692802

antibody from BioLegend
Targeting: RUNX2 AML3, CBFA1, CCD, CCD1, PEBP2A1, PEBP2aA1
Provider product page for 692802

Antibody data

Product number
692802 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#692802, RRID:AB_2632769
Product name
Purified anti-RUNX2
Antibody type
Monoclonal
Description
Runt Related Transcription Factor 2 (RUNX2), also known as CBFA1, belongs to the mammalian Runt-related transcription factor (RUNX) family. The RUNX family is comprised of three members: RUNX1, RUNX2, and RUNX3. The RUNX proteins are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. Among these members, RUNX2 contains one Runt domain and specifically expresses in osteoblasts. It plays critical roles in skeletal mineralization, osteoblast differentiation of mesenchymal stem cells, chondrocyte hypertrophy, endothelial cell migration, and vascular invasion of developing bones. Defects in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD) and defective endochondral and intramembranous bone formation. In some cases, defects in RUNX2 are exclusively associated with dental anomalies. RUNX2 binds DNA as a monomer or as a subunit of a heterodimeric complex. In osteoblasts, RUNX2 supports transcriptional activation by synergizing with SPEN/MINT. RUNX2 also functions to inhibit KAT6B (MYST4)-dependent transcriptional activation.
Reactivity
Human, Mouse
Host
Rat
Conjugate
Unconjugated
Antibody clone number
W15212A
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
RUNX2 protein structure - 692802 shown in red.