orb147483

antibody from Biorbyt
Targeting: CRYAB CRYA2, HSPB5
Provider product page for orb147483
Western blot
ELISA
Immunocytochemistry

Antibody data

Product number
orb147483 - Provider product page
Provider
Biorbyt
Product name
Alpha B Crystallin antibody
Antibody type
Monoclonal
Description
Mouse monoclonal to Alpha B Crystallin (Biotin). The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with Hsp25 and Hsp27. Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its phosphorylated state and may serve a structural control function and play a role in protein maintenance. In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA (3, 4, 5, 6, and 7). Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases. Specifically, alpha-B cystallin is found in many cells and organs outside the lens, and alpha B is overexpressed in several neurological disorders and in cell lines under stress conditions..
Reactivity
Human, Rat, Bovine, Porcine
Host
Mouse
Conjugate
Biotin
Isotype
IgG
Antibody clone number
1A7.D5
Vial size
200 ug
Concentration
1 mg/ml
Storage
Conjugated antibodies should be stored at 4°C
CRYAB protein structure - orb147483 shown in red.