10197-1-AP

antibody from Proteintech Group

Targeting: HDAC1 GON-10, HD1, KDAC1, RPD3L1

Provider product page for 10197-1-AP

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Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [96]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunoprecipitation [1]
Immunohistochemistry [1]

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Product number: 10197-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10197-1-AP, RRID:AB_2118062
Product name: HDAC1 antibody
Antibody type: Polyclonal
Description: KD/KO validated HDAC1 antibody (Cat. #10197-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

HDAC1 protein structure - 10197-1-AP shown in red.

Submitted references GSDMD suppresses keratinocyte differentiation by inhibiting FLG expression and attenuating KCTD6-mediated HDAC1 degradation in atopic dermatitis.

Zhong Y, Huang T, Li X, Luo P, Zhang B
PeerJ 2024;12:e16768

MDM2 accelerated renal senescence via ubiquitination and degradation of HDAC1.

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Acta pharmacologica Sinica 2024 Nov;45(11):2328-2338

PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer.

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Cell reports 2024 May 28;43(5):114176

SIRT2-mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma.

Zhang X, Xu Y, Li S, Qin Y, Zhu G, Zhang Q, Zhang Y, Guan F, Fan T, Liu H
Journal of cellular and molecular medicine 2024 Mar;28(6):e18129

Distinct regions within SAP25 recruit O-linked glycosylation, DNA demethylation, and ubiquitin ligase and hydrolase activities to the Sin3/HDAC complex.

Goswami P, Banks CAS, Thornton J, Bengs B, Sardiu ME, Florens L, Washburn MP
bioRxiv : the preprint server for biology 2024 Mar 8;

Securin acetylation prevents precocious separase activation and premature sister chromatid separation.

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Current biology : CB 2024 Mar 25;34(6):1295-1308.e5

NS1-mediated enhancement of MVC transcription and replication promoted by KAT5/H4K12ac.

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Journal of virology 2024 Mar 19;98(3):e0169523

Zinc finger protein 36 like 2-histone deacetylase 1 axis is involved in the bone responses to mechanical stress.

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ZNF787 and HDAC1 Mediate Blood-Brain Barrier Permeability in an In Vitro Model of Alzheimer's Disease Microenvironment.

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Neurotoxicity research 2024 Feb 8;42(1):12

Miz1 represses type I interferon production and limits viral clearance during influenza A virus infection.

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Science signaling 2024 Apr 9;17(831):eadg7867

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Sphingolipid metabolism controls mammalian heart regeneration.

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F-ATP synthase inhibitory factor 1 regulates metabolic reprogramming involving its interaction with c-Myc and PGC1α.

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Pb inhibited C2C12 myoblast differentiation by regulating HDAC2.

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Toxicology 2023 Nov;499:153639

The HDAC inhibitor HFY-4A improves TUSC2 transcription to induce immunogenic cell death in breast cancer.

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Toxicology and applied pharmacology 2023 Nov 1;478:116698

Peptidase Inhibitor 16 Attenuates Left Ventricular Injury and Remodeling After Myocardial Infarction by Inhibiting the HDAC1-Wnt3a-β-Catenin Signaling Axis.

Wang L, Du A, Lu Y, Zhao Y, Qiu M, Su Z, Shu H, Shen H, Sun W, Kong X
Journal of the American Heart Association 2023 May 16;12(10):e028866

ARID1A Inactivation Increases Expression of circ0008399 and Promotes Cisplatin Resistance in Bladder Cancer.

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ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression.

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Oncogene 2023 Jun;42(27):2166-2182

ZNF451 favors triple-negative breast cancer progression by enhancing SLUG-mediated CCL5 transcriptional expression.

Zhang Y, Wang W, Min J, Liu S, Wang Q, Wang Y, Xiao Y, Li X, Zhou Z, Liu S
Cell reports 2023 Jun 27;42(6):112654

Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons.

Zheng HL, Sun SY, Jin T, Zhang M, Zeng Y, Liu Q, Yang K, Wei R, Pan Z, Lin F
Molecular pain 2023 Jan-Dec;19:17448069231152125

All-trans retinoic acid enhances the cytotoxic effect of decitabine on myelodysplastic syndromes and acute myeloid leukaemia by activating the RARα-Nrf2 complex.

