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- Antigen structure
- References [94]
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- Product number
- 66515-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- E2F1 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated E2F1 antibody (Cat. #66515-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 5D7G8
- Vial size
- 20ul, 150ul
Submitted references A novel recombinant peptide, rAnguillin, induces ferroptosis in nasopharyngeal carcinoma by promoting FOXM1 degradation and disrupting the FOXM1-PABPC1L-tryptophan metabolism axis.
Arecoline as a Novel Scaffold Targeting the ATAD2 Bromodomain for Cell Cycle Modulation.
E2F1-Driven WDHD1 Transcription Enhances Cell-Cycle Progression and Promotes Pancreatic Cancer Progression.
B3GNT3 facilitates NFKB2 processing and non-canonical NF-κB activation to drive lung adenocarcinoma progression.
Targeting MYC in T-Cell lymphoma via epigenetic modulation with a small-molecule inhibitor.
Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5-activating transcription factor 1-protein phosphatase 2 regulatory subunit 5A signaling.
Druggable target ATAD2 enhances the malignant progression and cooperates with E2F1 to up-regulate PDK1 expression in glioma.
Histone modification-regulated LncRNA DLEU1 interacts with ASCC2/ALKBH3 complex to drive DNA repair, antioxidant homeostasis and glucose metabolism in gastric cancer.
Engineered anchoring aptamers induce relocalization and functional inactivation of transcription factors.
Inhibition of Setd7 protects against cardiomyocyte hypertrophy via inhibiting lipid oxidation.
MASTL Promotes Hepatocellular Carcinoma Progression and Paclitaxel Resistance Through Mitotic Catastrophe.
Integrated bioinformatics and experimental validation identify CCDC78 as a prognostic biomarker in colon adenocarcinoma.
HPV16 E7 Enhances Cell Stemness via RTKN2-Mediated Activation of the NF-κB Pathway in Cervical Cancer.
NAT10 and E2F1 Orchestrate CKAP5-Mediated Progression in Esophageal Squamous Cell Carcinoma.
KLF11 interacts with MDM2 to stabilize E2F1 and promotes DNA damage repair to induce radioresistance in esophageal cancer cells.
BMX inhibition overcomes small cell lung cancer chemoresistance by stabilizing E2F1 via ERK1/2-Cyclin D1/CDK4/6 axis.
Nuclear Pirin promotes HCC by acting as a key inflammation-facilitating factor.
NCAPH Promotes the Proliferation of Prostate Cancer Cells Via Modulating the E2F1 Mediated PI3K/AKT/mTOR Axis.
Mitochondrial CCN1 drives ferroptosis via fatty acid β-oxidation.
BRD9-p53-E2F1 circuit orchestrates cell growth and DNA damage repair in gastric cancer.
LncRNA SNHG8 promotes myocardial fibrosis by binding to E2F1 to induce MAD2L1 transcription.
TRIB3 promotes endometrial cancer progression through interacting with E2F1 and enhancing PKM2-mediated tumor glycolysis.
NCOA5 induces sorafenib resistance in hepatocellular carcinoma by inhibiting ferroptosis.
NSUN2-mediated HCV RNA m5C Methylation Facilitates Viral RNA Stability and Replication.
NEAT1 promotes the perineural invasion of pancreatic cancer via the E2F1/GDNF axis.
DLGAP5 upregulates E2F1 to promote prostate adenocarcinoma neuroendocrine differentiation.
A novel piperine derivative HJ-23 exhibits anti-colorectal cancer effects by activating the p53 pathway.
Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes.
DDX5 super-enhancer promotes vasculogenic mimicry formation and metastasis in nasopharyngeal carcinoma by enhancing ADAM10 transcription.
TIFA enhances glycolysis through E2F1 and promotes the progression of glioma.
Down-regulation of E2F1 attenuates UVB-induced human lens epithelial cell oxidative stress and pyroptosis through inhibiting NLRP3.
Inhibition of METTL14 overcomes CDK4/6 inhibitor resistance driven by METTL14-m6A-E2F1-axis in ERα-positive breast cancer.
E2F1-autophagy-ALDH1A1 axis enhances self-renewal and drug resistance of lung cancer stem-like cells in a p53-dependent manner.
Interferon regulatory factor 4 mediates nonenzymatic IRE1 dependency in multiple myeloma cells.
The acidic microenvironment promotes pancreatic cancer progression via the lncRNA-LOC100507424/E2F1/FOXM1 axis.
ARL8B regulates lysosomal function and predicts poor prognosis in hepatocellular carcinoma.
In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis.
Deapioplatycodin D promotes cell senescence induced by P21 through the mediation of incomplete mitophagy via BNIP3L.
KDM1A, a potent and selective target, for the treatment of DNMT3A-deficient non-small cell lung cancer.
Identification of STAM-binding protein as a target for the treatment of gemcitabine resistance pancreatic cancer in a nutrient-poor microenvironment.
CHAC1 blockade suppresses progression of lung adenocarcinoma by interfering with glucose metabolism via hijacking PKM2 nuclear translocation.
SMEK1 promotes clear cell renal cell carcinoma progression via EGFR tyrosine-kinase dependent pathway.
Regular exercise suppresses steatosis-associated liver cancer development by degrading E2F1 and c-Myc via circadian gene upregulation.
Talaketides A-G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027.
ZNF652 exerts a tumor suppressor role in lung cancer by transcriptionally downregulating cyclin D3.
Classical prescription Floris Sophorae Powder treat colorectal cancer by regulating KRAS/MEK-ERK signaling pathway.
RNA m(5)C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer.
DDB2 promotes melanoma cell growth by transcriptionally regulating the expression of KMT2A and predicts a poor prognosis.
Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC.
