Ab107009

antibody from Aladdin Scientific
Targeting: HDAC1 GON-10, HD1, KDAC1, RPD3L1
Provider product page for Ab107009

Antibody data

Product number
Ab107009 - Provider product page
Provider
Aladdin Scientific
Product name
HDAC1 Mouse mAb
Antibody type
Monoclonal
Description
Mouse anti Human HDAC1 Antibody, Monoclonal (E22), could be used for WB, IHC, IF, ICC and so on.Application: ÊWB: 0.2-2_g/mLIHC: 5-20_g/mLICC/IF: 5-20_g/mLProtein FunctionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B.Post-translationalSumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.Ubiquitinated by CHFR, leading to its degradation by the proteasome.
Reactivity
Human, Mouse, Rat, Bovine
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
AA 1-482
Antibody clone number
E22
Vial size
100_l,10_l,1ml,20_l,50_l
Concentration
Lot by Lot
Storage
Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
HDAC1 protein structure - Ab107009 shown in red.