Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations [0]
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- Product number
- ABIN358109 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Checkpoint Kinase 1 (CHEK1) (pSer317) antibody
- Antibody type
- Polyclonal
- Description
- Protein G Affinity Chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- pSer317
- Vial size
- 0.4 mL
- Storage
- Store undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase.
Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains.
Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1.
Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding.
Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.
Krämer A, Mailand N, Lukas C, Syljuåsen RG, Wilkinson CJ, Nigg EA, Bartek J, Lukas J
Nature cell biology 2004 Sep;6(9):884-91
Nature cell biology 2004 Sep;6(9):884-91
Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains.
Ng CP, Lee HC, Ho CW, Arooz T, Siu WY, Lau A, Poon RY
The Journal of biological chemistry 2004 Mar 5;279(10):8808-19
The Journal of biological chemistry 2004 Mar 5;279(10):8808-19
Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1.
Xu X, Lee J, Stern DF
The Journal of biological chemistry 2004 Aug 13;279(33):34091-4
The Journal of biological chemistry 2004 Aug 13;279(33):34091-4
Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding.
Chen MS, Ryan CE, Piwnica-Worms H
Molecular and cellular biology 2003 Nov;23(21):7488-97
Molecular and cellular biology 2003 Nov;23(21):7488-97
Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.
Groth A, Lukas J, Nigg EA, Silljé HH, Wernstedt C, Bartek J, Hansen K
The EMBO journal 2003 Apr 1;22(7):1676-87
The EMBO journal 2003 Apr 1;22(7):1676-87
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