LncRNA LINC01703 promotes the proliferation, migration, and invasion of colorectal cancer by activating PI3K/AKT pathway.
P129, a pyrazole ring-containing isolongifolanone-derivate: synthesis and investigation of anti-glioma action mechanism.
MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation.
Integrated network pharmacology and transcriptomic approach reveal the role of equol in reducing colorectal cancer via regulating multiple cell cycle genes in HCT116 cells.
RRM1 promotes homologous recombination and radio/chemo-sensitivity via enhancing USP11 and E2F1-mediated RAD51AP1 transcription.
The Compromised Fanconi Anemia Pathway in Prelamin A-Expressing Cells Contributes to Replication Stress-Induced Genomic Instability.
Oncogene goosecoid is transcriptionally regulated by E2F1 and correlates with disease progression in prostate cancer.
E2F-mediated POLA2 upregulation is correlated with macrophage infiltration and poor prognosis in hepatocellular carcinoma.
GPC3 Promotes Lung Squamous Cell Carcinoma Progression and HLA-A2-Restricted GPC3 Antigenic Peptide-Modified Dendritic Cell-Induced Cytotoxic T Lymphocytes to Kill Lung Squamous Cell Carcinoma Cells.
Inhibition of IGF2BP1 attenuates renal injury and inflammation by alleviating m6A modifications and E2F1/MIF pathway.
Inhibition of USP10 induces myeloma cell apoptosis by promoting cyclin D3 degradation.
LncRNA AGPG Confers Endocrine Resistance in Breast Cancer by Promoting E2F1 Activity.
Overexpression of RACGAP1 by E2F1 Promotes Neuroendocrine Differentiation of Prostate Cancer by Stabilizing EZH2 Expression.
TRIM28 recruits E2F1 to regulate CBX8-mediated cell proliferation and tumor metastasis of ovarian cancer.
NCAPD2 promotes breast cancer progression through E2F1 transcriptional regulation of CDK1.
FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression.
TUBA1C: a new potential target of LncRNA EGFR-AS1 promotes gastric cancer progression.
N-Acetyl-L-Cysteine Reduces Cervical Carcinogenesis by Promoting Apoptosis.
Ubiquitin-specific peptidase 14 maintains estrogen receptor α stability via its deubiquitination activity in endometrial cancer.
E2F1 combined with LINC01004 super-enhancer to promote hepatocellular carcinoma cell proliferation and metastasis.
Transferrin Receptor-Mediated Iron Uptake Promotes Colon Tumorigenesis.
Inhibition of Angiogenesis by MiR-524-5p through Suppression of AKT and ERK Activation by Targeting CXCR7 in Colon Cancer Cells.
Analysis of regulating activities of 5'-epiequisetin on proliferation, apoptosis, and migration of prostate cancer cells in vitro and in vivo.
E2F1-mediated GINS2 transcriptional activation promotes tumor progression through PI3K/AKT/mTOR pathway in hepatocellular carcinoma.
POLD2 is activated by E2F1 to promote triple-negative breast cancer proliferation.
Thymidine Kinase 1 Drives Skin Cutaneous Melanoma Malignant Progression and Metabolic Reprogramming.
Icaritin inhibits CDK2 expression and activity to interfere with tumor progression.
Integrating network pharmacology deciphers the action mechanism of Zuojin capsule in suppressing colorectal cancer.
Long non-coding RNA SNHG1 activates glycolysis to promote hepatocellular cancer progression through the miR-326/PKM2 axis.
U2 small nuclear RNA auxiliary factor 2, transcriptionally activated by the transcription factor Dp-1/E2F transcription factor 1 complex, enhances the growth and aerobic glycolysis of leiomyosarcoma cells.
RFWD3 Participates in the Occurrence and Development of Colorectal Cancer via E2F1 Transcriptional Regulation of BIRC5.
Deletion of p16 accelerates fracture healing in geriatric mice.
FGF14-AS2 accelerates tumorigenesis in glioma by forming a feedback loop with miR-320a/E2F1 axis.
Myricanol Inhibits Platelet Derived Growth Factor-BB-Induced Vascular Smooth Muscle Cells Proliferation and Migration in vitro and Intimal Hyperplasia in vivo by Targeting the Platelet-Derived Growth Factor Receptor-β and NF-κB Signaling.
Down-regulation of lncRNA HCG11 promotes cell proliferation of oral squamous cell carcinoma through sponging miR-455-5p.
The influence of phenolic environmental estrogen on the transcriptome of uterine leiomyoma cells: A whole transcriptome profiling-based analysis.
Gypenoside LI arrests the cell cycle of breast cancer in G0/G1 phase by down-regulating E2F1.
FOXO1 inhibits prostate cancer cell proliferation via suppressing E2F1 activated NPRL2 expression.
High-dose copper activates p53-independent apoptosis through the induction of nucleolar stress in human cell lines.
Cell division cycle associated 8: A novel diagnostic and prognostic biomarker for hepatocellular carcinoma.
MicroRNA miR-188-5p as a mediator of long non-coding RNA MALAT1 regulates cell proliferation and apoptosis in multiple myeloma.
E2F1 mediated DDX11 transcriptional activation promotes hepatocellular carcinoma progression through PI3K/AKT/mTOR pathway.
Augmentation of the therapeutic efficacy of WEE1 kinase inhibitor AZD1775 by inhibiting the YAP-E2F1-DNA damage response pathway axis.
siRNA Delivery for Control of Cyclin D1 and E2F1 Expression in Crohn's Disease.
siRNA Delivery for Control of Cyclin D1 and E2F1 Expression in Crohn's Disease.
Yuan Q, Zhao Y, Zhou F, Zhang Y, Jia X, Yao J, Lv M, Wang J, Lv L
International journal of biological macromolecules 2026 May;361:151988
International journal of biological macromolecules 2026 May;361:151988
Arecoline as a Novel Scaffold Targeting the ATAD2 Bromodomain for Cell Cycle Modulation.
