Tissue expression
Cell line expression
Protein structure
MDM2
MDM2 proto-oncogeneHDM2, MGC5370
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Top validated antibodies |
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GeneTex | ![]() |
4 references | Polyclonal |
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Invitrogen Antibodies | ![]() |
20 references | Monoclonal |
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antibodies-online | ![]() |
2 references | Polyclonal |
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LSBio | ![]() |
Polyclonal |
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Novus Biologicals | ![]() |
1 references | Polyclonal |
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