R, Chen Q, Wen J, Wu T, Zhang Y, Lu H, Zhang J, Wang S
Oxidative medicine and cellular longevity 2022;2022:9144644
Oxidative medicine and cellular longevity 2022;2022:9144644
Pygo1 Regulates the Behavior of Human Non-Small-Cell Lung Cancer via the Wnt/β-Catenin Pathway.
Wen Y, Li Y, Yang B, Guo X, Lin L, Liang J, Zhang K, Li X, Jiang Z, Wang Y, Li Y, Wu X, Fan X, Li F, Yuan W
Disease markers 2022;2022:6993994
Disease markers 2022;2022:6993994
Nicotinamide Mononucleotide Ameliorates Cellular Senescence and Inflammation Caused by Sodium Iodate in RPE.
Ren C, Hu C, Wu Y, Li T, Zou A, Yu D, Shen T, Cai W, Yu J
Oxidative medicine and cellular longevity 2022;2022:5961123
Oxidative medicine and cellular longevity 2022;2022:5961123
Cigarette Smoke Exposure Increases Glucose-6-phosphate Dehydrogenase, Autophagy, Fibrosis, and Senescence in Kidney Cells In Vitro and In Vivo.
Liu WC, Chuang HC, Chou CL, Lee YH, Chiu YJ, Wang YL, Chiu HW
Oxidative medicine and cellular longevity 2022;2022:5696686
Oxidative medicine and cellular longevity 2022;2022:5696686
PGF2α-FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI-1 Signal Pathway.
Hu BA, Sai WW, Yuan J, Lan HT, Qi J, Wang D, Zhang W, Wang ZH, Zhong M, Shang YY
Oxidative medicine and cellular longevity 2022;2022:2908261
Oxidative medicine and cellular longevity 2022;2022:2908261
Reversion of glucocorticoid-induced senescence and collagen synthesis decrease by LY294002 is mediated through p38 in skin.
Le QV, Wen SY, Chen CJ, Huang CY, Kuo WW
International journal of biological sciences 2022;18(16):6102-6113
International journal of biological sciences 2022;18(16):6102-6113
Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity.
Pogacar Z, Johnson JL, Krenning L, De Conti G, Jochems F, Lieftink C, Velds A, Wardak L, Groot K, Schepers A, Wang L, Song JY, van de Ven M, van Tellingen O, Medema RH, Beijersbergen RL, Bernards R, Leite de Oliveira R
PloS one 2022;17(9):e0273182
PloS one 2022;17(9):e0273182
Mechanism of Ba Zhen Tang Delaying Skin Photoaging Based on Network Pharmacology and Molecular Docking.
Han M, Li H, Ke D, Tian LM, Hong Y, Zhang C, Tian DZ, Chen L, Zhan LR, Zong SQ
Clinical, cosmetic and investigational dermatology 2022;15:763-781
Clinical, cosmetic and investigational dermatology 2022;15:763-781
Mannan-Binding Lectin via Interaction With Cell Surface Calreticulin Promotes Senescence of Activated Hepatic Stellate Cells to Limit Liver Fibrosis Progression.
Luo J, Li L, Chang B, Zhu Z, Deng F, Hu M, Yu Y, Lu X, Chen Z, Zuo D, Zhou J
Cellular and molecular gastroenterology and hepatology 2022;14(1):75-99
Cellular and molecular gastroenterology and hepatology 2022;14(1):75-99
Long-Term Social Isolation-Induced Autophagy Inhibition and Cell Senescence Aggravate Cognitive Impairment in D(+)Galactose-Treated Male Mice.
Wang B, Ntim M, Xia M, Wang Y, Lu JC, Yang JY, Li S
Frontiers in aging neuroscience 2022;14:777700
Frontiers in aging neuroscience 2022;14:777700
NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma.
Xiong G, Feng Y, Yi X, Zhang X, Li X, Yang L, Yi Z, Sai B, Yang Z, Zhang Q, Kuang Y, Zhu Y
Frontiers in immunology 2022;13:989263
Frontiers in immunology 2022;13:989263
A novel signature to guide osteosarcoma prognosis and immune microenvironment: Cuproptosis-related lncRNA.
Yang M, Zheng H, Xu K, Yuan Q, Aihaiti Y, Cai Y, Xu P
Frontiers in immunology 2022;13:919231
Frontiers in immunology 2022;13:919231
Palmitic Acid, A Critical Metabolite, Aggravates Cellular Senescence Through Reactive Oxygen Species Generation in Kawasaki Disease.
Zhu Q, Dong Q, Wang X, Xia T, Fu Y, Wang Q, Wu R, Wu T
Frontiers in pharmacology 2022;13:809157
Frontiers in pharmacology 2022;13:809157
Prognostic and immune correlation evaluation of a novel cuproptosis-related genes signature in hepatocellular carcinoma.
Zhou Z, Zhou Y, Liu D, Yang Q, Tang M, Liu W
Frontiers in pharmacology 2022;13:1074123
Frontiers in pharmacology 2022;13:1074123
Stress-induced premature senescence is associated with a prolonged QT interval and recapitulates features of cardiac aging.
Lazzarini E, Lodrini AM, Arici M, Bolis S, Vagni S, Panella S, Rendon-Angel A, Saibene M, Metallo A, Torre T, Vassalli G, Ameri P, Altomare C, Rocchetti M, Barile L
Theranostics 2022;12(11):5237-5257
Theranostics 2022;12(11):5237-5257
Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration.
Luo L, Gong J, Wang Z, Liu Y, Cao J, Qin J, Zuo R, Zhang H, Wang S, Zhao P, Yang D, Zhang M, Wang Y, Zhang J, Zhou Y, Li C, Ni B, Tian Z, Liu M
Bioactive materials 2022 Sep;15:29-43
Bioactive materials 2022 Sep;15:29-43
High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER(+) breast cancer.
Palafox M, Monserrat L, Bellet M, Villacampa G, Gonzalez-Perez A, Oliveira M, Brasó-Maristany F, Ibrahimi N, Kannan S, Mina L, Herrera-Abreu MT, Òdena A, Sánchez-Guixé M, Capelán M, Azaro A, Bruna A, Rodríguez O, Guzmán M, Grueso J, Viaplana C, Hernández J, Su F, Lin K, Clarke RB, Caldas C, Arribas J, Michiels S, García-Sanz A, Turner NC, Prat A, Nuciforo P, Dienstmann R, Verma CS, Lopez-Bigas N, Scaltriti M, Arnedos M, Saura C, Serra V
Nature communications 2022 Sep 7;13(1):5258
Nature communications 2022 Sep 7;13(1):5258
Increasing cell size remodels the proteome and promotes senescence.
Lanz MC, Zatulovskiy E, Swaffer MP, Zhang L, Ilerten I, Zhang S, You DS, Marinov G, McAlpine P, Elias JE, Skotheim JM
Molecular cell 2022 Sep 1;82(17):3255-3269.e8
Molecular cell 2022 Sep 1;82(17):3255-3269.e8
Elimination of senescent cells inhibits epithelial-mesenchymal transition of retinal pigment epithelial cells.
Gao F, Wang L, Wu B, Ou Q, Tian H, Xu J, Jin C, Zhang J, Wang J, Lu L, Xu GT
Experimental eye research 2022 Oct;223:109207
Experimental eye research 2022 Oct;223:109207
Expression of active B-Raf proto-oncogene in kidney collecting ducts induces cyst formation in normal mice and accelerates cyst growth in mice with polycystic kidney disease.
Parnell SC, Raman A, Zhang Y, Daniel EA, Dai Y, Khanna A, Reif GA, Vivian JL, Fields TA, Wallace DP
Kidney international 2022 Nov;102(5):1103-1114
Kidney international 2022 Nov;102(5):1103-1114
Effective-component compatibility of Bufei Yishen formula III ameliorated COPD by improving airway epithelial cell senescence by promoting mitophagy via the NRF2/PINK1 pathway.
Li MY, Qin YQ, Tian YG, Li KC, Oliver BG, Liu XF, Zhao P, Li JS
BMC pulmonary medicine 2022 Nov 22;22(1):434
BMC pulmonary medicine 2022 Nov 22;22(1):434
Unveiling the anti-senescence effects and senescence-associated secretory phenotype (SASP) inhibitory mechanisms of Scutellaria baicalensis Georgi in low glucose-induced astrocytes based on boolean network.
Gao L, Yang WY, Qi H, Sun CJ, Qin XM, Du GH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:153990
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:153990
Avenanthramide C induces cellular senescence in colorectal cancer cells via suppressing β-catenin-mediated the transcription of miR-183/96/182 cluster.
Fu R, Dou Z, Li N, Zhang J, Li Z, Yang P
Biochemical pharmacology 2022 May;199:115021
Biochemical pharmacology 2022 May;199:115021
SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity.
Lee G, Kim YY, Jang H, Han JS, Nahmgoong H, Park YJ, Han SM, Cho C, Lim S, Noh JR, Oh WK, Lee CH, Kim S, Kim JB
Cell metabolism 2022 May 3;34(5):702-718.e5
Cell metabolism 2022 May 3;34(5):702-718.e5
Circular RNA PVT1 inhibits tendon stem/progenitor cell senescence by sponging microRNA-199a-5p.
Han W, Tao X, Weng T, Chen L
Toxicology in vitro : an international journal published in association with BIBRA 2022 Mar;79:105297
Toxicology in vitro : an international journal published in association with BIBRA 2022 Mar;79:105297
The LncRNA RP11-301G19.1/miR-582-5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway.
Wang F, Luo Y, Zhang L, Younis M, Yuan L
Cancer gene therapy 2022 Mar;29(3-4):292-303
Cancer gene therapy 2022 Mar;29(3-4):292-303
Loss of legumain induces premature senescence and mediates aging-related renal fibrosis.
Wang D, Kang L, Chen C, Guo J, Du L, Zhou D, Li G, Zhang Y, Mi X, Zhang M, Liu S, Tan X
Aging cell 2022 Mar;21(3):e13574
Aging cell 2022 Mar;21(3):e13574
P16ink4a overexpression ameliorates cardiac remodeling of mouse following myocardial infarction via CDK4/pRb pathway.
Shi J, Sun J, Liu L, Shan T, Meng H, Yang T, Wang S, Wei T, Chen B, Ma Y, Wang Q, Wang H, Liu J, Wang L
Biochemical and biophysical research communications 2022 Mar 5;595:62-68
Biochemical and biophysical research communications 2022 Mar 5;595:62-68
Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes.
Gautheron J, Lima L, Akinci B, Zammouri J, Auclair M, Ucar SK, Ozen S, Altay C, Bax BE, Nemazanyy I, Lenoir V, Prip-Buus C, Acquaviva-Bourdain C, Lascols O, Fève B, Vigouroux C, Noel E, Jéru I
BMC medicine 2022 Mar 28;20(1):95
BMC medicine 2022 Mar 28;20(1):95
Cholesteryl hemiazelate causes lysosome dysfunction impacting vascular smooth muscle cell homeostasis.
Alves LS, Marques ARA, Padrão N, Carvalho FA, Ramalho J, Lopes CS, Soares MIL, Futter CE, Pinho E Melo TMVD, Santos NC, Vieira OV
Journal of cell science 2022 Mar 1;135(5)
Journal of cell science 2022 Mar 1;135(5)
Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary.
Hense JD, Garcia DN, Isola JV, Alvarado-Rincón JA, Zanini BM, Prosczek JB, Stout MB, Mason JB, Walsh PT, Brieño-Enríquez MA, Schadock I, Barros CC, Masternak MM, Schneider A
GeroScience 2022 Jun;44(3):1747-1759
GeroScience 2022 Jun;44(3):1747-1759
A Small Molecule That Promotes Cellular Senescence Prevents Fibrogenesis and Tumorigenesis.
Meang MK, Kim S, Kim IH, Kim HS, Youn BS
International journal of molecular sciences 2022 Jun 20;23(12)
International journal of molecular sciences 2022 Jun 20;23(12)
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening.
Barnes RP, de Rosa M, Thosar SA, Detwiler AC, Roginskaya V, Van Houten B, Bruchez MP, Stewart-Ornstein J, Opresko PL
Nature structural & molecular biology 2022 Jul;29(7):639-652
Nature structural & molecular biology 2022 Jul;29(7):639-652
Loss of lamin-B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus.
Matias I, Diniz LP, Damico IV, Araujo APB, Neves LDS, Vargas G, Leite REP, Suemoto CK, Nitrini R, Jacob-Filho W, Grinberg LT, Hol EM, Middeldorp J, Gomes FCA
Aging cell 2022 Jan;21(1):e13521
Aging cell 2022 Jan;21(1):e13521
An in vitro senescence model of gingival epithelial cell induced by hydrogen peroxide treatment.
Giri S, Takada A, Paudel D, Yoshida K, Furukawa M, Kuramitsu Y, Matsushita K, Abiko Y, Furuichi Y
Odontology 2022 Jan;110(1):44-53
Odontology 2022 Jan;110(1):44-53
Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion-Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency.
Ling L, Hou J, Wang Y, Shu H, Huang Y
Cell transplantation 2022 Jan-Dec;31:9636897221129171
Cell transplantation 2022 Jan-Dec;31:9636897221129171
Galangin Reverses H(2)O(2)-Induced Dermal Fibroblast Senescence via SIRT1-PGC-1α/Nrf2 Signaling.
Lee JJ, Ng SC, Hsu JY, Liu H, Chen CJ, Huang CY, Kuo WW
International journal of molecular sciences 2022 Jan 26;23(3)
International journal of molecular sciences 2022 Jan 26;23(3)
Ubiquitin-specific protease 3 attenuates interleukin-1β-mediated chondrocyte senescence by deacetylating forkhead box O-3 via sirtuin-3.
Zhou Q, Wang W, Wu J, Qiu S, Yuan S, Fu PL, Qian QR, Xu YZ
Bioengineered 2022 Feb;13(2):2017-2027
Bioengineered 2022 Feb;13(2):2017-2027
Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis.
Kang D, Lee J, Jung J, Carlson BA, Chang MJ, Chang CB, Kang SB, Lee BC, Gladyshev VN, Hatfield DL, Lee BJ, Kim JH
Nature communications 2022 Feb 9;13(1):779
Nature communications 2022 Feb 9;13(1):779
Fulminant lung fibrosis in non-resolvable COVID-19 requiring transplantation.
Jyothula SSK, Peters A, Liang Y, Bi W, Shivshankar P, Yau S, Garcha PS, Yuan X, Akkanti B, Collum S, Wareing N, Thandavarayan RA, Poli de Frias F, Rosas IO, Zhao B, Buja LM, Eltzschig HK, Huang HJ, Karmouty-Quintana H
EBioMedicine 2022 Dec;86:104351
EBioMedicine 2022 Dec;86:104351
HMGB1 induces radioresistance through PI3K/AKT/ATM pathway in esophageal squamous cell carcinoma.
Zhang X, Zou N, Deng W, Song C, Yan K, Shen W, Zhu S
Molecular biology reports 2022 Dec;49(12):11933-11945
Molecular biology reports 2022 Dec;49(12):11933-11945
Lnc-IL7R alleviates PM(2.5)-mediated cellular senescence and apoptosis through EZH2 recruitment in chronic obstructive pulmonary disease.
Lee KY, Ho SC, Sun WL, Feng PH, Lin CW, Chen KY, Chuang HC, Tseng CH, Chen TT, Wu SM
Cell biology and toxicology 2022 Dec;38(6):1097-1120
Cell biology and toxicology 2022 Dec;38(6):1097-1120
Procyanidin B2 ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
Cai W, Zhang Y, Jin W, Wei S, Chen J, Zhong C, Zhong Y, Tu C, Peng H
International immunopharmacology 2022 Dec;113(Pt A):109336
International immunopharmacology 2022 Dec;113(Pt A):109336
Artesunate Inhibits the Cell Growth in Colorectal Cancer by Promoting ROS-Dependent Cell Senescence and Autophagy.
Huang Z, Gan S, Zhuang X, Chen Y, Lu L, Wang Y, Qi X, Feng Q, Huang Q, Du B, Zhang R, Liu Z
Cells 2022 Aug 9;11(16)
Cells 2022 Aug 9;11(16)
Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer.
Gupta P, Strange K, Telange R, Guo A, Hatch H, Sobh A, Elie J, Carter AM, Totenhagen J, Tan C, Sonawane YA, Neuzil J, Natarajan A, Ovens AJ, Oakhill JS, Wiederhold T, Pacak K, Ghayee HK, Meijer L, Reddy S, Bibb JA
Cell reports 2022 Aug 16;40(7):111218
Cell reports 2022 Aug 16;40(7):111218
CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation.
Zhang P, Gao K, Zhang L, Sun H, Zhao X, Liu Y, Lv Z, Shi Q, Chen Y, Jiao D, Li Y, Gu W, Wang C
Cell death and differentiation 2022 Apr;29(4):758-771
Cell death and differentiation 2022 Apr;29(4):758-771
Elevated FAM84B promotes cell proliferation via interacting with NPM1 in esophageal squamous cell carcinoma.
Wang F, Cheng C, Wang X, Chen F, Li H, Zhou Y, Wang Y, Hu X, Kong P, Zhang L, Cheng X, Cui Y
Cell death discovery 2022 Apr 8;8(1):182
Cell death discovery 2022 Apr 8;8(1):182
Downregulation of IGFBP5 contributes to replicative senescence via ERK2 activation in mouse embryonic fibroblasts.
Nojima I, Hosoda R, Toda Y, Saito Y, Ueda N, Horimoto K, Iwahara N, Horio Y, Kuno A
Aging 2022 Apr 4;14(7):2966-2988
Aging 2022 Apr 4;14(7):2966-2988
ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity.
Xiao FH, Yu Q, Deng ZL, Yang K, Ye Y, Ge MX, Yan D, Wang HT, Chen XQ, Yang LQ, Yang BY, Lin R, Zhang W, Yang XL, Dong L, He Y, Zhou J, Cai WW, Li J, Kong QP
Science advances 2022 Apr 29;8(17):eabf2017
Science advances 2022 Apr 29;8(17):eabf2017
LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation.
Yang Y, Liu S, He C, Lv T, Zeng L, Zhang F, Chen H, Zhao RC
Cell & bioscience 2022 Apr 21;12(1):45
Cell & bioscience 2022 Apr 21;12(1):45
FGFR2 accommodates osteogenic cell fate determination in human mesenchymal stem cells.
Zhang Y, Ling L, Ajay D/O Ajayakumar A, Eio YM, van Wijnen AJ, Nurcombe V, Cool SM
Gene 2022 Apr 15;818:146199
Gene 2022 Apr 15;818:146199
PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair.
Wang Y, Sui Y, Lian A, Han X, Liu F, Zuo K, Liu M, Sun W, Wang Z, Liu Z, Zou F, Lu R, Jin M, Du H, Xu K, Liu X, Liu J
Frontiers in cell and developmental biology 2021;9:739868
Frontiers in cell and developmental biology 2021;9:739868
Statins Mitigate Stress-Related Vascular Aging and Atherosclerosis in apoE-Deficient Mice Fed High Fat-Diet: The Role of Glucagon-Like Peptide-1/Adiponectin Axis.
Lei Y, Cui Q, Yang G, Piao L, Inoue A, Wu H, Li X, Kuzuya M, Cheng XW
Frontiers in cell and developmental biology 2021;9:687868
Frontiers in cell and developmental biology 2021;9:687868
P16 (I NK 4a) Deletion Ameliorates Damage of Intestinal Epithelial Barrier and Microbial Dysbiosis in a Stress-Induced Premature Senescence Model of Bmi-1 Deficiency.
Zhou J, Hou C, Chen H, Qin Z, Miao Z, Zhao J, Wang Q, Cui M, Xie C, Wang R, Li Q, Zuo G, Miao D, Jin J
Frontiers in cell and developmental biology 2021;9:671564
Frontiers in cell and developmental biology 2021;9:671564
MCC Regulator of WNT Signaling Pathway (MCC) Is a Podocyte Essential Gene.
Song H, Zhuang L, Xu X, Shi J, Hu W, Liu Z, Shi S
Frontiers in medicine 2021;8:777563
Frontiers in medicine 2021;8:777563
Neu-P11 - a novel melatonin receptor agonist, could improve the features of type-2 diabetes mellitus in rats.
Li X, He J, Li X, Li Y, Zhou Y, Cai S
Endokrynologia Polska 2021;72(6):634-642
Endokrynologia Polska 2021;72(6):634-642
PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway.
Zhang Y, Lv Z, Liu Y, Cao H, Yang J, Wang B
Oxidative medicine and cellular longevity 2021;2021:9980444
Oxidative medicine and cellular longevity 2021;2021:9980444
Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway.
Zhang S, Zhang R, Qiao P, Ma X, Lu R, Wang F, Li C, E L, Liu H
Stem cells international 2021;2021:6616240
Stem cells international 2021;2021:6616240
One-Two Punch Therapy for the Treatment of T-Cell Malignancies Involving p53-Dependent Cellular Senescence.
Qing Y, Li H, Zhao Y, Hu P, Wang X, Yu X, Zhu M, Wang H, Wang Z, Guo Q, Hui H
Oxidative medicine and cellular longevity 2021;2021:5529518
Oxidative medicine and cellular longevity 2021;2021:5529518
FAM134B-Mediated ER-phagy Upregulation Attenuates AGEs-Induced Apoptosis and Senescence in Human Nucleus Pulposus Cells.
Luo R, Li S, Li G, Lu S, Zhang W, Liu H, Lei J, Ma L, Ke W, Liao Z, Wang B, Song Y, Wang K, Zhang Y, Yang C
Oxidative medicine and cellular longevity 2021;2021:3843145
Oxidative medicine and cellular longevity 2021;2021:3843145
Expression of p16 Within Myenteric Neurons of the Aged Colon: A Potential Marker of Declining Function.
Palmer A, Epton S, Crawley E, Straface M, Gammon L, Edgar MM, Xu Y, Elahi S, Chin-Aleong J, Martin JE, Bishop CL, Knowles CH, Sanger GJ
Frontiers in neuroscience 2021;15:747067
Frontiers in neuroscience 2021;15:747067
TFCP2 Overcomes Senescence by Cooperating With SREBP2 to Activate Cholesterol Synthesis in Pancreatic Cancer.