Lin TS, Wan J, He J, Cui S, Huang Y, Zhang B, Huang HY, Zhu K, Chen J, Zhang T, Li S, Hu L, Wang Y, Huang HD, Tang P, Lin YC
Pharmaceutics 2026 Mar 3;18(3)
Pharmaceutics 2026 Mar 3;18(3)
E2F1-Driven WDHD1 Transcription Enhances Cell-Cycle Progression and Promotes Pancreatic Cancer Progression.
Yang X, Zhang Z, Lv S, Zhang B, Tao X, Liu C, Zhu Q
Current oncology (Toronto, Ont.) 2026 Mar 26;33(4)
Current oncology (Toronto, Ont.) 2026 Mar 26;33(4)
B3GNT3 facilitates NFKB2 processing and non-canonical NF-κB activation to drive lung adenocarcinoma progression.
Lin Y, Zhang Y, Yu B, Wang J, Wu Z, Wang H
Cellular oncology (Dordrecht, Netherlands) 2026 Mar 16;49(2)
Cellular oncology (Dordrecht, Netherlands) 2026 Mar 16;49(2)
Targeting MYC in T-Cell lymphoma via epigenetic modulation with a small-molecule inhibitor.
Liu B, Jiang B, Liu S, Zhang S, Huang Z, Zhang M, Zhao X, Li Q, Li X, Xia J, Huang D, Li H, Luo X, Ma N, Hu Y, Zhang X, Rao J
Molecular cancer 2026 Mar 13;25(1)
Molecular cancer 2026 Mar 13;25(1)
Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5-activating transcription factor 1-protein phosphatase 2 regulatory subunit 5A signaling.
Fan D, Zhong Y, Dong Y, Du M, Huang K, Li X
Journal of advanced research 2026 Jan;79:661-677
Journal of advanced research 2026 Jan;79:661-677
Druggable target ATAD2 enhances the malignant progression and cooperates with E2F1 to up-regulate PDK1 expression in glioma.
Zhuo S, Yang L, Chen Z, Chen S, Yang S, Chen T, Wu WS, Wang K, Yang K
Genes & diseases 2026 Jan;13(1):101810
Genes & diseases 2026 Jan;13(1):101810
Histone modification-regulated LncRNA DLEU1 interacts with ASCC2/ALKBH3 complex to drive DNA repair, antioxidant homeostasis and glucose metabolism in gastric cancer.
Zhang X, Wang X, Wang Q, Wang X, Sun H, Liu Y, Tan C, Ni S, Weng W, Zhang M, Wang L, Huang D, Chen J, Wang X, Gan L, Abudurexiti M, Wang W, Chang J, Sheng W, Xu M
Biomarker research 2026 Jan 2;14(1):1
Biomarker research 2026 Jan 2;14(1):1
Engineered anchoring aptamers induce relocalization and functional inactivation of transcription factors.
Ling N, Wu H, Zhang Y, Yao S, Liu F, Tang X, Xie T, Yuan Y, Wei X, Dai J, Chen W, Yan M, Wang Z, Peng T, Zhang Y, Wang H, Wu J, Ye M, Wu W
Science advances 2026 Jan 2;12(1):eadw6496
Science advances 2026 Jan 2;12(1):eadw6496
Inhibition of Setd7 protects against cardiomyocyte hypertrophy via inhibiting lipid oxidation.
Su HB, Wang JH, Zhang YY, Xu J, Liu JY, Li YH, Xiao CX, Wang CY, Chang J, Liu XH
Acta pharmacologica Sinica 2026 Feb;47(2):344-356
Acta pharmacologica Sinica 2026 Feb;47(2):344-356
MASTL Promotes Hepatocellular Carcinoma Progression and Paclitaxel Resistance Through Mitotic Catastrophe.
Wang K, Fu Z, Xiong C, Zhang J, Luo Q
Cancer science 2026 Feb;117(2):377-392
Cancer science 2026 Feb;117(2):377-392
Integrated bioinformatics and experimental validation identify CCDC78 as a prognostic biomarker in colon adenocarcinoma.
Mo Q, Du M, Zheng J, Yu J, Ma Z, Zhuang S, Jiang M
Scientific reports 2026 Feb 12;16(1)
Scientific reports 2026 Feb 12;16(1)
HPV16 E7 Enhances Cell Stemness via RTKN2-Mediated Activation of the NF-κB Pathway in Cervical Cancer.
Yang M, Ma Y, Cao Z, Zhan H, Jin Y, Huang X, Yang S
Biochemical genetics 2026 Apr;64(2):2582-2604
Biochemical genetics 2026 Apr;64(2):2582-2604
NAT10 and E2F1 Orchestrate CKAP5-Mediated Progression in Esophageal Squamous Cell Carcinoma.
Wei W, Wei L, Zhu A, Zhang Y, Yao W, Liu M, Lin X
Journal of gastroenterology and hepatology 2026 Apr;41(4):1254-1266
Journal of gastroenterology and hepatology 2026 Apr;41(4):1254-1266
KLF11 interacts with MDM2 to stabilize E2F1 and promotes DNA damage repair to induce radioresistance in esophageal cancer cells.
Xia Y, Wang J, Zhao D, Li Y, Li S, Li M, Dong R, Wang L
Pathology, research and practice 2026 Apr;280:156375
Pathology, research and practice 2026 Apr;280:156375
BMX inhibition overcomes small cell lung cancer chemoresistance by stabilizing E2F1 via ERK1/2-Cyclin D1/CDK4/6 axis.
