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- Antibody Data
- Antigen structure
- References [21]
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- Product number
- 14580-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14580-1-AP, RRID:AB_10639524
- Product name
- Perforin antibody
- Antibody type
- Polyclonal
- Description
- Perforin antibody (Cat. #14580-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Structural characterization and antitumor activity via immune modulation of an α-glucan from Grifola frondosa.
CD80-Mediated T-Cell Suppression by Cancer Stem-like Cells in Head and Neck Squamous Cell Carcinoma.
Activated T-cell membrane-derived nanocargoes displaying multi-immune checkpoints for enhanced cancer immunotherapy.
Engineered NK92 cell-derived exosomes inhibit ovarian cancer progression by degrading GPRC5A.
Chronic kidney disease facilitates TNF-α + neutrophils dysfunction and progression in oral squamous cell carcinoma.
HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer.
Luteolin targets peroxiredoxin 2 to augment T-cell-mediated cytotoxicity and suppress lung adenocarcinoma progression.
Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8(+) T lymphocytes and aggravates spinal cord injury.
Next-generation probiotics Alistipes onderdonkii enhances the efficacy of anti-PD-1 therapy in colorectal cancer.
Conserved functional features of natural killer cell subsets in chicken, human, and murine immune systems.
The development of anti-PD-1 antibody-induced spinal cord injury in bone marrow transplant C57BL/6 Rag1(-/-) mouse model.
Vimentin, inversely correlating with infiltration of CD8 + T lymphocytes, promotes nuclear translocation of PD-L1 in esophageal squamous cell carcinoma.
Picroside II promotes HSC apoptosis and inhibits the cholestatic liver fibrosis in Mdr2(-/-) mice by polarizing M1 macrophages and balancing immune responses.
The SIX1/LDHA Axis Promotes Lactate Accumulation and Leads to NK Cell Dysfunction in Pancreatic Cancer.
Perforin and granzyme A release as novel tool to measure NK cell activation in chickens.
Schisandrin B induces HepG2 cells pyroptosis by activating NK cells mediated anti-tumor immunity.
Tannins in Terminalia bellirica inhibits hepatocellular carcinoma growth via re-educating tumor-associated macrophages and restoring CD8(+)T cell function.
The Role of Tim-3 on dNK Cells Dysfunction During Abnormal Pregnancy With Toxoplasma gondii Infection.
Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells.
VEGF165b augments NK92 cytolytic activity against human K562 leukemia cells by upregulating the levels of perforin and granzyme B via the VEGR1-PLC pathway.
Characterization of cytotoxicity-related gene expression in response to virulent Marek's disease virus infection in the bursa of Fabricius.
Tian HX, Ruan QZ, Xie YZ, Chen W, Xiao C, Zhong W, Liu YC, Chen SD, Yong TQ, Hu HP, Li XM, Wu QP
Carbohydrate polymers 2026 Jun 15;382:125254
Carbohydrate polymers 2026 Jun 15;382:125254
CD80-Mediated T-Cell Suppression by Cancer Stem-like Cells in Head and Neck Squamous Cell Carcinoma.
Xiao M, Qiu L, Gao Q, Li R, Wang J, Feng Y, Li X, Ge X
Cells 2026 Jan 30;15(3)
Cells 2026 Jan 30;15(3)
Activated T-cell membrane-derived nanocargoes displaying multi-immune checkpoints for enhanced cancer immunotherapy.
Du L, Zhang X, Gong Y, Liu M, Sun J, Hu X, Peng J, Liu Z, Zhang T, Xu J, Gao F, Cheng W
Materials today. Bio 2026 Feb;36:102702
Materials today. Bio 2026 Feb;36:102702
Engineered NK92 cell-derived exosomes inhibit ovarian cancer progression by degrading GPRC5A.
Si C, Wang Y, Li Y, Chen Y, Fan Y, Wang Y, Tian Y, Gao J, Ma X
Frontiers in immunology 2025;16:1613178
Frontiers in immunology 2025;16:1613178
Chronic kidney disease facilitates TNF-α + neutrophils dysfunction and progression in oral squamous cell carcinoma.
Peihui Z, Jianing C, Chuwen L, Hanjin R, Wenyu Y, Jiaqi Z, Yujie L, Li W
International immunopharmacology 2025 Sep 23;162:115184
International immunopharmacology 2025 Sep 23;162:115184
HEBP2-governed glutamine competition between tumor and macrophages dictates immunotherapy efficacy in triple-negative breast cancer.
Xiao Y, Xu Y, Wang H, Yang F, Ding XH, Fu T, Chen L, Jin X, Zhao YX, Wang Y, Chen F, Shao ZM, Jiang YZ
Cell metabolism 2025 Oct 7;37(10):2030-2047.e7
Cell metabolism 2025 Oct 7;37(10):2030-2047.e7
Luteolin targets peroxiredoxin 2 to augment T-cell-mediated cytotoxicity and suppress lung adenocarcinoma progression.
Li X, Bai Y, Zhou J, Cheng A, Guo J, Chen M, Hu D, Wu J
European journal of pharmacology 2025 Oct 5;1004:177984
European journal of pharmacology 2025 Oct 5;1004:177984
Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8(+) T lymphocytes and aggravates spinal cord injury.
