PRF1

gene product
HPLH2, P1, PFP
This gene encodes a protein with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
578 antibodies from 42 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Novus Biologicals
34 antibodies
Invitrogen Antibodies
22 antibodies
Enzo Life Sciences
3 antibodies
GeneTex
8 antibodies
antibodies-online
147 antibodies
Antibodies.com
2 antibodies
LifeSpan BioSciences, Inc.
85 antibodies
OriGene
13 antibodies
Biorbyt
37 antibodies
Abnova Corporation
10 antibodies
HUABIO Research
1 antibody
BioLegend
48 antibodies
Proteintech Group
1 antibody
Bioworld Technology, Inc
1 antibody
St John's Laboratory
2 antibodies
Affinity Biosciences
1 antibody
NSJ Bioreagents
4 antibodies
R&D Systems
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
Cell Signaling Technology, Inc
4 antibodies
Boster Biological Technology
2 antibodies
NovoPro Bioscience Inc.
2 antibodies
Acris Antibodies GmbH
14 antibodies
Creative Biolabs
13 antibodies
GenWay
6 antibodies
ProSci
3 antibodies
Arigo
2 antibodies
Aviva Systems Biology
2 antibodies
Atlas Antibodies
1 antibody
Miltenyi Biotec
14 antibodies
United States Biological
27 antibodies
MyBioSource
12 antibodies
Abiocode, Inc.
4 antibodies
Abbexa
13 antibodies
RabMAbs
1 antibody
Signalway Antibody LLC
1 antibody
Creative Diagnostics
8 antibodies
eBioscience, An Affymetrix Company
12 antibodies
Abgent
1 antibody
Leading Biology
1 antibody
Sigma-Aldrich
2 antibodies