Wu T, Qi S, Shi C, Wu C, Liu Q, Hu C, Hu J, Wang A, Liu J, Qi Z, Wang W, Liu Q
Signal transduction and targeted therapy 2026 Apr 8;11(1)
Signal transduction and targeted therapy 2026 Apr 8;11(1)
Nuclear Pirin promotes HCC by acting as a key inflammation-facilitating factor.
Ma H, Cao T, Zhang F, Sun D, Chen L, Lin Y, Lai S, Jiang B, Zhou Y, You J, Liu X, Wang Y, Lin F, Liu Y, Wang J, He W, Li Q
Gut 2026 Apr 7;75(5):1016-1029
Gut 2026 Apr 7;75(5):1016-1029
NCAPH Promotes the Proliferation of Prostate Cancer Cells Via Modulating the E2F1 Mediated PI3K/AKT/mTOR Axis.
Shi Q, Ma J, Pan X, Liu T, Chen K, Xu M, Wu Z, Sun B, Zhang M, Luo Y
International journal of medical sciences 2025;22(4):940-954
International journal of medical sciences 2025;22(4):940-954
Mitochondrial CCN1 drives ferroptosis via fatty acid β-oxidation.
Guo W, Zhang C, Zhou Q, Chen T, Xu X, Zhang J, Yu X, Wu H, Zhang X, Ma L, Qian K, Klionsky DJ, Kang R, Kroemer G, Yu Y, Tang D, Wang J
Developmental cell 2025 Sep 8;60(17):2294-2312.e11
Developmental cell 2025 Sep 8;60(17):2294-2312.e11
BRD9-p53-E2F1 circuit orchestrates cell growth and DNA damage repair in gastric cancer.
Zhou Q, Wang Q, Duan Y, Zhang C, Liu T, Liu H, Zhao M, Hu Z
Molecular cancer 2025 Oct 2;24(1):239
Molecular cancer 2025 Oct 2;24(1):239
LncRNA SNHG8 promotes myocardial fibrosis by binding to E2F1 to induce MAD2L1 transcription.
Huang L, Liu C, Zhao Z, Xie S, Sun Z, Liao X, Bian X, Liu X, Ren X, Wang N
International journal of biological macromolecules 2025 Nov;331(Pt 1):148362
International journal of biological macromolecules 2025 Nov;331(Pt 1):148362
TRIB3 promotes endometrial cancer progression through interacting with E2F1 and enhancing PKM2-mediated tumor glycolysis.
Geng F, Wang Y, Cui G, Fan M
Gynecologic oncology 2025 Nov;202:41-52
Gynecologic oncology 2025 Nov;202:41-52
NCOA5 induces sorafenib resistance in hepatocellular carcinoma by inhibiting ferroptosis.
Gao S, Fan L, Wang H, Wang A, Hu M, Zhang L, Sun G
Cell death discovery 2025 May 2;11(1):215
Cell death discovery 2025 May 2;11(1):215
NSUN2-mediated HCV RNA m5C Methylation Facilitates Viral RNA Stability and Replication.
Li ZL, Xie Y, Wang Y, Wang J, Zhou X, Zhang XL
Genomics, proteomics & bioinformatics 2025 May 10;23(1)
Genomics, proteomics & bioinformatics 2025 May 10;23(1)
NEAT1 promotes the perineural invasion of pancreatic cancer via the E2F1/GDNF axis.
Gu J, Wang Q, Mo J, Qin T, Qian W, Duan W, Han L, Wang Z, Ma Q, Ma J
Cancer letters 2025 Mar 31;613:217497
Cancer letters 2025 Mar 31;613:217497
DLGAP5 upregulates E2F1 to promote prostate adenocarcinoma neuroendocrine differentiation.
Liang L, Shen Z, Zhang K, Zhang C, Dong L, Shi R, Hua L, Zhao R, Feng N
Life sciences 2025 Mar 15;365:123442
Life sciences 2025 Mar 15;365:123442
A novel piperine derivative HJ-23 exhibits anti-colorectal cancer effects by activating the p53 pathway.
Zhang M, Liu R, Jiang W, Li H, Zhang S, Cheng W, Ye X, He J, Liu Y, Jing A, Song Y, Wang D, Liu X, Zhang B, Wang X, Ji J
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jun;398(6):7121-7131
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jun;398(6):7121-7131
Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes.
O'Neill KM, Edgar KS, Pun SH, Campbell DC, Toh T, Wong XN, Botezatu B, Kandel J, McCoy U, Nicell J, McClintock C, McLoughlin KJ, Wu Y, Madishetti VV, Moez A, Alsaggaf M, Gill EK, Abudalo RA, O'Neill CL, Pedrini E, Guduric-Fuchs J, Brunssen C, Morawietz H, Dunne PD, Watson CJ, Medina RJ, Grieve DJ
Stem cell research & therapy 2025 Jun 2;16(1):275
Stem cell research & therapy 2025 Jun 2;16(1):275
DDX5 super-enhancer promotes vasculogenic mimicry formation and metastasis in nasopharyngeal carcinoma by enhancing ADAM10 transcription.
Xia T, Yin H, Zhu Q, Zhang K, Xie H, Shan Y, Zhang S, Zhu R, Li K, Miao M, Lu Y, Wang Z, Zhao J, You Y, You B
Cell reports. Medicine 2025 Jun 17;6(6):102146
Cell reports. Medicine 2025 Jun 17;6(6):102146
TIFA enhances glycolysis through E2F1 and promotes the progression of glioma.
Liu Z, He M, Yu Z, Ma L, Wang X, Ning F
Cellular signalling 2025 Jan;125:111498
Cellular signalling 2025 Jan;125:111498
Down-regulation of E2F1 attenuates UVB-induced human lens epithelial cell oxidative stress and pyroptosis through inhibiting NLRP3.
