Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-B10085 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Mouse anti-Human DFFA monoclonal antibody, clone 4B22
- Antibody type
- Monoclonal
- Description
- Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 4B22
- Vial size
- 100 _g
- Storage
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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