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Western blot
ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [139]
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- Product number
- MA1-12296 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Anti-Cyclin D1 Monoclonal Antibody (DCS-6)
- Antibody type
- Monoclonal
- Antigen
- Recombinant full-length protein
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- DCS-6
- Vial size
- 100 µg
- Concentration
- Lot Dependent
- Storage
- -20° C, Avoid Freeze/Thaw Cycles
Submitted references Hyper sensitive protein detection by Tandem-HTRF reveals Cyclin D1 dynamics in adult mouse.
Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis.
Overexpression of β-catenin and cyclinD1 predicts a poor prognosis in ovarian serous carcinomas.
Aberrant expression pattern and location of cullin 1 are associated with the development of papillary carcinoma in thyroid and cyclin D1 expression.
Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells.
WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear β-Catenin depend on active PI3K signaling.
SHIP2 signaling in normal and pathological situations: Its impact on cell proliferation.
Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway.
Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors.
Mechanisms of resveratrol-induced inhibition of clonal expansion and terminal adipogenic differentiation in 3T3-L1 preadipocytes.
Targeting cell cycle and hormone receptor pathways in cancer.
Nitric oxide production upregulates Wnt/β-catenin signaling by inhibiting Dickkopf-1.
CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.
Cell cycle activation contributes to increased neuronal activity in the posterior thalamic nucleus and associated chronic hyperesthesia after rat spinal cord contusion.
'Monster cell' melanoma with pulmonary metastasis and cyclin D1 amplification.
Carboplatin delays mammary cancer 4T1 growth in mice.
UBE2QL1 is disrupted by a constitutional translocation associated with renal tumor predisposition and is a novel candidate renal tumor suppressor gene.
Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63.
Identification of microRNA-mRNA functional interactions in UVB-induced senescence of human diploid fibroblasts.
EGFR inhibition in glioma cells modulates Rho signaling to inhibit cell motility and invasion and cooperates with temozolomide to reduce cell growth.
Synergistic Effect of Hyperglycemia and p27(kip1) Suppression on Adult Mouse Islet Beta Cell Replication.
Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma.
The role of cyclin D1 expression and patient's survival in non-small-cell lung cancer: a systematic review with meta-analysis.
ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice.
Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development.
The tumour suppressor FOXO3 is a key regulator of mantle cell lymphoma proliferation and survival.
Metabotropic glutamate receptor 5 promotes proliferation of human neural stem/progenitor cells with activation of mitogen-activated protein kinases signaling pathway in vitro.
Oncogenic role of EAPII in lung cancer development and its activation of the MAPK-ERK pathway.
Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane.
Hepatic carcinoma-associated fibroblasts promote an adaptative response in colorectal cancer cells that inhibit proliferation and apoptosis: nonresistant cells die by nonapoptotic cell death.
IDH1 and IDH2 mutations, immunohistochemistry and associations in a series of brain tumors.
Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer.
Melatonin delays cell proliferation by inducing G1 and G2 /M phase arrest in a human osteoblastic cell line hFOB 1.19.
Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression.
Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930.
Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin.
Classical membrane progesterone receptors in murine mammary carcinomas: agonistic effects of progestins and RU-486 mediating rapid non-genomic effects.
The adaptive compensations in endocrine pancreas from glucocorticoid-treated rats are reversible after the interruption of treatment.
Sansalvamide induces pancreatic cancer growth arrest through changes in the cell cycle.
1 Alpha,25-dihydroxyvitamin D3 and its TX527 analog inhibit the growth of endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein-coupled receptor in vitro and in vivo.
Hypoxia stimulates proliferation of rat neural stem cells with influence on the expression of cyclin D1 and c-Jun N-terminal protein kinase signaling pathway in vitro.
AMN082 promotes the proliferation and differentiation of neural progenitor cells with influence on phosphorylation of MAPK signaling pathways.
Expression of cyclin D2 is an independent predictor of the development of hepatic metastasis in colorectal cancer.
Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis.
E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin.
Interleukin-24 induces expression of beta4 integrin but suppresses anchorage-independent growth of rat mammary tumor cells by a mechanism that is independent of beta4.
Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2.
Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53.
Differential response of glioma cells to FOXO1-directed therapy.
Eukaryotic initiation factor-4E and cyclin D1 expression associated with patient survival in lung cancer.
PCDH24-induced contact inhibition involves downregulation of beta-catenin signaling.
Cyclin A is essential for the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells.
Relationship of phospho-pRb (Ser-807/811) level to exposure to tobacco smoke in primary non-small cell lung cancer.
High doses of dexamethasone induce increased beta-cell proliferation in pancreatic rat islets.
Immunophenotypic analysis of CD103+ B-lymphoproliferative disorders: hairy cell leukemia and its mimics.
Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo.
Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4.
TRPM6 expression and cell proliferation are up-regulated by phosphorylation of ERK1/2 in renal epithelial cells.
BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer.
Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo.
Functions of p21 and p27 in the regenerating epithelial linings of the mouse small and large intestine.
CCND1 polymorphisms (A870G and C1722G) modulate its protein expression and survival in oral carcinoma.
Deregulated expression of p16INK4a and p53 pathway members in benign and malignant myoepithelial tumours of the salivary glands.
Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis.
An acidic environment changes cyclin D1 localization and alters colony forming ability in gliomas.
The over-expression of p53 H179Y residue mutation causes the increase of cyclin A1 and Cdk4 expression in HELF cells.
Hydrocortisone and indomethacin negatively modulate EGF-R signaling in human fetal intestine.
Proliferation and migration mediated by Dkk-1/Wnt/beta-catenin cascade in a model of hepatocellular carcinoma cells.
The Ets transcription factor GABP is required for cell-cycle progression.
Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells.
The significance of Ki-67 proliferative index and cyclin D1 expression of dysplastic nevi in the biologic spectrum of melanocytic lesions.
Poorly differentiated follicular thyroid carcinoma: prognostic factors and relevance of histological classification.
Cyclin A but not cyclin D1 is essential for c-myc-modulated cell-cycle progression.
Cdk1 is sufficient to drive the mammalian cell cycle.
Intrasinusoidal bone marrow infiltration and splenic marginal zone lymphoma: a quantitative study.
The role of p28GANK in rat oval cells activation and proliferation.
Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways.
Correlation of cyclin D1 and cyclin D3 overexpression with the loss of PTEN expression in endometrial carcinoma.
Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis.
Differential utilization of cyclin D1 and cyclin D3 in the distinct mitogenic stimulations by growth factors and TSH of human thyrocytes in primary culture.
HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway.
Array-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma.
Absence of IHH and retention of PTHrP signalling in enchondromas and central chondrosarcomas.
Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria.
In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202.
Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells.
Coordinated expression of cyclin D1 and LEF-1/TCF transcription factor is restricted to a subset of hepatocellular carcinoma.
Expression of D-type cyclins in colon cancer and in cell lines from colon carcinomas.
ILK is required for the assembly of matrix-forming adhesions and capillary morphogenesis in endothelial cells.
Skp2-dependent degradation of p27kip1 is essential for cell cycle progression.
p53, p16 and cyclin D1: molecular determinants of radiotherapy treatment response in oral carcinoma.
Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation.
Overexpression of the colony-stimulating factor (CSF-1) and/or its receptor c-fms in mammary glands of transgenic mice results in hyperplasia and tumor formation.
Endogenous human prolactin and not exogenous human prolactin induces estrogen receptor alpha and prolactin receptor expression and increases estrogen responsiveness in breast cancer cells.
Differential expression of the calcium sensing receptor and combined loss of chromosomes 1q and 11q in parathyroid carcinoma.
Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver.
Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver.
Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition by p16(INK4a).
The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway.
Cdk4 is indispensable for postnatal proliferation of the anterior pituitary.
Role of the phosphatidylinositol 3'-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines.
Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen-stimulated rat hepatocytes.
G3139 (oblimersen) may inhibit prostate cancer cell growth in a partially bis-CpG-dependent non-antisense manner.
Validation of tissue array technology in head and neck squamous cell carcinoma.
Expression of angiotensin type II receptor downregulates Cdk4 synthesis and inhibits cell-cycle progression.
Differences in the pathologic and molecular features of intraductal breast carcinoma between younger and older women.
Cyclin D2 compensates for the loss of cyclin D1 in estrogen-induced mouse uterine epithelial cell proliferation.
Alterations of beta-catenin pathway in non-melanoma skin tumors: loss of alpha-ABC nuclear reactivity correlates with the presence of beta-catenin gene mutation.
Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas.
Roles of mitogen-activated protein kinase and phosphoinositide 3'-kinase in ErbB2/ErbB3 coreceptor-mediated heregulin signaling.
Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells.
Another case of mantle cell lymphoma presenting as breast masses.
Stage-dependent activation of cell cycle and apoptosis mechanisms in the right ventricle by pressure overload.
Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties.
Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)-dependent manner.
Overexpression of aromatase leads to hyperplasia and changes in the expression of genes involved in apoptosis, cell cycle, growth, and tumor suppressor functions in the mammary glands of transgenic mice.
Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts -- a possible mechanism for arsenite's comutagenicity.
Analysis of C-MYC function in normal cells via conditional gene-targeted mutation.
Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas.
Telomerase activation cooperates with inactivation of p16 in early head and neck tumorigenesis.
Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice.
Metabolic stabilization of p27 in senescent fibroblasts correlates with reduced expression of the F-box protein Skp2.
Regulation of cell cycle and cyclins by 16alpha-hydroxyestrone in MCF-7 breast cancer cells.
TGFbeta and PTHrP control chondrocyte proliferation by activating cyclin D1 expression.
Large cell variants of CD5+, CD23- B-cell lymphoma/leukemia.
Analysis of the transcriptional program induced by Raf in epithelial cells.
Abnormal expression of cell cycle regulatory proteins in ductal and lobular carcinomas of the breast.
Cyclin D1 overexpression is a critical event in gallbladder carcinogenesis and independently predicts decreased survival for patients with gallbladder carcinoma.
v-Jun overrides the mitogen dependence of S-phase entry by deregulating retinoblastoma protein phosphorylation and E2F-pocket protein interactions as a consequence of enhanced cyclin E-cdk2 catalytic activity.
Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity.
Progesterone inhibits estrogen-induced cyclin D1 and cdk4 nuclear translocation, cyclin E- and cyclin A-cdk2 kinase activation, and cell proliferation in uterine epithelial cells in mice.
Cyclin-D1 expression in node-positive (N+) and node-negative (N-) infiltrating human mammary carcinomas.
Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1.
Anchorage-independent transcription of the cyclin A gene induced by the E7 oncoprotein of human papillomavirus type 16.
Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum.
Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4.
Role of cyclins in neuronal differentiation of immortalized hippocampal cells.
The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.
A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes.
Zampieri A, Champagne J, Auzemery B, Fuentes I, Maurel B, Bienvenu F
Scientific reports 2015 Oct 27;5:15739
Scientific reports 2015 Oct 27;5:15739
Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis.
Casimiro MC, Di Sante G, Crosariol M, Loro E, Dampier W, Ertel A, Yu Z, Saria EA, Papanikolaou A, Li Z, Wang C, Addya S, Lisanti MP, Fortina P, Cardiff RD, Tozeren A, Knudsen ES, Arnold A, Pestell RG
Oncotarget 2015 Apr 20;6(11):8525-38
Oncotarget 2015 Apr 20;6(11):8525-38
Overexpression of β-catenin and cyclinD1 predicts a poor prognosis in ovarian serous carcinomas.
Wang H, Wang H, Makki MS, Wen J, Dai Y, Shi Q, Liu Q, Zhou X, Wang J
International journal of clinical and experimental pathology 2014;7(1):264-71
International journal of clinical and experimental pathology 2014;7(1):264-71
Aberrant expression pattern and location of cullin 1 are associated with the development of papillary carcinoma in thyroid and cyclin D1 expression.
Do SI, Kim K, Lee H, Kim HS, Do TG, Yun J, Kim DH, Chae SW, Park YL, Park CH, Sohn JH, Min KW, Pyo JS
Endocrine pathology 2014 Sep;25(3):282-7
Endocrine pathology 2014 Sep;25(3):282-7
Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells.
Tian L, Wang C, Hagen FK, Gormley M, Addya S, Soccio R, Casimiro MC, Zhou J, Powell MJ, Xu P, Deng H, Sauve AA, Pestell RG
Oncotarget 2014 Sep 15;5(17):7303-15
Oncotarget 2014 Sep 15;5(17):7303-15
WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear β-Catenin depend on active PI3K signaling.
Ormanns S, Neumann J, Horst D, Kirchner T, Jung A
Oncotarget 2014 May 30;5(10):2999-3011
Oncotarget 2014 May 30;5(10):2999-3011
SHIP2 signaling in normal and pathological situations: Its impact on cell proliferation.
Elong Edimo W, Schurmans S, Roger PP, Erneux C
Advances in biological regulation 2014 Jan;54:142-51
Advances in biological regulation 2014 Jan;54:142-51
Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway.
Shukla S, Bhaskaran N, Babcook MA, Fu P, Maclennan GT, Gupta S
Carcinogenesis 2014 Feb;35(2):452-60
Carcinogenesis 2014 Feb;35(2):452-60
Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors.
Cerqueira A, Martín A, Symonds CE, Odajima J, Dubus P, Barbacid M, Santamaría D
Molecular and cellular biology 2014 Apr;34(8):1452-9
Molecular and cellular biology 2014 Apr;34(8):1452-9
Mechanisms of resveratrol-induced inhibition of clonal expansion and terminal adipogenic differentiation in 3T3-L1 preadipocytes.
Mitterberger MC, Zwerschke W
The journals of gerontology. Series A, Biological sciences and medical sciences 2013 Nov;68(11):1356-76
The journals of gerontology. Series A, Biological sciences and medical sciences 2013 Nov;68(11):1356-76
Targeting cell cycle and hormone receptor pathways in cancer.
