APR03602G
antibody from Leading Biology
Targeting: CDKN2A
ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p14ARF, p16, p16INK4a, p19, p19Arf
Antibody data
- Antibody Data
- Antigen structure
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- Validations [0]
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- Product number
- APR03602G - Provider product page
- Provider
- Leading Biology
- Product name
- p16INK4a Antibody (C-term E119)
- Antibody type
- Polyclonal
- Description
- This gene generates several transcript variants whichdiffer in their first exons. At least three alternatively splicedvariants encoding distinct proteins have been reported, two ofwhich encode structurally related isoforms known to function asinhibitors of CDK4 kinase. The remaining transcript includes analternate first exon located 20 Kb upstream of the remainder of thegene; this transcript contains an alternate open reading frame(ARF) that specifies a protein which is structurally unrelated tothe products of the other variants. This ARF product functions as astabilizer of the tumor suppressor protein p53 as it can interactwith, and sequester, MDM1, a protein responsible for thedegradation of p53. In spite of the structural and functionaldifferences, the CDK inhibitor isoforms and the ARF product encodedby this gene, through the regulatory roles of CDK4 and p53 in cellcycle G1 progression, share a common functionality in cell cycle G1control. This gene is frequently mutated or deleted in a widevariety of tumors, and is known to be an important tumor suppressorgene.
- Reactivity
- Human
- Host
- Rabbit
- Storage
- Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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