Tissue expression
Cell line expression
Protein structure

CD40

CD40 molecule
Bp50, p50, TNFRSF5 
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
More gene data

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3207 antibodies from 54 providers.

Antibody properties

Applications

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
236 antibodies
Invitrogen Antibodies
238 antibodies
GeneTex
32 antibodies
R&D Systems
35 antibodies
NSJ Bioreagents
13 antibodies
Boster Biological Technology
8 antibodies
antibodies-online
797 antibodies
OriGene
119 antibodies
Enzo Life Sciences
17 antibodies
Atlas Antibodies
3 antibodies
Proteintech Group
13 antibodies
HUABIO Research
3 antibodies
Affinity Biosciences
3 antibodies
Bethyl Laboratories
1 antibody
Aviva Systems Biology
29 antibodies
St John's Laboratory
47 antibodies
Abnova Corporation
65 antibodies
BioLegend
78 antibodies
Cusabio Biotech Co., Ltd
9 antibodies
Aladdin Scientific Corporation
3 antibodies
Acris Antibodies GmbH
54 antibodies
NovoPro Bioscience Inc.
8 antibodies
Cell Signaling Technology, Inc
2 antibodies
Creative Biolabs
582 antibodies
Bioworld Technology, Inc
2 antibodies
Abgent
7 antibodies
Antibodies.com
4 antibodies
FineTest Biotech
1 antibody
Absolute Antibody
48 antibodies
ProSci
21 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
Miltenyi Biotec
47 antibodies
STEMCELL Technologies Inc
9 antibodies
Creative Diagnostics
40 antibodies
Sino Biological Inc.
11 antibodies
Spring Bioscience
4 antibodies
United States Biological
63 antibodies
MyBioSource
14 antibodies
Abbexa
38 antibodies
GenWay
19 antibodies
Leading Biology
9 antibodies
MilliporeSigma / Merck KGaA
8 antibodies
RayBiotech, Inc.
6 antibodies
Kerafast Inc.
1 antibody
eBioscience, An Affymetrix Company
17 antibodies
Abbiotec
5 antibodies
BioLegend (formerly Covance Antibody Products)
1 antibody
RabMAbs
1 antibody
Rockland Immunochemicals, Inc.
4 antibodies
CPTAC
1 antibody