Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 11-8001 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-RUNX2 Antibody
- Antibody type
- Polyclonal
- Description
- Runt-related transcription factor 2 (Runx2) is also known as core-binding factor subunit alpha-1 (CBF-alpha-1). RunX2 is one of the three mammalian transcription factors sharing the highly conserved DNA-binding Runt domain that represents a key class of lineage-specific gene regulators and is associated with different micro-environments during the cell cycle. RUNX2 has a primary role in the differentiation of osteoblasts and hypertrophy of cartilage at the growth plate, cell migration and vascular invasion of bone and is also expressed in vascular endothelial cells and breast cancer cells. It is a heterodimer of an alpha and a beta subunit. RUNX2 plays a role in the disease metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly, and cleidocranial dysplasia. By alternative splicing, several isoforms exist.
- Reactivity
- Human
- Host
- Rabbit
- Antigen sequence
A partial length recombinant RUNX2
protein (amino acids 161-482) was u
sed as the immunogen for this antib
ody.- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
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Supportive validation
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- ABEOMICS Inc. (provider)
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- Experimental details
- Western blot analysis of RUNX2/ AML-3. Anti-RUNX2/ AML-3 antibody (11-8001) was used at 1 µg/ml on MCF-7 lysate.