Wang L, Zhang Q, Ye L, Ye X, Yang W, Zhang H, Zhou X, Ren Y, Ma L, Zhang X, Mei C, Xu G, Li K, Luo Y, Jiang L, Lin P, Zhu S, Lang W, Wang Y, Shen C, Han Y, Liu X, Yang H, Lu C, Sun J, Jin J, Tong H
British journal of cancer 2023 Feb;128(4):691-701

B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin.

Zhou C, Zhu X, Liu N, Dong X, Zhang X, Huang H, Tang Y, Liu S, Hu M, Wang M, Deng X, Li S, Zhang R, Huang Y, Lyu H, Xiao S, Luo S, Ali DW, Michalak M, Chen XZ, Wang Z, Tang J
Signal transduction and targeted therapy 2023 Feb 17;8(1):66

ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.

Sun L, Suo C, Zhang T, Shen S, Gu X, Qiu S, Zhang P, Wei H, Ma W, Yan R, Chen R, Jia W, Cao J, Zhang H, Gao P
Nature chemical biology 2023 Dec;19(12):1492-1503

E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC.

Tang F, Lu C, He X, Lin W, Xie B, Gao X, Peng Y, Yang D, Sun L, Weng L
Cell reports 2023 Dec 26;42(12):113477

MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression.

Sun Y, Jin X, Meng J, Guo F, Chen T, Zhao X, Wu H, Ren D
The EMBO journal 2023 Dec 1;42(23):e114558

GAPDH facilitates homologous recombination repair by stabilizing RAD51 in an HDAC1-dependent manner.

Shi M, Hou J, Liang W, Li Q, Shao S, Ci S, Shu C, Zhao X, Zhao S, Huang M, Wu C, Hu Z, He L, Guo Z, Pan F
EMBO reports 2023 Aug 3;24(8):e56437

Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.

Chang T, Lian Z, Ma S, Liang Z, Ma X, Wen X, Wang Y, Liu R
The Prostate 2023 Apr;83(5):470-486

Sorafenib Attenuates Fibrotic Hepatic Injury Through Mediating Lysine Crotonylation.

Chen XF, Ji S
Drug design, development and therapy 2022;16:2133-2144

Targeting HNRNPM Inhibits Cancer Stemness and Enhances Antitumor Immunity in Wnt-activated Hepatocellular Carcinoma.

Zhu GQ, Wang Y, Wang B, Liu WR, Dong SS, Chen EB, Cai JL, Wan JL, Du JX, Song LN, Chen SP, Yu L, Zhou ZJ, Wang Z, Zhou J, Shi YH, Fan J, Dai Z
Cellular and molecular gastroenterology and hepatology 2022;13(5):1413-1447

Hepatic RACK1 deficiency protects against fulminant hepatitis through myeloid-derived suppressor cells.

Liu G, Wang Q, Deng L, Huang X, Yang G, Cheng Q, Guo T, Guo L, Niu C, Yang X, Dong J, Zhang J
Theranostics 2022;12(5):2248-2265

Post-translational control of beige fat biogenesis by PRDM16 stabilization.

Wang Q, Li H, Tajima K, Verkerke ARP, Taxin ZH, Hou Z, Cole JB, Li F, Wong J, Abe I, Pradhan RN, Yamamuro T, Yoneshiro T, Hirschhorn JN, Kajimura S
Nature 2022 Sep;609(7925):151-158

PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.

Yuan HF, Zhao M, Zhao LN, Yun HL, Yang G, Geng Y, Wang YF, Zheng W, Yuan Y, Song TQ, Niu JQ, Zhang XD
Acta pharmacologica Sinica 2022 Sep;43(9):2373-2385

The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots.

Yuan S, Huang T, Bao Z, Wang S, Wu X, Liu J, Liu H, Chen ZJ
Genome biology 2022 Sep 6;23(1):187

Histone deacetylase 1 and 3 inhibitors alleviate colon inflammation by inhibiting Th17 cell differentiation.