Comstock CE, Augello MA, Goodwin JF, de Leeuw R, Schiewer MJ, Ostrander WF Jr, Burkhart RA, McClendon AK, McCue PA, Trabulsi EJ, Lallas CD, Gomella LG, Centenera MM, Brody JR, Butler LM, Tilley WD, Knudsen KE
Oncogene 2013 Nov 28;32(48):5481-91
Oncogene 2013 Nov 28;32(48):5481-91
Nitric oxide production upregulates Wnt/β-catenin signaling by inhibiting Dickkopf-1.
Du Q, Zhang X, Liu Q, Zhang X, Bartels CE, Geller DA
Cancer research 2013 Nov 1;73(21):6526-37
Cancer research 2013 Nov 1;73(21):6526-37
CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.
Bisteau X, Paternot S, Colleoni B, Ecker K, Coulonval K, De Groote P, Declercq W, Hengst L, Roger PP
PLoS genetics 2013 May;9(5):e1003546
PLoS genetics 2013 May;9(5):e1003546
Cell cycle activation contributes to increased neuronal activity in the posterior thalamic nucleus and associated chronic hyperesthesia after rat spinal cord contusion.
Wu J, Raver C, Piao C, Keller A, Faden AI
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2013 Jul;10(3):520-38
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2013 Jul;10(3):520-38
'Monster cell' melanoma with pulmonary metastasis and cyclin D1 amplification.
Hawryluk EB, Baran JL, Gerami P, Sepehr A
Journal of cutaneous pathology 2013 Jan;40(1):61-5
Journal of cutaneous pathology 2013 Jan;40(1):61-5
Carboplatin delays mammary cancer 4T1 growth in mice.
Souza CM, Gamba Cde O, Campos CB, Lopes MT, Ferreira MA, Andrade SP, Cassali GD
Pathology, research and practice 2013 Jan 15;209(1):24-9
Pathology, research and practice 2013 Jan 15;209(1):24-9
UBE2QL1 is disrupted by a constitutional translocation associated with renal tumor predisposition and is a novel candidate renal tumor suppressor gene.
Wake NC, Ricketts CJ, Morris MR, Prigmore E, Gribble SM, Skytte AB, Brown M, Clarke N, Banks RE, Hodgson S, Turnell AS, Maher ER, Woodward ER
Human mutation 2013 Dec;34(12):1650-61
Human mutation 2013 Dec;34(12):1650-61
Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63.
Liu L, Xu Y, Reiter RJ
Bone 2013 Aug;55(2):432-8
Bone 2013 Aug;55(2):432-8
Identification of microRNA-mRNA functional interactions in UVB-induced senescence of human diploid fibroblasts.
Greussing R, Hackl M, Charoentong P, Pauck A, Monteforte R, Cavinato M, Hofer E, Scheideler M, Neuhaus M, Micutkova L, Mueck C, Trajanoski Z, Grillari J, Jansen-Dürr P
BMC genomics 2013 Apr 4;14:224
BMC genomics 2013 Apr 4;14:224
EGFR inhibition in glioma cells modulates Rho signaling to inhibit cell motility and invasion and cooperates with temozolomide to reduce cell growth.
Ramis G, Thomàs-Moyà E, Fernández de Mattos S, Rodríguez J, Villalonga P
PloS one 2012;7(6):e38770
PloS one 2012;7(6):e38770
Synergistic Effect of Hyperglycemia and p27(kip1) Suppression on Adult Mouse Islet Beta Cell Replication.
Chen ST, Fu SH, Hsu S, Huang YY, Hsu BR
International journal of endocrinology 2012;2012:417390
International journal of endocrinology 2012;2012:417390
Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma.
Naganuma S, Whelan KA, Natsuizaka M, Kagawa S, Kinugasa H, Chang S, Subramanian H, Rhoades B, Ohashi S, Itoh H, Herlyn M, Diehl JA, Gimotty PA, Klein-Szanto AJ, Nakagawa H
American journal of cancer research 2012;2(4):459-75
American journal of cancer research 2012;2(4):459-75
The role of cyclin D1 expression and patient's survival in non-small-cell lung cancer: a systematic review with meta-analysis.
Zhang LQ, Jiang F, Xu L, Wang J, Bai JL, Yin R, Wu YQ, Meng LJ
Clinical lung cancer 2012 May;13(3):188-95
Clinical lung cancer 2012 May;13(3):188-95
ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice.
Casimiro MC, Crosariol M, Loro E, Ertel A, Yu Z, Dampier W, Saria EA, Papanikolaou A, Stanek TJ, Li Z, Wang C, Fortina P, Addya S, Tozeren A, Knudsen ES, Arnold A, Pestell RG
The Journal of clinical investigation 2012 Mar;122(3):833-43
The Journal of clinical investigation 2012 Mar;122(3):833-43
Combined effect of cyclin D3 expression and abrogation of cyclin D1 prevent mouse skin tumor development.
Wang X, Sistrunk C, Miliani de Marval PL, Kim Y, Rodriguez-Puebla ML
Cell cycle (Georgetown, Tex.) 2012 Jan 15;11(2):335-42
Cell cycle (Georgetown, Tex.) 2012 Jan 15;11(2):335-42
The tumour suppressor FOXO3 is a key regulator of mantle cell lymphoma proliferation and survival.
Obrador-Hevia A, Serra-Sitjar M, Rodríguez J, Villalonga P, Fernández de Mattos S
British journal of haematology 2012 Feb;156(3):334-45
British journal of haematology 2012 Feb;156(3):334-45
Metabotropic glutamate receptor 5 promotes proliferation of human neural stem/progenitor cells with activation of mitogen-activated protein kinases signaling pathway in vitro.
Zhao L, Jiao Q, Yang P, Chen X, Zhang J, Zhao B, Zheng P, Liu Y
Neuroscience 2011 Sep 29;192:185-94
Neuroscience 2011 Sep 29;192:185-94
Oncogenic role of EAPII in lung cancer development and its activation of the MAPK-ERK pathway.
Li C, Fan S, Owonikoko TK, Khuri FR, Sun SY, Li R
Oncogene 2011 Sep 1;30(35):3802-12
Oncogene 2011 Sep 1;30(35):3802-12
Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane.
Gierut J, Zheng Y, Bie W, Carroll RE, Ball-Kell S, Haegebarth A, Tyner AL
Gastroenterology 2011 Oct;141(4):1371-80, 1380.e1-2
Gastroenterology 2011 Oct;141(4):1371-80, 1380.e1-2
Hepatic carcinoma-associated fibroblasts promote an adaptative response in colorectal cancer cells that inhibit proliferation and apoptosis: nonresistant cells die by nonapoptotic cell death.
Berdiel-Acer M, Bohem ME, López-Doriga A, Vidal A, Salazar R, Martínez-Iniesta M, Santos C, Sanjuan X, Villanueva A, Molleví DG
Neoplasia (New York, N.Y.) 2011 Oct;13(10):931-46
Neoplasia (New York, N.Y.) 2011 Oct;13(10):931-46
IDH1 and IDH2 mutations, immunohistochemistry and associations in a series of brain tumors.
Mellai M, Piazzi A, Caldera V, Monzeglio O, Cassoni P, Valente G, Schiffer D
Journal of neuro-oncology 2011 Nov;105(2):345-57
Journal of neuro-oncology 2011 Nov;105(2):345-57
Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer.