Wang F, Yang F, Yang G, Zhou Q, Lv H
Human & experimental toxicology 2025 Jan-Dec;44:9603271241309258
Human & experimental toxicology 2025 Jan-Dec;44:9603271241309258
Inhibition of METTL14 overcomes CDK4/6 inhibitor resistance driven by METTL14-m6A-E2F1-axis in ERα-positive breast cancer.
Liu C, Fan D, Sun J, Li G, Du R, Zuo X, Zhang K, Zhang W, Wang S, Li X, Du M, Wang D, Hao Q, Zhang Y, Li M, Zhang C, Gao Y
Journal of nanobiotechnology 2025 Jan 3;23(1):3
Journal of nanobiotechnology 2025 Jan 3;23(1):3
E2F1-autophagy-ALDH1A1 axis enhances self-renewal and drug resistance of lung cancer stem-like cells in a p53-dependent manner.
Li J, Chen Y, Wang J, Liu L, Qadir J, Xie D, Wan X, Luo Y, Xian J, Ye T
Journal of experimental & clinical cancer research : CR 2025 Aug 30;44(1):261
Journal of experimental & clinical cancer research : CR 2025 Aug 30;44(1):261
Interferon regulatory factor 4 mediates nonenzymatic IRE1 dependency in multiple myeloma cells.
Oikonomidi I, Kameswaran V, Pham VC, Zuazo-Gaztelu I, Gutgesell LM, Marsters S, Daniel B, Lill JR, Modrusan Z, Ashkenazi A
PLoS biology 2025 Apr;23(4):e3003096
PLoS biology 2025 Apr;23(4):e3003096
The acidic microenvironment promotes pancreatic cancer progression via the lncRNA-LOC100507424/E2F1/FOXM1 axis.
Mu D, Shi Y, Sun R, Han B, Zhong K, Ye Y, Zhang J
BMC cancer 2025 Apr 10;25(1):655
BMC cancer 2025 Apr 10;25(1):655
ARL8B regulates lysosomal function and predicts poor prognosis in hepatocellular carcinoma.
Wu L, Weng Z, Yang X, Huang Y, Lin Y, Li S, Fu L, Yun J
Scientific reports 2025 Apr 10;15(1):12278
Scientific reports 2025 Apr 10;15(1):12278
In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis.
Tran NT, Graf R, Acevedo-Ochoa E, Trombke J, Weber T, Sommermann T, Salomon C, Kühn R, Rajewsky K, Chu VT
Leukemia 2024 Sep;38(9):2003-2015
Leukemia 2024 Sep;38(9):2003-2015
Deapioplatycodin D promotes cell senescence induced by P21 through the mediation of incomplete mitophagy via BNIP3L.
Li Y, Xiao P, Sun Y, Li Y, Zhao H, Sun J, Wang X, Han X, Jin N, Li X, Bao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117215
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117215
KDM1A, a potent and selective target, for the treatment of DNMT3A-deficient non-small cell lung cancer.
Zhao Y, Zheng Y, Fu J, Zhang J, Shao H, Liu S, Lai J, Zhou X, Liang R, Jia L, Cui W, Yang J, Wu C, Wang L
British journal of cancer 2024 Sep;131(4):655-667
British journal of cancer 2024 Sep;131(4):655-667
Identification of STAM-binding protein as a target for the treatment of gemcitabine resistance pancreatic cancer in a nutrient-poor microenvironment.
Zhang W, Xu Z, Du Y, Liu T, Xiong Z, Hu J, Chen L, Peng X, Zhou F
Cell death & disease 2024 Sep 6;15(9):657
Cell death & disease 2024 Sep 6;15(9):657
CHAC1 blockade suppresses progression of lung adenocarcinoma by interfering with glucose metabolism via hijacking PKM2 nuclear translocation.
Pan J, Wu S, Pan Q, Zhang Y, He L, Yao Q, Chen J, Li J, Xu Y
Cell death & disease 2024 Oct 5;15(10):728
Cell death & disease 2024 Oct 5;15(10):728
SMEK1 promotes clear cell renal cell carcinoma progression via EGFR tyrosine-kinase dependent pathway.
Wang J, Bi W, Lv R, Wang Z, Xin Q, Li K, Chen Y, Liu Q, Zhang X
Cancer letters 2024 Oct 1;601:217148
Cancer letters 2024 Oct 1;601:217148
Regular exercise suppresses steatosis-associated liver cancer development by degrading E2F1 and c-Myc via circadian gene upregulation.
Huyen VT, Echizen K, Yamagishi R, Kumagai M, Nonaka Y, Kodama T, Ando T, Yano M, Takada N, Takasugi M, Kamachi F, Ohtani N
Genes to cells : devoted to molecular & cellular mechanisms 2024 Nov;29(11):1012-1025
Genes to cells : devoted to molecular & cellular mechanisms 2024 Nov;29(11):1012-1025
Talaketides A-G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027.
Chen C, Wang X, Fang W, Liang J, Cai J, Yang D, Luo X, Gao C, Yi X, Liu Y, Zhou X
Chinese journal of natural medicines 2024 Nov;22(11):1047-1056
Chinese journal of natural medicines 2024 Nov;22(11):1047-1056
ZNF652 exerts a tumor suppressor role in lung cancer by transcriptionally downregulating cyclin D3.
Xie C, Zhou X, Wu J, Chen W, Ren D, Zhong C, Meng Z, Shi Y, Zhu J
Cell death & disease 2024 Nov 5;15(11):792
Cell death & disease 2024 Nov 5;15(11):792
Classical prescription Floris Sophorae Powder treat colorectal cancer by regulating KRAS/MEK-ERK signaling pathway.
Han LY, Yu H, Wang S, Bao YR, Li TJ, Zheng Y, Luo X, Jia MN, Zhang Q, Meng XS
Journal of ethnopharmacology 2024 May 10;325:117805
Journal of ethnopharmacology 2024 May 10;325:117805
RNA m(5)C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer.
Liu X, Wei Q, Yang C, Zhao H, Xu J, Mobet Y, Luo Q, Yang D, Zuo X, Chen N, Yang Y, Li L, Wang W, Yu J, Xu J, Liu T, Yi P
Experimental & molecular medicine 2024 Mar;56(3):600-615
Experimental & molecular medicine 2024 Mar;56(3):600-615
DDB2 promotes melanoma cell growth by transcriptionally regulating the expression of KMT2A and predicts a poor prognosis.
Zhang C, Li W, Liu L, Li M, Sun H, Zhang C, Zhong L, Huang J, Li T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jun 30;38(12):e23735
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jun 30;38(12):e23735
Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC.
Mirzapoiazova T, Tseng L, Mambetsariev B, Li H, Lou CH, Pozhitkov A, Ramisetty SK, Nam S, Mambetsariev I, Armstrong B, Malhotra J, Arvanitis L, Nasser MW, Batra SK, Rosen ST, Wheeler DL, Singhal SS, Kulkarni P, Salgia R
iScience 2024 Jun 21;27(6):110132
iScience 2024 Jun 21;27(6):110132
LncRNA LINC01703 promotes the proliferation, migration, and invasion of colorectal cancer by activating PI3K/AKT pathway.
Xu Y, Jia K, Zhao X, Li Y, Zhang Z
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23594
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23594
P129, a pyrazole ring-containing isolongifolanone-derivate: synthesis and investigation of anti-glioma action mechanism.
Jiang Y, Wang Y, Zhao L, Yang W, Pan L, Bai Y, Wang Y, Li Y
Discover oncology 2024 Jan 6;15(1):6
Discover oncology 2024 Jan 6;15(1):6
MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation.
Ma J, Li L, Ma B, Liu T, Wang Z, Ye Q, Peng Y, Wang B, Chen Y, Xu S, Wang K, Dang F, Wang X, Zeng Z, Jian Y, Ren Z, Fan Y, Li X, Liu J, Gao Y, Wei W, Li L
Nature communications 2024 Feb 29;15(1):1871
Nature communications 2024 Feb 29;15(1):1871
Integrated network pharmacology and transcriptomic approach reveal the role of equol in reducing colorectal cancer via regulating multiple cell cycle genes in HCT116 cells.
Mao K, Wang X, Hou Y, He X, Geng S, Sadiq FA, Lian Y, Sang Y
International journal of biological macromolecules 2024 Dec;282(Pt 2):136832
International journal of biological macromolecules 2024 Dec;282(Pt 2):136832
RRM1 promotes homologous recombination and radio/chemo-sensitivity via enhancing USP11 and E2F1-mediated RAD51AP1 transcription.
Yang S, Wang R, Liu L, Xu F, Zhao X, Yao Z, Zhang J, Cheng X, Xu A, Wu L, Zhao G
Cell death discovery 2024 Dec 18;10(1):496
Cell death discovery 2024 Dec 18;10(1):496
The Compromised Fanconi Anemia Pathway in Prelamin A-Expressing Cells Contributes to Replication Stress-Induced Genomic Instability.
Nie P, Zhang C, Wu F, Chen S, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2307751
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2307751
Oncogene goosecoid is transcriptionally regulated by E2F1 and correlates with disease progression in prostate cancer.
Ge Y, Ma S, Zhou Q, Xiong Z, Wang Y, Li L, Chao Z, Zhang J, Li T, Wu Z, Gao Y, Qu G, Xi Z, Liu B, Wu X, Wang Z
Chinese medical journal 2024 Aug 5;137(15):1844-1856
Chinese medical journal 2024 Aug 5;137(15):1844-1856
E2F-mediated POLA2 upregulation is correlated with macrophage infiltration and poor prognosis in hepatocellular carcinoma.
Teng Y, Liu R
Translational cancer research 2024 Apr 30;13(4):1848-1860
Translational cancer research 2024 Apr 30;13(4):1848-1860
GPC3 Promotes Lung Squamous Cell Carcinoma Progression and HLA-A2-Restricted GPC3 Antigenic Peptide-Modified Dendritic Cell-Induced Cytotoxic T Lymphocytes to Kill Lung Squamous Cell Carcinoma Cells.
Ning J, Ding J, Wang S, Jiang Y, Wang D, Jiang S
Journal of immunology research 2023;2023:5532617
Journal of immunology research 2023;2023:5532617
Inhibition of IGF2BP1 attenuates renal injury and inflammation by alleviating m6A modifications and E2F1/MIF pathway.
Mao Y, Jiang F, Xu XJ, Zhou LB, Jin R, Zhuang LL, Juan CX, Zhou GP
International journal of biological sciences 2023;19(2):593-609
International journal of biological sciences 2023;19(2):593-609
Inhibition of USP10 induces myeloma cell apoptosis by promoting cyclin D3 degradation.
Xu YJ, Zeng K, Ren Y, Mao CY, Ye YH, Zhu XT, Sun ZY, Cao BY, Zhang ZB, Xu GQ, Huang ZQ, Mao XL
Acta pharmacologica Sinica 2023 Sep;44(9):1920-1931
Acta pharmacologica Sinica 2023 Sep;44(9):1920-1931
LncRNA AGPG Confers Endocrine Resistance in Breast Cancer by Promoting E2F1 Activity.
Yu S, Wang Y, Gong X, Fan Z, Wang Z, Liang Z, Wu R, Cao B, Wang N, Bi C, Lv D, Sun H
Cancer research 2023 Oct 2;83(19):3220-3236
Cancer research 2023 Oct 2;83(19):3220-3236
Overexpression of RACGAP1 by E2F1 Promotes Neuroendocrine Differentiation of Prostate Cancer by Stabilizing EZH2 Expression.
