PRF1

gene product
HPLH2, P1, PFP
The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
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Antibodies

 

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Antibodypedia Validation Initiative

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529 antibodies from 39 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Enzo Life Sciences
3 antibodies
Novus Biologicals
24 antibodies
Invitrogen Antibodies
18 antibodies
GeneTex
8 antibodies
antibodies-online
147 antibodies
Antibodies.com
2 antibodies
Biorbyt
34 antibodies
Abnova Corporation
10 antibodies
BioLegend
48 antibodies
LifeSpan BioSciences, Inc.
74 antibodies
Bioworld Technology, Inc
1 antibody
St John's Laboratory
2 antibodies
Affinity Biosciences
1 antibody
Proteintech Group
1 antibody
NSJ Bioreagents
4 antibodies
OriGene
15 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Boster Biological Technology
2 antibodies
NovoPro Bioscience Inc.
2 antibodies
Acris Antibodies GmbH
14 antibodies
GenWay
6 antibodies
Creative Biolabs
4 antibodies
Abbexa
8 antibodies
ProSci
3 antibodies
Arigo
2 antibodies
Aviva Systems Biology
2 antibodies
Atlas Antibodies
1 antibody
Miltenyi Biotec
14 antibodies
United States Biological
27 antibodies
MyBioSource
12 antibodies
Abiocode, Inc.
4 antibodies
Cell Signaling Technology, Inc
1 antibody
RabMAbs
1 antibody
Signalway Antibody LLC
1 antibody
Creative Diagnostics
5 antibodies
eBioscience, An Affymetrix Company
12 antibodies
Abgent
1 antibody
Sigma-Aldrich
2 antibodies