ABIN357628

antibody from antibodies-online

Targeting: CHEK1 CHK1

Western blot (Recommended by provider)

Antibody Data

Product number

ABIN357628

Provider

antibodies-online

Product name

anti-Checkpoint Kinase 1 (CHEK1) antibody

Antibody type

Polyclonal

Description

Protein A Chromatography followed by peptide affinity purification.

Reactivity

Human

Host

Rabbit

Vial size

0.4 mL

Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.

Krause DR, Jonnalagadda JC, Gatei MH, Sillje HH, Zhou BB, Nigg EA, Khanna K
Oncogene 2003 Sep 4;22(38):5927-37

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Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding.

Chen MS, Ryan CE, Piwnica-Worms H
Molecular and cellular biology 2003 Nov;23(21):7488-97

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Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents.

Xiao Z, Chen Z, Gunasekera AH, Sowin TJ, Rosenberg SH, Fesik S, Zhang H
The Journal of biological chemistry 2003 Jun 13;278(24):21767-73

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Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex.

Goudelock DM, Jiang K, Pereira E, Russell B, Sanchez Y
The Journal of biological chemistry 2003 Aug 8;278(32):29940-7

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An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells.

Wang X, Khadpe J, Hu B, Iliakis G, Wang Y
The Journal of biological chemistry 2003 Aug 15;278(33):30869-74