abx200257

antibody from Abbexa

Targeting: CD40 Bp50, p50, TNFRSF5

Flow cytometry (Recommended by provider)

Antibody Data

Product number

abx200257

Provider

Abbexa

Product name

TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40) Antibody (PE)

Antibody type

Monoclonal

Description

CD40 is a member of the tumour necrosis factor (TNF) receptor super family, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40 ligand (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin.

Reactivity

Human

Host

Mouse

Conjugate

Yellow dye

Isotype

IgG

Vial size

100 tests

Storage

Aliquot and store in the dark at 2°C to 8°C. Avoid exposure to light.