19058-1-AP

antibody from Proteintech Group

Targeting: MDM2 HDM2, MGC5370

Provider product page for 19058-1-AP

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Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [50]
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Validations
Western blot [2]

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Product number: 19058-1-AP - Provider product page
Provider: Proteintech Group
Product name: MDM2 antibody
Antibody type: Polyclonal
Description: KD/KO validated MDM2 antibody (Cat. #19058-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MDM2 protein structure - 19058-1-AP shown in red.

Submitted references The Long Non-Coding RNA NR3C2-8:1 Promotes p53-Mediated Apoptosis through the miR-129-5p/USP10 Axis in Amyotrophic Lateral Sclerosis.

Pang D, Yu Y, Zhao B, Huang J, Cui Y, Li T, Li C, Shang H
Molecular neurobiology 2024 Oct;61(10):7466-7480

Peptide PDRPS6 attenuates myocardial ischemia injury by improving mitochondrial function.

Feng M, Zhang L, Yin A, Zhang H, Wu X, Qian L
European journal of pharmacology 2024 Jul 5;974:176570

Hepatic RACK1 deficiency protects against fulminant hepatitis through myeloid-derived suppressor cells.

Liu G, Wang Q, Deng L, Huang X, Yang G, Cheng Q, Guo T, Guo L, Niu C, Yang X, Dong J, Zhang J
Theranostics 2022;12(5):2248-2265

Transcription factor YY1 contributes to human melanoma cell growth through modulating the p53 signalling pathway.

Zhou S, Li P, Qin L, Huang S, Dang N
Experimental dermatology 2022 Oct;31(10):1563-1578

USP22-mediated deubiquitination of PTEN inhibits pancreatic cancer progression by inducing p21 expression.

Ren D, Sun Y, Li D, Wu H, Jin X
Molecular oncology 2022 Mar;16(5):1200-1217

Genome-wide CRISPR/Cas9 screening for therapeutic targets in NSCLC carrying wild-type TP53 and receptor tyrosine kinase genes.

Wang Q, Li J, Zhu J, Mao J, Duan C, Liang X, Zhu L, Zhu M, Zhang Z, Lin F, Guo R
Clinical and translational medicine 2022 Jun;12(6):e882

Identification of a novel native peptide derived from 60S ribosomal protein L23a that translationally regulates p53 to reduce myocardial ischemia-reperfusion.

Yin A, Feng M, Zhang L, Cheng Z, Li Y, Qian L
Pharmacological research 2022 Jan;175:105988

MiR-4521 plays a tumor repressive role in growth and metastasis of hepatocarcinoma cells by suppressing phosphorylation of FAK/AKT pathway via targeting FAM129A.

Ayesha M, Majid A, Zhao D, Greenaway FT, Yan N, Liu Q, Liu S, Sun MZ
Journal of advanced research 2022 Feb;36:147-161

Erianin, the main active ingredient of Dendrobium chrysotoxum Lindl, inhibits precancerous lesions of gastric cancer (PLGC) through suppression of the HRAS-PI3K-AKT signaling pathway as revealed by network pharmacology and in vitro experimental verification.

Wang Y, Chu F, Lin J, Li Y, Johnson N, Zhang J, Gai C, Su Z, Cheng H, Wang L, Ding X
Journal of ethnopharmacology 2021 Oct 28;279:114399

Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.

Guo Y, Li Q, Zhao G, Zhang J, Yuan H, Feng T, Ou D, Gu R, Li S, Li K, Lin P
Cell death & disease 2021 Oct 14;12(10):945

Long noncoding RNA AFAP1-AS1 promotes tumor progression and invasion by regulating the miR-2110/Sp1 axis in triple-negative breast cancer.

Zhang X, Li F, Zhou Y, Mao F, Lin Y, Shen S, Li Y, Zhang S, Sun Q
Cell death & disease 2021 Jun 18;12(7):627

PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53.

Wang W, Wei J, Zhang H, Zheng X, Zhou H, Luo Y, Yang J, Deng Q, Huang S, Fu Z
Cell death & disease 2021 Jun 11;12(6):605

Regulation of telomere homeostasis and genomic stability in cancer by N (6)-adenosine methylation (m(6)A).

Lee JH, Hong J, Zhang Z, de la Peña Avalos B, Proietti CJ, Deamicis AR, Guzmán G P, Lam HM, Garcia J, Roudier MP, Sisk AE, De La Rosa R, Vu K, Yang M, Liao Y, Scheirer J, Pechacek D, Yadav P, Rao MK, Zheng S, Johnson-Pais TL, Leach RJ, Elizalde PV, Dray E, Xu K
Science advances 2021 Jul;7(31)

AURKA Increase the Chemosensitivity of Colon Cancer Cells to Oxaliplatin by Inhibiting the TP53-Mediated DNA Damage Response Genes.

