CD37

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Description

CD37 molecule

Tissue specificity

Tissue enhanced (bone marrow, intestine, lymphoid tissue)

Subcell location

Golgi apparatus, Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (49335171 - 49343335)

Ensembl ID

ENSG00000104894  (ver. 103.38)

Orthologs

Mouse Cd37: ENSMUSG00000030798

UniProt

P11049

neXtProt

NX_P11049

Human splice variants
Mouse splice variants

Protein structure