Cerliani JP, Guillardoy T, Giulianelli S, Vaque JP, Gutkind JS, Vanzulli SI, Martins R, Zeitlin E, Lamb CA, Lanari C
Cancer research 2011 May 15;71(10):3720-31
Cancer research 2011 May 15;71(10):3720-31
Melatonin delays cell proliferation by inducing G1 and G2 /M phase arrest in a human osteoblastic cell line hFOB 1.19.
Liu L, Zhu Y, Xu Y, Reiter RJ
Journal of pineal research 2011 Mar;50(2):222-31
Journal of pineal research 2011 Mar;50(2):222-31
Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression.
de Cárcer G, Escobar B, Higuero AM, García L, Ansón A, Pérez G, Mollejo M, Manning G, Meléndez B, Abad-Rodríguez J, Malumbres M
Molecular and cellular biology 2011 Mar;31(6):1225-39
Molecular and cellular biology 2011 Mar;31(6):1225-39
Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930.
Yap TA, Walton MI, Hunter LJ, Valenti M, de Haven Brandon A, Eve PD, Ruddle R, Heaton SP, Henley A, Pickard L, Vijayaraghavan G, Caldwell JJ, Thompson NT, Aherne W, Raynaud FI, Eccles SA, Workman P, Collins I, Garrett MD
Molecular cancer therapeutics 2011 Feb;10(2):360-71
Molecular cancer therapeutics 2011 Feb;10(2):360-71
Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin.
Wei W, Chua MS, Grepper S, So SK
Molecular cancer 2011 Feb 11;10:16
Molecular cancer 2011 Feb 11;10:16
Classical membrane progesterone receptors in murine mammary carcinomas: agonistic effects of progestins and RU-486 mediating rapid non-genomic effects.
Bottino MC, Cerliani JP, Rojas P, Giulianelli S, Soldati R, Mondillo C, Gorostiaga MA, Pignataro OP, Calvo JC, Gutkind JS, Panomwat Amornphimoltham, Molinolo AA, Lüthy IA, Lanari C
Breast cancer research and treatment 2011 Apr;126(3):621-36
Breast cancer research and treatment 2011 Apr;126(3):621-36
The adaptive compensations in endocrine pancreas from glucocorticoid-treated rats are reversible after the interruption of treatment.
Rafacho A, Quallio S, Ribeiro DL, Taboga SR, Paula FM, Boschero AC, Bosqueiro JR
Acta physiologica (Oxford, England) 2010 Nov;200(3):223-35
Acta physiologica (Oxford, England) 2010 Nov;200(3):223-35
Sansalvamide induces pancreatic cancer growth arrest through changes in the cell cycle.
Heiferman MJ, Salabat MR, Ujiki MB, Strouch MJ, Cheon EC, Silverman RB, Bentrem DJ
Anticancer research 2010 Jan;30(1):73-8
Anticancer research 2010 Jan;30(1):73-8
1 Alpha,25-dihydroxyvitamin D3 and its TX527 analog inhibit the growth of endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein-coupled receptor in vitro and in vivo.
Gonzalez-Pardo V, Martin D, Gutkind JS, Verstuyf A, Bouillon R, de Boland AR, Boland RL
Endocrinology 2010 Jan;151(1):23-31
Endocrinology 2010 Jan;151(1):23-31
Hypoxia stimulates proliferation of rat neural stem cells with influence on the expression of cyclin D1 and c-Jun N-terminal protein kinase signaling pathway in vitro.
Chen X, Tian Y, Yao L, Zhang J, Liu Y
Neuroscience 2010 Feb 3;165(3):705-14
Neuroscience 2010 Feb 3;165(3):705-14
AMN082 promotes the proliferation and differentiation of neural progenitor cells with influence on phosphorylation of MAPK signaling pathways.
Tian Y, Liu Y, Chen X, Kang Q, Zhang J, Shi Q, Zhang H
Neurochemistry international 2010 Aug;57(1):8-15
Neurochemistry international 2010 Aug;57(1):8-15
Expression of cyclin D2 is an independent predictor of the development of hepatic metastasis in colorectal cancer.
Sarkar R, Hunter IA, Rajaganeshan R, Perry SL, Guillou P, Jayne DG
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 2010 Apr;12(4):316-23
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 2010 Apr;12(4):316-23
Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis.
Li Y, Tan X, Dai C, Stolz DB, Wang D, Liu Y
Journal of the American Society of Nephrology : JASN 2009 Sep;20(9):1907-18
Journal of the American Society of Nephrology : JASN 2009 Sep;20(9):1907-18
E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin.
Chimploy K, Díaz GD, Li Q, Carter O, Dashwood WM, Mathews CK, Williams DE, Bailey GS, Dashwood RH
International journal of cancer 2009 Nov 1;125(9):2086-94
International journal of cancer 2009 Nov 1;125(9):2086-94
Interleukin-24 induces expression of beta4 integrin but suppresses anchorage-independent growth of rat mammary tumor cells by a mechanism that is independent of beta4.
Xuan W, Li YJ, Liu G, Ben-David Y, Archer MC
Molecular cancer research : MCR 2009 Mar;7(3):433-42
Molecular cancer research : MCR 2009 Mar;7(3):433-42
Multiple division cycles and long-term survival of hepatocytes are distinctly regulated by extracellular signal-regulated kinases ERK1 and ERK2.
Frémin C, Bessard A, Ezan F, Gailhouste L, Régeard M, Le Seyec J, Gilot D, Pagès G, Pouysségur J, Langouët S, Baffet G
Hepatology (Baltimore, Md.) 2009 Mar;49(3):930-9
Hepatology (Baltimore, Md.) 2009 Mar;49(3):930-9
Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53.
Sohn D, Graupner V, Neise D, Essmann F, Schulze-Osthoff K, Jänicke RU
Cell death and differentiation 2009 Jun;16(6):869-78
Cell death and differentiation 2009 Jun;16(6):869-78
Differential response of glioma cells to FOXO1-directed therapy.
Lau CJ, Koty Z, Nalbantoglu J
Cancer research 2009 Jul 1;69(13):5433-40
Cancer research 2009 Jul 1;69(13):5433-40
Eukaryotic initiation factor-4E and cyclin D1 expression associated with patient survival in lung cancer.
Khoury T, Alrawi S, Ramnath N, Li Q, Grimm M, Black J, Tan D
Clinical lung cancer 2009 Jan;10(1):58-66
Clinical lung cancer 2009 Jan;10(1):58-66
PCDH24-induced contact inhibition involves downregulation of beta-catenin signaling.
Ose R, Yanagawa T, Ikeda S, Ohara O, Koga H
Molecular oncology 2009 Feb;3(1):54-66
Molecular oncology 2009 Feb;3(1):54-66
Cyclin A is essential for the p53-modulated inhibition from benzo(a)pyrene toxicity in A549 cells.
Wang Z, Qi Y, Chen Q, Yang D, Tang S, Jin X, Gao J, Fu J, Zhou Z, Wang J, Xiao X
Toxicology 2009 Feb 4;256(1-2):1-6
Toxicology 2009 Feb 4;256(1-2):1-6
Relationship of phospho-pRb (Ser-807/811) level to exposure to tobacco smoke in primary non-small cell lung cancer.