Song Z, Cao Q, Guo B, Zhao Y, Li X, Lou N, Zhu C, Luo G, Peng S, Li G, Chen K, Wang Y, Ruan H, Guo Y
Aging and disease 2023 Oct 1;14(5):1757-1774
Aging and disease 2023 Oct 1;14(5):1757-1774
TRIM28 recruits E2F1 to regulate CBX8-mediated cell proliferation and tumor metastasis of ovarian cancer.
Zhang F, Zhu T, Wu C, Shen D, Liu L, Chen X, Guan Y, Ding H, Tong X
Human cell 2023 Nov;36(6):2113-2128
Human cell 2023 Nov;36(6):2113-2128
NCAPD2 promotes breast cancer progression through E2F1 transcriptional regulation of CDK1.
He J, Gao R, Yang J, Li F, Fu Y, Cui J, Liu X, Huang K, Guo Q, Zhou Z, Wei W
Cancer science 2023 Mar;114(3):896-907
Cancer science 2023 Mar;114(3):896-907
FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression.
Zhang Y, He B, Zhang D, Zhang Y, Chen C, Zhang W, Yang S, Yao M, Cui G, Gu J, Wang T, Lin Z, Fan Y, Xiong Z, Hao Y
Cell reports 2023 Mar 28;42(3):112188
Cell reports 2023 Mar 28;42(3):112188
TUBA1C: a new potential target of LncRNA EGFR-AS1 promotes gastric cancer progression.
Wang H, Cui H, Yang X, Peng L
BMC cancer 2023 Mar 20;23(1):258
BMC cancer 2023 Mar 20;23(1):258
N-Acetyl-L-Cysteine Reduces Cervical Carcinogenesis by Promoting Apoptosis.
Guo W, Jing W
Drugs in R&D 2023 Jun;23(2):165-174
Drugs in R&D 2023 Jun;23(2):165-174
Ubiquitin-specific peptidase 14 maintains estrogen receptor α stability via its deubiquitination activity in endometrial cancer.
Su Y, Zeng K, Liu S, Wu Y, Wang C, Wang S, Lin L, Zou R, Sun G, Luan R, Zhou B, Bai Y, Niu J, Zhang Y, Zhao Y
The Journal of biological chemistry 2023 Jan;299(1):102734
The Journal of biological chemistry 2023 Jan;299(1):102734
E2F1 combined with LINC01004 super-enhancer to promote hepatocellular carcinoma cell proliferation and metastasis.
Li J, Wang J, Wang Y, Zhao X, Su T
Clinical epigenetics 2023 Jan 31;15(1):17
Clinical epigenetics 2023 Jan 31;15(1):17
Transferrin Receptor-Mediated Iron Uptake Promotes Colon Tumorigenesis.
Kim H, Villareal LB, Liu Z, Haneef M, Falcon DM, Martin DR, Lee HJ, Dame MK, Attili D, Chen Y, Varani J, Spence JR, Kovbasnjuk O, Colacino JA, Lyssiotis CA, Lin HC, Shah YM, Xue X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(10):e2207693
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(10):e2207693
Inhibition of Angiogenesis by MiR-524-5p through Suppression of AKT and ERK Activation by Targeting CXCR7 in Colon Cancer Cells.
Li X, Li Z, Li C, Fang Y, Zhang G, Yan Y, Zhao X, Song X, Zhang Z
Journal of oncology 2022;2022:7224840
Journal of oncology 2022;2022:7224840
Analysis of regulating activities of 5'-epiequisetin on proliferation, apoptosis, and migration of prostate cancer cells in vitro and in vivo.
Wang X, Luo X, Gan X, Chen C, Yang Z, Wen J, Fang W, Huang H, Gao C, Zhou X, Feng X, Liu Y
Frontiers in pharmacology 2022;13:920554
Frontiers in pharmacology 2022;13:920554
E2F1-mediated GINS2 transcriptional activation promotes tumor progression through PI3K/AKT/mTOR pathway in hepatocellular carcinoma.
Zhang Y, Hao X, Han G, Lu Y, Chen Z, Zhang L, Wu J, Wang X
American journal of cancer research 2022;12(4):1707-1726
American journal of cancer research 2022;12(4):1707-1726
POLD2 is activated by E2F1 to promote triple-negative breast cancer proliferation.
Zhang Z
Frontiers in oncology 2022;12:981329
Frontiers in oncology 2022;12:981329
Thymidine Kinase 1 Drives Skin Cutaneous Melanoma Malignant Progression and Metabolic Reprogramming.
Zuo S, Wang H, Li L, Pan H, Lu L
Frontiers in oncology 2022;12:802807
Frontiers in oncology 2022;12:802807
Icaritin inhibits CDK2 expression and activity to interfere with tumor progression.
Zhang C, Wang X, Zhang C
iScience 2022 Sep 16;25(9):104991
iScience 2022 Sep 16;25(9):104991
Integrating network pharmacology deciphers the action mechanism of Zuojin capsule in suppressing colorectal cancer.
Fan JH, Xu MM, Zhou LM, Gui ZW, Huang L, Li XG, Ye XL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153881
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153881
Long non-coding RNA SNHG1 activates glycolysis to promote hepatocellular cancer progression through the miR-326/PKM2 axis.
Wang Y, Yang F, Peng Q, Mei K, He H, Yang Q
The journal of gene medicine 2022 Aug;24(8):e3440
The journal of gene medicine 2022 Aug;24(8):e3440
U2 small nuclear RNA auxiliary factor 2, transcriptionally activated by the transcription factor Dp-1/E2F transcription factor 1 complex, enhances the growth and aerobic glycolysis of leiomyosarcoma cells.