Zhang D, Lu P, Zhu K, Wu H, Dai Y
Frontiers in oncology 2021;11:724437
Frontiers in oncology 2021;11:724437
IL-21 Is an Accomplice of PD-L1 in the Induction of PD-1-Dependent Treg Generation in Head and Neck Cancer.
Zhao Y, Zhang Z, Lei W, Wei Y, Ma R, Wen Y, Wei F, Fan J, Xu Y, Chen L, Lyu K, Lin H, Wen W, Sun W
Frontiers in oncology 2021;11:648293
Frontiers in oncology 2021;11:648293
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Pei Z, Yang C, Guo Y, Dong M, Wang F
Aging 2021 Sep 14;13(17):21700-21711
Aging 2021 Sep 14;13(17):21700-21711
Targeting CDK4/6 Represents a Therapeutic Vulnerability in Acquired BRAF/MEK Inhibitor-Resistant Melanoma.
Nassar KW, Hintzsche JD, Bagby SM, Espinoza V, Langouët-Astrié C, Amato CM, Chimed TS, Fujita M, Robinson W, Tan AC, Schweppe RE
Molecular cancer therapeutics 2021 Oct;20(10):2049-2060
Molecular cancer therapeutics 2021 Oct;20(10):2049-2060
TFEB protein expression is reduced in aged brains and its overexpression mitigates senescence-associated biomarkers and memory deficits in mice.
Wang H, Muthu Karuppan MK, Devadoss D, Nair M, Chand HS, Lakshmana MK
Neurobiology of aging 2021 Oct;106:26-36
Neurobiology of aging 2021 Oct;106:26-36
NFATc4 mediates ethanol-triggered hepatocyte senescence.
Wu R, Wang X, Shao Y, Jiang Y, Zhou Y, Lu C
Toxicology letters 2021 Oct 10;350:10-21
Toxicology letters 2021 Oct 10;350:10-21
Th17/IL-17 induces endothelial cell senescence via activation of NF-κB/p53/Rb signaling pathway.
Zhang L, Liu M, Liu W, Hu C, Li H, Deng J, Cao Q, Wang Y, Hu W, Li Q
Laboratory investigation; a journal of technical methods and pathology 2021 Nov;101(11):1418-1426
Laboratory investigation; a journal of technical methods and pathology 2021 Nov;101(11):1418-1426
Design and synthesis of water-soluble grifolin prodrugs for DNA methyltransferase 1 (DNMT1) down-regulation.
Wang L, Wu Y, Li Z, Lan T, Zhao X, Lv W, Shi F, Luo X, Rao Y, Cao Y
RSC advances 2021 Nov 29;11(61):38907-38914
RSC advances 2021 Nov 29;11(61):38907-38914
Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease.
Zhang J, Gao F, Ma Y, Xue T, Shen Y
iScience 2021 Nov 19;24(11):103327
iScience 2021 Nov 19;24(11):103327
Dipeptidyl peptidase-4 inhibition prevents lung injury in mice under chronic stress via the modulation of oxidative stress and inflammation.
Zhang S, Li P, Xin M, Jin X, Zhao L, Nan Y, Cheng XW
Experimental animals 2021 Nov 10;70(4):541-552
Experimental animals 2021 Nov 10;70(4):541-552
Muse Cells Have Higher Stress Tolerance than Adipose Stem Cells due to the Overexpression of the CCNA2 Gene.
Wang P, Wang S, Ji F, Zhang R
Stem cells and development 2021 Nov 1;30(21):1056-1069
Stem cells and development 2021 Nov 1;30(21):1056-1069
Aging-associated lncRNAs are evolutionarily conserved and participate in NFκB signaling.
Cai D, Han JJ
Nature aging 2021 May;1(5):438-453
Nature aging 2021 May;1(5):438-453
Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury.
Uryga AK, Grootaert MOJ, Garrido AM, Oc S, Foote K, Chappell J, Finigan A, Rossiello F, d'Adda di Fagagna F, Aravani D, Jorgensen HF, Bennett MR
Communications biology 2021 May 21;4(1):611
Communications biology 2021 May 21;4(1):611
Smad4 deficiency substitutes Cdkn2b but not Cdkn2a downregulation in pancreatic cancer following induction of genetic events in adult mice.
Jia X, Sun B, Tu Q, Qi H, Li L, Liu X, Yan L, Dai H, Kong Q, Tang C, Zhao X
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2021 Mar;21(2):418-427
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2021 Mar;21(2):418-427
The miR-623/CXCL12 axis inhibits LPS-induced nucleus pulposus cell apoptosis and senescence.
Zhong H, Zhou Z, Guo L, Liu F, Zheng B, Bi S, Tian C
Mechanisms of ageing and development 2021 Mar;194:111417
Mechanisms of ageing and development 2021 Mar;194:111417
Bmi-1 alleviates adventitial fibroblast senescence by eliminating ROS in pulmonary hypertension.
Li K, Li Y, Yu Y, Ding J, Huang H, Chu C, Hu L, Yu Y, Cao Y, Xu P, Fulton D, Chen F
BMC pulmonary medicine 2021 Mar 5;21(1):80
BMC pulmonary medicine 2021 Mar 5;21(1):80
BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.
Shao Y, Zhao C, Pan J, Zeng C, Zhang H, Liu L, Fan K, Liu X, Luo B, Fang H, Bai X, Zhang H, Cai D
Aging 2021 Mar 19;13(7):9646-9664
Aging 2021 Mar 19;13(7):9646-9664
Paricalcitol inhibits oxidative stress-induced cell senescence of the bile duct epithelium dependent on modulating Sirt1 pathway in cholestatic mice.
Jia R, Yang F, Yan P, Ma L, Yang L, Li L
Free radical biology & medicine 2021 Jun;169:158-168
Free radical biology & medicine 2021 Jun;169:158-168
Baicalein Delays H(2)O(2)-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism.
Gao L, Zheng WG, Wu XK, Du GH, Qin XM
ACS chemical neuroscience 2021 Jul 7;12(13):2320-2335
ACS chemical neuroscience 2021 Jul 7;12(13):2320-2335
Targeting senescent cells improves functional recovery after spinal cord injury.
Paramos-de-Carvalho D, Martins I, Cristóvão AM, Dias AF, Neves-Silva D, Pereira T, Chapela D, Farinho A, Jacinto A, Saúde L
Cell reports 2021 Jul 6;36(1):109334
Cell reports 2021 Jul 6;36(1):109334
Hypoxic preconditioning rejuvenates mesenchymal stem cells and enhances neuroprotection following intracerebral hemorrhage via the miR-326-mediated autophagy.
Liu J, He J, Ge L, Xiao H, Huang Y, Zeng L, Jiang Z, Lu M, Hu Z
Stem cell research & therapy 2021 Jul 22;12(1):413
Stem cell research & therapy 2021 Jul 22;12(1):413
Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities.
Li P, Liu X, Zhao T, Li F, Wang Q, Zhang P, Hirayama R, Chen W, Jin X, Zheng X, Wang Z, Li Q
Cell death discovery 2021 Jul 20;7(1):184
Cell death discovery 2021 Jul 20;7(1):184
Irradiation Accelerates Plaque Formation and Cellular Senescence in Flow-Altered Carotid Arteries of Apolipoprotein E Knock-Out Mice.
Yamamoto Y, Minami M, Yoshida K, Nagata M, Miyata T, Yang T, Takayama N, Suzuki K, Okawa M, Yamada K, Miyamoto S
Journal of the American Heart Association 2021 Jul 20;10(14):e020712
Journal of the American Heart Association 2021 Jul 20;10(14):e020712
Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes.
Sun X, Fu P, Xie L, Chai S, Xu Q, Zeng L, Wang X, Jiang N, Sang M
International journal of molecular medicine 2021 Jan;47(1):335-345
International journal of molecular medicine 2021 Jan;47(1):335-345
CDC25B induces cellular senescence and correlates with tumor suppression in a p53-dependent manner.
Chen YC, Hsieh HH, Chang HC, Wang HC, Lin WJ, Lin JJ
The Journal of biological chemistry 2021 Jan-Jun;296:100564
The Journal of biological chemistry 2021 Jan-Jun;296:100564
Huaier Inhibits Proliferation, Migration, and Invasion of Cutaneous Squamous Cell Carcinoma Cells by Inhibiting the Methylation Levels of CDKN2A and TP53.
Wang L, Xu L, Wang Y
Integrative cancer therapies 2021 Jan-Dec;20:15347354211031646
Integrative cancer therapies 2021 Jan-Dec;20:15347354211031646
Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome.
Kang SM, Yoon MH, Ahn J, Kim JE, Kim SY, Kang SY, Joo J, Park S, Cho JH, Woo TG, Oh AY, Chung KJ, An SY, Hwang TS, Lee SY, Kim JS, Ha NC, Song GY, Park BJ
Communications biology 2021 Jan 4;4(1):5
Communications biology 2021 Jan 4;4(1):5
Isolation methodology is essential to the evaluation of the extracellular vesicle component of the senescence-associated secretory phenotype.
Wallis R, Josipovic N, Mizen H, Robles-Tenorio A, Tyler EJ, Papantonis A, Bishop CL
Journal of extracellular vesicles 2021 Feb;10(4):e12041
Journal of extracellular vesicles 2021 Feb;10(4):e12041
Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma.
Chen T, Liu L, Zou Y, Hu X, Zhang W, Zhou T, Luo X, Fu W, Xu J
Cancer biology & medicine 2021 Feb 15;18(1):227-244
Cancer biology & medicine 2021 Feb 15;18(1):227-244
Knockdown of RREB1 inhibits cell proliferation via enhanced p16 expression in gastric cancer.
Gao Q, Wu Y, Lu C, Kai W, Xie W, Wang Q, Wang L, Liu S, Pan Y
Cell cycle (Georgetown, Tex.) 2021 Dec;20(23):2465-2475
Cell cycle (Georgetown, Tex.) 2021 Dec;20(23):2465-2475
eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer.
Chen YX, Wang CJ, Xiao DS, He BM, Li M, Yi XP, Zhang W, Yin JY, Liu ZQ
Pharmacological research 2021 Dec;174:105934
Pharmacological research 2021 Dec;174:105934
Pim1 knockout alleviates sarcopenia in aging mice via reducing adipogenic differentiation of PDGFRα(+) mesenchymal progenitors.
Shang GK, Han L, Wang ZH, Song M, Wang D, Tan YM, Li YH, Li YL, Zhang W, Zhong M
Journal of cachexia, sarcopenia and muscle 2021 Dec;12(6):1741-1756
Journal of cachexia, sarcopenia and muscle 2021 Dec;12(6):1741-1756
Artesunate treatment ameliorates ultraviolet irradiation-driven skin photoaging via increasing β-catenin expression.
Tian L, Ke D, Hong Y, Zhang C, Tian D, Chen L, Zhan L, Zong S
Aging 2021 Dec 9;13(23):25325-25341
Aging 2021 Dec 9;13(23):25325-25341
Urolithin a alleviates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells through SIRT1/PGC-1α pathway.
