Tissue expression
Cell line expression
Protein structure

CDKN2A

Cyclin dependent kinase inhibitor 2A
ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p14ARF, p16, p16INK4a, p19, p19Arf 
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
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2127 antibodies from 56 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
3 antibodies
Novus Biologicals
84 antibodies
Invitrogen Antibodies
259 antibodies
GeneTex
18 antibodies
Abnova Corporation
44 antibodies
Biorbyt
468 antibodies
NovoPro Bioscience Inc.
7 antibodies
FineTest Biotech
1 antibody
OriGene
163 antibodies
NSJ Bioreagents
28 antibodies
Abgent
22 antibodies
Boster Biological Technology
8 antibodies
HUABIO Research
3 antibodies
St John's Laboratory
33 antibodies
Aviva Systems Biology
14 antibodies
R&D Systems
1 antibody
Affinity Biosciences
7 antibodies
Cusabio Biotech Co., Ltd
12 antibodies
Cell Signaling Technology, Inc
9 antibodies
Exalpha Biologicals, Inc.
2 antibodies
Bioworld Technology, Inc
3 antibodies
Everest Biotech
2 antibodies
Progen Biotechnik GmbH
2 antibodies
SignalChem
1 antibody
ProSci
9 antibodies
Bethyl Laboratories
4 antibodies
Antibodies.com
3 antibodies
Rockland Immunochemicals, Inc.
3 antibodies
Santa Cruz Biotechnology
1 antibody
RabMAbs
7 antibodies
Abbiotec
7 antibodies
BioLegend
1 antibody
PeproTech Inc.
6 antibodies
Abbkine Scientific Co.Ltd.
4 antibodies
FabGennix
9 antibodies
Creative Biolabs
86 antibodies
MyBioSource
36 antibodies
RayBiotech, Inc.
5 antibodies
Creative Diagnostics
9 antibodies
United States Biological
186 antibodies
Arigo
6 antibodies
Abbexa
49 antibodies
Leading Biology
19 antibodies
MilliporeSigma / Merck KGaA
12 antibodies
GenWay
9 antibodies
EMD Millipore
5 antibodies
Atlas Antibodies
1 antibody
Miltenyi Biotec
6 antibodies
Spring Bioscience
4 antibodies
Abiocode, Inc.
1 antibody
Absolute Antibody
1 antibody
DB Biotech
1 antibody
MS Validated Antibodies GmbH
1 antibody
ONCOdianova
1 antibody