Ge X, Zhu Y, Xiong J, Gu Y, Wang X, Ye W, Wang H, Gao Y, Cai W, Zhou X, Liu W
Neuron 2025 Jul 23;113(14):2280-2296.e8
Neuron 2025 Jul 23;113(14):2280-2296.e8
Next-generation probiotics Alistipes onderdonkii enhances the efficacy of anti-PD-1 therapy in colorectal cancer.
Xin J, Xiang Y, Jiang J, Jiang Z, Yi B
Biochimica et biophysica acta. Molecular basis of disease 2025 Aug;1871(6):167891
Biochimica et biophysica acta. Molecular basis of disease 2025 Aug;1871(6):167891
Conserved functional features of natural killer cell subsets in chicken, human, and murine immune systems.
Woo SJ, Kim J, Lee HJ, Lee KY, Park KJ, Kim JK, Kim JL, Park BC, Seo M, Han JY
iScience 2025 Aug 15;28(8):113144
iScience 2025 Aug 15;28(8):113144
The development of anti-PD-1 antibody-induced spinal cord injury in bone marrow transplant C57BL/6 Rag1(-/-) mouse model.
Chen H, Lu Z, Ni X, Zhang H, Chen G, Wu X, Ding M
Immunotherapy 2024;16(14-15):975-985
Immunotherapy 2024;16(14-15):975-985
Vimentin, inversely correlating with infiltration of CD8 + T lymphocytes, promotes nuclear translocation of PD-L1 in esophageal squamous cell carcinoma.
Liang Y, He S, Liu Q, Liu T, Tan Y, Peng T, Huang C, Lu X, Zheng S
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119781
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119781
Picroside II promotes HSC apoptosis and inhibits the cholestatic liver fibrosis in Mdr2(-/-) mice by polarizing M1 macrophages and balancing immune responses.
Jia K, Ma Z, Zhang Y, Xie K, Li J, Wu J, Qu J, Li F, Li X
Chinese journal of natural medicines 2024 Jul;22(7):582-598
Chinese journal of natural medicines 2024 Jul;22(7):582-598
The SIX1/LDHA Axis Promotes Lactate Accumulation and Leads to NK Cell Dysfunction in Pancreatic Cancer.
Ge W, Meng L, Cao S, Hou C, Zhu X, Huang D, Li Q, Peng Y, Jiang K
Journal of immunology research 2023;2023:6891636
Journal of immunology research 2023;2023:6891636
Perforin and granzyme A release as novel tool to measure NK cell activation in chickens.
Ijaz A, Broere F, Rutten VPMG, Jansen CA, Veldhuizen EJA
Developmental and comparative immunology 2023 Dec;149:105047
Developmental and comparative immunology 2023 Dec;149:105047
Schisandrin B induces HepG2 cells pyroptosis by activating NK cells mediated anti-tumor immunity.
Song A, Ding T, Wei N, Yang J, Ma M, Zheng S, Jin H
Toxicology and applied pharmacology 2023 Aug 1;472:116574
Toxicology and applied pharmacology 2023 Aug 1;472:116574
Tannins in Terminalia bellirica inhibits hepatocellular carcinoma growth via re-educating tumor-associated macrophages and restoring CD8(+)T cell function.
Chang Z, Zhang Q, Hu Q, Liu Y, Zhang L, Liu R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113543
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113543
The Role of Tim-3 on dNK Cells Dysfunction During Abnormal Pregnancy With Toxoplasma gondii Infection.
Li T, Cui L, Xu X, Zhang H, Jiang Y, Ren L, Yang C, Liu X, Hu X
Frontiers in cellular and infection microbiology 2021;11:587150
Frontiers in cellular and infection microbiology 2021;11:587150
Targeting MUS81 promotes the anticancer effect of WEE1 inhibitor and immune checkpoint blocking combination therapy via activating cGAS/STING signaling in gastric cancer cells.
Li C, Shen Q, Zhang P, Wang T, Liu W, Li R, Ma X, Zeng X, Yin Y, Tao K
Journal of experimental & clinical cancer research : CR 2021 Oct 8;40(1):315
Journal of experimental & clinical cancer research : CR 2021 Oct 8;40(1):315
VEGF165b augments NK92 cytolytic activity against human K562 leukemia cells by upregulating the levels of perforin and granzyme B via the VEGR1-PLC pathway.
Wang X, Liang C, Xia W, Guo C, Niu Z, Zhu W, Zhang H
Molecular immunology 2020 Dec;128:41-46
Molecular immunology 2020 Dec;128:41-46
Characterization of cytotoxicity-related gene expression in response to virulent Marek's disease virus infection in the bursa of Fabricius.
Chen CY, Xie QM, Xue Y, Ji J, Chang S, Ma JY, Bi YZ
Research in veterinary science 2013 Jun;94(3):496-503
Research in veterinary science 2013 Jun;94(3):496-503
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Perforin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Perforin. This antibody recognizes human, mouse antigen. The Perforin antibody has been validated for the following applications: ELISA, WB analysis.
