RA0671

antibody from Oursmab

Targeting: SELL CD62L, hLHRc, LAM-1, LAM1, Leu-8, LNHR, LSEL, Lyam-1, LYAM1, PLNHR

Western blot (Data presented on provider website)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0671

Provider

Oursmab

Product name

Aselizumab (Biosimilar Reference Antibody) (SELL)

Antibody type

Monoclonal

Description

Aselizumab is a humanized monoclonal antibody of the IgG4 isotype that functions as an antagonist targeting the CD62L receptor, also known as L-selectin. By blocking this adhesion molecule, Aselizumab aims to prevent the extravasation (migration) of leukocytes (white blood cells), particularly neutrophils and monocytes, from the blood vessels into inflamed tissues. The IgG4 isotype minimizes the risk of cell depletion via Fc effector functions. Aselizumab was investigated in the early 2000s for the treatment of inflammatory conditions where excessive leukocyte recruitment drives pathology, such as acute respiratory distress syndrome (ARDS), but its development was discontinued following clinical trials.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.