orb148112

antibody from Biorbyt

Targeting: CENPA CenH3, CENP-A

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

orb148112

Provider

Biorbyt

Product name

CENP-A antibody

Antibody type

Monoclonal

Description

Mouse monoclonal to CENP-A (HRP). A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The Centromere Protein-A, CENP-A, is a Histone H3-like protein that contains a C-terminal H3-like domain, which is required for centromere localization of CENP-A, and an antigenic N-terminal domain. CENP-A, originally isolated from HeLa cells, is essential for kinetochore targeting of CENP-C. In the presence of DNA CENP-A forms an octa-meric complex with histones H4, H2A, H2B. CENP-A specifically localizes to active centromeres and is a component of specialized centromeric nucleosomes, on which kinetochores are assembled. CENP-A is essential for nucleosomal packaging of centromeric DNA at interphase and functions as a centromere formation marker on the chromosome..

Reactivity

Human

Host

Mouse

Conjugate

Horseradish Peroxidase

Isotype

IgG

Antibody clone number

5A7-2E11

Vial size

100 ug

Concentration

1 mg/ml

Storage

Conjugated antibodies should be stored at 4°C