Shi PZ, Wang JW, Wang PC, Han B, Lu XH, Ren YX, Feng XM, Cheng XF, Zhang L
World journal of stem cells 2021 Dec 26;13(12):1928-1946
World journal of stem cells 2021 Dec 26;13(12):1928-1946
PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
Gulluni F, Prever L, Li H, Krafcikova P, Corrado I, Lo WT, Margaria JP, Chen A, De Santis MC, Cnudde SJ, Fogerty J, Yuan A, Massarotti A, Sarijalo NT, Vadas O, Williams RL, Thelen M, Powell DR, Schueler M, Wiesener MS, Balla T, Baris HN, Tiosano D, McDermott BM Jr, Perkins BD, Ghigo A, Martini M, Haucke V, Boura E, Merlo GR, Buchner DA, Hirsch E
Science (New York, N.Y.) 2021 Dec 10;374(6573):eabk0410
Science (New York, N.Y.) 2021 Dec 10;374(6573):eabk0410
Protective effects of galangin against H(2)O(2)/UVB-induced dermal fibroblast collagen degradation via hsa-microRNA-4535-mediated TGFβ/Smad signaling.
Lee JJ, Ng SC, Ni YT, Liu JS, Chen CJ, Padma VV, Huang CY, Kuo WW
Aging 2021 Dec 10;13(23):25342-25364
Aging 2021 Dec 10;13(23):25342-25364
SETD4 in the Proliferation, Migration, Angiogenesis, Myogenic Differentiation and Genomic Methylation of Bone Marrow Mesenchymal Stem Cells.
Liao X, Wu C, Shao Z, Zhang S, Zou Y, Wang K, Ha Y, Xing J, Zheng A, Shen Z, Zheng S, Guo J, Jie W
Stem cell reviews and reports 2021 Aug;17(4):1374-1389
Stem cell reviews and reports 2021 Aug;17(4):1374-1389
EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence.
Gautheron J, Morisseau C, Chung WK, Zammouri J, Auclair M, Baujat G, Capel E, Moulin C, Wang Y, Yang J, Hammock BD, Cerame B, Phan F, Fève B, Vigouroux C, Andreelli F, Jeru I
eLife 2021 Aug 3;10
eLife 2021 Aug 3;10
The Extracellular Metabolome Stratifies Low and High Risk Potentially Premalignant Oral Keratinocytes and Identifies Citrate as a Potential Non-Invasive Marker of Tumour Progression.
Karen-Ng LP, James EL, Stephen A, Bennett MH, Mycielska ME, Parkinson EK
Cancers 2021 Aug 21;13(16)
Cancers 2021 Aug 21;13(16)
HIV TAT-mediated microglial senescence: Role of SIRT3-dependent mitochondrial oxidative stress.
Thangaraj A, Chivero ET, Tripathi A, Singh S, Niu F, Guo ML, Pillai P, Periyasamy P, Buch S
Redox biology 2021 Apr;40:101843
Redox biology 2021 Apr;40:101843
Extracts of Jasminum sambac flowers fermented by Lactobacillus rhamnosus inhibit H(2) O(2) - and UVB-induced aging in human dermal fibroblasts.
Ho CC, Ng SC, Chuang HL, Wen SY, Kuo CH, Mahalakshmi B, Huang CY, Kuo WW
Environmental toxicology 2021 Apr;36(4):607-619
Environmental toxicology 2021 Apr;36(4):607-619
miR-127-3p Is an Epigenetic Activator of Myofibroblast Senescence Situated within the MicroRNA-Enriched Dlk1-Dio3‒Imprinted Domain on Mouse Chromosome 12.
Auler M, Bergmeier V, Georgieva VS, Pitzler L, Frie C, Nüchel J, Eckes B, Hinz B, Brachvogel B
The Journal of investigative dermatology 2021 Apr;141(4S):1076-1086.e3
The Journal of investigative dermatology 2021 Apr;141(4S):1076-1086.e3
Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell-Derived Exosomes on the Senescence of Nucleus Pulposus Cells.
Chen CC, Chen J, Wang WL, Xie L, Shao CQ, Zhang YX
Orthopaedic surgery 2021 Apr;13(2):583-591
Orthopaedic surgery 2021 Apr;13(2):583-591
Melatonin induces the rejuvenation of long-term ex vivo expanded periodontal ligament stem cells by modulating the autophagic process.
Tan YZ, Xu XY, Dai JM, Yin Y, He XT, Zhang YL, Zhu TX, An Y, Tian BM, Chen FM
Stem cell research & therapy 2021 Apr 29;12(1):254
Stem cell research & therapy 2021 Apr 29;12(1):254
Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A.
Kang SM, Yoon MH, Lee SJ, Ahn J, Yi SA, Nam KH, Park S, Woo TG, Cho JH, Lee J, Ha NC, Park BJ
Scientific reports 2021 Apr 27;11(1):9122
Scientific reports 2021 Apr 27;11(1):9122
CDKN2a/p16 Antagonizes Hepatic Stellate Cell Activation and Liver Fibrosis by Modulating ROS Levels.
Lv F, Li N, Kong M, Wu J, Fan Z, Miao D, Xu Y, Ye Q, Wang Y
Frontiers in cell and developmental biology 2020;8:176
Frontiers in cell and developmental biology 2020;8:176
Resveratrol Inhibits Ischemia-Induced Myocardial Senescence Signals and NLRP3 Inflammasome Activation.
Feng H, Mou SQ, Li WJ, Zhang N, Zhou ZY, Ding W, Bian ZY, Liao HH
Oxidative medicine and cellular longevity 2020;2020:2647807
Oxidative medicine and cellular longevity 2020;2020:2647807
Piwi-interacting RNAs play a role in vitamin C-mediated effects on endothelial aging.
Zheng S, Zheng H, Huang A, Mai L, Huang X, Hu Y, Huang Y
International journal of medical sciences 2020;17(7):946-952
International journal of medical sciences 2020;17(7):946-952
HIV antiretroviral drugs, dolutegravir, maraviroc and ritonavir-boosted atazanavir use different pathways to affect inflammation, senescence and insulin sensitivity in human coronary endothelial cells.
Auclair M, Guénantin AC, Fellahi S, Garcia M, Capeau J
PloS one 2020;15(1):e0226924
PloS one 2020;15(1):e0226924
Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells.
Stojanović SD, Fuchs M, Kunz M, Xiao K, Just A, Pich A, Bauersachs J, Fiedler J, Sedding D, Thum T
Frontiers in physiology 2020;11:520
Frontiers in physiology 2020;11:520
High Phosphate Induces and Klotho Attenuates Kidney Epithelial Senescence and Fibrosis.
Maique J, Flores B, Shi M, Shepard S, Zhou Z, Yan S, Moe OW, Hu MC
Frontiers in pharmacology 2020;11:1273
Frontiers in pharmacology 2020;11:1273
Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.
Zou G, Zhang X, Wang L, Li X, Xie T, Zhao J, Yan J, Wang L, Ye H, Jiao S, Xiang R, Shi Y
Theranostics 2020;10(15):6839-6853
Theranostics 2020;10(15):6839-6853
LncRNA TRPC7-AS1 regulates nucleus pulposus cellular senescence and ECM synthesis via competing with HPN for miR-4769-5p binding.
Wang X, Li D, Wu H, Liu F, Liu F, Zhang Q, Li J
Mechanisms of ageing and development 2020 Sep;190:111293
Mechanisms of ageing and development 2020 Sep;190:111293
TRIM71 binds to IMP1 and is capable of positive and negative regulation of target RNAs.
Foster DJ, Chang HM, Haswell JR, Gregory RI, Slack FJ
Cell cycle (Georgetown, Tex.) 2020 Sep;19(18):2314-2326
Cell cycle (Georgetown, Tex.) 2020 Sep;19(18):2314-2326
Internalization of the TAT-PBX1 fusion protein significantly enhances the proliferation of human hair follicle-derived mesenchymal stem cells and delays their senescence.
Wang B, Liu F, Liu Z, Han X, Lian A, Zhang Y, Zuo K, Wang Y, Liu M, Zou F, Jiang Y, Jin M, Liu X, Liu J
Biotechnology letters 2020 Oct;42(10):1877-1885
Biotechnology letters 2020 Oct;42(10):1877-1885
Paclitaxel exposure downregulates miR-522 expression and its downregulation induces paclitaxel resistance in ovarian cancer cells.
Miyamoto M, Sawada K, Nakamura K, Yoshimura A, Ishida K, Kobayashi M, Shimizu A, Yamamoto M, Kodama M, Hashimoto K, Kimura T
Scientific reports 2020 Oct 7;10(1):16755
Scientific reports 2020 Oct 7;10(1):16755
Metformin promotes the osseointegration of titanium implants under osteoporotic conditions by regulating BMSCs autophagy, and osteogenic differentiation.
Lin J, Xu R, Shen X, Jiang H, Du S
Biochemical and biophysical research communications 2020 Oct 15;531(2):228-235
Biochemical and biophysical research communications 2020 Oct 15;531(2):228-235
HO-1 overexpression alleviates senescence by inducing autophagy via the mitochondrial route in human nucleus pulposus cells.
Yi W, Lan H, Wen Y, Wang Y, He D, Bai Z, Zhang Y, Jiang W, Liu B, Shen J, Hu Z
Journal of cellular physiology 2020 Nov;235(11):8402-8415
Journal of cellular physiology 2020 Nov;235(11):8402-8415
FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping.
Wang L, Chen R, Li G, Wang Z, Liu J, Liang Y, Liu JP
Cell metabolism 2020 Nov 3;32(5):860-877.e9
Cell metabolism 2020 Nov 3;32(5):860-877.e9
A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence.
Jia Y, Jin H, Gao L, Yang X, Wang F, Ding H, Chen A, Tan S, Zhang F, Shao J, Wang S, Zheng S
Journal of cellular and molecular medicine 2020 May;24(9):5304-5316
Journal of cellular and molecular medicine 2020 May;24(9):5304-5316
PAI-1 Regulation of TGF-β1-induced Alveolar Type II Cell Senescence, SASP Secretion, and SASP-mediated Activation of Alveolar Macrophages.
Rana T, Jiang C, Liu G, Miyata T, Antony V, Thannickal VJ, Liu RM
American journal of respiratory cell and molecular biology 2020 Mar;62(3):319-330
American journal of respiratory cell and molecular biology 2020 Mar;62(3):319-330
Knockdown of lncRNA MIR503HG suppresses proliferation and promotes apoptosis of non-small cell lung cancer cells by regulating miR-489-3p and miR-625-5p.
Dao R, Wudu M, Hui L, Jiang J, Xu Y, Ren H, Qiu X
Pathology, research and practice 2020 Mar;216(3):152823
Pathology, research and practice 2020 Mar;216(3):152823
Augmentation of Bone Regeneration by Depletion of Stress-Induced Senescent Cells Using Catechin and Senolytics.
