MA1-10259
antibody from Invitrogen Antibodies
Targeting: SELL
CD62L, hLHRc, LAM-1, LAM1, Leu-8, LNHR, LSEL, Lyam-1, LYAM1, PLNHR
Antibody data
- Antibody Data
- Antigen structure
- References [25]
- Comments [0]
- Validations
- Flow cytometry [2]
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Validation data
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- Product number
- MA1-10259 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD62L Monoclonal Antibody (DREG56)
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- This antibody recognizes an extracellular epitope of CD62L / L-selectin, a 65-76 kDa cell surface protein, expressed by neutrophils, monocytes, and subsets of T, B, and NK cells, that interacts with specific carbohydrates exposed on activated endothelial cells. Western Blot: non-reducing conditions.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- DREG56
- Vial size
- 100 µg
- Concentration
- 1 mg/mL
- Storage
- 4° C, do not freeze
Submitted references Long-term culture with lipopolysaccharide induces dose-dependent cytostatic and cytotoxic effects in THP-1 monocytes.
Strain-specific Plasmodium falciparum multifunctional CD4(+) T cell cytokine expression in Malian children immunized with the FMP2.1/AS02A vaccine candidate.
Mimicking the tumour microenvironment of chronic lymphocytic leukaemia in vitro critically depends on the type of B-cell receptor stimulation.
Cross-reactive multifunctional CD4+ T cell responses against Salmonella enterica serovars Typhi, Paratyphi A and Paratyphi B in humans following immunization with live oral typhoid vaccine Ty21a.
Differential Immune Profiles in Two Pandemic Influenza A(H1N1)pdm09 Virus Waves at Pandemic Epicenter.
HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4+ T Lymphocytes.
IL-12-secreting CD19-targeted cord blood-derived T cells for the immunotherapy of B-cell acute lymphoblastic leukemia.
Monitoring of antigen-specific CD8 T cells in patients with type 1 diabetes treated with antiCD3 monoclonal antibodies.
A role for the L-selectin adhesion system in mediating cytotrophoblast emigration from the placenta.
Nicotine downregulates the l-selectin system that mediates cytotrophoblast emigration from cell columns and attachment to the uterine wall.
Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood.
Contemporaneous fluctuations in T cell responses to persistent herpes virus infections.
Role of L-selectin in the vascular homing of peripheral blood-derived endothelial progenitor cells.
Role of L-selectin in the vascular homing of peripheral blood-derived endothelial progenitor cells.
Phenotypic and functional differences between human saphenous vein (HSVEC) and umbilical vein (HUVEC) endothelial cells.
Proinflammatory phenotype of endothelial cells after coculture with biomaterial-treated blood cells.
Proinflammatory phenotype of endothelial cells after coculture with biomaterial-treated blood cells.
Characterization of multiple CD34+ cell populations in cord blood.
Role for granulocyte colony-stimulating factor in the generation of human T regulatory type 1 cells.
Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markers.
Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markers.
Expression and coreceptor activity of STRL33/Bonzo on primary peripheral blood lymphocytes.
Relationship between selectin-mediated rolling of hematopoietic stem and progenitor cells and progression in hematopoietic development.
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages.
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages.
Mytych J, Romerowicz-Misielak M, Koziorowski M
Toxicology in vitro : an international journal published in association with BIBRA 2017 Aug;42:1-9
Toxicology in vitro : an international journal published in association with BIBRA 2017 Aug;42:1-9
Strain-specific Plasmodium falciparum multifunctional CD4(+) T cell cytokine expression in Malian children immunized with the FMP2.1/AS02A vaccine candidate.
Graves SF, Kouriba B, Diarra I, Daou M, Niangaly A, Coulibaly D, Keita Y, Laurens MB, Berry AA, Vekemans J, Ripley Ballou W, Lanar DE, Dutta S, Gray Heppner D, Soisson L, Diggs CL, Thera MA, Doumbo OK, Plowe CV, Sztein MB, Lyke KE
Vaccine 2016 May 17;34(23):2546-55
Vaccine 2016 May 17;34(23):2546-55
Mimicking the tumour microenvironment of chronic lymphocytic leukaemia in vitro critically depends on the type of B-cell receptor stimulation.