Ko E, Kim Y, Lee BB, Han J, Song SY, Shim YM, Park J, Kim DH
Cancer letters 2009 Feb 18;274(2):225-32
Cancer letters 2009 Feb 18;274(2):225-32
High doses of dexamethasone induce increased beta-cell proliferation in pancreatic rat islets.
Rafacho A, Cestari TM, Taboga SR, Boschero AC, Bosqueiro JR
American journal of physiology. Endocrinology and metabolism 2009 Apr;296(4):E681-9
American journal of physiology. Endocrinology and metabolism 2009 Apr;296(4):E681-9
Immunophenotypic analysis of CD103+ B-lymphoproliferative disorders: hairy cell leukemia and its mimics.
Dong HY, Weisberger J, Liu Z, Tugulea S
American journal of clinical pathology 2009 Apr;131(4):586-95
American journal of clinical pathology 2009 Apr;131(4):586-95
Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo.
Tiedemann RE, Schmidt J, Keats JJ, Shi CX, Zhu YX, Palmer SE, Mao X, Schimmer AD, Stewart AK
Blood 2009 Apr 23;113(17):4027-37
Blood 2009 Apr 23;113(17):4027-37
Phosphorylation of p27Kip1 regulates assembly and activation of cyclin D1-Cdk4.
Larrea MD, Liang J, Da Silva T, Hong F, Shao SH, Han K, Dumont D, Slingerland JM
Molecular and cellular biology 2008 Oct;28(20):6462-72
Molecular and cellular biology 2008 Oct;28(20):6462-72
TRPM6 expression and cell proliferation are up-regulated by phosphorylation of ERK1/2 in renal epithelial cells.
Ikari A, Okude C, Sawada H, Yamazaki Y, Sugatani J, Miwa M
Biochemical and biophysical research communications 2008 May 16;369(4):1129-33
Biochemical and biophysical research communications 2008 May 16;369(4):1129-33
BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast cancer.
Xia W, Nagase S, Montia AG, Kalachikov SM, Keniry M, Su T, Memeo L, Hibshoosh H, Parsons R
Cancer research 2008 Mar 15;68(6):1667-74
Cancer research 2008 Mar 15;68(6):1667-74
Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo.
Dagvadorj A, Kirken RA, Leiby B, Karras J, Nevalainen MT
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Mar 1;14(5):1317-24
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Mar 1;14(5):1317-24
Functions of p21 and p27 in the regenerating epithelial linings of the mouse small and large intestine.
Zheng Y, Bie W, Yang R, Perekatt AO, Poole AJ, Tyner AL
Cancer biology & therapy 2008 Jun;7(6):873-9
Cancer biology & therapy 2008 Jun;7(6):873-9
CCND1 polymorphisms (A870G and C1722G) modulate its protein expression and survival in oral carcinoma.
Sathyan KM, Nalinakumari KR, Abraham T, Kannan S
Oral oncology 2008 Jul;44(7):689-97
Oral oncology 2008 Jul;44(7):689-97
Deregulated expression of p16INK4a and p53 pathway members in benign and malignant myoepithelial tumours of the salivary glands.
Vékony H, Röser K, Löning T, Raaphorst FM, Leemans CR, Van der Waal I, Bloemena E
Histopathology 2008 Dec;53(6):658-66
Histopathology 2008 Dec;53(6):658-66
Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis.
Giulianelli S, Cerliani JP, Lamb CA, Fabris VT, Bottino MC, Gorostiaga MA, Novaro V, Góngora A, Baldi A, Molinolo A, Lanari C
International journal of cancer 2008 Dec 1;123(11):2518-31
International journal of cancer 2008 Dec 1;123(11):2518-31
An acidic environment changes cyclin D1 localization and alters colony forming ability in gliomas.
Schnier JB, Nishi K, Harley WR, Gorin FA
Journal of neuro-oncology 2008 Aug;89(1):19-26
Journal of neuro-oncology 2008 Aug;89(1):19-26
The over-expression of p53 H179Y residue mutation causes the increase of cyclin A1 and Cdk4 expression in HELF cells.
Yang D, Qi Y, Chen Q, Wang Z, Jin X, Gao J, Fu J, Xiao X, Zhou Z
Molecular and cellular biochemistry 2007 Oct;304(1-2):219-26
Molecular and cellular biochemistry 2007 Oct;304(1-2):219-26
Hydrocortisone and indomethacin negatively modulate EGF-R signaling in human fetal intestine.
Kajanne R, Leppä S, Luukkainen P, Ustinov J, Thiel A, Ristimäki A, Miettinen PJ
Pediatric research 2007 Nov;62(5):570-5
Pediatric research 2007 Nov;62(5):570-5
Proliferation and migration mediated by Dkk-1/Wnt/beta-catenin cascade in a model of hepatocellular carcinoma cells.
Qin X, Zhang H, Zhou X, Wang C, Zhang H, Zhang X, Ye L
Translational research : the journal of laboratory and clinical medicine 2007 Nov;150(5):281-94
Translational research : the journal of laboratory and clinical medicine 2007 Nov;150(5):281-94
The Ets transcription factor GABP is required for cell-cycle progression.
Yang ZF, Mott S, Rosmarin AG
Nature cell biology 2007 Mar;9(3):339-46
Nature cell biology 2007 Mar;9(3):339-46
Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells.
Wiseman DA, Werner SR, Crowell PL
The Journal of pharmacology and experimental therapeutics 2007 Mar;320(3):1163-70
The Journal of pharmacology and experimental therapeutics 2007 Mar;320(3):1163-70
The significance of Ki-67 proliferative index and cyclin D1 expression of dysplastic nevi in the biologic spectrum of melanocytic lesions.
Lebe B, Pabuççuoğlu U, Ozer E
Applied immunohistochemistry & molecular morphology : AIMM 2007 Jun;15(2):160-4
Applied immunohistochemistry & molecular morphology : AIMM 2007 Jun;15(2):160-4
Poorly differentiated follicular thyroid carcinoma: prognostic factors and relevance of histological classification.
Pulcrano M, Boukheris H, Talbot M, Caillou B, Dupuy C, Virion A, De Vathaire F, Schlumberger M
Thyroid : official journal of the American Thyroid Association 2007 Jul;17(7):639-46
Thyroid : official journal of the American Thyroid Association 2007 Jul;17(7):639-46
Cyclin A but not cyclin D1 is essential for c-myc-modulated cell-cycle progression.
Qi Y, Tu Y, Yang D, Chen Q, Xiao J, Chen Y, Fu J, Xiao X, Zhou Z
Journal of cellular physiology 2007 Jan;210(1):63-71
Journal of cellular physiology 2007 Jan;210(1):63-71
Cdk1 is sufficient to drive the mammalian cell cycle.
Santamaría D, Barrière C, Cerqueira A, Hunt S, Tardy C, Newton K, Cáceres JF, Dubus P, Malumbres M, Barbacid M
Nature 2007 Aug 16;448(7155):811-5
Nature 2007 Aug 16;448(7155):811-5
Intrasinusoidal bone marrow infiltration and splenic marginal zone lymphoma: a quantitative study.
