MDM2

gene product
HDM2, MGC5370
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
1589 antibodies from 42 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
GeneTex
17 antibodies
Novus Biologicals
79 antibodies
Invitrogen Antibodies
19 antibodies
antibodies-online
604 antibodies
Abnova Corporation
21 antibodies
Abgent
7 antibodies
R&D Systems
3 antibodies
Santa Cruz Biotechnology
1 antibody
Affinity Biosciences
5 antibodies
Biorbyt
99 antibodies