Gu Z, Chen X, Zhu D, Wu S, Yu C
Journal of clinical laboratory analysis 2022 Oct;36(10):e24699

Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.

Zhao AN, Yang Z, Wang DD, Shi B, Zhang H, Bai Y, Yan BW, Zhang Y, Wen JK, Wang XL, Qu CB
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22602

KTN1-AS1, a SOX2-mediated lncRNA, activates epithelial-mesenchymal transition process in esophageal squamous cell carcinoma.

Chen L, Lu J, Xu T, Yan Z, Guo Y, Dong Z, Guo W
Scientific reports 2022 Nov 23;12(1):20186

The function of Sphingosine-1-phosphate receptor 2 (S1PR2) in maintaining intestinal barrier and inducing ulcerative colitis.

Chen T, Gu K, Lin R, Liu Y, Shan Y
Bioengineered 2022 May;13(5):13703-13717

Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex.

Wang T, Xu J, Xu Y, Xiao J, Bi N, Gu X, Wang HL
Cell reports 2022 Mar 8;38(10):110478

PFKM inhibits doxorubicin-induced cardiotoxicity by enhancing oxidative phosphorylation and glycolysis.

Zhou M, Sun X, Wang C, Wang F, Fang C, Hu Z
Scientific reports 2022 Jul 8;12(1):11684

Acetylation of p62 regulates base excision repair through interaction with APE1.

Li M, Xiong J, Yang L, Huang J, Zhang Y, Liu M, Wang L, Ji J, Zhao Y, Zhu WG, Luo J, Wang H
Cell reports 2022 Jul 19;40(3):111116

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy.

Sun X, Shu Y, Ye G, Wu C, Xu M, Gao R, Huang D, Zhang J
Acta pharmaceutica Sinica. B 2022 Feb;12(2):838-852

PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression.

Lan X, Ding S, Zhang T, Yi Y, Li C, Jin W, Chen J, Liang K, Wang H, Jiang W
Nature communications 2022 Aug 6;13(1):4601

Damage of uremic myocardium by p-cresyl sulfate and the ameliorative effect of Klotho by regulating SIRT6 ubiquitination.

Chen C, Xie C, Xiong Y, Wu H, Wu L, Zhu J, Xing C, Mao H
Toxicology letters 2022 Aug 15;367:19-31

miR-AB, a miRNA-based shRNA viral toolkit for multicolor-barcoded multiplex RNAi at a single-cell level.

Wang D, Xiu J, Zhao J, Luo J
EMBO reports 2022 Apr 5;23(4):e53691

Activation of TAF9 via Danshensu-Induced Upregulation of HDAC1 Expression Alleviates Non-alcoholic Fatty Liver Disease.

Wang R, Wang Z, Sun R, Fu R, Sun Y, Zhu M, Geng Y, Gao D, Tian X, Zhao Y, Yao J
Frontiers in pharmacology 2021;12:775528

Positive Reciprocal Feedback of lncRNA ZEB1-AS1 and HIF-1α Contributes to Hypoxia-Promoted Tumorigenesis and Metastasis of Pancreatic Cancer.

Jin Y, Zhang Z, Yu Q, Zeng Z, Song H, Huang X, Kong Q, Hu H, Xia Y
Frontiers in oncology 2021;11:761979

LncRNA ZNFTR functions as an inhibitor in pancreatic cancer by modulating ATF3/ZNF24/VEGFA pathway.

Li W, Han S, Hu P, Chen D, Zeng Z, Hu Y, Xu F, Tang J, Wang F, Zhao Y, Huang M, Zhao G
Cell death & disease 2021 Sep 3;12(9):830

Epigenetic derepression converts PPARγ into a druggable target in triple-negative and endocrine-resistant breast cancers.

Loo SY, Syn NL, Koh AP, Teng JC, Deivasigamani A, Tan TZ, Thike AA, Vali S, Kapoor S, Wang X, Wang JW, Tan PH, Yip GW, Sethi G, Huang RY, Hui KM, Wang L, Goh BC, Kumar AP
Cell death discovery 2021 Sep 27;7(1):265

MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail.

Huang W, Chen J, Liu X, Liu X, Duan S, Chen L, Liu X, Lan J, Zou Y, Guo D, Zhou J
Experimental cell research 2021 Sep 1;406(1):112722

Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.