Pich A, Fraire F, Fornari A, Bonino LD, Godio L, Bortolin P, Chiusa L, Palestro G
European journal of haematology 2006 May;76(5):392-8
European journal of haematology 2006 May;76(5):392-8
The role of p28GANK in rat oval cells activation and proliferation.
Shan YF, Zhou WP, Fu XY, Yan HX, Yang W, Liu SQ, Cao HF, Kang B, Wu MC, Wang HY
Liver international : official journal of the International Association for the Study of the Liver 2006 Mar;26(2):240-7
Liver international : official journal of the International Association for the Study of the Liver 2006 Mar;26(2):240-7
Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways.
Friedrichsen BN, Neubauer N, Lee YC, Gram VK, Blume N, Petersen JS, Nielsen JH, Møldrup A
The Journal of endocrinology 2006 Mar;188(3):481-92
The Journal of endocrinology 2006 Mar;188(3):481-92
Correlation of cyclin D1 and cyclin D3 overexpression with the loss of PTEN expression in endometrial carcinoma.
Wu W, Slomovitz BM, Soliman PT, Schmeler KM, Celestino J, Milam MR, Lu KH
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2006 Jul-Aug;16(4):1668-72
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2006 Jul-Aug;16(4):1668-72
Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis.
Kanungo A, Medeiros LJ, Abruzzo LV, Lin P
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2006 Jan;19(1):25-33
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2006 Jan;19(1):25-33
Differential utilization of cyclin D1 and cyclin D3 in the distinct mitogenic stimulations by growth factors and TSH of human thyrocytes in primary culture.
Paternot S, Dumont JE, Roger PP
Molecular endocrinology (Baltimore, Md.) 2006 Dec;20(12):3279-92
Molecular endocrinology (Baltimore, Md.) 2006 Dec;20(12):3279-92
HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway.
Toschi E, Bacigalupo I, Strippoli R, Chiozzini C, Cereseto A, Falchi M, Nappi F, Sgadari C, Barillari G, Mainiero F, Ensoli B
Molecular biology of the cell 2006 Apr;17(4):1985-94
Molecular biology of the cell 2006 Apr;17(4):1985-94
Array-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma.
Hui AB, Or YY, Takano H, Tsang RK, To KF, Guan XY, Sham JS, Hung KW, Lam CN, van Hasselt CA, Kuo WL, Gray JW, Huang DP, Lo KW
Cancer research 2005 Sep 15;65(18):8125-33
Cancer research 2005 Sep 15;65(18):8125-33
Absence of IHH and retention of PTHrP signalling in enchondromas and central chondrosarcomas.
Rozeman LB, Hameetman L, Cleton-Jansen AM, Taminiau AH, Hogendoorn PC, Bovée JV
The Journal of pathology 2005 Mar;205(4):476-82
The Journal of pathology 2005 Mar;205(4):476-82
Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria.
Yu D, Petermann A, Kunter U, Rong S, Shankland SJ, Floege J
Journal of the American Society of Nephrology : JASN 2005 Jun;16(6):1733-41
Journal of the American Society of Nephrology : JASN 2005 Jun;16(6):1733-41
In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202.
Raynaud FI, Whittaker SR, Fischer PM, McClue S, Walton MI, Barrie SE, Garrett MD, Rogers P, Clarke SJ, Kelland LR, Valenti M, Brunton L, Eccles S, Lane DP, Workman P
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Jul 1;11(13):4875-87
Clinical cancer research : an official journal of the American Association for Cancer Research 2005 Jul 1;11(13):4875-87
Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells.
Lewis JS, Thomas TJ, Pestell RG, Albanese C, Gallo MA, Thomas T
Journal of molecular endocrinology 2005 Feb;34(1):91-105
Journal of molecular endocrinology 2005 Feb;34(1):91-105
Coordinated expression of cyclin D1 and LEF-1/TCF transcription factor is restricted to a subset of hepatocellular carcinoma.
Schmitt-Graeff A, Ertelt-Heitzmann V, Allgaier HP, Olschewski M, Nitschke R, Haxelmans S, Koelble K, Behrens J, Blum HE
Liver international : official journal of the International Association for the Study of the Liver 2005 Aug;25(4):839-47
Liver international : official journal of the International Association for the Study of the Liver 2005 Aug;25(4):839-47
Expression of D-type cyclins in colon cancer and in cell lines from colon carcinomas.
Mermelshtein A, Gerson A, Walfisch S, Delgado B, Shechter-Maor G, Delgado J, Fich A, Gheber L
British journal of cancer 2005 Aug 8;93(3):338-45
British journal of cancer 2005 Aug 8;93(3):338-45
ILK is required for the assembly of matrix-forming adhesions and capillary morphogenesis in endothelial cells.
Vouret-Craviari V, Boulter E, Grall D, Matthews C, Van Obberghen-Schilling E
Journal of cell science 2004 Sep 1;117(Pt 19):4559-69
Journal of cell science 2004 Sep 1;117(Pt 19):4559-69
Skp2-dependent degradation of p27kip1 is essential for cell cycle progression.
Kossatz U, Dietrich N, Zender L, Buer J, Manns MP, Malek NP
Genes & development 2004 Nov 1;18(21):2602-7
Genes & development 2004 Nov 1;18(21):2602-7
p53, p16 and cyclin D1: molecular determinants of radiotherapy treatment response in oral carcinoma.
Jayasurya R, Francis G, Kannan S, Lekshminarayanan K, Nalinakumari KR, Abraham T, Abraham EK, Nair MK
International journal of cancer 2004 May 1;109(5):710-6
International journal of cancer 2004 May 1;109(5):710-6
Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation.
van den Brink GR, Bleuming SA, Hardwick JC, Schepman BL, Offerhaus GJ, Keller JJ, Nielsen C, Gaffield W, van Deventer SJ, Roberts DJ, Peppelenbosch MP
Nature genetics 2004 Mar;36(3):277-82
Nature genetics 2004 Mar;36(3):277-82
Overexpression of the colony-stimulating factor (CSF-1) and/or its receptor c-fms in mammary glands of transgenic mice results in hyperplasia and tumor formation.
Kirma N, Luthra R, Jones J, Liu YG, Nair HB, Mandava U, Tekmal RR
Cancer research 2004 Jun 15;64(12):4162-70
Cancer research 2004 Jun 15;64(12):4162-70
Endogenous human prolactin and not exogenous human prolactin induces estrogen receptor alpha and prolactin receptor expression and increases estrogen responsiveness in breast cancer cells.
Gutzman JH, Miller KK, Schuler LA
The Journal of steroid biochemistry and molecular biology 2004 Jan;88(1):69-77
The Journal of steroid biochemistry and molecular biology 2004 Jan;88(1):69-77
Differential expression of the calcium sensing receptor and combined loss of chromosomes 1q and 11q in parathyroid carcinoma.
