RA0092

antibody from Oursmab
Targeting: CD37 TSPAN26
Provider product page for RA0092
Western blot
ELISA
Immunocytochemistry
Flow cytometry
Functional assay

Antibody data

Product number
RA0092 - Provider product page
Provider
Oursmab
Product name
Naratuximab (Biosimilar Reference Antibody) (CD37)
Antibody type
Monoclonal
Description
Naratuximab emtansine (also known as IMGN-529 or KVA-12123) is an investigational antibody-drug conjugate (ADC) consisting of a humanized monoclonal antibody targeting CD37, a tetraspanin protein highly expressed on B cells and B-cell malignancies, conjugated to the potent cytotoxic maytansinoid DM1 via a cleavable linker. Upon binding to CD37 on the surface of tumor cells, the ADC is internalized, and DM1 is released intracellularly, where it disrupts microtubule assembly, leading to cell cycle arrest and apoptosis. It has been clinically evaluated for the treatment of relapsed or refractory B-cell non-Hodgkin lymphoma (NHL), including diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma.
Reactivity
Human
Isotype
IgG
Vial size
100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg
Concentration
Bottled at the concentration indicated on the vial.
Storage
Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.
CD37 protein structure - RA0092 shown in red.