Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations [0]
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- Product number
- ABIN357628 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Checkpoint Kinase 1 (CHEK1) antibody
- Antibody type
- Polyclonal
- Description
- Protein A Chromatography followed by peptide affinity purification.
- Reactivity
- Human
- Host
- Rabbit
- Vial size
- 0.4 mL
- Storage
- Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.
Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding.
Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.
Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex.
An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells.
Krause DR, Jonnalagadda JC, Gatei MH, Sillje HH, Zhou BB, Nigg EA, Khanna K
Oncogene 2003 Sep 4;22(38):5927-37
Oncogene 2003 Sep 4;22(38):5927-37
Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding.
Chen MS, Ryan CE, Piwnica-Worms H
Molecular and cellular biology 2003 Nov;23(21):7488-97
Molecular and cellular biology 2003 Nov;23(21):7488-97
Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.
Xiao Z, Chen Z, Gunasekera AH, Sowin TJ, Rosenberg SH, Fesik S, Zhang H
The Journal of biological chemistry 2003 Jun 13;278(24):21767-73
The Journal of biological chemistry 2003 Jun 13;278(24):21767-73
Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex.
Goudelock DM, Jiang K, Pereira E, Russell B, Sanchez Y
The Journal of biological chemistry 2003 Aug 8;278(32):29940-7
The Journal of biological chemistry 2003 Aug 8;278(32):29940-7
An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells.
Wang X, Khadpe J, Hu B, Iliakis G, Wang Y
The Journal of biological chemistry 2003 Aug 15;278(33):30869-74
The Journal of biological chemistry 2003 Aug 15;278(33):30869-74
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