Honda Y, Huang A, Tanaka T, Han X, Gao B, Liu H, Wang X, Zhao J, Hashimoto Y, Yamamoto K, Matsumoto N, Baba S, Umeda M
International journal of molecular sciences 2020 Jun 13;21(12)
International journal of molecular sciences 2020 Jun 13;21(12)
Nrf2 modulates immunosuppressive ability and cellular senescence of human umbilical cord mesenchymal stem cells.
Jie Z, Huan Y, Mengyun W, Yasha L, Huafeng P, Ke Y
Biochemical and biophysical research communications 2020 Jun 11;526(4):1021-1027
Biochemical and biophysical research communications 2020 Jun 11;526(4):1021-1027
Senolytic CAR T cells reverse senescence-associated pathologies.
Amor C, Feucht J, Leibold J, Ho YJ, Zhu C, Alonso-Curbelo D, Mansilla-Soto J, Boyer JA, Li X, Giavridis T, Kulick A, Houlihan S, Peerschke E, Friedman SL, Ponomarev V, Piersigilli A, Sadelain M, Lowe SW
Nature 2020 Jul;583(7814):127-132
Nature 2020 Jul;583(7814):127-132
In Utero Exposure to Gestational Diabetes Alters DNA Methylation and Gene Expression of CDKN2A/B in Langerhans Islets of Rat Offspring.
Nazari Z, Shahryari A, Ghafari S, Nabiuni M, Golalipour MJ
Cell journal 2020 Jul;22(2):203-211
Cell journal 2020 Jul;22(2):203-211
Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16(INK4A).
Göbl C, Morris VK, van Dam L, Visscher M, Polderman PE, Hartlmüller C, de Ruiter H, Hora M, Liesinger L, Birner-Gruenberger R, Vos HR, Reif B, Madl T, Dansen TB
Redox biology 2020 Jan;28:101316
Redox biology 2020 Jan;28:101316
Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression.
Dang Y, An Y, He J, Huang B, Zhu J, Gao M, Zhang S, Wang X, Yang B, Xie Z
Aging cell 2020 Jan;19(1):e13060
Aging cell 2020 Jan;19(1):e13060
The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin - SCL/TAL1 - CD44 axis.
Godavarthy PS, Kumar R, Herkt SC, Pereira RS, Hayduk N, Weissenberger ES, Aggoune D, Manavski Y, Lucas T, Pan KT, Voutsinas JM, Wu Q, Müller MC, Saussele S, Oellerich T, Oehler VG, Lausen J, Krause DS
Haematologica 2020 Jan;105(1):136-147
Haematologica 2020 Jan;105(1):136-147
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function.
Wang J, Li S, Wang J, Wu F, Chen Y, Zhang H, Guo Y, Lin Y, Li L, Yu X, Liu T, Zhao Y
Aging 2020 Jan 6;12(1):650-671
Aging 2020 Jan 6;12(1):650-671
Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR.
Feng X, Pan J, Li J, Zeng C, Qi W, Shao Y, Liu X, Liu L, Xiao G, Zhang H, Bai X, Cai D
Aging 2020 Jan 16;12(2):1087-1103
Aging 2020 Jan 16;12(2):1087-1103
Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model.
Sethi NS, Kikuchi O, Duronio GN, Stachler MD, McFarland JM, Ferrer-Luna R, Zhang Y, Bao C, Bronson R, Patil D, Sanchez-Vega F, Liu JB, Sicinska E, Lazaro JB, Ligon KL, Beroukhim R, Bass AJ
Nature genetics 2020 Feb;52(2):219-230
Nature genetics 2020 Feb;52(2):219-230
Acetyl-11-keto-β-boswellic acid triggers premature senescence via induction of DNA damage accompanied by impairment of DNA repair genes in hepatocellular carcinoma cells in vitro and in vivo.
Wang S, Wang H, Sun B, Li D, Wu J, Li J, Tian X, Qin C, Chang H, Liu Y
Fundamental & clinical pharmacology 2020 Feb;34(1):65-76
Fundamental & clinical pharmacology 2020 Feb;34(1):65-76
Role and mechanism of FLNa and UCP2 in the development of cervical cancer.
Wang A, Liu L, Yuan M, Han S, You X, Zhang H, Lei F, Zhang Y
Oncology reports 2020 Dec;44(6):2656-2668
Oncology reports 2020 Dec;44(6):2656-2668
Increased production of functional small extracellular vesicles in senescent endothelial cells.
Riquelme JA, Takov K, Santiago-Fernández C, Rossello X, Lavandero S, Yellon DM, Davidson SM
Journal of cellular and molecular medicine 2020 Apr;24(8):4871-4876
Journal of cellular and molecular medicine 2020 Apr;24(8):4871-4876
A novel STAT3 inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma.
Li Z, Zhu T, Xu Y, Wu C, Chen J, Ren Y, Kong L, Sun S, Guo W, Wang Y, Jing C, Dong J, Zhou J, Zhang L, Shen Q, Zhou X
American journal of cancer research 2019;9(4):699-713
American journal of cancer research 2019;9(4):699-713
Novel Breast-Specific Long Non-coding RNA LINC00993 Acts as a Tumor Suppressor in Triple-Negative Breast Cancer.
Guo S, Jian L, Tao K, Chen C, Yu H, Liu S
Frontiers in oncology 2019;9:1325
Frontiers in oncology 2019;9:1325
Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence.
Li Y, Li X, Cao M, Jiang Y, Yan J, Liu Z, Yang R, Chen X, Sun P, Xiang R, Wang L, Shi Y
Signal transduction and targeted therapy 2019;4:50
Signal transduction and targeted therapy 2019;4:50
NANOG Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence by Upregulating PBX1 and Activating AKT Signaling.
Liu F, Shi J, Zhang Y, Lian A, Han X, Zuo K, Liu M, Zheng T, Zou F, Liu X, Jin M, Mu Y, Li G, Su G, Liu J
Oxidative medicine and cellular longevity 2019;2019:4286213
Oxidative medicine and cellular longevity 2019;2019:4286213
New Insights into Chronological Mobility of Retrotransposons In Vivo.
Ghanam AR, Cao J, Ouyang X, Song X
Oxidative medicine and cellular longevity 2019;2019:2818415
Oxidative medicine and cellular longevity 2019;2019:2818415
Overexpression of P16 reversed the MDR1-mediated DDP resistance in the cervical adenocarcinoma by activating the ERK1/2 signaling pathway.
Xiao Y, Liang MR, Liu CC, Wang YN, Zeng Y, Zhou J, Zhu HT, Wang Q, Zou Y, Zeng SY
Cell division 2019;14:6
Cell division 2019;14:6
Interferon Regulatory Factor 3 Deficiency Induces Age-Related Alterations of the Retina in Young and Old Mice.
Zhang X, Zhu J, Chen X, Jie-Qiong Z, Li X, Luo L, Huang H, Liu W, Zhou X, Yan J, Lin S, Ye J
Frontiers in cellular neuroscience 2019;13:272
Frontiers in cellular neuroscience 2019;13:272
P16 Methylation Leads to Paclitaxel Resistance of Advanced Non-Small Cell Lung Cancer.
Liu Z, Lin H, Gan Y, Cui C, Zhang B, Gu L, Zhou J, Zhu G, Deng D
Journal of Cancer 2019;10(7):1726-1733
Journal of Cancer 2019;10(7):1726-1733
Inhibition of polycomb repressor complex 2 ameliorates neointimal hyperplasia by suppressing trimethylation of H3K27 in vascular smooth muscle cells.
Liang J, Li Q, Cai W, Zhang X, Yang B, Li X, Jiang S, Tian S, Zhang K, Song H, Ai D, Zhang X, Wang C, Zhu Y
British journal of pharmacology 2019 Sep;176(17):3206-3219
British journal of pharmacology 2019 Sep;176(17):3206-3219
Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence.
Saxena S, Vekaria H, Sullivan PG, Seifert AW
Nature communications 2019 Sep 27;10(1):4400
Nature communications 2019 Sep 27;10(1):4400
Tumor necrosis factor-inducible gene 6 reprograms hepatic stellate cells into stem-like cells, which ameliorates liver damage in mouse.
Wang S, Kim J, Lee C, Oh D, Han J, Kim TJ, Kim SW, Seo YS, Oh SH, Jung Y
Biomaterials 2019 Oct;219:119375
Biomaterials 2019 Oct;219:119375
Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications.
Tian S, Feng J, Cao Y, Shen S, Cai Y, Yang D, Yan R, Wang L, Zhang H, Zhong X, Gao P
Life science alliance 2019 Oct;2(5)
Life science alliance 2019 Oct;2(5)
Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer.
Yang J, Zeng Z, Qiao L, Jiang X, Ma J, Wang J, Ye S, Ma Q, Wei J, Wu M, Huang X, Ma D, Gao Q
Molecular cancer research : MCR 2019 Oct;17(10):2015-2028
Molecular cancer research : MCR 2019 Oct;17(10):2015-2028
Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development.
Malaise O, Tachikart Y, Constantinides M, Mumme M, Ferreira-Lopez R, Noack S, Krettek C, Noël D, Wang J, Jorgensen C, Brondello JM
Aging 2019 Oct 22;11(20):9128-9146
Aging 2019 Oct 22;11(20):9128-9146
Degradation of Caytaxin Causes Learning and Memory Deficits via Activation of DAPK1 in Aging.
Guo Y, Li H, Ke X, Deng M, Wu Z, Cai Y, Afewerky HK, Zhang X, Pei L, Lu Y
Molecular neurobiology 2019 May;56(5):3368-3379
Molecular neurobiology 2019 May;56(5):3368-3379
The Molecular Chaperone Heat Shock Protein 70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA Damage and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling Pathways.
Cho W, Jin X, Pang J, Wang Y, Mivechi NF, Moskophidis D
Molecular and cellular biology 2019 May 1;39(9)
Molecular and cellular biology 2019 May 1;39(9)
Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence.
Li R, Liu Y, Xie J, Huang X, Zhang L, Liu H, Li L
Free radical biology & medicine 2019 May 1;135:116-124
Free radical biology & medicine 2019 May 1;135:116-124
Radiosensitization of esophageal carcinoma cells by knockdown of HMGB1 expression.
Zhang X, Yang X, Zhu S, Li Q, Zou N
Oncology reports 2019 Mar;41(3):1960-1970
Oncology reports 2019 Mar;41(3):1960-1970
Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways.
Liang X, Ding Y, Lin F, Zhang Y, Zhou X, Meng Q, Lu X, Jiang G, Zhu H, Chen Y, Lian Q, Fan H, Liu Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Mar;33(3):4559-4570
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Mar;33(3):4559-4570
Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways.
Wei X, Luo D, Yan Y, Yu H, Sun L, Wang C, Song F, Ge H, Qian H, Li X, Tang X, Liu P
Experimental eye research 2019 Mar;180:174-183
Experimental eye research 2019 Mar;180:174-183
Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability.
Shen Z, Liao X, Shao Z, Feng M, Yuan J, Wang S, Gan S, Ha Y, He Z, Jie W
BMC cancer 2019 Mar 22;19(1):262
BMC cancer 2019 Mar 22;19(1):262
Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis.
