Tissue expression
Cell line expression
Protein structure
RUNX2
RUNX family transcription factor 2AML3, CBFA1, CCD, CCD1, PEBP2A1, PEBP2aA1
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016]
Top validated antibodies |
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Novus Biologicals | H00000860-M06 | 8 references | Monoclonal |
WB
EL
ICC
IHC
FA
ChIP |
|
Atlas Antibodies | HPA022040 | 3 references | Polyclonal |
WB
ICC
IHC
|
|
antibodies-online | ABIN514045 | 5 references | Monoclonal |
WB
EL
ICC
IHC |
|
Abnova Corporation | H00000860-M01 | 2 references | Monoclonal |
WB
EL
ICC
IHC |
|
Acris Antibodies GmbH | AM20580PU-N | Monoclonal |
WB
EL
ICC
IHC |
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Supportive data in Antibodypedia
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Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider