Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10-7574-25 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-Cyclin D1 Antibody
- Antibody type
- Monoclonal
- Description
- Cyclin D1 (CCND1) is an important positive regulator of the G1/S phase of the cell cycle. It regulate cell cycle transition from G1 phase to S phase It is a well-established human oncogene which is frequently amplified or overexpressed in cancers (25409185). Cyclin D1b is one of two proteins translated from Cyclin D1 transcripts (isoforms a and b) that are generated due to gene polymorphism. Low Cyclin D1b expression in cervical cancer tissue, with an expression level in moderately or poorly differentiated tissues was significantly lower than that in well-differentiated tissues (25120779). Diseases associated with CCND1 include multiple myeloma and mantle cell lymphoma.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
A partial length recombinant Cyclin
D1 protein (amino acids 107-275) w
as used as the immunogen for this a
ntibody.- Isotype
- IgG
- Antibody clone number
- ABM47F5
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
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Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of Cyclin D1 in Mantle cell using Cyclin D1 antibody (Clone: ABM47F5) at 5 µg/ml.
- Protocol
- Protocol