Saito N, Araya J, Ito S, Tsubouchi K, Minagawa S, Hara H, Ito A, Nakano T, Hosaka Y, Ichikawa A, Kadota T, Yoshida M, Fujita Y, Utsumi H, Kurita Y, Kobayashi K, Hashimoto M, Wakui H, Numata T, Kaneko Y, Asano H, Odaka M, Ohtsuka T, Morikawa T, Nakayama K, Kuwano K
Journal of immunology (Baltimore, Md. : 1950) 2019 Mar 1;202(5):1428-1440
Journal of immunology (Baltimore, Md. : 1950) 2019 Mar 1;202(5):1428-1440
MDM2 promotes genome instability by ubiquitinating the transcription factor HBP1.
Cao Z, Xue J, Cheng Y, Wang J, Liu Y, Li H, Jiang W, Li G, Gui Y, Zhang X
Oncogene 2019 Jun;38(24):4835-4855
Oncogene 2019 Jun;38(24):4835-4855
Fra-1 plays a critical role in angiotensin II-induced vascular senescence.
Yang D, Xiao C, Long F, Wu W, Huang M, Qu L, Liu X, Zhu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jun;33(6):7603-7614
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jun;33(6):7603-7614
The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathway.
Xu S, Wu W, Huang H, Huang R, Xie L, Su A, Liu S, Zheng R, Yuan Y, Zheng HL, Sun X, Xiong XD, Liu X
Aging cell 2019 Jun;18(3):e12918
Aging cell 2019 Jun;18(3):e12918
Correlation of p16 and nm23-H1 expression levels with incidence and prognosis of soft tissue sarcoma.
Jia J, Yin P, Zhang X, Yang F, Song G, Bi W, Han G, Xu M, Wang W, Zheng X
Oncology letters 2019 Jun;17(6):4865-4870
Oncology letters 2019 Jun;17(6):4865-4870
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells.
Delfarah A, Parrish S, Junge JA, Yang J, Seo F, Li S, Mac J, Wang P, Fraser SE, Graham NA
The Journal of biological chemistry 2019 Jul 5;294(27):10564-10578
The Journal of biological chemistry 2019 Jul 5;294(27):10564-10578
Overexpression of KLF5 is associated with poor survival and G1/S progression in pancreatic cancer.
Li Y, Kong R, Chen H, Zhao Z, Li L, Li J, Hu J, Zhang G, Pan S, Wang Y, Wang G, Chen H, Sun B
Aging 2019 Jul 21;11(14):5035-5057
Aging 2019 Jul 21;11(14):5035-5057
Cathepsin S Deficiency Mitigated Chronic Stress-Related Neointimal Hyperplasia in Mice.
Wang H, Meng X, Piao L, Inoue A, Xu W, Yu C, Nakamura K, Hu L, Sasaki T, Wu H, Unno K, Umegaki H, Murohara T, Shi GP, Kuzuya M, Cheng XW
Journal of the American Heart Association 2019 Jul 16;8(14):e011994
Journal of the American Heart Association 2019 Jul 16;8(14):e011994
Aberrant methylation-induced dysfunction of p16 is associated with osteoblast activation caused by fluoride.
Wu S, Yan W, Qiu B, Liao Y, Gu J, Wei S, Zhang A, Pan X
Environmental toxicology 2019 Jan;34(1):37-47
Environmental toxicology 2019 Jan;34(1):37-47
S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α.
Su Y, Xu C, Sun Z, Liang Y, Li G, Tong T, Chen J
Aging 2019 Jan 23;11(2):549-572
Aging 2019 Jan 23;11(2):549-572
lncRNA-ES3/miR-34c-5p/BMF axis is involved in regulating high-glucose-induced calcification/senescence of VSMCs.
Lin X, Zhan JK, Zhong JY, Wang YJ, Wang Y, Li S, He JY, Tan P, Chen YY, Liu XB, Cui XJ, Liu YS
Aging 2019 Jan 17;11(2):523-535
Aging 2019 Jan 17;11(2):523-535
Phenotypic and functional differences between senescent and aged murine microglia.
Stojiljkovic MR, Ain Q, Bondeva T, Heller R, Schmeer C, Witte OW
Neurobiology of aging 2019 Feb;74:56-69
Neurobiology of aging 2019 Feb;74:56-69
Shuttling SLC2A4RG is regulated by 14-3-3θ to modulate cell survival via caspase-3 and caspase-6 in human glioma.
Yun D, Wang H, Wang Y, Chen Y, Zhao Z, Ma J, Ji Y, Huang Q, Chen J, Chen H, Lu D
EBioMedicine 2019 Feb;40:163-175
EBioMedicine 2019 Feb;40:163-175
p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation.
Yoon MH, Kang SM, Lee SJ, Woo TG, Oh AY, Park S, Ha NC, Park BJ
Cell death & disease 2019 Feb 6;10(2):107
Cell death & disease 2019 Feb 6;10(2):107
A basal-enriched microRNA is required for prostate tumorigenesis in a Pten knockout mouse model.
Fan X, Bjerke GA, Riemondy K, Wang L, Yi R
Molecular carcinogenesis 2019 Dec;58(12):2241-2253
Molecular carcinogenesis 2019 Dec;58(12):2241-2253
Ribociclib (LEE011) suppresses cell proliferation and induces apoptosis of MDA-MB-231 by inhibiting CDK4/6-cyclin D-Rb-E2F pathway.
Li T, Xiong Y, Wang Q, Chen F, Zeng Y, Yu X, Wang Y, Zhou F, Zhou Y
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):4001-4011
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):4001-4011
Roles of p38α and p38β mitogen‑activated protein kinase isoforms in human malignant melanoma A375 cells.
Wen SY, Cheng SY, Ng SC, Aneja R, Chen CJ, Huang CY, Kuo WW
International journal of molecular medicine 2019 Dec;44(6):2123-2132
International journal of molecular medicine 2019 Dec;44(6):2123-2132
Releasing Behavior of Lipopolysaccharide from Gelatin Modulates Inflammation, Cellular Senescence, and Bone Formation in Critical-Sized Bone Defects in Rat Calvaria.
Zhao J, Honda Y, Tanaka T, Hashimoto Y, Matsumoto N
Materials (Basel, Switzerland) 2019 Dec 23;13(1)
Materials (Basel, Switzerland) 2019 Dec 23;13(1)
Dipeptidyl peptidase-4 inhibition prevents vascular aging in mice under chronic stress: Modulation of oxidative stress and inflammation.
Xin M, Jin X, Cui X, Jin C, Piao L, Wan Y, Xu S, Zhang S, Yue X, Wang H, Nan Y, Cheng X
Chemico-biological interactions 2019 Dec 1;314:108842
Chemico-biological interactions 2019 Dec 1;314:108842
Senescence caused by inactivation of the homeodomain transcription factor Pdx1 in adult pancreatic acinar cells in mice.
Horiguchi M, Yoshida M, Hirata K, Furuyama K, Masui T, Uemoto S, Kawaguchi Y
FEBS letters 2019 Aug;593(16):2226-2234
FEBS letters 2019 Aug;593(16):2226-2234
Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells.
Sui A, Xu Y, Pan B, Guo T, Wu J, Shen Y, Yang J, Guo X
Journal of cellular physiology 2019 Aug;234(10):17990-17998
Journal of cellular physiology 2019 Aug;234(10):17990-17998
MRTF-A regulates proliferation and survival properties of pro-atherogenic macrophages.
An J, Naruse TK, Hinohara K, Soejima Y, Sawabe M, Nakagawa Y, Kuwahara K, Kimura A
Journal of molecular and cellular cardiology 2019 Aug;133:26-35
Journal of molecular and cellular cardiology 2019 Aug;133:26-35
PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis.
Jiang Y, Liu F, Zou F, Zhang Y, Wang B, Zhang Y, Lian A, Han X, Liu Z, Liu X, Jin M, Wang D, Li G, Liu J
Stem cell research & therapy 2019 Aug 23;10(1):268
Stem cell research & therapy 2019 Aug 23;10(1):268
Stem cell competition orchestrates skin homeostasis and ageing.
Liu N, Matsumura H, Kato T, Ichinose S, Takada A, Namiki T, Asakawa K, Morinaga H, Mohri Y, De Arcangelis A, Geroges-Labouesse E, Nanba D, Nishimura EK
Nature 2019 Apr;568(7752):344-350
Nature 2019 Apr;568(7752):344-350
Histone Deacetylation in the Promoter of p16 Is Involved in Fluoride-Induced Human Osteoblast Activation via the Inhibition of Sp1 Binding.
Ming J, Wu S, You T, Wang X, Yu C, Luo P, Zhang A, Pan X
Biological trace element research 2019 Apr;188(2):373-383
Biological trace element research 2019 Apr;188(2):373-383
Ribociclib, a selective cyclin D kinase 4/6 inhibitor, inhibits proliferation and induces apoptosis of human cervical cancer in vitro and in vivo.
Xiong Y, Li T, Assani G, Ling H, Zhou Q, Zeng Y, Zhou F, Zhou Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108602
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108602
A novel pancreatic cancer model originated from transformation of acinar cells in adult tree shrew, a primate-like animal.
Tu Q, Yang D, Zhang X, Jia X, An S, Yan L, Dai H, Ma Y, Tang C, Tong W, Hou Z, Lv L, Tan J, Zhao X
Disease models & mechanisms 2019 Apr 15;12(4)
Disease models & mechanisms 2019 Apr 15;12(4)
Coxsackievirus A6 Induces Cell Cycle Arrest in G0/G1 Phase for Viral Production.
Wang Z, Wang Y, Wang S, Meng X, Song F, Huo W, Zhang S, Chang J, Li J, Zheng B, Liu Y, Zhang Y, Zhang W, Yu J
Frontiers in cellular and infection microbiology 2018;8:279
Frontiers in cellular and infection microbiology 2018;8:279
NRF2-regulated cell cycle arrest at early stage of oxidative stress response mechanism.
Márton M, Tihanyi N, Gyulavári P, Bánhegyi G, Kapuy O
PloS one 2018;13(11):e0207949
PloS one 2018;13(11):e0207949
Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence.
Li Y, Peng Z, Wang C, Li L, Leng Y, Chen R, Yuan H, Zhou S, Zhang Z, Chen AF
American journal of physiology. Heart and circulatory physiology 2018 Sep 1;315(3):H571-H580
American journal of physiology. Heart and circulatory physiology 2018 Sep 1;315(3):H571-H580
Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3.
Xing SS, Li J, Chen L, Yang YF, He PL, Li J, Yang J
Mechanisms of ageing and development 2018 Oct;175:1-6
Mechanisms of ageing and development 2018 Oct;175:1-6
Lack of Cardiac Improvement After Cardiosphere-Derived Cell Transplantation in Aging Mouse Hearts.
Zhao ZA, Han X, Lei W, Li J, Yang Z, Wu J, Yao M, Lu XA, He L, Chen Y, Zhou B, Hu S
Circulation research 2018 Oct 26;123(10):e21-e31
Circulation research 2018 Oct 26;123(10):e21-e31
Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma.
Mohamed AD, Shah N, Hettmer S, Vargesson N, Wackerhage H
Scientific reports 2018 Oct 23;8(1):15674
Scientific reports 2018 Oct 23;8(1):15674
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Chen X, Liu C, Zhao R, Zhao P, Wu J, Zhou N, Ying M
Molecular pharmaceutics 2018 Nov 5;15(11):4974-4984
Molecular pharmaceutics 2018 Nov 5;15(11):4974-4984
Comparative characterization of SHED and DPSCs during extended cultivation in vitro.
