CRYAB

gene product
CRYA2, HSPB5
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
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983 antibodies from 34 providers.

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AntibodyRefsTypeKDWBELICCIPIHCFC
Enzo Life Sciences
12 antibodies
OriGene
16 antibodies
Novus Biologicals
57 antibodies
antibodies-online
374 antibodies
GeneTex
17 antibodies
LifeSpan BioSciences, Inc.
138 antibodies
Abnova Corporation
17 antibodies
Proteintech Group
1 antibody
NovoPro Bioscience Inc.
11 antibodies
Invitrogen Antibodies
8 antibodies
Acris Antibodies GmbH
19 antibodies
Biorbyt
82 antibodies
Abgent
13 antibodies