Haven CJ, van Puijenbroek M, Karperien M, Fleuren GJ, Morreau H
The Journal of pathology 2004 Jan;202(1):86-94
The Journal of pathology 2004 Jan;202(1):86-94
Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver.
Cui X, Li S, Shraim A, Kobayashi Y, Hayakawa T, Kanno S, Yamamoto M, Hirano S
Toxicologic pathology 2004 Jan-Feb;32(1):64-72
Toxicologic pathology 2004 Jan-Feb;32(1):64-72
Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver.
Cui X, Li S, Shraim A, Kobayashi Y, Hayakawa T, Kanno S, Yamamoto M, Hirano S
Toxicologic pathology 2004 Jan-Feb;32(1):64-72
Toxicologic pathology 2004 Jan-Feb;32(1):64-72
Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition by p16(INK4a).
Faast R, White J, Cartwright P, Crocker L, Sarcevic B, Dalton S
Oncogene 2004 Jan 15;23(2):491-502
Oncogene 2004 Jan 15;23(2):491-502
The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway.
Whittaker SR, Walton MI, Garrett MD, Workman P
Cancer research 2004 Jan 1;64(1):262-72
Cancer research 2004 Jan 1;64(1):262-72
Cdk4 is indispensable for postnatal proliferation of the anterior pituitary.
Jirawatnotai S, Aziyu A, Osmundson EC, Moons DS, Zou X, Kineman RD, Kiyokawa H
The Journal of biological chemistry 2004 Dec 3;279(49):51100-6
The Journal of biological chemistry 2004 Dec 3;279(49):51100-6
Role of the phosphatidylinositol 3'-kinase-Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines.
Takeda A, Osaki M, Adachi K, Honjo S, Ito H
Pancreas 2004 Apr;28(3):353-8
Pancreas 2004 Apr;28(3):353-8
Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen-stimulated rat hepatocytes.
Papeleu P, Loyer P, Vanhaecke T, Elaut G, Geerts A, Guguen-Guillouzo C, Rogiers V
Journal of hepatology 2003 Sep;39(3):374-82
Journal of hepatology 2003 Sep;39(3):374-82
G3139 (oblimersen) may inhibit prostate cancer cell growth in a partially bis-CpG-dependent non-antisense manner.
Lai JC, Benimetskaya L, Santella RM, Wang Q, Miller PS, Stein CA
Molecular cancer therapeutics 2003 Oct;2(10):1031-43
Molecular cancer therapeutics 2003 Oct;2(10):1031-43
Validation of tissue array technology in head and neck squamous cell carcinoma.
Chen B, van den Brekel MW, Buschers W, Balm AJ, van Velthuysen ML
Head & neck 2003 Nov;25(11):922-30
Head & neck 2003 Nov;25(11):922-30
Expression of angiotensin type II receptor downregulates Cdk4 synthesis and inhibits cell-cycle progression.
Gingras B, Rodier G, Giasson E, Coulombe P, Chassagne C, Meloche S
Oncogene 2003 May 1;22(17):2633-42
Oncogene 2003 May 1;22(17):2633-42
Differences in the pathologic and molecular features of intraductal breast carcinoma between younger and older women.
Rodrigues NA, Dillon D, Carter D, Parisot N, Haffty BG
Cancer 2003 Mar 15;97(6):1393-403
Cancer 2003 Mar 15;97(6):1393-403
Cyclin D2 compensates for the loss of cyclin D1 in estrogen-induced mouse uterine epithelial cell proliferation.
Chen B, Pollard JW
Molecular endocrinology (Baltimore, Md.) 2003 Jul;17(7):1368-81
Molecular endocrinology (Baltimore, Md.) 2003 Jul;17(7):1368-81
Alterations of beta-catenin pathway in non-melanoma skin tumors: loss of alpha-ABC nuclear reactivity correlates with the presence of beta-catenin gene mutation.
Doglioni C, Piccinin S, Demontis S, Cangi MG, Pecciarini L, Chiarelli C, Armellin M, Vukosavljevic T, Boiocchi M, Maestro R
The American journal of pathology 2003 Dec;163(6):2277-87
The American journal of pathology 2003 Dec;163(6):2277-87
Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas.
De Leng WW, Westerman AM, Weterman MA, De Rooij FW, Dekken Hv Hv, De Goeij AF, Gruber SB, Wilson JH, Offerhaus GJ, Giardiello FM, Keller JJ
Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Aug 1;9(8):3065-72
Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Aug 1;9(8):3065-72
Roles of mitogen-activated protein kinase and phosphoinositide 3'-kinase in ErbB2/ErbB3 coreceptor-mediated heregulin signaling.
Vijapurkar U, Kim MS, Koland JG
Experimental cell research 2003 Apr 1;284(2):291-302
Experimental cell research 2003 Apr 1;284(2):291-302
Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells.
Law BK, Chytil A, Dumont N, Hamilton EG, Waltner-Law ME, Aakre ME, Covington C, Moses HL
Molecular and cellular biology 2002 Dec;22(23):8184-98
Molecular and cellular biology 2002 Dec;22(23):8184-98
Another case of mantle cell lymphoma presenting as breast masses.
Fadare O, Shukla P
Journal of clinical pathology 2002 Aug;55(8):640
Journal of clinical pathology 2002 Aug;55(8):640
Stage-dependent activation of cell cycle and apoptosis mechanisms in the right ventricle by pressure overload.
Ecarnot-Laubriet A, Assem M, Poirson-Bichat F, Moisant M, Bernard C, Lecour S, Solary E, Rochette L, Teyssier JR
Biochimica et biophysica acta 2002 Apr 24;1586(3):233-42
Biochimica et biophysica acta 2002 Apr 24;1586(3):233-42
Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties.
Bearss DJ, Lee RJ, Troyer DA, Pestell RG, Windle JJ
Cancer research 2002 Apr 1;62(7):2077-84
Cancer research 2002 Apr 1;62(7):2077-84
Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)-dependent manner.
Reutens AT, Fu M, Wang C, Albanese C, McPhaul MJ, Sun Z, Balk SP, Jänne OA, Palvimo JJ, Pestell RG
Molecular endocrinology (Baltimore, Md.) 2001 May;15(5):797-811
Molecular endocrinology (Baltimore, Md.) 2001 May;15(5):797-811
Overexpression of aromatase leads to hyperplasia and changes in the expression of genes involved in apoptosis, cell cycle, growth, and tumor suppressor functions in the mammary glands of transgenic mice.
Kirma N, Gill K, Mandava U, Tekmal RR
Cancer research 2001 Mar 1;61(5):1910-8
Cancer research 2001 Mar 1;61(5):1910-8
Effects of arsenite on p53, p21 and cyclin D expression in normal human fibroblasts -- a possible mechanism for arsenite's comutagenicity.
Vogt BL, Rossman TG
Mutation research 2001 Jul 1;478(1-2):159-68
Mutation research 2001 Jul 1;478(1-2):159-68
Analysis of C-MYC function in normal cells via conditional gene-targeted mutation.
de Alboran IM, O'Hagan RC, Gärtner F, Malynn B, Davidson L, Rickert R, Rajewsky K, DePinho RA, Alt FW
Immunity 2001 Jan;14(1):45-55
Immunity 2001 Jan;14(1):45-55
Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas.