Chen M, Sun X, Wei W, Cucarella C, Martín-Sanz P, Casado M, Pi L, Ren B, Cao Q
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52

GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple-negative breast cancer.

Wei JL, Wu SY, Yang YS, Xiao Y, Jin X, Xu XE, Hu X, Li DQ, Jiang YZ, Shao ZM
Journal for immunotherapy of cancer 2021 Jul;9(7)

ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.

Ma L, Yu L, Jiang BC, Wang J, Guo X, Huang Y, Ren J, Sun N, Gao DS, Ding H, Lu J, Zhou H, Zou L, Gao Y, Wang L, Sun K, Ming Y, Meng Z, Tao YX, Yan M
The Journal of experimental medicine 2021 Dec 6;218(12)

The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression.

Li X, Yuan B, Lu M, Wang Y, Ding N, Liu C, Gao M, Yao Z, Zhang S, Zhao Y, Xie L, Chen Z
Nature communications 2021 Dec 10;12(1):7213

PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.

Yan L, Jin W, Zhao Q, Cui X, Shi T, Xu Y, Li F, Jin W, Zhang Z, Zhang Z, Tang QQ, Pan D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Aug;8(16):e2102060

Aberrant HDAC3 expression correlates with brain metastasis in breast cancer patients.

Ma L, Qi L, Li S, Yin Q, Liu J, Wang J, She C, Li P, Liu Q, Wang X, Li W
Thoracic cancer 2020 Sep;11(9):2493-2505

Crosstalk between cardiomyocytes and noncardiomyocytes is essential to prevent cardiomyocyte apoptosis induced by proteasome inhibition.

Guo F, Zhang CC, Yin XH, Li T, Fang CH, He XB
Cell death & disease 2020 Sep 19;11(9):783

The RNA exosome complex degrades expanded hexanucleotide repeat RNA in C9orf72 FTLD/ALS.

Kawabe Y, Mori K, Yamashita T, Gotoh S, Ikeda M
The EMBO journal 2020 Oct 1;39(19):e102700

HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo.

Sanna S, Esposito S, Masala A, Sini P, Nieddu G, Galioto M, Fais M, Iaccarino C, Cestra G, Crosio C
Cell death & disease 2020 May 14;11(5):369

USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.

Zhan W, Liao X, Liu J, Tian T, Yu L, Li R
Oncogenesis 2020 May 13;9(5):48

Increased NRSF/REST in anterior cingulate cortex contributes to diabetes-related neuropathic pain.

Xiao-Die X, Xiao-Hong W, Cheng-Feng H, Zhong-Yu Y, Jian-Tao W, Hou-Guang Z, Jing-Chun G
Biochemical and biophysical research communications 2020 Jun 30;527(3):785-790

Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.

Feng S, Zhang L, Liu X, Li G, Zhang B, Wang Z, Zhang H, Ma H
Journal of cellular and molecular medicine 2020 Jul;24(14):7789-7801

EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression.

Zhao H, Wang Y, Yang C, Zhou J, Wang L, Yi K, Li Y, Wang Q, Shi J, Kang C, Zeng L
Clinical and translational medicine 2020 Jan 28;9(1):10

Signatures of host-pathogen evolutionary conflict reveal MISTR-A conserved MItochondrial STress Response network.

Sorouri M, Chang T, Jesudhasan P, Pinkham C, Elde NC, Hancks DC
PLoS biology 2020 Dec;18(12):e3001045

Hypoxia-induced feedback of HIF-1α and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein.

Liu M, Zhong J, Zeng Z, Huang K, Ye Z, Deng S, Chen H, Xu F, Li Q, Zhao G
Theranostics 2019;9(16):4795-4810

Purification and enzymatic assay of class I histone deacetylase enzymes.

Adams MK, Banks CAS, Miah S, Killer M, Washburn MP
Methods in enzymology 2019;626:23-40

SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2.

