gene product
Bp50, p50, TNFRSF5
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
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Featured antibodies




Antibodypedia Validation Initiative

Validation method






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  or   Clear
Validated by best practice
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
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Eligible for validation within AVI
1386 antibodies from 39 providers.

Antibody properties


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457 antibodies
Novus Biologicals
122 antibodies
Enzo Life Sciences
17 antibodies
R&D Systems
14 antibodies
LifeSpan BioSciences, Inc.
193 antibodies
Aviva Systems Biology
29 antibodies
Abnova Corporation
56 antibodies