Shan B, Zhao R, Zhou J, Zhang M, Qi X, Wang T, Gong J, Wu Y, Zhu Y, Yang W, Zhang Y, Wang G, Li X
BioMed research international 2020;2020:8916729

Target molecular treatment markers in Intrahepatic Cholangiocarcinoma based on Chinese population.

Pu X, Zhu L, Li F, Zheng J, Wu H, Fu Y, Chen J, Qi L
Pathology, research and practice 2020 Sep;216(9):153116

Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.

Wang Y, Chen J, Li S, Zhang X, Guo Z, Hu J, Shao X, Song N, Zhao Y, Li H, Yang G, Xu C, Wei C
Redox biology 2020 May;32:101514

Ubiquitination of P53 by E3 ligase MKRN2 promotes melanoma cell proliferation.

Zhang Y, Cui N, Zheng G
Oncology letters 2020 Mar;19(3):1975-1984

BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses.

Wang J, Li GL, Ming SL, Wang CF, Shi LJ, Su BQ, Wu HT, Zeng L, Han YQ, Liu ZH, Jiang DW, Du YK, Li XD, Zhang GP, Yang GY, Chu BB
PLoS pathogens 2020 Mar;16(3):e1008429

Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.

Zhao Q, Zhu HP, Xie X, Mao Q, Liu YQ, He XH, Peng C, Jiang QL, Huang W
International journal of molecular sciences 2020 Mar 7;21(5)

All-trans retinoic acid enhances the effect of Fra-1 to inhibit cell proliferation and metabolism in cervical cancer.

Dou Y, Huang D, Zeng X, Zhou Y, Jiang X, Yue C, He J, Xiao S
Biotechnology letters 2020 Jun;42(6):1051-1060

Neurotoxicity of aluminum oxide nanoparticles and their mechanistic role in dopaminergic neuron injury involving p53-related pathways.

Liu H, Zhang W, Fang Y, Yang H, Tian L, Li K, Lai W, Bian L, Lin B, Liu X, Xi Z
Journal of hazardous materials 2020 Jun 15;392:122312

MeCP2 facilitates breast cancer growth via promoting ubiquitination-mediated P53 degradation by inhibiting RPL5/RPL11 transcription.

Tong D, Zhang J, Wang X, Li Q, Liu LY, Yang J, Guo B, Ni L, Zhao L, Huang C
Oncogenesis 2020 Jun 1;9(5):56

Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN).

Duan TL, Jiao H, He GJ, Yan YB
Cells 2020 Jan 9;9(1)

Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation.

Li S, Han J, Guo G, Sun Y, Zhang T, Zhao M, Xu Y, Cui Y, Liu Y, Zhang J
FEBS letters 2020 Feb;594(3):497-508

MDM2 inhibition-mediated autophagy contributes to the pro-apoptotic effect of berberine in p53-null leukemic cells.

Liu J, Zhu Z, Liu Y, Wei L, Li B, Mao F, Zhang J, Wang Y, Liu Y
Life sciences 2020 Feb 1;242:117228

miR-4521-FAM129A axial regulation on ccRCC progression through TIMP-1/MMP2/MMP9 and MDM2/p53/Bcl2/Bax pathways.

Feng X, Yan N, Sun W, Zheng S, Jiang S, Wang J, Guo C, Hao L, Tian Y, Liu S, Sun MZ
Cell death discovery 2019;5:89

DpdtbA-Induced Growth Inhibition in Human Esophageal Cancer Cells Involved Inactivation of the p53/EGFR/AKT Pathway.

Wang Z, Li C, Li Y, Guo X, Yan Z, Gao F, Li C
Oxidative medicine and cellular longevity 2019;2019:5414670

MDM2 inhibitor RG7388 potently inhibits tumors by activating p53 pathway in nasopharyngeal carcinoma.

Fan X, Wang Y, Song J, Wu H, Yang M, Lu L, Weng X, Liu L, Nie G
Cancer biology & therapy 2019;20(10):1328-1336

SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.

Wang Q, Jia S, Jiao Y, Xu L, Wang D, Chen X, Hu X, Liang H, Wen N, Zhang S, Guo B, Zhang L
International journal of medical sciences 2019;16(12):1573-1582

Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.

Liang M, Li H, Wang Z, Cai L, Yang L
Journal of the science of food and agriculture 2019 Oct;99(13):6097-6107

Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth.

Fu R, Yang P, Sajid A, Li Z
Journal of agricultural and food chemistry 2019 May 1;67(17):4808-4816

PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis.

Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, Chen Q, Wei L, Wang Y, Chen H
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):135-144

Notch1 Drives the Formation and Proliferation of Intrahepatic Cholangiocarcinoma.

Guo J, Fu W, Xiang M, Zhang Y, Zhou K, Xu CR, Li L, Kuang D, Ye F
Current medical science 2019 Dec;39(6):929-937

Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.