Zhang N, Zhang H, Liu Y, Su P, Zhang J, Wang X, Sun M, Chen B, Zhao W, Wang L, Wang H, Moran MS, Haffty BG, Yang Q
Cell death and differentiation 2019 May;26(5):843-859

Histone deacetylase-1 as a prognostic factor and mediator of gastric cancer progression by enhancing glycolysis.

Jiang Z, Yang H, Zhang X, Wang Z, Rong R, Wang X
Human pathology 2019 Mar;85:194-201

Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1.

Feng K, Deng F, Hu Z, Wang H, Ning YJ
The Journal of biological chemistry 2019 Jun 14;294(24):9503-9517

Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.

Zhong S, Li L, Zhang YL, Zhang L, Lu J, Guo S, Liang N, Ge J, Zhu M, Tao Y, Wu YC, Yin H
The Journal of clinical investigation 2019 Jan 2;129(1):252-267

Reversal of increased mammary tumorigenesis by valproic acid and hydralazine in offspring of dams fed high fat diet during pregnancy.

Andrade FO, Nguyen NM, Warri A, Hilakivi-Clarke L
Scientific reports 2019 Dec 30;9(1):20271

Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells.

Bando H, Sakaguchi N, Lee Y, Pradipta A, Ma JS, Tanaka S, Lai DH, Liu J, Lun ZR, Nishikawa Y, Sasai M, Yamamoto M
Frontiers in immunology 2018;9:2073

Impaired FGF10 Signaling and Epithelial Development in Experimental Lung Hypoplasia With Esophageal Atresia.

Wang J, Liu H, Gao L, Liu X
Frontiers in pediatrics 2018;6:109

The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction.

He B, Dai L, Zhang X, Chen D, Wu J, Feng X, Zhang Y, Xie H, Zhou L, Wu J, Zheng S
International journal of biological sciences 2018;14(13):1845-1858

Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice.

Duan HY, Zhou KY, Wang T, Zhang Y, Li YF, Hua YM, Wang C
Chinese medical journal 2018 Sep 5;131(17):2080-2088

Differential HDAC1/2 network analysis reveals a role for prefoldin/CCT in HDAC1/2 complex assembly.

Banks CAS, Miah S, Adams MK, Eubanks CG, Thornton JL, Florens L, Washburn MP
Scientific reports 2018 Sep 12;8(1):13712

Reciprocal loop of hypoxia-inducible factor-1α (HIF-1α) and metastasis-associated protein 2 (MTA2) contributes to the progression of pancreatic carcinoma by suppressing E-cadherin transcription.

Zhu S, Deng S, He C, Liu M, Chen H, Zeng Z, Zhong J, Ye Z, Deng S, Wu H, Wang C, Zhao G
The Journal of pathology 2018 Jul;245(3):349-360

The roles of SMYD4 in epigenetic regulation of cardiac development in zebrafish.

Xiao D, Wang H, Hao L, Guo X, Ma X, Qian Y, Chen H, Ma J, Zhang J, Sheng W, Shou W, Huang G, Ma D
PLoS genetics 2018 Aug;14(8):e1007578

ABIN1 inhibits HDAC1 ubiquitination and protects it from both proteasome- and lysozyme-dependent degradation.

Ma Y, Yuan S, Tian X, Lin S, Wei S, Hu T, Chen S, Li X, Chen S, Wu D, Wang M, Guo D
Journal of cellular biochemistry 2018 Apr;119(4):3030-3043

Regulatory Roles of Histone Deacetylases 1 and 2 in Pb-induced Neurotoxicity.

Wu Y, Xu Y, Huang X, Ye D, Han M, Wang HL
Toxicological sciences : an official journal of the Society of Toxicology 2018 Apr 1;162(2):688-701

HDAC2 was involved in placental P-glycoprotein regulation both in vitro and vivo.

Duan H, Zhou K, Zhang Y, Yue P, Wang T, Li Y, Qiu D, Wu J, Hua Y, Wang C
Placenta 2017 Oct;58:105-114

Effect of Histone Deacetylase Inhibition on the Expression of Multidrug Resistance-associated Protein 2 in a Human Placental Trophoblast Cell Line.

Duan HY, Ma D, Zhou KY, Wang T, Zhang Y, Li YF, Wu JL, Hua YM, Wang C
Chinese medical journal 2017 Jun 5;130(11):1352-1360

The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placental trophoblast cell lines.

