CD40

gene product
Bp50, p50, TNFRSF5
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
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2651 antibodies from 46 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
234 antibodies
GeneTex
32 antibodies
NSJ Bioreagents
11 antibodies
antibodies-online
797 antibodies
Boster Biological Technology
7 antibodies
Enzo Life Sciences
17 antibodies
Atlas Antibodies
3 antibodies
Biorbyt
93 antibodies
Affinity Biosciences
3 antibodies
OriGene
70 antibodies
Invitrogen Antibodies
38 antibodies
LifeSpan BioSciences, Inc.
377 antibodies
R&D Systems
35 antibodies
Aviva Systems Biology
29 antibodies
Abnova Corporation
65 antibodies
BioLegend
73 antibodies
Acris Antibodies GmbH
54 antibodies
NovoPro Bioscience Inc.
8 antibodies
Cell Signaling Technology, Inc
2 antibodies
Creative Biolabs
342 antibodies
Bioworld Technology, Inc
2 antibodies
Abgent
7 antibodies
Antibodies.com
4 antibodies
Absolute Antibody
29 antibodies
ProSci
21 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
Proteintech Group
1 antibody
Miltenyi Biotec
47 antibodies
STEMCELL Technologies Inc
9 antibodies
Creative Diagnostics
40 antibodies
Abbexa
17 antibodies
St John's Laboratory
7 antibodies
Sino Biological Inc.
11 antibodies
Spring Bioscience
4 antibodies
United States Biological
63 antibodies
MyBioSource
14 antibodies
Rockland Immunochemicals, Inc.
4 antibodies
GenWay
19 antibodies
RayBiotech, Inc.
6 antibodies
eBioscience, An Affymetrix Company
17 antibodies
Abbiotec
5 antibodies
BioLegend (formerly Covance Antibody Products)
1 antibody
RabMAbs
1 antibody
Sigma-Aldrich
4 antibodies