Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations [0]
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- Product number
- MAB1485 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#MAB1485, RRID:AB_1709916
- Product name
- SMAD4 monoclonal antibody, clone IMD-89
- Antibody type
- Monoclonal
- Description
- Mouse monoclonal antibody raised against full length recombinant SMAD4.
- Isotype
- IgG
- Antibody clone number
- IMD-89
- Storage
- Store at -20°C on dry atmosphere.After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C or lower.Aliquot to avoid repeated freezing and thawing.
Submitted references Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.
Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases.
Mutations in the SMAD4/DPC4 gene in juvenile polyposis.
Kim BG, Li C, Qiao W, Mamura M, Kasprzak B, Anver M, Wolfraim L, Hong S, Mushinski E, Potter M, Kim SJ, Fu XY, Deng C, Letterio JJ
Nature 2006 Jun 22;441(7096):1015-9
Nature 2006 Jun 22;441(7096):1015-9
Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases.
Houlston R, Bevan S, Williams A, Young J, Dunlop M, Rozen P, Eng C, Markie D, Woodford-Richens K, Rodriguez-Bigas MA, Leggett B, Neale K, Phillips R, Sheridan E, Hodgson S, Iwama T, Eccles D, Bodmer W, Tomlinson I
Human molecular genetics 1998 Nov;7(12):1907-12
Human molecular genetics 1998 Nov;7(12):1907-12
Mutations in the SMAD4/DPC4 gene in juvenile polyposis.
Howe JR, Roth S, Ringold JC, Summers RW, Järvinen HJ, Sistonen P, Tomlinson IP, Houlston RS, Bevan S, Mitros FA, Stone EM, Aaltonen LA
Science (New York, N.Y.) 1998 May 15;280(5366):1086-8
Science (New York, N.Y.) 1998 May 15;280(5366):1086-8
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