Qin F, Wang Y, Jiang X, Wang Y, Zhang N, Wen X, Wang L, Jiang Q, He G
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926

Combination of dihydromyricetin and ondansetron strengthens antiproliferative efficiency of adriamycin in K562/ADR through downregulation of SORCIN: A new strategy of inhibiting P-glycoprotein.

Sun Y, Liu W, Wang C, Meng Q, Liu Z, Huo X, Yang X, Sun P, Sun H, Ma X, Peng J, Liu K
Journal of cellular physiology 2019 Apr;234(4):3685-3696

Co-culture with TM4 cells enhances the proliferation and migration of rat adipose-derived mesenchymal stem cells with high stemness.

Luo Y, Mohsin A, Xu C, Wang Q, Hang H, Zhuang Y, Chu J, Guo M
Cytotechnology 2018 Oct;70(5):1409-1422

USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization.

Yang S, Liu L, Cao C, Song N, Wang Y, Ma S, Zhang Q, Yu N, Ding X, Yang F, Tian S, Zhang K, Sun T, Yang J, Yao Z, Wu S, Shi L
Nature communications 2018 Mar 29;9(1):1285

The Potential Roles of the Apoptosis-Related Protein PDRG1 in Diapause Embryo Restarting of Artemia sinica.

Zhang W, Yao F, Zhang H, Li N, Zou X, Sui L, Hou L
International journal of molecular sciences 2018 Jan 2;19(1)

SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.

Xiong Y, Wang L, Wang S, Wang M, Zhao J, Zhang Z, Li X, Jia L, Han Y
Journal of cancer research and clinical oncology 2018 Feb;144(2):189-198

The long non-coding RNA FOXD2-AS1 promotes bladder cancer progression and recurrence through a positive feedback loop with Akt and E2F1.

Su F, He W, Chen C, Liu M, Liu H, Xue F, Bi J, Xu D, Zhao Y, Huang J, Lin T, Jiang C
Cell death & disease 2018 Feb 14;9(2):233

MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development.

Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, Chen Q, Wei L, Wang Y, Chen H
Journal of experimental & clinical cancer research : CR 2018 Feb 13;37(1):28

Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.

Liu L, Sun Y, Zhao Y, Wang Q, Guo H, Guo R, Liu Y, Fu S, Zhang L, Li Y, Meng Y
Cancer science 2018 Dec;109(12):3762-3773

RasGRP3 controls cell proliferation and migration in papillary thyroid cancer by regulating the Akt-MDM2 pathway.

Qiu W, Xia X, Qiu Z, Guo M, Yang Z
Gene 2017 Oct 30;633:35-41

PADI2-Mediated Citrullination Promotes Prostate Cancer Progression.

Wang L, Song G, Zhang X, Feng T, Pan J, Chen W, Yang M, Bai X, Pang Y, Yu J, Han J, Han B
Cancer research 2017 Nov 1;77(21):5755-5768

Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.

Xue C, Wang C, Sun Y, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Ma X, Peng J, Liu K
Oncotarget 2017 Jan 31;8(5):8622-8632

Regulation of the Abundance of Kaposi's Sarcoma-Associated Herpesvirus ORF50 Protein by Oncoprotein MDM2.

Chang TH, Wang SS, Chen LW, Shih YJ, Chang LK, Liu ST, Chang PJ
PLoS pathogens 2016 Oct;12(10):e1005918

Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma.

Zhang XF, Pan QZ, Pan K, Weng DS, Wang QJ, Zhao JJ, He J, Liu Q, Wang DD, Jiang SS, Zheng HX, Lv L, Chen CL, Zhang HX, Xia JC
Molecular carcinogenesis 2016 Jan;55(1):64-76

Decreased TPD52 expression is associated with poor prognosis in primary hepatocellular carcinoma.

Wang Y, Chen CL, Pan QZ, Wu YY, Zhao JJ, Jiang SS, Chao J, Zhang XF, Zhang HX, Zhou ZQ, Tang Y, Huang XQ, Zhang JH, Xia JC
Oncotarget 2016 Feb 2;7(5):6323-34

RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker.

Jin Y, Cao B, Zhang M, Zhan Q, Herman JG, Yu M, Guo M
Genes & cancer 2015 May;6(5-6):231-40

Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop.

Zhang J, Sun Q, Zhang Z, Ge S, Han ZG, Chen WT
Oncogene 2013 Jan 3;32(1):61-9

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The MDM2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human MDM2. This antibody recognizes human,mouse,rat antigen. The MDM2 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 19058-1-AP.pdf

: Show more

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HepG2 cells were subjected to SDS PAGE followed by western blot with 19058-1-AP(MDM2 antibody) at dilution of 1:200
Other comments: WB
Appendix: 19058-1-AP.pdf

: Show more