Wang H, Zhong Q, Yang T, Qi Y, Fu M, Yang X, Qiao L, Ling Q, Liu S, Zhao Y
Molecular medicine reports 2018 May;17(5):6551-6559
Molecular medicine reports 2018 May;17(5):6551-6559
Counteracting survival functions of EBNA3C in Epstein-Barr virus (EBV)-driven lymphoproliferative diseases by combination of SAHA and bortezomib.
Hui KF, Yeung PL, Tam KP, Chiang AKS
Oncotarget 2018 May 18;9(38):25101-25114
Oncotarget 2018 May 18;9(38):25101-25114
Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice.
Beaver LM, Lӧhr CV, Clarke JD, Glasser ST, Watson GW, Wong CP, Zhang Z, Williams DE, Dashwood RH, Shannon J, Thuillier P, Ho E
Current developments in nutrition 2018 Mar;2(3):nzy002
Current developments in nutrition 2018 Mar;2(3):nzy002
Glutaredoxin-1 Silencing Induces Cell Senescence via p53/p21/p16 Signaling Axis.
Yang F, Yi M, Liu Y, Wang Q, Hu Y, Deng H
Journal of proteome research 2018 Mar 2;17(3):1091-1100
Journal of proteome research 2018 Mar 2;17(3):1091-1100
The protein kinase D1-mediated classical protein secretory pathway regulates the Ras oncogene-induced senescence response.
Su Y, Wang P, Shen H, Sun Z, Xu C, Li G, Tong T, Chen J
Journal of cell science 2018 Mar 16;131(6)
Journal of cell science 2018 Mar 16;131(6)
Therapeutic Challenge with a CDK 4/6 Inhibitor Induces an RB-Dependent SMAC-Mediated Apoptotic Response in Non-Small Cell Lung Cancer.
Thangavel C, Boopathi E, Liu Y, McNair C, Haber A, Perepelyuk M, Bhardwaj A, Addya S, Ertel A, Shoyele S, Birbe R, Salvino JM, Dicker AP, Knudsen KE, Den RB
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Mar 15;24(6):1402-1414
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Mar 15;24(6):1402-1414
Identification of early indicators of altered metabolism in normal development using a rodent model system.
Prabakaran AD, Karakkat JV, Vijayan R, Chalissery J, Ibrahim MF, Kaimala S, Adeghate EA, Al-Marzouqi AH, Ansari SA, Mensah-Brown E, Emerald BS
Disease models & mechanisms 2018 Mar 1;11(3)
Disease models & mechanisms 2018 Mar 1;11(3)
Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice.
Roselló-Díez A, Madisen L, Bastide S, Zeng H, Joyner AL
PLoS biology 2018 Jun;16(6):e2005086
PLoS biology 2018 Jun;16(6):e2005086
Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells.
Sun Y, Zheng Y, Wang C, Liu Y
Cell death & disease 2018 Jul 9;9(7):753
Cell death & disease 2018 Jul 9;9(7):753
Overexpression of PP1-NIPP1 limits the capacity of cells to repair DNA double-strand breaks.
Winkler C, Rouget R, Wu D, Beullens M, Van Eynde A, Bollen M
Journal of cell science 2018 Jul 9;131(13)
Journal of cell science 2018 Jul 9;131(13)
Atorvastatin exerts inhibitory effect on endothelial senescence in hyperlipidemic rats through a mechanism involving down-regulation of miR-21-5p/203a-3p.
Zhang JJ, Zhang YZ, Peng JJ, Li NS, Xiong XM, Ma QL, Luo XJ, Liu B, Peng J
Mechanisms of ageing and development 2018 Jan;169:10-18
Mechanisms of ageing and development 2018 Jan;169:10-18
Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma.
Hamada S, Shimosegawa T, Taguchi K, Nabeshima T, Yamamoto M, Masamune A
American journal of physiology. Gastrointestinal and liver physiology 2018 Jan 1;314(1):G65-G74
American journal of physiology. Gastrointestinal and liver physiology 2018 Jan 1;314(1):G65-G74
EZH2 inhibition sensitizes tamoxifen‑resistant breast cancer cells through cell cycle regulation.
Chen S, Yao F, Xiao Q, Liu Q, Yang Y, Li X, Jiang G, Kuno T, Fang Y
Molecular medicine reports 2018 Feb;17(2):2642-2650
Molecular medicine reports 2018 Feb;17(2):2642-2650
Young plasma reverses age-dependent alterations in hepatic function through the restoration of autophagy.
Liu A, Guo E, Yang J, Yang Y, Liu S, Jiang X, Hu Q, Dirsch O, Dahmen U, Zhang C, Gewirtz DA, Fang H
Aging cell 2018 Feb;17(1)
Aging cell 2018 Feb;17(1)
Antrocin Sensitizes Prostate Cancer Cells to Radiotherapy through Inhibiting PI3K/AKT and MAPK Signaling Pathways.
Chen YA, Tzeng DTW, Huang YP, Lin CJ, Lo UG, Wu CL, Lin H, Hsieh JT, Tang CH, Lai CH
Cancers 2018 Dec 31;11(1)
Cancers 2018 Dec 31;11(1)
LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1.
Liu Y, Wang LL, Chen S, Zong ZH, Guan X, Zhao Y
Journal of cellular and molecular medicine 2018 Aug;22(8):3955-3964
Journal of cellular and molecular medicine 2018 Aug;22(8):3955-3964
Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis.
Masaldan S, Clatworthy SAS, Gamell C, Meggyesy PM, Rigopoulos AT, Haupt S, Haupt Y, Denoyer D, Adlard PA, Bush AI, Cater MA
Redox biology 2018 Apr;14:100-115
Redox biology 2018 Apr;14:100-115
H(2)S Donor NaHS Changes the Production of Endogenous H(2)S and NO in D-Galactose-Induced Accelerated Ageing.
Wu W, Hou CL, Mu XP, Sun C, Zhu YC, Wang MJ, Lv QZ
Oxidative medicine and cellular longevity 2017;2017:5707830
Oxidative medicine and cellular longevity 2017;2017:5707830
Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation.
Tamgue O, Lei M
Asian Pacific journal of cancer prevention : APJCP 2017 Sep 27;18(9):2519-2526
Asian Pacific journal of cancer prevention : APJCP 2017 Sep 27;18(9):2519-2526
Increased dipeptidyl peptidase-4 accelerates diet-related vascular aging and atherosclerosis in ApoE-deficient mice under chronic stress.
Lei Y, Yang G, Hu L, Piao L, Inoue A, Jiang H, Sasaki T, Zhao G, Yisireyili M, Yu C, Xu W, Takeshita K, Okumura K, Kuzuya M, Cheng XW, FAHA
International journal of cardiology 2017 Sep 15;243:413-420
International journal of cardiology 2017 Sep 15;243:413-420
Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice.
Suzuki Y, Sato T, Sugimoto M, Baskoro H, Karasutani K, Mitsui A, Nurwidya F, Arano N, Kodama Y, Hirano SI, Ishigami A, Seyama K, Takahashi K
Biochemical and biophysical research communications 2017 Oct 7;492(1):74-81
Biochemical and biophysical research communications 2017 Oct 7;492(1):74-81
5-fluorouracil causes endothelial cell senescence: potential protective role of glucagon-like peptide 1.
Altieri P, Murialdo R, Barisione C, Lazzarini E, Garibaldi S, Fabbi P, Ruggeri C, Borile S, Carbone F, Armirotti A, Canepa M, Ballestrero A, Brunelli C, Montecucco F, Ameri P, Spallarossa P
British journal of pharmacology 2017 Nov;174(21):3713-3726
British journal of pharmacology 2017 Nov;174(21):3713-3726
Potency of Human Cardiosphere-Derived Cells from Patients with Ischemic Heart Disease Is Associated with Robust Vascular Supportive Ability.
Harvey E, Zhang H, Sepúlveda P, Garcia SP, Sweeney D, Choudry FA, Castellano D, Thomas GN, Kattach H, Petersen R, Blake DJ, Taggart DP, Frontini M, Watt SM, Martin-Rendon E
Stem cells translational medicine 2017 May;6(5):1399-1411
Stem cells translational medicine 2017 May;6(5):1399-1411
A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis.
Wang S, Cao Z, Xue J, Li H, Jiang W, Cheng Y, Li G, Zhang X
The Journal of biological chemistry 2017 May 19;292(20):8207-8222
The Journal of biological chemistry 2017 May 19;292(20):8207-8222
Activation of Wnt/β-catenin signaling by lithium chloride attenuates d-galactose-induced neurodegeneration in the auditory cortex of a rat model of aging.
Xia MY, Zhao XY, Huang QL, Sun HY, Sun C, Yuan J, He C, Sun Y, Huang X, Kong W, Kong WJ
FEBS open bio 2017 Jun;7(6):759-776
FEBS open bio 2017 Jun;7(6):759-776
miR-21-5p/203a-3p promote ox-LDL-induced endothelial cell senescence through down-regulation of mitochondrial fission protein Drp1.
Zhang JJ, Liu WQ, Peng JJ, Ma QL, Peng J, Luo XJ
Mechanisms of ageing and development 2017 Jun;164:8-19
Mechanisms of ageing and development 2017 Jun;164:8-19
Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8.
Peng C, Hu W, Weng X, Tong R, Cheng S, Ding C, Xiao H, Lv Z, Xie H, Zhou L, Wu J, Zheng S
Scientific reports 2017 Jun 23;7(1):4186
Scientific reports 2017 Jun 23;7(1):4186
CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.
Mao X, Li P, Wang Y, Liang Z, Liu J, Li J, Jiang Y, Bao G, Li L, Zhu B, Ren Y, Zhao X, Zhang J, Liu Y, Yang J, Liu P
Cell death & disease 2017 Jan 12;8(1):e2546
Cell death & disease 2017 Jan 12;8(1):e2546
Knockout of 4.1B triggers malignant transformation in SV40T-immortalized mouse embryo fibroblast cells.
Wang Z, Zhang J, Zeng Y, Sun S, Zhang J, Zhang B, Zhu M, Ouyang R, Ma B, Ye M, An X, Liu J
Molecular carcinogenesis 2017 Feb;56(2):538-549
Molecular carcinogenesis 2017 Feb;56(2):538-549
MicroRNA let-7g inhibited hypoxia-induced proliferation of PASMCs via G(0)/G(1) cell cycle arrest by targeting c-myc.
Zhang WF, Xiong YW, Zhu TT, Xiong AZ, Bao HH, Cheng XS
Life sciences 2017 Feb 1;170:9-15
Life sciences 2017 Feb 1;170:9-15
IGFBP-rP1 acts as a potential tumor suppressor via the suppression of ERK signaling pathway in endometrial cancer cells.
Ma Y, Jiang J, Zhang Y, Ding Y, Xu T, Lu B
Molecular medicine reports 2017 Aug;16(2):1445-1450
Molecular medicine reports 2017 Aug;16(2):1445-1450
Murine mesenchymal cells that express elevated levels of the CDK inhibitor p16(Ink4a) in vivo are not necessarily senescent.