Maitra A, Roberts H, Weinberg AG, Geradts J
International journal of cancer 2001 Jan 20;95(1):34-8
International journal of cancer 2001 Jan 20;95(1):34-8
Telomerase activation cooperates with inactivation of p16 in early head and neck tumorigenesis.
Soria JC, Morat L, Commo F, Dabit D, Perie S, Sabatier L, Fouret P
British journal of cancer 2001 Feb;84(4):504-11
British journal of cancer 2001 Feb;84(4):504-11
Genetic evidence for the interactions of cyclin D1 and p27(Kip1) in mice.
Tong W, Pollard JW
Molecular and cellular biology 2001 Feb;21(4):1319-28
Molecular and cellular biology 2001 Feb;21(4):1319-28
Metabolic stabilization of p27 in senescent fibroblasts correlates with reduced expression of the F-box protein Skp2.
Wagner M, Hampel B, Hütter E, Pfister G, Krek W, Zwerschke W, Jansen-Dürr P
Experimental gerontology 2001 Dec;37(1):41-55
Experimental gerontology 2001 Dec;37(1):41-55
Regulation of cell cycle and cyclins by 16alpha-hydroxyestrone in MCF-7 breast cancer cells.
Lewis JS, Thomas TJ, Klinge CM, Gallo MA, Thomas T
Journal of molecular endocrinology 2001 Dec;27(3):293-307
Journal of molecular endocrinology 2001 Dec;27(3):293-307
TGFbeta and PTHrP control chondrocyte proliferation by activating cyclin D1 expression.
Beier F, Ali Z, Mok D, Taylor AC, Leask T, Albanese C, Pestell RG, LuValle P
Molecular biology of the cell 2001 Dec;12(12):3852-63
Molecular biology of the cell 2001 Dec;12(12):3852-63
Large cell variants of CD5+, CD23- B-cell lymphoma/leukemia.
Dunphy CH, Perkins SL
Archives of pathology & laboratory medicine 2001 Apr;125(4):513-8
Archives of pathology & laboratory medicine 2001 Apr;125(4):513-8
Analysis of the transcriptional program induced by Raf in epithelial cells.
Schulze A, Lehmann K, Jefferies HB, McMahon M, Downward J
Genes & development 2001 Apr 15;15(8):981-94
Genes & development 2001 Apr 15;15(8):981-94
Abnormal expression of cell cycle regulatory proteins in ductal and lobular carcinomas of the breast.
Geradts J, Ingram CD
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2000 Sep;13(9):945-53
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2000 Sep;13(9):945-53
Cyclin D1 overexpression is a critical event in gallbladder carcinogenesis and independently predicts decreased survival for patients with gallbladder carcinoma.
Hui AM, Li X, Shi YZ, Takayama T, Torzilli G, Makuuchi M
Clinical cancer research : an official journal of the American Association for Cancer Research 2000 Nov;6(11):4272-7
Clinical cancer research : an official journal of the American Association for Cancer Research 2000 Nov;6(11):4272-7
v-Jun overrides the mitogen dependence of S-phase entry by deregulating retinoblastoma protein phosphorylation and E2F-pocket protein interactions as a consequence of enhanced cyclin E-cdk2 catalytic activity.
Clark W, Black EJ, MacLaren A, Kruse U, LaThangue N, Vogt PK, Gillespie DA
Molecular and cellular biology 2000 Apr;20(7):2529-42
Molecular and cellular biology 2000 Apr;20(7):2529-42
Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity.
Tsutsui T, Hesabi B, Moons DS, Pandolfi PP, Hansel KS, Koff A, Kiyokawa H
Molecular and cellular biology 1999 Oct;19(10):7011-9
Molecular and cellular biology 1999 Oct;19(10):7011-9
Progesterone inhibits estrogen-induced cyclin D1 and cdk4 nuclear translocation, cyclin E- and cyclin A-cdk2 kinase activation, and cell proliferation in uterine epithelial cells in mice.
Tong W, Pollard JW
Molecular and cellular biology 1999 Mar;19(3):2251-64
Molecular and cellular biology 1999 Mar;19(3):2251-64
Cyclin-D1 expression in node-positive (N+) and node-negative (N-) infiltrating human mammary carcinomas.
Collecchi P, Passoni A, Rocchetta M, Gnesi E, Baldini E, Bevilacqua G
International journal of cancer 1999 Apr 20;84(2):139-44
International journal of cancer 1999 Apr 20;84(2):139-44
Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1.
Zwijsen RM, Buckle RS, Hijmans EM, Loomans CJ, Bernards R
Genes & development 1998 Nov 15;12(22):3488-98
Genes & development 1998 Nov 15;12(22):3488-98
Anchorage-independent transcription of the cyclin A gene induced by the E7 oncoprotein of human papillomavirus type 16.
Schulze A, Mannhardt B, Zerfass-Thome K, Zwerschke W, Jansen-Dürr P
Journal of virology 1998 Mar;72(3):2323-34
Journal of virology 1998 Mar;72(3):2323-34
Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum.
Kornmann M, Arber N, Korc M
The Journal of clinical investigation 1998 Jan 15;101(2):344-52
The Journal of clinical investigation 1998 Jan 15;101(2):344-52
Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4.
Neuman E, Ladha MH, Lin N, Upton TM, Miller SJ, DiRenzo J, Pestell RG, Hinds PW, Dowdy SF, Brown M, Ewen ME
Molecular and cellular biology 1997 Sep;17(9):5338-47
Molecular and cellular biology 1997 Sep;17(9):5338-47
Role of cyclins in neuronal differentiation of immortalized hippocampal cells.
Xiong W, Pestell R, Rosner MR
Molecular and cellular biology 1997 Nov;17(11):6585-97
Molecular and cellular biology 1997 Nov;17(11):6585-97
The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.
Reynisdóttir I, Massagué J
Genes & development 1997 Feb 15;11(4):492-503
Genes & development 1997 Feb 15;11(4):492-503
A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes.
Arber N, Han EK, Sgambato A, Piazza GA, Delohery TM, Begemann M, Weghorst CM, Kim NH, Pamukcu R, Ahnen DJ, Reed JC, Weinstein IB, Holt PR
Gastroenterology 1997 Dec;113(6):1892-900
Gastroenterology 1997 Dec;113(6):1892-900
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Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot analysis of Cyclin D1 in A431 whole cell lysate (Lane 1) and HepG2 cell lysates (Lane 2). Samples were loaded at 20µg per lane onto a 15% SDS-polyacrylamide gel, transferred to a PVDF membrane (semi-dry) and blocked with TBS containing TBST and 5% non-fat dry milk for 2 hrs at room temperature. The membrane was washed in TBST and probed with an anti-Cyclin D1 monoclonal antibody (Product # MA1-12296) at a dilution of 1:1000 overnight at 4ºC and washed in TBST. Secondary detection was performed using a Goat anti-Mouse IgG (H+L) Cross Adsorbed Secondary Antibody, HRP conjugate (Product # 31446) at a dilution of 1:5000, followed by ECL detection. Data provided courtesy of Antibody Resource.
