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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Product number
- ABIN362481 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) (pSer166) antibody
- Antibody type
- Polyclonal
- Antigen
- Peptide sequence around phosphorylation site of pSer166 (A-I-S (p) -E-T) derived from Human MDM2. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- Description
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- pSer166
- Isotype
- IgG
- Vial size
- 50 μL
- Concentration
- 1 mg/mL
- Storage
- Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Submitted references Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53.
N-acetylcysteine suppresses retinal detachment in an experimental model of proliferative vitreoretinopathy.
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus.
p300/MDM2 complexes participate in MDM2-mediated p53 degradation.
Mdm2 promotes the rapid degradation of p53.
Lei H, Velez G, Kazlauskas A
Molecular and cellular biology 2011 May;31(9):1788-99
Molecular and cellular biology 2011 May;31(9):1788-99
N-acetylcysteine suppresses retinal detachment in an experimental model of proliferative vitreoretinopathy.
Lei H, Velez G, Cui J, Samad A, Maberley D, Matsubara J, Kazlauskas A
The American journal of pathology 2010 Jul;177(1):132-40
The American journal of pathology 2010 Jul;177(1):132-40
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus.
Mayo LD, Donner DB
Proceedings of the National Academy of Sciences of the United States of America 2001 Sep 25;98(20):11598-603
Proceedings of the National Academy of Sciences of the United States of America 2001 Sep 25;98(20):11598-603
p300/MDM2 complexes participate in MDM2-mediated p53 degradation.
Grossman SR, Perez M, Kung AL, Joseph M, Mansur C, Xiao ZX, Kumar S, Howley PM, Livingston DM
Molecular cell 1998 Oct;2(4):405-15
Molecular cell 1998 Oct;2(4):405-15
Mdm2 promotes the rapid degradation of p53.
Haupt Y, Maya R, Kazaz A, Oren M
Nature 1997 May 15;387(6630):296-9
Nature 1997 May 15;387(6630):296-9
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