Frescas D, Hall BM, Strom E, Virtuoso LP, Gupta M, Gleiberman AS, Rydkina E, Balan V, Vujcic S, Chernova OB, Gudkov AV
Cell cycle (Georgetown, Tex.) 2017 Aug 18;16(16):1526-1533
Cell cycle (Georgetown, Tex.) 2017 Aug 18;16(16):1526-1533
Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions.
Watanabe R, Fujita N, Sato Y, Kobayashi T, Morita M, Oike T, Miyamoto K, Kuro-O M, Michigami T, Fukumoto S, Tsuji T, Toyama Y, Nakamura M, Matsumoto M, Miyamoto T
Scientific reports 2017 Aug 10;7(1):7786
Scientific reports 2017 Aug 10;7(1):7786
Long-term effects of repeated superovulation on the uterus and mammary gland in rhesus monkeys.
Yan P, Xu J, Zeng Y, Dong G, Cao H, Zheng M, Zhu H
Journal of assisted reproduction and genetics 2017 Apr;34(4):535-545
Journal of assisted reproduction and genetics 2017 Apr;34(4):535-545
N-Stearoyl-L-Tyrosine Inhibits the Senescence of Neural Stem/Progenitor Cells Induced by Aβ 1-42 via the CB2 Receptor.
Li WQ, Wang ZJ, Liu S, Hu Y, Yin M, Lu Y
Stem cells international 2016;2016:7419389
Stem cells international 2016;2016:7419389
Antiaging Effect of Inula britannica on Aging Mouse Model Induced by D-Galactose.
Chen H, Long Y, Guo L
Evidence-based complementary and alternative medicine : eCAM 2016;2016:6049083
Evidence-based complementary and alternative medicine : eCAM 2016;2016:6049083
Inhibition of BMI1 induces autophagy-mediated necroptosis.
Dey A, Mustafi SB, Saha S, Kumar Dhar Dwivedi S, Mukherjee P, Bhattacharya R
Autophagy 2016;12(4):659-70
Autophagy 2016;12(4):659-70
Chemoproteomic Evaluation of Target Engagement by the Cyclin-Dependent Kinase 4 and 6 Inhibitor Palbociclib Correlates with Cancer Cell Response.
Nomanbhoy TK, Sharma G, Brown H, Wu J, Aban A, Vogeti S, Alemayehu S, Sykes M, Rosenblum JS, Kozarich JW
Biochemistry 2016 Sep 27;55(38):5434-41
Biochemistry 2016 Sep 27;55(38):5434-41
Macrophage Migration Inhibitory Factor (MIF) Deficiency Exacerbates Aging-Induced Cardiac Remodeling and Dysfunction Despite Improved Inflammation: Role of Autophagy Regulation.
Xu X, Pang J, Chen Y, Bucala R, Zhang Y, Ren J
Scientific reports 2016 Mar 4;6:22488
Scientific reports 2016 Mar 4;6:22488
miR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4/E2F1 signal activation.
Feng T, Shao F, Wu Q, Zhang X, Xu D, Qian K, Xie Y, Wang S, Xu N, Wang Y, Qi C
Oncotarget 2016 Mar 29;7(13):16205-16
Oncotarget 2016 Mar 29;7(13):16205-16
HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis.
Chen Y, Pan K, Wang P, Cao Z, Wang W, Wang S, Hu N, Xue J, Li H, Jiang W, Li G, Zhang X
The Journal of biological chemistry 2016 Jun 10;291(24):12688-12705
The Journal of biological chemistry 2016 Jun 10;291(24):12688-12705
The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity.
Lazzarini E, Balbi C, Altieri P, Pfeffer U, Gambini E, Canepa M, Varesio L, Bosco MC, Coviello D, Pompilio G, Brunelli C, Cancedda R, Ameri P, Bollini S
Scientific reports 2016 Jul 21;6:29994
Scientific reports 2016 Jul 21;6:29994
Testosterone Antagonizes Doxorubicin-Induced Senescence of Cardiomyocytes.
Altieri P, Barisione C, Lazzarini E, Garuti A, Bezante GP, Canepa M, Spallarossa P, Tocchetti CG, Bollini S, Brunelli C, Ameri P
Journal of the American Heart Association 2016 Jan 8;5(1)
Journal of the American Heart Association 2016 Jan 8;5(1)
Comparison of liver oncogenic potential among human RAS isoforms.
Chung SI, Moon H, Ju HL, Kim DY, Cho KJ, Ribback S, Dombrowski F, Calvisi DF, Ro SW
Oncotarget 2016 Feb 9;7(6):7354-66
Oncotarget 2016 Feb 9;7(6):7354-66
Mechanism of BRG1 silencing in primary cancers.
Marquez-Vilendrer SB, Thompson K, Lu L, Reisman D
Oncotarget 2016 Aug 30;7(35):56153-56169
Oncotarget 2016 Aug 30;7(35):56153-56169
Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis.
Vermeer DW, Coppock JD, Zeng E, Lee KM, Spanos WC, Onken MD, Uppaluri R, Lee JH, Vermeer PD
Oncotarget 2016 Apr 26;7(17):24194-207
Oncotarget 2016 Apr 26;7(17):24194-207
Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon.
Rajendran P, Dashwood WM, Li L, Kang Y, Kim E, Johnson G, Fischer KA, Löhr CV, Williams DE, Ho E, Yamamoto M, Lieberman DA, Dashwood RH
Clinical epigenetics 2015;7(1):102
Clinical epigenetics 2015;7(1):102
Lentivirus-mediated gene silencing of NOB1 suppresses non-small cell lung cancer cell proliferation.
Huang W, Zhong W, Xu J, Su B, Huang G, Du J, Liu Q
Oncology reports 2015 Sep;34(3):1510-6
Oncology reports 2015 Sep;34(3):1510-6
Evaluation of Protein Profiles From Treated Xenograft Tumor Models Identifies an Antibody Panel for Formalin-fixed and Paraffin-embedded (FFPE) Tissue Analysis by Reverse Phase Protein Arrays (RPPA).
Bader S, Zajac M, Friess T, Ruge E, Rieder N, Gierke B, Heubach Y, Thomas M, Pawlak M
Molecular & cellular proteomics : MCP 2015 Oct;14(10):2775-85
Molecular & cellular proteomics : MCP 2015 Oct;14(10):2775-85
Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability.
Wang J, Uryga AK, Reinhold J, Figg N, Baker L, Finigan A, Gray K, Kumar S, Clarke M, Bennett M
Circulation 2015 Nov 17;132(20):1909-19
Circulation 2015 Nov 17;132(20):1909-19
Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction.
Al-Wahab Z, Mert I, Tebbe C, Chhina J, Hijaz M, Morris RT, Ali-Fehmi R, Giri S, Munkarah AR, Rattan R
Oncotarget 2015 May 10;6(13):10908-23
Oncotarget 2015 May 10;6(13):10908-23
Cathepsin K knockout alleviates aging-induced cardiac dysfunction.
Hua Y, Robinson TJ, Cao Y, Shi GP, Ren J, Nair S
Aging cell 2015 Jun;14(3):345-51
Aging cell 2015 Jun;14(3):345-51
mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.
Damsky W, Micevic G, Meeth K, Muthusamy V, Curley DP, Santhanakrishnan M, Erdelyi I, Platt JT, Huang L, Theodosakis N, Zaidi MR, Tighe S, Davies MA, Dankort D, McMahon M, Merlino G, Bardeesy N, Bosenberg M
Cancer cell 2015 Jan 12;27(1):41-56
Cancer cell 2015 Jan 12;27(1):41-56
Patient-derived bladder cancer xenografts in the preclinical development of novel targeted therapies.
Jäger W, Xue H, Hayashi T, Janssen C, Awrey S, Wyatt AW, Anderson S, Moskalev I, Haegert A, Alshalalfa M, Erho N, Davicioni E, Fazli L, Li E, Collins C, Wang Y, Black PC
Oncotarget 2015 Aug 28;6(25):21522-32
Oncotarget 2015 Aug 28;6(25):21522-32
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
Fullerenol protects retinal pigment epithelial cells from oxidative stress-induced premature senescence via activating SIRT1.
Zhuge CC, Xu JY, Zhang J, Li W, Li P, Li Z, Chen L, Liu X, Shang P, Xu H, Lu Y, Wang F, Lu L, Xu GT
Investigative ophthalmology & visual science 2014 May 20;55(7):4628-38
Investigative ophthalmology & visual science 2014 May 20;55(7):4628-38
BCL6 overexpression is associated with decreased p19 ARF expression and confers an independent prognosticator in gallbladder carcinoma.
Liang PI, Li CF, Chen LT, Sun DP, Chen TJ, Hsing CH, Hsu HP, Lin CY
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014 Feb;35(2):1417-26
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014 Feb;35(2):1417-26
Ocular expression and distribution of products of the POAG-associated chromosome 9p21 gene region.
Chidlow G, Wood JP, Sharma S, Dimasi DP, Burdon KP, Casson RJ, Craig JE
PloS one 2013;8(9):e75067
PloS one 2013;8(9):e75067
Teng-Long-Bu-Zhong-Tang, a Chinese herbal formula, enhances anticancer effects of 5--Fluorouracil in CT26 colon carcinoma.
Deng S, Hu B, An HM, Du Q, Xu L, Shen KP, Shi XF, Wei MM, Wu Y
BMC complementary and alternative medicine 2013 Jun 8;13:128
BMC complementary and alternative medicine 2013 Jun 8;13:128
Notch1 signaling contributes to the oncogenic effect of HBx on human hepatic cells.
Wang F, Xia X, Wang J, Sun Q, Luo J, Cheng B
Biotechnology letters 2013 Jan;35(1):29-37
Biotechnology letters 2013 Jan;35(1):29-37
Deficiency of insulin-like growth factor 1 attenuates aging-induced changes in hepatic function: role of autophagy.
Xu X, Hueckstaedt LK, Ren J
Journal of hepatology 2013 Aug;59(2):308-17
Journal of hepatology 2013 Aug;59(2):308-17
Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells.
Motterle A, Pu X, Wood H, Xiao Q, Gor S, Ng FL, Chan K, Cross F, Shohreh B, Poston RN, Tucker AT, Caulfield MJ, Ye S
Human molecular genetics 2012 Sep 15;21(18):4021-9
Human molecular genetics 2012 Sep 15;21(18):4021-9
Correlation of MTS1/p16 and nm23 mRNA expression with survival in patients with peripheral synovial sarcoma.
Golouh R, Stanta G, Bracko M, Bonin S
Journal of surgical oncology 2001 Feb;76(2):83-8
Journal of surgical oncology 2001 Feb;76(2):83-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10883-1-AP(P16 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of SH-SY5Y cells, using CDKN2A antibody 10883-1-AP at 1:50 dilution and FITC-labeled donkey anti-rabbit IgG(green). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-P16 (IP:10883-1-AP, 4ug; Detection:10883-1-AP 1:1000) with HEK-293 cells lysate 4500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 10883-1-AP(P16 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 10883-1-AP(P16 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
