CABT-BL8198

antibody from Creative Diagnostics

Targeting: PRF1 HPLH2, P1, PFP

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-BL8198

Provider

Creative Diagnostics

Product name

Anti-PRF1 Monoclonal antibody, clone eH0 [PE]

Antibody type

Monoclonal

Description

Perforin is one of the major cytolytic proteins of cytolytic granules. One of the main pathways of lymphocyte mediated cytolysis entails the secretion onto target membranes of cytolytic granules contained in cytolytic effector lymphocytes of T-cell or NK-cell type. Perforin is a cytolytic mediator and is stored in and released by cytoplasmic granules. Perforin (PRF) is involved in the killing mediated by cytotoxic lymphocytes which represents an important mechanism in the immune defense against tumors and virus infections. Human PRF is a 555 amino acid protein with a 21 amino acid signal peptide. It has a molecular weight of 70 to 75 kD. PRF is a pore forming protein with a mechanism of transmembrane channel formation similar to C9 and homology between perforin and C9 has been demonstrated at their respective functionally conserved regions. Studies show that perforin is expressed only in killer cell lines and not in helper T lymphocytes or other tumor cells tested.

Reactivity

Human, Porcine

Host

Mouse

Conjugate

Yellow dye

Isotype

IgG