Duan H, Wang C, Zhou K, Wang T, Li Y, Qiu D, Li Q, Zhang Y, Hua Y
Placenta 2017 Jan;49:37-47

Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition.

Wang F, Zhao J, Liu D, Zhao T, Lu Z, Zhu L, Cao L, Yang J, Jin J, Cai Y
Cancer biology & therapy 2016 Nov;17(11):1117-1125

miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells.

He XH, Zhu W, Yuan P, Jiang S, Li D, Zhang HW, Liu MF
Oncogene 2016 Nov 17;35(46):6015-6025

The long non-coding RNA TUG1 indicates a poor prognosis for colorectal cancer and promotes metastasis by affecting epithelial-mesenchymal transition.

Sun J, Ding C, Yang Z, Liu T, Zhang X, Zhao C, Wang J
Journal of translational medicine 2016 Feb 8;14:42

Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.

Zhu L, Yang J, Zhao L, Yu X, Wang L, Wang F, Cai Y, Jin J
International journal of oncology 2015;46(6):2535-45

Identification of NOD2 as a novel target of RNA-binding protein HuR: evidence from NADPH oxidase-mediated HuR signaling in diabetic nephropathy.

Shang J, Wan Q, Wang X, Duan Y, Wang Z, Wei X, Zhang Y, Wang H, Wang R, Yi F
Free radical biology & medicine 2015 Feb;79:217-27

Expression of hMOF in different ovarian tissues and its effects on ovarian cancer prognosis.

Cai M, Hu Z, Liu J, Gao J, Tan M, Zhang D, Zhu L, Liu S, Hou R, Lin B
Oncology reports 2015 Feb;33(2):685-92

Specific immunotherapy in combination with Clostridium butyricum inhibits allergic inflammation in the mouse intestine.

Shi Y, Xu LZ, Peng K, Wu W, Wu R, Liu ZQ, Yang G, Geng XR, Liu J, Liu ZG, Liu Z, Yang PC
Scientific reports 2015 Dec 2;5:17651

Connexin32 regulates hepatoma cell metastasis and proliferation via the p53 and Akt pathways.

Zhao B, Zhao W, Wang Y, Xu Y, Xu J, Tang K, Zhang S, Yin Z, Wu Q, Wang X
Oncotarget 2015 Apr 30;6(12):10116-33

Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi‑1 leukemia cells.

Zhang ZH, Hao CL, Liu P, Tian X, Wang LH, Zhao L, Zhu CM
Molecular medicine reports 2014 Feb;9(2):443-9

Histone cross-talk connects protein phosphatase 1α (PP1α) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression.

Hu X, Lu X, Liu R, Ai N, Cao Z, Li Y, Liu J, Yu B, Liu K, Wang H, Zhou C, Wang Y, Han A, Ding F, Chen R
The Journal of biological chemistry 2014 Aug 15;289(33):23154-23167

PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating hypoxia-inducible factor 1α expression and protein stability.

Liu Y, Zhang JB, Qin Y, Wang W, Wei L, Teng Y, Guo L, Zhang B, Lin Z, Liu J, Ren ZG, Ye QH, Xie Y
Hepatology (Baltimore, Md.) 2013 Aug;58(2):692-705

FLASH knockdown sensitizes cells to Fas-mediated apoptosis via down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip short.

Chen S, Evans HG, Evans DR
PloS one 2012;7(3):e32971

Modulation of Tcf3 repressor complex composition regulates cdx4 expression in zebrafish.

Ro H, Dawid IB
The EMBO journal 2011 Jun 10;30(14):2894-907

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HepG2 cells were subjected to SDS PAGE followed by western blot with 10197-1-AP(HDAC1 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of SH-SY5Y cells, using HDAC1 antibody 10197-1-AP at 1:50 dilution and FITC-labeled donkey anti-rabbit IgG(green).
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-HDAC1 (IP:10197-1-AP, 3ug; Detection:10197-1-AP 1:500) with mouse testis tissue lysate 10000ug.
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human pancreas cancer using 10197-1-AP(HDAC1 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue