Tissue expression
Cell line expression
Protein structure
TNFRSF8
TNF receptor superfamily member 8CD30, D1S166E, KI-1
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Invitrogen Antibodies | ![]() |
Monoclonal |
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antibodies-online | ![]() |
2 references | Polyclonal |
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Novus Biologicals | ![]() |
Monoclonal |
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Acris Antibodies GmbH | ![]() |
Monoclonal |
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LSBio | ![]() |
Monoclonal |
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