Li Y, Chen S, Zhang X, Zhuo N
Bioengineered 2022 Apr;13(4):10200-10212
Bioengineered 2022 Apr;13(4):10200-10212
RFWD3 Participates in the Occurrence and Development of Colorectal Cancer via E2F1 Transcriptional Regulation of BIRC5.
Xu F, Xiao Z, Fan L, Ruan G, Cheng Y, Tian Y, Chen M, Chen D, Wei Y
Frontiers in cell and developmental biology 2021;9:675356
Frontiers in cell and developmental biology 2021;9:675356
Deletion of p16 accelerates fracture healing in geriatric mice.
Ding Q, Liu H, Liu L, Ma C, Qin H, Wei Y, Ren Y
American journal of translational research 2021;13(10):11107-11125
American journal of translational research 2021;13(10):11107-11125
FGF14-AS2 accelerates tumorigenesis in glioma by forming a feedback loop with miR-320a/E2F1 axis.
Zhang P, Gu X, Zhang N, Liu L, Dong X, Li H, Cheng S, Li S, Yuan J, Li Y, Dong J
Journal of Cancer 2021;12(21):6429-6438
Journal of Cancer 2021;12(21):6429-6438
Myricanol Inhibits Platelet Derived Growth Factor-BB-Induced Vascular Smooth Muscle Cells Proliferation and Migration in vitro and Intimal Hyperplasia in vivo by Targeting the Platelet-Derived Growth Factor Receptor-β and NF-κB Signaling.
Fan S, Wang C, Huang K, Liang M
Frontiers in physiology 2021;12:790345
Frontiers in physiology 2021;12:790345
Down-regulation of lncRNA HCG11 promotes cell proliferation of oral squamous cell carcinoma through sponging miR-455-5p.
Wu J, Li Y, Liu J, Xu Y
The journal of gene medicine 2021 Mar;23(3):e3293
The journal of gene medicine 2021 Mar;23(3):e3293
The influence of phenolic environmental estrogen on the transcriptome of uterine leiomyoma cells: A whole transcriptome profiling-based analysis.
Li Z, Yin H, Shen Y, Ren M, Xu X
Ecotoxicology and environmental safety 2021 Mar 15;211:111945
Ecotoxicology and environmental safety 2021 Mar 15;211:111945
Gypenoside LI arrests the cell cycle of breast cancer in G0/G1 phase by down-regulating E2F1.
Zu ML, Duan Y, Xie JB, Qi YS, Xie P, Borjigidai A, Piao XL
Journal of ethnopharmacology 2021 Jun 12;273:114017
Journal of ethnopharmacology 2021 Jun 12;273:114017
FOXO1 inhibits prostate cancer cell proliferation via suppressing E2F1 activated NPRL2 expression.
Tang Y, Jiang L, Zhao X, Hu D, Zhao G, Luo S, Du X, Tang W
Cell biology international 2021 Dec;45(12):2510-2520
Cell biology international 2021 Dec;45(12):2510-2520
High-dose copper activates p53-independent apoptosis through the induction of nucleolar stress in human cell lines.
Chen CH, Chou YT, Yang YW, Lo KY
Apoptosis : an international journal on programmed cell death 2021 Dec;26(11-12):612-627
Apoptosis : an international journal on programmed cell death 2021 Dec;26(11-12):612-627
Cell division cycle associated 8: A novel diagnostic and prognostic biomarker for hepatocellular carcinoma.
Cui XH, Peng QJ, Li RZ, Lyu XJ, Zhu CF, Qin XH
Journal of cellular and molecular medicine 2021 Dec;25(24):11097-11112
Journal of cellular and molecular medicine 2021 Dec;25(24):11097-11112
MicroRNA miR-188-5p as a mediator of long non-coding RNA MALAT1 regulates cell proliferation and apoptosis in multiple myeloma.
Liu H, Chi Z, Jin H, Yang W
Bioengineered 2021 Dec;12(1):1611-1626
Bioengineered 2021 Dec;12(1):1611-1626
E2F1 mediated DDX11 transcriptional activation promotes hepatocellular carcinoma progression through PI3K/AKT/mTOR pathway.
Yu Y, Zhao D, Li K, Cai Y, Xu P, Li R, Li J, Chen X, Chen P, Cui G
Cell death & disease 2020 Apr 24;11(4):273
Cell death & disease 2020 Apr 24;11(4):273
Augmentation of the therapeutic efficacy of WEE1 kinase inhibitor AZD1775 by inhibiting the YAP-E2F1-DNA damage response pathway axis.
Oku Y, Nishiya N, Tazawa T, Kobayashi T, Umezawa N, Sugawara Y, Uehara Y
FEBS open bio 2018 Jun;8(6):1001-1012
FEBS open bio 2018 Jun;8(6):1001-1012
siRNA Delivery for Control of Cyclin D1 and E2F1 Expression in Crohn's Disease.
Russo I, Carrizzo A, Bochicchio S, Piazza O, Lamberti G, Barba AA, Vecchione C, Zeppa P, Iovino P, Bucci C, Santonicola A, Ciacci C
Translational medicine @ UniSa 2017 Jul;17:25-33
Translational medicine @ UniSa 2017 Jul;17:25-33
siRNA Delivery for Control of Cyclin D1 and E2F1 Expression in Crohn's Disease.
Russo I, Carrizzo A, Bochicchio S, Piazza O, Lamberti G, Barba AA, Vecchione C, Zeppa P, Iovino P, Bucci C, Santonicola A, Ciacci C
Translational medicine @ UniSa 2017 Jul;17:22-30
Translational medicine @ UniSa 2017 Jul;17:22-30
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