Rombout A, Lust S, Offner F, Naessens E, Verhasselt B, Philippé J
British journal of cancer 2016 Mar 15;114(6):704-12
British journal of cancer 2016 Mar 15;114(6):704-12
Cross-reactive multifunctional CD4+ T cell responses against Salmonella enterica serovars Typhi, Paratyphi A and Paratyphi B in humans following immunization with live oral typhoid vaccine Ty21a.
Wahid R, Fresnay S, Levine MM, Sztein MB
Clinical immunology (Orlando, Fla.) 2016 Dec;173:87-95
Clinical immunology (Orlando, Fla.) 2016 Dec;173:87-95
Differential Immune Profiles in Two Pandemic Influenza A(H1N1)pdm09 Virus Waves at Pandemic Epicenter.
Arriaga-Pizano L, Ferat-Osorio E, Rodríguez-Abrego G, Mancilla-Herrera I, Domínguez-Cerezo E, Valero-Pacheco N, Pérez-Toledo M, Lozano-Patiño F, Laredo-Sánchez F, Malagón-Rangel J, Nellen-Hummel H, González-Bonilla C, Arteaga-Troncoso G, Cérbulo-Vázquez A, Pastelin-Palacios R, Klenerman P, Isibasi A, López-Macías C
Archives of medical research 2015 Nov;46(8):651-8
Archives of medical research 2015 Nov;46(8):651-8
HIV-1 Nef and Vpu Interfere with L-Selectin (CD62L) Cell Surface Expression To Inhibit Adhesion and Signaling in Infected CD4+ T Lymphocytes.
Vassena L, Giuliani E, Koppensteiner H, Bolduan S, Schindler M, Doria M
Journal of virology 2015 May;89(10):5687-700
Journal of virology 2015 May;89(10):5687-700
IL-12-secreting CD19-targeted cord blood-derived T cells for the immunotherapy of B-cell acute lymphoblastic leukemia.
Pegram HJ, Purdon TJ, van Leeuwen DG, Curran KJ, Giralt SA, Barker JN, Brentjens RJ
Leukemia 2015 Feb;29(2):415-22
Leukemia 2015 Feb;29(2):415-22
Monitoring of antigen-specific CD8 T cells in patients with type 1 diabetes treated with antiCD3 monoclonal antibodies.
Cernea S, Herold KC
Clinical immunology (Orlando, Fla.) 2010 Feb;134(2):121-9
Clinical immunology (Orlando, Fla.) 2010 Feb;134(2):121-9
A role for the L-selectin adhesion system in mediating cytotrophoblast emigration from the placenta.
Prakobphol A, Genbacev O, Gormley M, Kapidzic M, Fisher SJ
Developmental biology 2006 Oct 1;298(1):107-17
Developmental biology 2006 Oct 1;298(1):107-17
Nicotine downregulates the l-selectin system that mediates cytotrophoblast emigration from cell columns and attachment to the uterine wall.
Zdravkovic T, Genbacev O, Prakobphol A, Cvetkovic M, Schanz A, McMaster M, Fisher SJ
Reproductive toxicology (Elmsford, N.Y.) 2006 Jul;22(1):69-76
Reproductive toxicology (Elmsford, N.Y.) 2006 Jul;22(1):69-76
Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood.
Bratke K, Kuepper M, Bade B, Virchow JC Jr, Luttmann W
European journal of immunology 2005 Sep;35(9):2608-16
European journal of immunology 2005 Sep;35(9):2608-16
Contemporaneous fluctuations in T cell responses to persistent herpes virus infections.
Crough T, Burrows JM, Fazou C, Walker S, Davenport MP, Khanna R
European journal of immunology 2005 Jan;35(1):139-49
European journal of immunology 2005 Jan;35(1):139-49
Role of L-selectin in the vascular homing of peripheral blood-derived endothelial progenitor cells.
Biancone L, Cantaluppi V, Duò D, Deregibus MC, Torre C, Camussi G
Journal of immunology (Baltimore, Md. : 1950) 2004 Oct 15;173(8):5268-74
Journal of immunology (Baltimore, Md. : 1950) 2004 Oct 15;173(8):5268-74
Role of L-selectin in the vascular homing of peripheral blood-derived endothelial progenitor cells.
Biancone L, Cantaluppi V, Duò D, Deregibus MC, Torre C, Camussi G
Journal of immunology (Baltimore, Md. : 1950) 2004 Oct 15;173(8):5268-74
Journal of immunology (Baltimore, Md. : 1950) 2004 Oct 15;173(8):5268-74
Phenotypic and functional differences between human saphenous vein (HSVEC) and umbilical vein (HUVEC) endothelial cells.
Tan PH, Chan C, Xue SA, Dong R, Ananthesayanan B, Manunta M, Kerouedan C, Cheshire NJ, Wolfe JH, Haskard DO, Taylor KM, George AJ
Atherosclerosis 2004 Apr;173(2):171-83
Atherosclerosis 2004 Apr;173(2):171-83
Proinflammatory phenotype of endothelial cells after coculture with biomaterial-treated blood cells.
Lester EA, Babensee JE
Journal of biomedical materials research. Part A 2003 Mar 1;64(3):397-410
Journal of biomedical materials research. Part A 2003 Mar 1;64(3):397-410
Proinflammatory phenotype of endothelial cells after coculture with biomaterial-treated blood cells.
Lester EA, Babensee JE
Journal of biomedical materials research. Part A 2003 Mar 1;64(3):397-410
Journal of biomedical materials research. Part A 2003 Mar 1;64(3):397-410
Characterization of multiple CD34+ cell populations in cord blood.
Greco NJ, Lee WR, Kurtz J, Seetharaman S, Moroff G
Journal of hematotherapy & stem cell research 2003 Apr;12(2):199-213
Journal of hematotherapy & stem cell research 2003 Apr;12(2):199-213
Role for granulocyte colony-stimulating factor in the generation of human T regulatory type 1 cells.
Rutella S, Pierelli L, Bonanno G, Sica S, Ameglio F, Capoluongo E, Mariotti A, Scambia G, d'Onofrio G, Leone G
Blood 2002 Oct 1;100(7):2562-71
Blood 2002 Oct 1;100(7):2562-71
Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markers.
Ku CC, Padilla JA, Grose C, Butcher EC, Arvin AM
Journal of virology 2002 Nov;76(22):11425-33
Journal of virology 2002 Nov;76(22):11425-33
Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markers.
Ku CC, Padilla JA, Grose C, Butcher EC, Arvin AM
Journal of virology 2002 Nov;76(22):11425-33
Journal of virology 2002 Nov;76(22):11425-33
Expression and coreceptor activity of STRL33/Bonzo on primary peripheral blood lymphocytes.
Sharron M, Pöhlmann S, Price K, Lolis E, Tsang M, Kirchhoff F, Doms RW, Lee B
Blood 2000 Jul 1;96(1):41-9
Blood 2000 Jul 1;96(1):41-9
Relationship between selectin-mediated rolling of hematopoietic stem and progenitor cells and progression in hematopoietic development.
Greenberg AW, Kerr WG, Hammer DA
Blood 2000 Jan 15;95(2):478-86
Blood 2000 Jan 15;95(2):478-86
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages.
Lee B, Sharron M, Montaner LJ, Weissman D, Doms RW
Proceedings of the National Academy of Sciences of the United States of America 1999 Apr 27;96(9):5215-20
Proceedings of the National Academy of Sciences of the United States of America 1999 Apr 27;96(9):5215-20
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages.
Lee B, Sharron M, Montaner LJ, Weissman D, Doms RW
Proceedings of the National Academy of Sciences of the United States of America 1999 Apr 27;96(9):5215-20
Proceedings of the National Academy of Sciences of the United States of America 1999 Apr 27;96(9):5215-20
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Flow cytometry surface staining pattern of human peripheral blood stained using anti-human CD62L (DREG56) purified Monoclonal antibody (Product # MA1-10259); concentration in sample 1 µg/mL, GAM APC.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Separation of human CD62L positive lymphocytes (red-filled) from CD62L negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD62L (DREG56) purified Monoclonal antibody (Product # MA1-10259); concentration in sample 1 µg/mL, GAM APC.