DCABH-2623

antibody from Creative Diagnostics

Targeting: DFFA DFF-45, DFF1, DFF45, ICAD

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

DCABH-2623

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DCABH-2623, RRID:AB_2476514

Product name

Rabbit Anti-Human DFFA polyclonal antibody

Antibody type

Polyclonal

Description

Apoptosis is induced through a number of cell death receptors and their ligands like TNF and TNF receptor. The signaling cascade is carried further by adaptor proteins containing death domains and by caspase family of proteins. DFF-45 and DFF-40 (ICAD and CAD) are two subunits of heterodimeric caspase activated DNAse. DFF-45/ICAD (Inhibitor of Caspase Activated DNAse) acts as a chaperon for appropriate folding of DFF-40 and it also acts as inhibitor of DFF-40. Caspase 3 upon activation cleaves DFF to release DFF-40/CAD, which oligomerizes into a large active complex and eventually causes the degradation of DNA in nuclei. Hence cleavage of DFF-45 is an important step in apoptosis.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Storage

2-8°C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date.