Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 308111 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#308111, RRID:AB_830872
- Product name
- APC anti-human Perforin
- Antibody type
- Monoclonal
- Antigen
- Purified granules from the human lymphoma cell line
- Description
- Perforin is a 70 kD cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis.
- Reactivity
- Human, Bovine, Feline
- Host
- Mouse
- Conjugate
- Red dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references HLA-B7-restricted EBV-specific CD8+ T cells are dysregulated in multiple sclerosis.
Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity.
Jilek S, Schluep M, Harari A, Canales M, Lysandropoulos A, Zekeridou A, Pantaleo G, Du Pasquier RA
Journal of immunology (Baltimore, Md. : 1950) 2012 May 1;188(9):4671-80
Journal of immunology (Baltimore, Md. : 1950) 2012 May 1;188(9):4671-80
Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity.
Wood SM, Meeths M, Chiang SC, Bechensteen AG, Boelens JJ, Heilmann C, Horiuchi H, Rosthøj S, Rutynowska O, Winiarski J, Stow JL, Nordenskjöld M, Henter JI, Ljunggren HG, Bryceson YT
Blood 2009 Nov 5;114(19):4117-27
Blood 2009 Nov 5;114(19):4117-27
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes intracellular stained with DG9 APC
- Conjugate
- Red dye