WDR13

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. A similar protein in mouse is thought to be a negative regulator of the pancreatic beta cell proliferation. Mice lacking this gene exhibit increased pancreatic islet mass and higher serum insulin levels, and are mildly obese. [provided by RefSeq, Nov 2016]

Description

WD repeat domain 13

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Plasma membrane, Centriolar satellite

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X:p11.23 (48590042 - 48608869)

Ensembl ID

ENSG00000101940  (ver. 103.38)

Orthologs

Mouse Wdr13: ENSMUSG00000031166

UniProt

Q9H1Z4

neXtProt

NX_Q9H1Z4

Human splice variants
Mouse splice variants